Major interaction on record — check this product against your medications before combining. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

Hydroxycut Hardcore Ingredients & Drug Interactions

by MuscleTech Pro Series

Hydroxycut Hardcore label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hydroxycut Hardcore against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Hydroxycut Hardcore is a dietary supplement by MuscleTech Pro Series with 6 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 1,003 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin C, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hydroxycut Hardcore by MuscleTech Pro Series

Ask about any prescription or over-the-counter medication and we check it for interactions with Hydroxycut Hardcore by MuscleTech Pro Series — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Hydroxycut Hardcore by MuscleTech Pro Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 14 active ingredients.
  • “Hydroxycut Hardcore Pro Series Blend” is a proprietary blend — the label gives one combined amount (680 mg) without saying how much of each component you get.
  • “Epidyne” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “HydroxyPro” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Hydroxycut Hardcore contains 14 active and inactive ingredients. The active components include calcium for bone and mineral support, amino acids (L-leucine, L-methionine, L-tyrosine, and L-proline), vitamin C for immune function, caffeine anhydrous for energy and focus, oleic acid from oils for heart health, and plant extracts including capsicum (hot pepper), cumin, olive, and Alchemilla (lady's mantle).

Several ingredients are listed as proprietary blends—Hydroxycut Hardcore Pro Series Blend, Epidyne, HydroxyPro, Lipidrol, and Capsicore—whose specific component amounts aren't broken out on the label. Inactive ingredients include gelatin capsules, sesame oil, tricalcium phosphate, caramel color, and other capsule materials.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: weight loss and energy support.
  • We looked for evidence on: Athletic performance, Cognitive function, Appetite suppression, Metabolic rate.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Tyrosine is rated "Possibly Effective" for Cognitive function.
  • Also on file: Tyrosine is rated "Possibly Ineffective" for Athletic performance.

The evidence for this product's ingredients is mixed. Calcium is effective for bone health and mineral balance.

L-tyrosine is effective for a genetic condition called PKU and possibly helpful for cognitive function and memory, though athletic performance claims lack support. Vitamin C is effective for vitamin C deficiency and possibly helpful for anemia and cataracts.

Capsicum is likely effective for nerve pain conditions like postherpetic neuralgia and diabetic neuropathy, and possibly helpful for back pain and cluster headaches. For most other claimed uses in the blends—such as weight loss, metabolic boost, and fat burning—the product facts we hold don't provide effectiveness data.

Talk to your pharmacist about whether the specific claims match what the research supports.

The evidence, ingredient by ingredient Calcium Vitamin C

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 12 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 12 of 12.
  • General safety write-ups exist for 12 of 12.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended amounts, though high doses can cause constipation, diarrhea, and in rare cases kidney stones or calcification problems. Very high calcium intake (over 1500–2000 mg daily) has been weakly linked to increased prostate cancer risk and possibly cardiovascular disease, though the evidence is debated.

Caffeine commonly causes anxiety, insomnia, jitteriness, nausea, and diarrhea, especially at high doses, and rarely can trigger stroke or anaphylaxis in sensitive people. Vitamin C at high doses (above 2 grams daily) can cause kidney stones, heartburn, and diarrhea.

Capsicum causes burning, stomach upset, and diarrhea orally and burning when applied to skin. L-tyrosine may cause fatigue, headache, heartburn, and nausea.

L-methionine can raise homocysteine levels at high doses, a risk factor for heart disease. Alchemilla vulgaris and trans-ferulic acid lack established long-term safety data.

Side effects, ingredient by ingredient Calcium Vitamin C

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 8 of the 12 matched ingredients can interact with medications — Cumin, Alchemilla, Calcium, Capsicum, Caffeine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,003 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Hydroxycut Hardcore, double-check if you take HIV integrase inhibitors (dolutegravir, elvitegravir, raltegravir—Major risk from calcium), intravenous antibiotics like ceftriaxone (Major), or ephedrine or other stimulants (Major risk from caffeine). Also check for levothyroxine, sotalol, blood thinners like warfarin, diabetes medications, clozapine, quinolone antibiotics, barbiturate or non-barbiturate sedatives, anticonvulsants (phenobarbital, carbamazepine), and theophylline.

No interactions are documented for L-leucine and Menta longifolia extract, which we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is not appropriate if you take HIV medications, blood thinners, thyroid drugs, or antiseizure medications—calcium and other ingredients will interfere. It's also risky alongside stimulant drugs or high caffeine intake.

If you take diabetes drugs, heart medications, or any prescription, check your specific list with the tool below before starting. Talk to your pharmacist about whether the blend's claims match the evidence and whether the caffeine and stimulant load is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 12 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hydroxycut Hardcore, straight from the product label.

Brand MuscleTech Pro Series
Net contents 210 Liquid Capsule(s)
Market status On market
Date entered into DSLD Mar 23, 2012
DSLD ID 6503
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Women (not pregnant or lactating), Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hydroxycut Hardcore by MuscleTech Pro Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
105
IngredientAmount% DV
Calcium50 mg5%
L-Leucine0 NP--
L-Methionine0 NP--
L-Tyrosine0 NP--
L-Proline0 NP--
Vitamin C7 mg12%
Oleic Acid0 NP--
Trans-Ferulic Acid0 NP--
Hydroxycut Hardcore Pro Series Blend680 mg--
Epidyne0 NP--
Caffeine anhydrous0 NP--
HydroxyPro0 NP--
Alchemilla vulgaris extract0 NP--
Olea europaea extract0 NP--
Cuminum cyminum extract0 NP--
Menta longifolia extract0 NP--
Lipidrol0 NP--
Capsicore0 NP--
Capsicum annuum0 NP--

Other ingredients: Gelatin Capsule, SESAME OIL, Tricalcium Phosphate, Caramel color, INK, Gelatin, Polysorbate 80

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

DIRECTIONS: To assess individual tolerance, for the first two days, start with one (1) capsule, taken with a glass of water two (2) times daily, approximately 30 minutes before your two main meals. Do not snack after dinner or between meals. For days three and beyond, follow the chart below. Do not exceed two (2) caplets in a 4-hour period and/or six (6) caplets in a 24-hour period. Do not take within 5 hours of bedtime. For best results use HydroxycutTM Hardcore Pro SeriesTM for 8-12 weeks in conjunction with a calorie-reduced diet and regular exercise program. Consume 8-10 glasses of water per day. Read the entire label before use and follow directions.

Day 1 and Day 2 1 Capsule 2x daily Day 3 and Day 4 2 Capsules 2x daily Day 5 and Beyond 2 Capsules 3x daily

Precautions

KEEP OUT OF REACH OF CHILDREN.

Do not use if pregnant or nursing.

CONTAINS SOY AND WHEAT INGREDIENTS.

Discontinue use and consult a medical doctor if you experience unusual symptoms. Consult a medical doctor before use if you have been treated for, diagnosed with or have a family history of any medical condition or if you are using any prescription or over-the-counter drug(s), including blood thinners. One serving (2 capsules) of this product contains up to as much caffeine as three cups of coffee (325mg). Caffeine sensitive individuals may experience the following symptoms including (but not limited to) restlessness, nervousness, tremors, headache, anxiety, palpitations, increased heart rate, or difficulty sleeping. Do not combine with other sources of caffeine. Consult a medical doctor before starting any diet or exercise plan. Do not exceed recommended serving. Improper use of this product will not improve results and is not advised. Use only as directed.

Do not use if packaging has been tampered with.

WARNING: Not intended for use by persons under 18.

FDA Disclaimer Statement

?These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place (60(0)F to 80(0)F).

General Statements

• LOSE WEIGHT! ?,1,2 GET RIPPED! • Clinically Proven in 2 Studies: STUDY #1: Test Subjects Lost 7.3 Times More Weight than Placebo?, 3 STUDY #2: Subjects Lost 7.1 Times More Weight than Placebo?, 3 • Delivers Extreme Energy for Hardcore Intensity ?, 4

Capture this QR code with a QR code application on your Smartphone. www.hhps.com

Made in the U.S.A. from international and domestic ingredients.

NEW POWERFUL FORMULA

Research and development

Brand IP Statement(s)

(C) 2010. For lot no. and expiry date: see box.

BACKED BY CLINICAL RESEARCH STUDIES Backed by two gold-standard clinical studies on its powerful weight-loss complex, HydroxycutTM Hardcore Pro SeriesTM is dedicated to uncompromising quality, efficacy and results. If you train hard, eat with precision and are looking for a hardcore weight-loss formula that will help get you lean and ripped, you need to get on HydroxycutTM Hardcore Pro SeriesTM.?

CLINICALLY PROVEN IN 2 STUDIES! The key complex in HydroxycutTM Hardcore Pro SeriesTM was proven in two clinical studies! HydroxycutTM Hardcore Pro SeriesTM has two separate studies to support its ultra-effective key complex. 1 Study One: In one twelve-week, randomized, double-blind, placebo- controlled human clinical trial, 29 test subjects were given the key complex HydroxyPro(TM) (Alchemilla vulgaris extract, Olea europaea extract, Cuminum cyminum extract, Mentha longifolia extract) contained in HydroxycutTM Hardcore Pro SeriesTM or a placebo. Subjects using this key complex lost an average of 20.94 lbs. vs. those using the placebo, who lost an average of 1.70 lbs. Both groups followed a calorie reduced diet.? 2 Study Two: A separate eight-week clinical research trial on 61 human subjects, funded by the makers of HydroxycutTM Hardcore Pro SeriesTM, demonstrated that those who used the same key complex contained in HydroxycutTM Hardcore Pro SeriesTM lost an average of 16.50 lbs. vs. those using the placebo, who lost an average of 1.73 lbs.? Both groups followed a calorie-reduced diet. TEST SUBJECTS LOST 7 TIMES MORE WEIGHT THAN PLACEBO!? 3 Data analysis of the results from both clinical trials on the key ingredients in HydroxycutTM Hardcore Pro SeriesTM showed that there is statistical significance for test subjects losing 7 times more weight than placebo subjects.? DELIVERS EXTREME ENERGY FOR HARDCORE INTENSITY!? 4 HydroxycutTM Hardcore Pro SeriesTM also contains an ingredient (caffeine [1,3,7-trimethylxanthine]) that’s been shown to increase energy.? After your very first dose you’ll experience extreme energy for hardcore intensity!?

Go Online Now for FREE workout and nutrition tips and to learn more about HydroxycutTM Hardcore Pro SeriesTM.

In the second clinical trial, subjects who used the same key complex contained in HydroxycutTM Hardcore Pro SeriesTM lost an average of 16.50 lbs. vs. those using the placebo, who lost an average of 1.73 lbs.? See back panel for important study details. 5.0 10.0 15.0 20.0 STUDY #2: 8 WEEKS KEY INGREDIENTS IN HYDROXYCUT HARDCORE PRO SERIES(TM)16.50 LBS. PLACEBO LOST LOST 1.73 LBS.

LiquiTech(TM) Capsule shown not actual size.

LOSE WEIGHT! GET RIPPED!? Scientifically formulated with a clinically proven key complex, HydroxycutTM Hardcore Pro SeriesTM has been designed to deliver significant weight-loss results to help you get ripped! There are many weight-loss claims on the market today that are not supported by scientific evidence. As a leader, the HydroxycutTM Hardcore Pro SeriesTM key ingredients are backed by 2 clinical studies proving its ability to deliver real results.?

PROVEN WEIGHT-LOSS RESULTS IN 2 CLINICAL STUDIES!? In the first clinical trial, subjects using the key complex in HydroxycutTM Hardcore Pro SeriesTM lost an average of 20.94 lbs. vs. those using the placebo, who lost an average of 1.70 lbs.? See back panel for important study details. 5.0 10.0 15.0 20.0 STUDY #1: 12 WEEKS PLACEBO LOST 1.70 LBS. KEY INGREDIENTS IN HYDROXYCUT HARDCORE PRO SERIES(TM) LOST 20.94 LBS.

Seals/Symbols

Featuring LIQUITECH CAPSULES HYDROXYCUT HARDCORE

WEIGHT LOSS Clinically Proven KEY INGREDIENTS

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hydroxycut Hardcore by MuscleTech Pro Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hydroxycut Hardcore label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hydroxycut Hardcore by MuscleTech Pro Series

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container105 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Calcium

Interacts with
168 drugs
50 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Vitamin C

Interacts with
207 drugs
7 mg per serving Form: Ascorbic Acid

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

Hydroxycut Hardcore Pro Series Blend

680 mg per serving
  • › Epidyne
  • › HydroxyPro
  • › Lipidrol
  • › Capsicore

Other (inactive) ingredients: Gelatin Capsule, SESAME OIL, Tricalcium Phosphate, Caramel color, INK, Gelatin, Polysorbate 80. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hydroxycut Hardcore by MuscleTech Pro Series Drug Interactions

Want to check YOUR meds against Hydroxycut Hardcore?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,003Drugs
15 Major 682 Moderate 306 Minor

Ingredients driving the most interactions

Vitamin C 207
Calcium 168

Individual Drug Interactions

The ingredients in Hydroxycut Hardcore interact with 1,003 drugs. Click any drug to see the details.

2 of the 6 ingredients in Hydroxycut Hardcore interact with drugs. Each result below shows which ingredient is responsible. Vitamin C Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in Hydroxycut Hardcore with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Vitamin C full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hydroxycut Hardcore, from the product label.

MuscleTech Pro Series

See all MuscleTech Pro Series products
Name
Iovate Health Sciences U.S.A. Inc.
Street Address
1105 North Market Street, Suite 1330
City
Wilmington
State
DE
ZipCode
19801
Pharmacist Counseling Corner

Hydroxycut Hardcore by MuscleTech Pro Series: Common Questions

Does Hydroxycut Hardcore by MuscleTech Pro Series interact with any medications?
Yes. Based on its ingredients, Hydroxycut Hardcore has a known interaction with 1,003 medications, including 15 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hydroxycut Hardcore contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
Calcium is likely safe at normal amounts in pregnancy, but vitamin C at high doses may be unsafe—the product facts advise against high-dose vitamin C supplements unless your doctor approves. Caffeine's safety in pregnancy is not rated in this data, so ask your doctor. Trans-ferulic acid and Alchemilla should be avoided. For the other ingredients, there isn't enough safety data to know either way. Talk with your doctor before starting any weight-loss or stimulant product during pregnancy.
Will this interact with my blood thinner?
Yes, possibly. Vitamin C at high doses and cumin and capsicum all theoretically increase bleeding risk when taken with blood thinners like warfarin. Calcium doesn't directly thin blood but interacts with some other medications. Get your specific medication checked with the tool on this page.
What's the caffeine dose in this product?
The product facts don't specify the exact amount of caffeine anhydrous in each serving. Check the nutrition label on the bottle or contact the manufacturer. High caffeine can cause jitteriness, insomnia, anxiety, and may interact with other medications.
Does this work for weight loss?
The product facts don't include effectiveness data for weight loss or fat burning. The active ingredients—caffeine for energy, capsicum for metabolism support, and amino acids—have some research behind them, but the strength and dose in this blend aren't spelled out. Talk to your pharmacist about whether clinical evidence backs the specific claims on the label.
What are the most common side effects?
From caffeine: anxiety, insomnia, jitteriness, nausea, diarrhea, tremor, and headache. From capsicum: burning mouth, stomach upset, diarrhea, bloating. From vitamin C at higher doses: diarrhea, heartburn, abdominal cramps. Calcium can cause constipation or diarrhea. L-tyrosine may cause fatigue, headache, and heartburn. Most of these are mild if the dose is moderate, but caffeine sensitivity varies widely.
Is this safe to take with my diabetes medication?
Not without checking first. Oleic acid, cumin, and capsicum all theoretically increase the effects of diabetes drugs, raising the risk of low blood sugar (hypoglycemia). Talk to your pharmacist before adding this product so your blood sugar can be monitored and your dose adjusted if needed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hydroxycut Hardcore label
Go deeper

The Full Monographs Behind Hydroxycut Hardcore’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph →
Sources

Sources & How We Checked

Hydroxycut Hardcore's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 490 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
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  38. Neuhofel, A. L., Wilton, J. H., Victory, J. M., Hejmanowsk, L. G., and Amsden, G. W. Lack of bioequivalence of ciprofloxacin when administered with calcium-fortified orange juice: a new twist on an old interaction. J Clin Pharmacol. 2002;42(4):461-466. DOI
  39. Dickinson, H. O., Nicolson, D. J., Cook, J. V., Campbell, F., Beyer, F. R., Ford, G. A., and Mason, J. Calcium supplementation for the management of primary hypertension in adults. Cochrane.Database.Syst.Rev. 2006;(2):CD004639. PubMed
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  42. Castelo-Branco, C., Ciria-Recasens, M., Cancelo-Hidalgo, M. J., Palacios, S., Haya-Palazuelos, J., Carbonell-Abello, J., Blanch-Rubio, J., Martinez-Zapata, M. J., Manasanch, J., and Perez-Edo, L. Efficacy of ossein-hydroxyapatite complex compared with ca
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  47. Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. PubMed
  48. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
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  50. Insentress [package insert]. Whitehouse Station, NJ: Merck Sharp & Dohme Corp.; 2014.
  51. Roberts JL, Kiser JJ, Hindman JT, Meditz AL. Virologic failure with a raltegravir-containing antiretroviral regimen and concomitant calcium administration. Pharmacotherapy 2011;31(10):298e-302e. DOI
  52. Vitekta [package insert]. Foster City, CA: Gilead Sciences, Inc.; 2014.
  53. Storan ER, O'Gorman SM, Murphy A, Laing M. Case Report of Calciphylaxis Secondary to Calcium and Vitamin D<sub>3</sub> Supplementation. J Cutan Med Surg. 2017;21(2):162-163. DOI
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  55. Borkenhagen JF, Connor EL, Stafstrom CE. Neonatal hypocalcemic seizures due to excessive maternal calcium ingestion. Pediatr Neurol 2013;48(6):469-71. PubMed
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  59. Zhang Y, Li Y, Liu J, et al. Association of Vitamin D or Calcium Supplementation with Cardiovascular Outcomes and Mortality: A Meta-Analysis with Trial Sequential Analysis. J Nutr Health Aging 2021;25(2):263-270. PubMed
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See these in context on the Calcium monograph →

Methionine 12 references
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See these in context on the Methionine monograph →

Tyrosine 4 references
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See these in context on the Tyrosine monograph →

Proline 4 references
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See these in context on the Proline monograph →

Vitamin C 51 references
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  29. Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
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Alchemilla 1 reference
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Olive 2 references
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Cumin 10 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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