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Dietary supplement

L-Theanine 100 mg Mint Flavored Ingredients & Drug Interactions

by Country Life

L-Theanine 100 mg Mint Flavored label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Theanine 100 mg Mint Flavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

L-Theanine 100 mg Mint Flavored is a dietary supplement by Country Life with 2 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 571 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Suntheanine, Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against L-Theanine 100 mg Mint Flavored by Country Life

Ask about any prescription or over-the-counter medication and we check it for interactions with L-Theanine 100 mg Mint Flavored by Country Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of L-Theanine 100 mg Mint Flavored by Country Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients. Vitamin B6 is an essential B vitamin your body needs to convert food into energy, make neurotransmitters, and support immune function.

Suntheanine is a branded form of L-theanine, an amino acid found naturally in tea that is thought to promote calm focus without drowsiness. The remaining ingredients are inactive — mint flavor, sweeteners, and standard tablet binders like cellulose and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promote relaxation, mental calmness and sleep quality.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Insomnia, Stress, Cognitive function, Sleep quality — and 1 related terms.
  • The strongest evidence on file: Theanine is rated "Possibly Effective" for Cognitive function (Natural Medicines).
  • Also on file: Vitamin B6 is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Cognitive function, Insomnia.
  • Also on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD), Insomnia, Stress.

Vitamin B6 is proven effective for treating sideroblastic anemia (a blood disorder) and B6 deficiency itself, and it's likely effective for lowering high homocysteine levels (a heart risk factor). It's possibly effective for pregnancy-related nausea and vomiting, though only under a doctor's supervision.

For L-theanine, evidence suggests it may help cognitive function, but the data on age-related cognitive decline, Alzheimer's disease, anxiety disorders, and cancer is not yet established well enough to rate it one way or the other.

The evidence, ingredient by ingredient Vitamin B6 Theanine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses under 100 mg daily — the amount in this product. Common side effects at any dose can include headache, nausea, and heartburn.

However, high doses over time (especially above 1,000 mg daily) may cause nerve damage (sensory neuropathy), a serious effect that is dose- and duration-dependent. L-theanine is generally well tolerated in healthy adults for short-term use, with occasional headache, drowsiness, or vivid dreams reported.

Long-term safety data for theanine is limited. There is not enough safety data to know whether either ingredient is safe in pregnancy or while breastfeeding; talk with your doctor or pharmacist before taking this product if you're pregnant or nursing.

Side effects, ingredient by ingredient Vitamin B6 Theanine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin B6, Theanine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 571 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product before starting if you take seizure medications (phenytoin or phenobarbital — vitamin B6 at high doses may reduce their effectiveness), blood pressure medications (both ingredients may lower pressure further), amiodarone (a heart rhythm drug), levodopa without carbidopa for Parkinson's, or CNS depressants like sedatives or opioids. No interactions are documented in our data for the theanine ingredient's effect on serotonin-modulating drugs, although research on its mechanism is mixed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a reasonable option if you're looking to support focus and calm without caffeine jitters, and you don't take seizure medications, blood pressure drugs, or certain heart medications. If you're on any prescription medication — especially phenytoin, phenobarbital, amiodarone, levodopa, or blood pressure meds — check with your pharmacist first.

Avoid high-dose B6 supplements separately, since this product's B6 content is moderate but can add up.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Theanine 100 mg Mint Flavored, straight from the product label.

Brand Country Life
Barcode (UPC) 015794014140
Net contents 60 Chewable Tablet(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 333295
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Theanine 100 mg Mint Flavored by Country Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Chewable Tablet(s)
Maximum serving Sizes:
1 Chewable Tablet(s)
Servings per container
60
UPC/BARCODE
015794014140
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Vitamin B62.5 mg147%
Added Sugars1 Gram(s)2%
Total Sugars1 Gram(s)--
Suntheanine100 mg--

Other ingredients: Sucrose, Cellulose, Citric Acid, Stearic Acid, Medium Chain Triglyceride, Mint Flavor, Natural, Magnesium Stearate, Silica, Stevia Leaf Extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Made with you in mind, Country Life offers L-Theanine in a delicious mint flavored, chewable tablet. Our L- Theanine is formulated with clinically researched Suntheanine, a form of L-Theanine with over 50 studies and patents.

Suntheanine

Formulation

Suntheanine helps promote relaxation, mental calmness and can help improve sleep quality.

Yes certified gluten-free by gfco.org No yeast or wheat No soy, milk or salt No artificial colors or flavors Igen Non-GMO Tested This product does not contain common GE genes or proteins. Visit igenprogram.com

Yes certified vegan by the AVA

Yes manufacturing supports wind power

This product has been manufactured at a GMP registered facility.

Igen Non-GMO Tested This product does not contain common GE genes or proteins. Visit igenprogram.com Certified B Corporation GF Certified Gluten-free

Fast acting Based on laboratory disintegration testing. Compared to non-chewable capsules and tablets.

Mint flavored chewable tablet - no pills Promotes relaxation and mental calmness

Brand IP Statement(s)

Suntheanine is a registered trademark of Taiyo International, Inc.

Established 1971 Country Life

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Yes recyclable packaging

Our Pledge of Integrity Authenticity Cleanliness Freshness Consistency Accuracy

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults chew one (1) chewable tablet with or without food.

Precautions

As a reminder, discuss the supplements and medication that you take with your health care providers. Caution: If you are pregnant, nursing, or taking medication, have a medical condition or planning surgery, consult a doctor before using this product.

Stop using and consult a doctor if any adverse reactions occur. Do not accept if a seal is broken.

Keep out of the reach of children.

Storage

Store in a dry place between 59 degrees - 89 degrees F.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Theanine 100 mg Mint Flavored by Country Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Theanine 100 mg Mint Flavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Theanine 100 mg Mint Flavored by Country Life

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Chewable Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
2.5 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Suntheanine

Interacts with
565 drugs
100 mg per serving Form: L-Theanine

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

Suntheanine monograph & interactions

Other (inactive) ingredients: Sucrose, Cellulose, Citric Acid, Stearic Acid, Medium Chain Triglyceride, Mint Flavor, Natural, Magnesium Stearate, Silica, Stevia Leaf Extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Theanine 100 mg Mint Flavored by Country Life Drug Interactions

Want to check YOUR meds against L-Theanine 100 mg Mint Flavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
571Drugs
205 Moderate 366 Minor

Ingredients driving the most interactions

Suntheanine 565
Vitamin B6 210

Individual Drug Interactions

The ingredients in L-Theanine 100 mg Mint Flavored interact with 571 drugs. Click any drug to see the details.

2 of the 2 ingredients in L-Theanine 100 mg Mint Flavored interact with drugs. Each result below shows which ingredient is responsible. Suntheanine Vitamin B6

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Theanine 100 mg Mint Flavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Suntheanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
Suntheanine full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for L-Theanine 100 mg Mint Flavored, from the product label.

Country Life

See all Country Life products
Name
Country Life, LLC
Street Address
180 Vanderbilt Motor Parkway
City
Hauppauge
State
NY
ZipCode
11788
Web Address
CountryLifeVitamins.com
Pharmacist Counseling Corner

L-Theanine 100 mg Mint Flavored by Country Life: Common Questions

Does L-Theanine 100 mg Mint Flavored by Country Life interact with any medications?
Yes. Based on its ingredients, L-Theanine 100 mg Mint Flavored has a known interaction with 571 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Theanine 100 mg Mint Flavored contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take every day?
Vitamin B6 at this dose is well tolerated for daily use. L-theanine is generally well tolerated in healthy adults short-term, but long-term safety isn't well studied, so ongoing daily use should be discussed with your pharmacist to see if it fits your needs.
Will this help me focus without caffeine?
L-theanine is possibly effective for cognitive function based on current evidence, and it doesn't contain caffeine, so it may help you feel calm and focused without jitters. The strength of evidence isn't as high as for some other approaches, though.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data on either ingredient to know whether it's safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist for personalized advice before taking this product in either situation.
What side effects should I watch for?
Most common are headache, nausea, and drowsiness. High doses of B6 over time can cause nerve damage, but the 100 mg dose here is moderate. If you develop headache, unusual sleepiness, or tingling in your hands or feet, stop and contact your pharmacist.
Why does this have vitamin B6 in it?
Vitamin B6 is an essential nutrient that supports energy metabolism and brain health. It's likely paired with L-theanine here to complement its calming effects, though the product facts don't specify their intended combined purpose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Theanine 100 mg Mint Flavored is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Theanine 100 mg Mint Flavored label
Go deeper

The Full Monographs Behind L-Theanine 100 mg Mint Flavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph →
Sources

Sources & How We Checked

L-Theanine 100 mg Mint Flavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 38 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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