Major interaction on record — check this product against your medications before combining. Based on 3 of 9 ingredients. Check your meds →
Dietary supplement

Equalizer Tangerine Tarantula Ingredients & Drug Interactions

by Chaotic Labz

Equalizer Tangerine Tarantula label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Equalizer Tangerine Tarantula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Equalizer Tangerine Tarantula is a dietary supplement by Chaotic Labz with 9 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 1,368 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin B6, Zinc, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Equalizer Tangerine Tarantula by Chaotic Labz

Ask about any prescription or over-the-counter medication and we check it for interactions with Equalizer Tangerine Tarantula by Chaotic Labz — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Equalizer Tangerine Tarantula by Chaotic Labz

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 40 active ingredients.
  • “Equalizer Pre-Workout Matrix” is a proprietary blend — the label gives one combined amount (7.50 Gram(s)) without saying how much of each component you get.
  • “(CNS) Stimulation/Focus Cocktail” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Arginase Inhibiting/Anti Converting Cocktail” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Equalizer Tangerine Tarantula contains 40 ingredients total, with several active compounds. The creatine forms (monohydrate and ethyl ester HCl) support muscle strength and athletic performance.

L-arginine appears in three versions (alpha-ketoglutarate, HCl, and malate) to support blood flow and nitric oxide production. Yerba mate extract brings caffeine for energy and focus.

Supporting nutrients include agmatine sulfate, magnesium aspartate, vitamin B6, vitamin B12 (both methylcobalamin and cyanocobalamin), zinc (two forms), theobromine anhydrous (cocoa stimulant), and beta-phenylethylamine. Quebracho blanco extract rounds out the formula.

The product also contains inactive ingredients like malic acid, citric acid, natural and artificial flavors, acesulfame K, sucralose, beet powder, and silicon dioxide.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: athletic performance muscle strength and mental focus.
  • We looked for evidence on: Athletic performance, Attention, Age-related testosterone deficiency, Exercise endurance, Muscle hypertrophy, Nitric oxide production — and 1 related terms.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Athletic performance.
  • Also on file: Beta-alanine is rated "Possibly Effective" for Athletic performance.

Evidence for most of this product's actives is limited or mixed. Creatine is possibly effective for muscle strength, athletic performance, and certain metabolic disorders, though it showed no benefit for Huntington disease or bone density.

Yerba mate, L-arginine, agmatine sulfate, beta-phenylethylamine, and quebracho blanco all lack sufficient reliable evidence to rate their effectiveness for the claims typically made about pre-workout supplements. Vitamin B6 is effective for B6 deficiency and sideroblastic anemia, likely effective for high homocysteine, and possibly effective for pregnancy-related nausea.

Vitamin B12 is effective for B12 deficiency and possibly effective for certain nerve pain. Magnesium is effective for constipation and dyspepsia, and effective for preventing pre-eclampsia in pregnancy.

Zinc is effective for zinc deficiency and likely effective for Wilson disease. Theobromine (cocoa) is possibly effective for heart health but showed no benefit for stretch marks.

Overall, the product lacks established clinical evidence for typical pre-workout outcomes like strength gains beyond creatine's modest support.

The evidence, ingredient by ingredient Vitamin B6 Zinc Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 18 of the 18 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 18 of 18.
  • General safety write-ups exist for 18 of 18.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Creatine is generally well tolerated in healthy adults but those with kidney disease should be cautious; it's unsafe in pregnancy and there's insufficient data for nursing. Common side effects include dehydration, diarrhea, muscle cramps, and water retention.

Yerba mate is possibly unsafe in pregnancy (high caffeine intake) and possibly unsafe while breastfeeding; it may cause insomnia, nervousness, tremors, and nausea, especially at high or long-term doses. L-arginine is possibly safe in pregnancy but has insufficient data for breastfeeding; it can lower blood pressure and cause bloating, nausea, diarrhea, and headache.

Agmatine is unsafe in pregnancy and breastfeeding due to lack of safety data; short-term use appears tolerable but long-term human safety is not well studied. Vitamin B6 at normal dietary levels is likely safe in pregnancy and breastfeeding, though high doses over time may cause nerve damage (neuropathy); common side effects include headache, nausea, and heartburn.

Vitamin B12 is very safe and needed in pregnancy and breastfeeding at recommended amounts. Magnesium is likely safe in pregnancy and breastfeeding at recommended doses; oral forms can cause diarrhea, nausea, and gastrointestinal upset.

Zinc is likely safe in pregnancy but high doses are unsafe; common side effects include nausea, diarrhea, and metallic taste. Theobromine (cocoa) is possibly safe in pregnancy and breastfeeding in small amounts but is possibly unsafe at higher intakes; it can cause heartburn, nausea, and gastrointestinal discomfort.

Beta-phenylethylamine is unsafe in pregnancy and breastfeeding. Quebracho blanco has limited human safety data and should be avoided in pregnancy and breastfeeding.

Side effects, ingredient by ingredient Vitamin B6 Zinc Vitamin B12

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 15 of the 18 matched ingredients can interact with medications — Inosine, Cocoa, Yerba Mate, L-arginine, Glutamine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,369 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any of these: blood pressure medications or ACE inhibitors (risk of dangerous drops in pressure), blood thinners or antiplatelet drugs, seizure medications like phenytoin or phenobarbital, psychiatric drugs (especially clozapine), diabetes medications, Parkinson's levodopa/carbidopa, heart rhythm drugs like amiodarone, muscle relaxants, potassium-sparing diuretics, quinolone or tetracycline antibiotics, cephalexin, penicillamine, HIV drugs (ritonavir, integrase inhibitors, bictegravir-containing products), disulfiram (Antabuse), dipyridamole, MAOIs or serotonergic antidepressants, beta-agonist inhalers, metformin, calcium channel blockers, or chemotherapy agents like cisplatin. No interactions are documented for the few ingredients we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This 40-ingredient pre-workout powder relies heavily on creatine for muscle support—the most evidence-backed component—alongside high caffeine content from yerba mate and cocoa. It contains multiple agents that lower blood pressure, affect blood sugar, and interact with seizure or psychiatric medications, making it essential to discuss with your doctor or pharmacist before taking, especially if you take any prescription drugs.

People with kidney disease, heart conditions, high blood pressure, or diabetes should check first. Pregnant or nursing individuals should avoid it or seek guidance from their healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 27 of 40 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Equalizer Tangerine Tarantula, straight from the product label.

Brand Chaotic Labz
Barcode (UPC) 283333505057
Net contents 8.5 Ounce(s); 240 Gram(s)
Market status On market
Date entered into DSLD Apr 21, 2023
DSLD ID 271700
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Equalizer Tangerine Tarantula by Chaotic Labz, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8 Gram(s), 16 Gram(s)
Maximum serving Sizes:
8 Gram(s), 16 Gram(s)
Servings per container
15
UPC/BARCODE
283333505057
IngredientAmount% DV
Creatine Monohydrate0 NP, 0 NP--
Yerba Mate Extract0 NP, 0 NP--
L-Arginine Alpha Ketoglutarate0 NP, 0 NP--
Agmatine Sulfate0 NP, 0 NP--
Creatinol-O-Phosphate0 NP, 0 NP--
Vitamin B63.75 mg, 7.5 mg221%, 441%
Methylcobalamin0 NP, 0 NP--
Theobromine Anhydrous0 NP, 0 NP--
Beta-Phenylethylamine0 NP, 0 NP--
Cyanocobalamin0 NP, 0 NP--
Creatine Ethyl Ester HCl0 NP, 0 NP--
Magnesium Aspartate0 NP, 0 NP--
Zinc Monomethionine Aspartate0 NP, 0 NP--
Zinc15 mg, 30 mg137%, 273%
L-Norvaline0 NP, 0 NP--
D-Aspartic Acid0 NP, 0 NP--
L-Arginine HCl0 NP, 0 NP--
Pyridoxine HCl0 NP, 0 NP--
Di-Creatine Malate0 NP, 0 NP--
Vitamin B12100 mcg, 200 mcg4167%, 8333%
L-Arginine Malate0 NP, 0 NP--
Quebracho Blanco extract0 NP, 0 NP--
Equalizer Pre-Workout Matrix7.5 Gram(s), 15 Gram(s)--
(CNS) Stimulation/Focus Cocktail0 NP, 0 NP--
Glycine-L-Arginine-Alpha-Ketoisocaproic Acid0 NP, 0 NP--
Adenosine Triphosphate Sodium0 NP, 0 NP--
Taurine Ethyl Ester HCl0 NP, 0 NP--
Guanidinop Proprionic Acid0 NP, 0 NP--
Inosine-Ethyl Ester HCl0 NP, 0 NP--
Disodium Creatine Phosphate Tetrahydrate0 NP, 0 NP--
Arginase Inhibiting/Anti Converting Cocktail0 NP, 0 NP--
2(S)-Amino-6-Boronohexanoic Acid0 NP, 0 NP--
S-(2-Boronethyl)-L-Cysteine HCl0 NP, 0 NP--
Caffeine Anyhydrous0 NP, 0 NP--
R-Beta-Methylphenylethylamine 0 NP, 0 NP--
N-Methyl-Beta-Phenylethylamine0 NP, 0 NP--
L-Tyrosine Ethyl Ester HCl0 NP, 0 NP--
Cell Expansion/Vasodilation Cocktail0 NP, 0 NP--
L-Arginine Ethyl Ester Dihydrochloride0 NP, 0 NP--
Muscular Strength / Energy / Endurance Cocktail0 NP, 0 NP--
Beta-Alanine Ethyl Ester HCl0 NP, 0 NP--
Test Amplification Cocktail0 NP, 0 NP--
Nutrient Primer / Recovery Cocktail0 NP, 0 NP--
L-Leucine Ethyl Ester HCl0 NP, 0 NP--
L-Isoleucine Ethyl Ester HCl0 NP, 0 NP--
L-Valine Ethyl Ester HCl0 NP, 0 NP--
L-Glutamine Ethyl Ester HCl0 NP, 0 NP--

Other ingredients: Malic Acid, Citric Acid, Natural & Artificial flavors, Acesulfame K, Sucralose, Beet powder, Grape, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Some ingredients in Equalizer are hygroscopic (sensitive to air and moisture) in nature. Therefor some occasional clumping may occur. (This is normal) if so, you may smash the clumps with a fork/spoon or simply close the container, squeeze and shake with vigor. Note: this does not diminish the effectiveness of the product.

Exquisite mental focus and stimulation. Nitric-oxide pump production overkill. Helps block estrogen and spike test levels. Explosive muscular strength and endurance. Helps muscle cell growth (amplified swoll factor). Helps increase muscle cell hydration. Helps increase vascularity and muscle recovery. Helps improve athletic performance.

Wake the f#ck up

AM Pre-workout

Storage

Always store with the lid on tight and always refrigerate after opening.

Keep container tightly closed and stored in a cool, dry and dark place.

Suggested/Recommended/Usage/Directions

Suggested use: Attention first time users: take 1/2 scoop to assess tolerance. P.S. We're f@ckin serious!!! Intense training: take 1 scoop in 6-18oz (depending on taste preference) of ice cold water 30 minutes prior to training.

Precautions

Do not exceed recommended daily intake. Do not take on an empty stomach. Use only as directed.

Warning: Do not use if pregnant or nursing.

This product is only intended to be consumed by healthy adults 18 years of age or older.

Before using this product, consult with your physician if you are using any prescription or over the counter medication or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAOI (monoamine oxidase inhibitor) or any other medication.

Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.

Keep out of reach of children and animals.

Warning: Consuming this product can expose you to chemicals including lead and cadmium, which is known to the State of California to cause cancer, and lead and cadmium, which is known to the State of California to cause birth defects, and/or other reproductive harm. For more information go to www.P65Warnings.ca.gov

Processed in a facility that may also process milk, soy, peanuts, tree nuts, eggs, wheat, fish, & shellfish.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration, This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in the USA

GMP Good Manufacturing Practice

General Statements

Servings per container: 30 Servings per container: 15

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Equalizer Tangerine Tarantula by Chaotic Labz label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Equalizer Tangerine Tarantula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Equalizer Tangerine Tarantula by Chaotic Labz

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size8 Gram(s) Dosage formPowder Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
3.75 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Zinc

Interacts with
67 drugs
15 mg per serving Form: Zinc Monomethionine Aspartate

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Vitamin B12

Interacts with
20 drugs
100 mcg per serving Form: Cyanocobalamin, Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Equalizer Pre-Workout Matrix

7.5 Gram(s) per serving
  • › (CNS) Stimulation/Focus Cocktail
  • › Arginase Inhibiting/Anti Converting Cocktail
  • › Cell Expansion/Vasodilation Cocktail
  • › Muscular Strength / Energy / Endurance Cocktail
  • › Test Amplification Cocktail
  • › Nutrient Primer / Recovery Cocktail

Other (inactive) ingredients: Malic Acid, Citric Acid, Natural & Artificial flavors, Acesulfame K, Sucralose, Beet powder, Grape, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Equalizer Tangerine Tarantula by Chaotic Labz Drug Interactions

Want to check YOUR meds against Equalizer Tangerine Tarantula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,368Drugs
16 Major 1,001 Moderate 351 Minor

Ingredients driving the most interactions

Vitamin B6 210
Zinc 67
Vitamin B12 20

Individual Drug Interactions

The ingredients in Equalizer Tangerine Tarantula interact with 1,368 drugs. Click any drug to see the details.

3 of the 9 ingredients in Equalizer Tangerine Tarantula interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Zinc Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Equalizer Tangerine Tarantula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Equalizer Tangerine Tarantula, from the product label.

Chaotic Labz

Name
Bloodline Holdings, LLC
City
Atkins
State
AR
ZipCode
72823
Phone Number
1-888-315-6764
Web Address
www.chaoticlabx.com
Pharmacist Counseling Corner

Equalizer Tangerine Tarantula by Chaotic Labz: Common Questions

Does Equalizer Tangerine Tarantula by Chaotic Labz interact with any medications?
Yes. Based on its ingredients, Equalizer Tangerine Tarantula has a known interaction with 1,368 medications, including 16 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Equalizer Tangerine Tarantula contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
No—several key ingredients are unsafe or have insufficient data in pregnancy. Creatine, agmatine, and beta-phenylethylamine should be avoided. Yerba mate's high caffeine is possibly unsafe. Vitamin B6 at normal pregnancy doses is likely safe, but you need your doctor's personalized guidance for this product as a whole. Talk to your doctor before considering it.
Is this safe while breastfeeding?
Not recommended without medical advice. Creatine and agmatine lack safety data for nursing; yerba mate's and cocoa's caffeine pass into breast milk and may make your baby fussy. Vitamins B6 and B12 are safe at normal amounts, but the product's overall safety for breastfeeding has not been established. Check with your doctor or pharmacist.
What's in this for muscle growth and strength?
Creatine monohydrate and creatine ethyl ester HCl are possibly effective for muscle strength and athletic performance, backed by the most reliable evidence in the formula. The L-arginine forms and agmatine are intended to boost blood flow and performance but lack sufficient research support. Evidence for the other 30+ ingredients toward muscle or strength goals is not established in our data.
Does this have caffeine?
Yes—significantly. Yerba mate extract and theobromine anhydrous (cocoa) both deliver caffeine and related stimulants. This means it can raise heart rate, blood pressure, and anxiety, and may interfere with sleep. If you're sensitive to caffeine or take any heart or psychiatric medications, you must check with your doctor first.
Why does it have so many ingredients?
The product includes 40 ingredients: multiple forms of creatine and L-arginine, B vitamins, minerals, plant extracts, and sweeteners and flavorings. Most of the actives lack robust evidence for pre-workout benefits. Simplicity isn't always a sign of quality—more ingredients mean more potential for interactions with your medications.
What are the most common side effects I should expect?
Creatine commonly causes water retention, dehydration, and diarrhea. Yerba mate and cocoa may trigger insomnia, nervousness, tremors, and nausea, especially with high intake. L-arginine can cause bloating, nausea, and headache. Magnesium often causes diarrhea. Zinc may produce nausea and a metallic taste. Individual tolerance varies widely.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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The Full Monographs Behind Equalizer Tangerine Tarantula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

Equalizer Tangerine Tarantula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 941 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Creatine 86 references
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  26. Volek, J. S., Duncan, N. D., Mazzetti, S. A., Putukian, M., Gomez, A. L., and Kraemer, W. J. No effect of heavy resistance training and creatine supplementation on blood lipids. Int J Sport Nutr.Exerc.Metab 2000;10(2):144-156. PubMed
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  36. Tyler, T. F., Nicholas, S. J., Hershman, E. B., Glace, B. W., Mullaney, M. J., and McHugh, M. P. The effect of creatine supplementation on strength recovery after anterior cruciate ligament (ACL) reconstruction: a randomized, placebo-controlled, double-b DOI
  37. Groeneveld, G. J., Beijer, C., Veldink, J. H., Kalmijn, S., Wokke, J. H., and van den Berg, L. H. Few adverse effects of long-term creatine supplementation in a placebo-controlled trial. Int J Sports Med 2005;26(4):307-313. PubMed
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See these in context on the Creatine monograph →

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See these in context on the Yerba Mate monograph →

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Quebracho Blanco 1 reference
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  3. Bellinger PM, Minahan CL. The effect of ß-alanine supplementation on cycling time trials of different length. Eur J Sport Sci 2016;16(7):829-36.
  4. Chung W, Shaw G, Anderson ME, et al. Effect of 10 week beta-alanine supplementation on competition and training performance in elite swimmers. Nutrients 2012;4(10):1441-53. PubMed
  5. Glenn JM, Gray M, Stewart R, et al. Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists. Amino Acids 2015;47(12):2593-600. PubMed
  6. Gross M, Bieri K, Hoppeler H, Norman B, Vogt M. Beta-alanine supplementation improves jumping power and affects severe-intensity performance in professional alpine skiers. Int J Sport Nutr Exerc Metab 2014;24(6):665-73. PubMed
  7. Howe ST, Bellinger PM, Driller MW, Shing CM, Fell JW. The effect of beta-alanine supplementation on isokinetic force and cycling performance in highly trained cyclists. Int J Sport Nutr Exerc Metab 2013;23(6):562-70. PubMed
  8. Sweeney KM, Wright GA, Glenn Brice A, Doberstein ST. The effect of beta-alanine supplementation on power performance during repeated sprint activity. J Strength Cond Res 2010;24(1):79-87.
  9. Décombaz J, Beaumont M, Vuichoud J, Bouisset F, Stellingwerff T. Effect of slow-release ß-alanine tablets on absorption kinetics and paresthesia. Amino Acids 2012;43(1):67-76. Erratum in: Amino Acids 2013;45(4):1015.
  10. Stellingwerff T, Anwander H, Egger A, et al. Effect of two ß-alanine dosing protocols on muscle carnosine synthesis and washout. Amino Acids 2012;42(6):2461-72. PubMed
  11. da Silva RP, de Oliveira LF, Saunders B, et al. Effects of ß-alanine and sodium bicarbonate supplementation on the estimated energy system contribution during high-intensity intermittent exercise. Amino Acids. 2019;51(1):83-96. PubMed
  12. Varanoske AN, Hoffman JR, Church DD, et al. Comparison of sustained-release and rapid-release ß-alanine formulations on changes in skeletal muscle carnosine and histidine content and isometric performance following a muscle-damaging protocol. Amino Acids. PubMed
  13. Perim P, Gobbi N, Duarte B, et al. Beta-alanine did not improve high-intensity performance throughout simulated road cycling. Eur J Sport Sci 2021. PubMed

See these in context on the Beta-alanine monograph →

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
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  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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