Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Gravi-Agari Ingredients & Drug Interactions

by Amazon Therapeutics

Gravi-Agari label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gravi-Agari against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gravi-Agari is a dietary supplement by Amazon Therapeutics with 4 active ingredients. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agaricus brasiliensis, Graviola. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gravi-Agari by Amazon Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Gravi-Agari by Amazon Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gravi-Agari by Amazon Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.

Gravi-Agari is a liquid supplement with 4 ingredients. The two active ones are graviola and agaricus brasiliensis (a medicinal mushroom).

The product also contains distilled water and 30–40% organic alcohol as the liquid base and preservative. There are no other inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: muscle wellness.
  • We looked for evidence on: muscle strength, muscle function, musculoskeletal health.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for both active ingredients is limited. Graviola has been studied for human papillomavirus (HPV), headache, and use as an insect repellent, as well as male infertility, but we do not have sufficient reliable evidence to rate it for any of these.

Agaricus mushroom has been studied for allergic rhinitis (hay fever), osteoporosis, cancer, cardiovascular disease, chemotherapy side effects, and Crohn disease, but again the reliable evidence is insufficient to rate it. Neither ingredient has established effectiveness in our data.

The evidence, ingredient by ingredient Graviola Agaricus Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both ingredients carry safety cautions. Graviola has limited safety data and lab studies raise concerns about possible nerve toxicity with long-term use.

The most common side effects from graviola are stomach pain and nausea. Rare but serious effects include movement disorders and nerve damage (myeloneuropathy) — symptoms similar to Parkinson disease.

People with Parkinson disease should avoid it, as even small amounts may worsen motor and cognitive symptoms. Agaricus mushroom is generally well tolerated as a food, but supplement safety and long-term effects are not well established.

Most common side effects are abdominal discomfort, diarrhea, and nausea. Rare serious effects include allergic reactions, liver damage, and interstitial lung disease (a lung condition).

Graviola is rated possibly unsafe in pregnancy and should be avoided while breastfeeding. Agaricus mushroom should be avoided at supplement doses during pregnancy and breastfeeding — not enough safety data exists for either.

Side effects, ingredient by ingredient Graviola Agaricus Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Graviola, Agaricus Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 87 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take carbamazepine (Tegretol) for seizures — graviola may significantly lower its levels. Also check if you take any antidiabetes drugs, as agaricus mushroom may increase the risk of low blood sugar.

Use the search tool on this page to verify your exact medications before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines two ingredients with limited evidence of effectiveness and several safety concerns, particularly around nerve and liver effects. If you take seizure medication or antidiabetes drugs, you must check with your doctor or pharmacist before using it — both ingredients may interfere with how these medications work.

If you are pregnant, breastfeeding, or have a history of movement disorders or liver issues, talk with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gravi-Agari, straight from the product label.

Brand Amazon Therapeutics
Barcode (UPC) 838451007688
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 217771
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gravi-Agari by Amazon Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Drop(s)
Maximum serving Sizes:
15 Drop(s)
UPC/BARCODE
838451007688
IngredientAmount% DV
distilled Water0 NP--
30-40% organic Alcohol0 NP--
Graviola0 NP--
Agaricus brasiliensis0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Your Selection You hold in your hands the finest traditional botanical available. This botanical is a long-standing favorite of South America where it has been empirically selected for its effectiveness over many generations.

Direct from the source

Traditional Ethnobotanical Information Amazon Therapeutics works for the preservation of rainforests and to uphold the intellectual property rights of native healers and their traditional medicines.

Suggested/Recommended/Usage/Directions

Suggested Directions Take 10-15 drops two to three times daily or as recommended by a health care practitioner.

Precautions

Cautions: Information provided on this label should not be used as medical advice. Not intended for long-term use.

Not intended for pregnant or nursing women.

Keep out of the reach of children.

Formulation

Muscle wellness

Wild crafted sustainable harvest

Gluten free

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

EarthKosher

Formula

EarthKosher

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gravi-Agari by Amazon Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gravi-Agari label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gravi-Agari by Amazon Therapeutics

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 Drop(s) Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Distilled Water

0 NP per serving

30-40% organic Alcohol

0 NP per serving

Graviola

Interacts with
1 drug
0 NP per serving

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...

Graviola monograph & interactions

Agaricus brasiliensis

Interacts with
86 drugs
0 NP per serving

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects...

Agaricus brasiliensis monograph & interactions
Interaction report

Gravi-Agari by Amazon Therapeutics Drug Interactions

Want to check YOUR meds against Gravi-Agari?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Agaricus brasiliensis 86
Graviola 1

Individual Drug Interactions

The ingredients in Gravi-Agari interact with 87 drugs. Click any drug to see the details.

2 of the 4 ingredients in Gravi-Agari interact with drugs. Each result below shows which ingredient is responsible. Agaricus brasiliensis Graviola

Each ingredient & the kinds of drugs it affects

For each ingredient in Gravi-Agari with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Agaricus brasiliensis1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
Agaricus brasiliensis full monograph & interactions

Graviola1 drug type · 1 drug

Carbamazepine (Tegretol)

Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.

Likelihood Possible Evidence D
Graviola full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gravi-Agari, from the product label.

Amazon Therapeutics

See all Amazon Therapeutics products
Name
Herbs America
Street Address
PO Box 446
City
Murphy
State
OR
ZipCode
97533
Phone Number
541-846-6222
Web Address
www.amazonmedicine.com
Pharmacist Counseling Corner

Gravi-Agari by Amazon Therapeutics: Common Questions

Does Gravi-Agari by Amazon Therapeutics interact with any medications?
Yes. Based on its ingredients, Gravi-Agari has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gravi-Agari contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are graviola and agaricus mushroom supposed to do?
Graviola has been studied for human papillomavirus, headache, and insect repellent properties, among other uses. Agaricus mushroom has been studied for allergic rhinitis, osteoporosis, cancer, heart disease, and Crohn disease. However, we don't have enough reliable evidence to say either one works for any of these — the research is still inconclusive.
Can I take this while I'm pregnant or breastfeeding?
No. Graviola is rated possibly unsafe in pregnancy and should be avoided while breastfeeding. Agaricus mushroom doesn't have enough safety data, so it's best to avoid supplement doses during both pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What are the most common side effects?
From graviola, the most common are stomach pain and nausea. From agaricus mushroom, they are abdominal discomfort, diarrhea, and nausea. Both are generally mild, but graviola raises concerns about nerve toxicity with long-term use, and agaricus mushroom carries a rare risk of liver damage.
I have Parkinson disease — is this safe for me?
No. Studies show that even small amounts of graviola, which is in this product, are associated with worsening movement and cognitive symptoms in people with Parkinson disease. You should avoid this product. Talk with your doctor if you have questions.
Why does this product have 30–40% alcohol in it?
Organic alcohol is used in liquid supplements as a preservative and to help extract and dissolve the plant ingredients. We do not hold interaction data for alcohol itself in this product context, so if you have concerns about the alcohol content, discuss them with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gravi-Agari label
Go deeper

The Full Monographs Behind Gravi-Agari’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Graviola

Interacts with 1 drug

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...

Read the full Graviola monograph → Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph →
Sources

Sources & How We Checked

Gravi-Agari's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Graviola 4 references
  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

See these in context on the Graviola monograph →

Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

See these in context on the Agaricus Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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