Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Helix-24 Ingredients & Drug Interactions

by Rivalus

Helix-24 label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Helix-24 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Helix-24 is a dietary supplement by Rivalus with 3 active ingredients. Its ingredients are commonly taken for improving high-intensity exercise performance, building muscle strength and size, sports and athletic training.Based on those ingredients, 419 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are y-aminobutyric acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Helix-24 by Rivalus

Ask about any prescription or over-the-counter medication and we check it for interactions with Helix-24 by Rivalus — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Helix-24 by Rivalus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “HELIX-24 Proprietary Blend(TM)” is a proprietary blend — the label gives one combined amount (2,960 mg) without saying how much of each component you get.

Helix-24 contains 3 active ingredients in a proprietary blend. The first is creatine (a-methyl guanidino acetic acid), a compound your muscles use for energy — it's been studied for muscle strength, sarcopenia (age-related muscle loss), and athletic performance.

The second is GABA (gamma-aminobutyric acid), a brain chemical involved in relaxation and sleep. The third is gamma-oryzanol, a plant compound from rice bran.

The capsule also contains inactive ingredients: gelatin, magnesium stearate, silica, and microcrystalline cellulose.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: enhance growth factors muscle strength and athletic performance.
  • We looked for evidence on: Athletic performance, Muscle strength, Physical performance.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Muscle strength.
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

Creatine is possibly effective for sarcopenia, cerebral creatine deficiency syndromes, muscle strength, and athletic performance, but possibly ineffective for Huntington disease and osteopenia. GABA's effectiveness is not established in the data we hold — anxiety, ADHD, athletic performance, and other uses have insufficient reliable evidence to rate.

Gamma-oryzanol is possibly effective for dyslipidemia (abnormal cholesterol levels), but athletic performance and eczema have insufficient evidence.

The evidence, ingredient by ingredient Creatine Gamma-aminobutyric Acid (gaba) Gamma-oryzanol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Creatine is generally well tolerated orally, though common side effects include dehydration, diarrhea, stomach upset, muscle cramps, and water retention. Rare serious effects (case reports only) include kidney inflammation, kidney problems, muscle breakdown, and blood clots; however, liver injury has not been confirmed in clinical studies.

People with kidney disease should be cautious. GABA is often well tolerated short-term, with common side effects being drowsiness, stomach upset, throat burning, muscle weakness, and nausea — though long-term safety is not well studied.

Gamma-oryzanol is generally well tolerated in studies, but long-term safety data are limited. Creatine safety has not been established in pregnancy and is best avoided; there is not enough information for nursing mothers, so avoid use.

GABA and gamma-oryzanol both lack sufficient safety data in pregnancy and lactation — talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Creatine Gamma-aminobutyric Acid (gaba) Gamma-oryzanol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Gamma-aminobutyric Acid (gaba).
  • The most serious interaction on file is rated Moderate.
  • For scale: 419 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Helix-24, double-check with your doctor or pharmacist if you take antihypertensive drugs (blood pressure medications) — GABA may lower blood pressure further. Also confirm if you use any CNS depressants such as sedatives, sleep aids, anxiety medications, or opioids, since GABA could add to their drowsy effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Helix-24 may interest you if you're looking to support muscle strength or athletic performance through creatine, though the evidence for GABA and gamma-oryzanol in this product is less clear. If you take blood pressure medication or any CNS depressant (including sleep aids or anxiety medications), check with your doctor or pharmacist before starting, since GABA may interact.

Those with kidney problems should also talk to their healthcare provider first. This product is best avoided in pregnancy and lactation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Helix-24, straight from the product label.

Brand Rivalus
Net contents 240 Sustained-Release Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2013
DSLD ID 17997
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Helix-24 by Rivalus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
IngredientAmount% DV
HELIX-24 Proprietary Blend(TM)2960 mg--
a-methyl guanidino acetic acid0 NP--
y-aminobutyric acid0 NP--
y-oryzanol0 NP--

Other ingredients: Gelatin, Magnesium Sterate, Silica, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Use: Dr. Darren Burke (PhD) recommends 4 capsules in the morning with 1-2 glasses of water. For best results use HELIX-24 every day and combine with resistance exercise 3-5 days per week.

General Statements

HELIX-24 is a dietary supplement used by male and female athletes during training, competition and recovery to immediately enhance endogenous (natural) growth factors.* HELIX-24 is the first 24 hour growth factor release formula ever created.* It is scientifically designed to activate anabolic growth 24 hours a day at the gene level by increasing growth factor production. The ingredients in HELIX-24 help you overcome your genetic limitations by activating natural cellular processes that trigger dramatic increases in muscle size and strength. The Sustained-Release HELIX-24 formula targets the many pulses of growth that occur all day long, amplifying the peak and duration of each secretion. This results in more total daily growth factor release than those supplements targeting only night-time growth factor release. Daily elevation in total growth factors lead to dramatic growth in muscle size and strength.*

HELIX-24

In a 6-week clinical trial subjects consuming HELIX-24 and ENPULSE and following a structured weight training program increased growth factor markers, free testosterone and increased muscle mass and strength significantly more than placebo group subjects.

NEW

ANABOLIC PRESCRIPTION is a dietary supplement used by male and female athletes during training, competition and recovery to immediately enhance natural anabolic hormone levels, gene expression, and stimulate muscle growth.* ANABOLIC PRESCRIPTION is the most powerful stack ever created.* It is the ultimate combination of the two most powerful hormone support supplements available on the market today: ENPULSE and HELIX-24. Our team of leading scientists tested the combination of ENPULSE and HELIX-24 and found INCREDIBLE increases in anabolic hormone levels, gene expression, and muscle growth. These changes were more that the significant gains noted when taking ENPULSE or HELIX-24 alone and can only be attributed to the synergistic effect of these unique formulae on human hormone and muscle gene therapy. "I recommend ANABOLIC PRESCRIPTION for creating functional muscle gains fast" RIVALUS CEO & Founder, Dr. Darren Burke RIVALUS Sponsors Athletes and Supports Academic Research.

OWN YOUR PERFORMANCE

MOST POWERFUL MUSCLE GROWTH STACK EVER CREATED

CREATES FUNCTIONAL MUSCLE GAINS FAST INCREASES RECOVERY, GROWTH & AGGRESSION

CLINICALLY TESTED

ANABOLIC PRESCRIPTION Study Reports Rapid Increase in Muscle Mass & Strength In a randomized, double-blind, placebo controlled study thirty male athletes consuming ANABOLIC PRESCRIPTION for 6 weeks and exercising regularly increased muscle mass by up to 31% and 1 RM bench press strength by up to 38% compared to changes of 6% and 15% respectively for placebo group subjects.

(graph) % INCREASE 40 35 30 25 20 15 10 5 0 ANABOLIC PRESCRIPTION PLACEBO 6% 31% 15% 38% MASS STRENGTH

ANABOLIC PRESCRIPTION was clinically tested on athletes to confirm that it maintains normal physiological function (Safe) while improving performance (Effective).

Made in USA

Precautions

Discontinue use two weeks prior to surgery. Do not exceed maximum daily dosage. Do not use if safety seal is broken.

For adult use only. KEEP OUT OF REACH OF CHILDREN.

Warning: Consult a physician before using if you are unaware of your current health status, if you have a medical condition, or if you or your family has a medical history of cardiovascular disease, diabetes, psychological disorders, hormonal abnormalities, or if you are taking any prescription drug. This product is not intended for use by those with a serious medical condition or pregnant or lactating women.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, cure, treat or prevent any disease.

Brand IP Statement(s)

(C)2010 RIVALUS Inc.

powered by PERMEATE(TM) Delivery Technology 8x Greater Absorption & Effects

Formula

DESIGNED FOR ATHLETES

FDA Statement of Identity

DIETARY SUPPLEMENT

Seals/Symbols

(CHECK) THIS PRODUCT WILL NOT CAUSE AN ADVERSE ANALYTICAL FINDING AS DEFINED BY THE INTERNATIONAL OLYMPIC COMMITTEE (IOC) OR WORLD ANTI-DOPING AGENCY (WADA).

(check) SAFE Safe And Effective First(TM)

Good Manufacturing Practices GMP

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Helix-24 by Rivalus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Helix-24 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Helix-24 by Rivalus

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

HELIX-24 Proprietary Blend(TM)

2960 mg per serving

Other (inactive) ingredients: Gelatin, Magnesium Sterate, Silica, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Helix-24 by Rivalus Drug Interactions

Want to check YOUR meds against Helix-24?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
419Drugs
172 Moderate 247 Minor

Ingredients driving the most interactions

y-aminobutyric acid 419

Individual Drug Interactions

The ingredients in Helix-24 interact with 419 drugs. Click any drug to see the details.

1 of the 3 ingredients in Helix-24 interact with drugs. Each result below shows which ingredient is responsible. y-aminobutyric acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Helix-24 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

y-aminobutyric acid2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
y-aminobutyric acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Helix-24, from the product label.

Rivalus

See all Rivalus products
Web Address
www.rivalus.net
Pharmacist Counseling Corner

Helix-24 by Rivalus: Common Questions

Does Helix-24 by Rivalus interact with any medications?
Yes. Based on its ingredients, Helix-24 has a known interaction with 419 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Helix-24 contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is creatine, and why is it in this product?
Creatine is a compound your muscles naturally use for energy during exercise. It's included here because evidence suggests it may help with muscle strength, athletic performance, and sarcopenia (age-related muscle loss).
What are the most common side effects of creatine?
The most common side effects are dehydration, diarrhea, stomach upset, muscle cramps, and water retention. Serious side effects are rare but have been reported in case studies.
Can I take Helix-24 if I have kidney problems?
The safety data advises caution if you have kidney issues. Talk with your doctor or pharmacist before taking this product, since creatine needs careful monitoring in that situation.
Is it safe to take Helix-24 while pregnant or breastfeeding?
Creatine safety has not been established in pregnancy and is best avoided. There is not enough information for nursing mothers either. Talk with your doctor or pharmacist about whether this product is appropriate for you.
Does this product have any fillers or binders?
Yes — the capsule contains gelatin, magnesium stearate, silica, and microcrystalline cellulose as inactive ingredients.
What does GABA do?
GABA is a brain chemical involved in relaxation and sleep. However, evidence for its effectiveness in anxiety, ADHD, and other uses is insufficient — we don't have solid data showing it works for those purposes yet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Helix-24 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Helix-24 label
Go deeper

The Full Monographs Behind Helix-24’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph → Herb & supplement monograph

Gamma-oryzanol

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes fro...

Read the full Gamma-oryzanol monograph →
Sources

Sources & How We Checked

Helix-24's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 98 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Creatine 86 references
  1. Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999;340:814-5. PubMed
  2. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  3. Greenhaff P. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;352:233-4. PubMed
  4. Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training (abstract). J Appl Physiol 1997;83:2055-63. PubMed
  5. Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. J Appl Physiol 1996;81:232-7. PubMed
  6. Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;351:1252-3. PubMed
  7. Poortmans JR, Auquier H, Renaut V, et al. Effect of short-term creatine supplementation on renal responses in men (abstract). Eur J Appl Physiol Occup Physiol 1997;76:566-7. PubMed
  8. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108-10. PubMed
  9. Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc 2000;32:291-6. PubMed
  10. Rawson ES, Wehnert ML, Clarkson PM. Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol Occup Physiol 1999;80:139-44. PubMed
  11. Earnest CP, Almada AL, Mitchell TL. High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin Sci (Colch) 1996;91:113-8. PubMed
  12. Juhn MS. Oral creatine supplementation. Separating fact from hype. Phys Sportsmed 1999;27:47-50,53-54,56,61,89. PubMed
  13. Juhn MS, O'Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999;99:593-5.
  14. Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 1996;271:E821-6. PubMed
  15. Balsom PD, Soderlund K, Sjodin B, Ekblom B. Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation. Acta Physiol Scand 1995;154:303-10. PubMed
  16. Snow RJ, McKenna MJ, Selig SE, et al. Effect of creatine supplementation on sprint exercise performance and muscle metabolism. (abstract) J Appl Physiol 1998;84:1667-73. PubMed
  17. McNaughton LR, Dalton B, Tarr J. The effects of creatine supplementation on high-intensity exercise performance in elite performers. (abstract) Eur J Appl Physiol Occup Physiol 1998;78:236-40. PubMed
  18. Groeneveld GJ, Veldink JH, van der Tweel I, et al. A randomized sequential trial of creatine in amyotrophic lateral sclerosis. Ann Neurol 2003;53:437-45. . PubMed
  19. Robinson SJ. Acute quadriceps compartment syndrome and rhabdomyolysis in a weight lifter using high-dose creatine supplementation. J Am Board Fam Pract 2000;13:134-7. PubMed
  20. Kammer RT. Lone atrial fibrillation associated with creatine monohydrate supplementation. Pharmacotherapy 2005;25:762-4. PubMed
  21. Gualano B, Ugrinowitsch C, Novaes RB, et al. Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial. Eur J Appl Physiol 2008;103:33-40. PubMed
  22. Pfeffer, G., Majamaa, K., Turnbull, D. M., Thorburn, D., and Chinnery, P. F. Treatment for mitochondrial disorders. Cochrane Database.Syst.Rev. 2012;4:CD004426. PubMed
  23. Boos, C. J., White, S. H., Bland, S. A., and McAllister, P. D. Dietary supplements and military operations: caution is advised. J R.Army Med Corps 2010;156(1):41-43. PubMed
  24. Kreider, R. B. Dietary supplements and the promotion of muscle growth with resistance exercise. Sports Med 1999;27(2):97-110. PubMed
  25. Juhn, M. S., O'Kane, J. W., and Vinci, D. M. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am.Diet.Assoc 1999;99(5):593-595.
  26. Volek, J. S., Duncan, N. D., Mazzetti, S. A., Putukian, M., Gomez, A. L., and Kraemer, W. J. No effect of heavy resistance training and creatine supplementation on blood lipids. Int J Sport Nutr.Exerc.Metab 2000;10(2):144-156. PubMed
  27. Robinson, T. M., Sewell, D. A., Casey, A., Steenge, G., and Greenhaff, P. L. Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function. Br.J Sports Med 2000;34(4):284-288. PubMed
  28. Tarnopolsky, M. A. Potential benefits of creatine monohydrate supplementation in the elderly. Curr.Opin.Clin Nutr.Metab Care 2000;3(6):497-502. PubMed
  29. Tarnopolsky, M. A. and MacLennan, D. P. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr.Exerc.Metab 2000;10(4):452-463. PubMed
  30. Arciero, P. J., Hannibal, N. S., III, Nindl, B. C., Gentile, C. L., Hamed, J., and Vukovich, M. D. Comparison of creatine ingestion and resistance training on energy expenditure and limb blood flow. Metabolism 2001;50(12):1429-1434. PubMed
  31. Chrusch, M. J., Chilibeck, P. D., Chad, K. E., Davison, K. S., and Burke, D. G. Creatine supplementation combined with resistance training in older men. Med Sci.Sports Exerc. 2001;33(12):2111-2117. PubMed
  32. Cox, G., Mujika, I., Tumilty, D., and Burke, L. Acute creatine supplementation and performance during a field test simulating match play in elite female soccer players. Int J Sport Nutr.Exerc.Metab 2002;12(1):33-46. PubMed
  33. Kilduff, L. P., Vidakovic, P., Cooney, G., Twycross-Lewis, R., Amuna, P., Parker, M., Paul, L., and Pitsiladis, Y. P. Effects of creatine on isometric bench-press performance in resistance-trained humans. Med Sci.Sports Exerc. 2002;34(7):1176-1183. PubMed
  34. Brose, A., Parise, G., and Tarnopolsky, M. A. Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J Gerontol A Biol.Sci.Med Sci. 2003;58(1):11-19. PubMed
  35. Volek, J. S., Ratamess, N. A., Rubin, M. R., Gomez, A. L., French, D. N., McGuigan, M. M., Scheett, T. P., Sharman, M. J., Hakkinen, K., and Kraemer, W. J. The effects of creatine supplementation on muscular performance and body composition responses to
  36. Tyler, T. F., Nicholas, S. J., Hershman, E. B., Glace, B. W., Mullaney, M. J., and McHugh, M. P. The effect of creatine supplementation on strength recovery after anterior cruciate ligament (ACL) reconstruction: a randomized, placebo-controlled, double-b DOI
  37. Groeneveld, G. J., Beijer, C., Veldink, J. H., Kalmijn, S., Wokke, J. H., and van den Berg, L. H. Few adverse effects of long-term creatine supplementation in a placebo-controlled trial. Int J Sports Med 2005;26(4):307-313. PubMed
  38. Astorino, T. A., Marrocco, A. C., Gross, S. M., Johnson, D. L., Brazil, C. M., Icenhower, M. E., and Kneessi, R. J. Is running performance enhanced with creatine serum ingestion? J Strength.Cond.Res 2005;19(4):730-734. PubMed
  39. Cramer, J. T., Stout, J. R., Culbertson, J. Y., and Egan, A. D. Effects of creatine supplementation and three days of resistance training on muscle strength, power output, and neuromuscular function. J Strength.Cond.Res 2007;21(3):668-677. PubMed
  40. Young, P., De, Jonghe P., Stogbauer, F., and Butterfass-Bahloul, T. Treatment for Charcot-Marie-Tooth disease. Cochrane.Database.Syst.Rev. 2008;(1):CD006052. PubMed
  41. Ostojic, S. M. and Ahmetovic, Z. Gastrointestinal distress after creatine supplementation in athletes: are side effects dose dependent? Res.Sports Med. 2008;16(1):15-22. PubMed
  42. Whitt, K. N., Ward, S. C., Deniz, K., Liu, L., Odin, J. A., and Qin, L. Cholestatic liver injury associated with whey protein and creatine supplements. Semin.Liver Dis. 2008;28(2):226-231. PubMed
  43. Koenig CA, Benardot D Cody M Thompson WR. Comparison of creatine monohydrate and carbohydrate supplementation on repeated jump height performance. J Strength Cond Res. 2008;22(4):1081-1086. PubMed
  44. Gordon, P. H., Cheung, Y. K., Levin, B., Andrews, H., Doorish, C., Macarthur, R. B., Montes, J., Bednarz, K., Florence, J., Rowin, J., Boylan, K., Mozaffar, T., Tandan, R., Mitsumoto, H., Kelvin, E. A., Chapin, J., Bedlack, R., Rivner, M., McCluskey, L.
  45. Bender, A., Samtleben, W., Elstner, M., and Klopstock, T. Long-term creatine supplementation is safe in aged patients with Parkinson disease. Nutr.Res. 2008;28(3):172-178. PubMed
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  47. Gualano, B., Ferreira, D. C., Sapienza, M. T., Seguro, A. C., and Lancha, A. H., Jr. Effect of short-term high-dose creatine supplementation on measured GFR in a young man with a single kidney. Am.J.Kidney Dis. 2010;55(3):e7-e9. PubMed
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