Major interaction on record — check this product against your medications before combining. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Leukic Pro Series Ingredients & Drug Interactions

by MuscleTech

Leukic Pro Series label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Leukic Pro Series against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Leukic Pro Series is a dietary supplement by MuscleTech with 5 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 1,525 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Melatonin, Calcium Alpha-Ketoisocaproate Dihydrate, Zinc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Leukic Pro Series by MuscleTech

Ask about any prescription or over-the-counter medication and we check it for interactions with Leukic Pro Series by MuscleTech — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Leukic Pro Series by MuscleTech

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Leukic Pro Series Proprietary Blend” is a proprietary blend — the label gives one combined amount (3,768 mg) without saying how much of each component you get.

Leukic Pro Series contains 5 active ingredients. The main one is L-leucine, an amino acid that supports muscle protein building.

You also get zinc, which is essential for immune function and wound healing; melatonin, a sleep-regulating hormone; L-carnitine (as carnitine fumarate), which helps cells produce energy; and calcium alpha-ketoisocaproate, a form of calcium. The product also includes inactive ingredients like microcrystalline cellulose, hydroxypropylcellulose, croscarmellose sodium, and magnesium stearate, which are binders, fillers, and flow agents used to form the tablet.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: muscle growth and athletic performance support.
  • We looked for evidence on: Athletic performance, Muscle protein synthesis, Anabolic response, Resistance training adaptation.
  • The closest evidence on file: Melatonin is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Zinc is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.
  • Also on file: L-carnitine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

Effectiveness data in our files covers only some of the ingredients. Zinc is effective for zinc deficiency and likely effective for Wilson disease (a copper storage disorder), and possibly effective for acne, diabetes, and age-related macular degeneration.

Melatonin is likely effective for non-24-hour sleep-wake disorder and delayed sleep phase syndrome (a circadian rhythm condition), and possibly effective for pre-procedural anxiety and sunburn. L-carnitine is effective for carnitine deficiency and possibly effective for high cholesterol, heart failure, and angina.

Calcium is effective for kidney failure, indigestion, high potassium, and osteoporosis. We have no effectiveness data on file for L-leucine or the proprietary blend component.

The evidence, ingredient by ingredient Zinc Melatonin L-carnitine Calcium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zinc is generally well tolerated in doses below 40 mg daily for adults but can cause nausea, diarrhea, abdominal cramps, and a metallic taste — high doses increase the risk of copper deficiency. Melatonin is generally well tolerated for short-term use, though long-term safety is less certain; common side effects are drowsiness, headache, dizziness, and nausea, and rare serious effects include seizures and mood changes.

L-carnitine is well tolerated at typical doses but can cause stomach upset, diarrhea, and a fish-like body odor; high doses carry a rare risk of seizures. Calcium is well tolerated at recommended amounts and causes mainly mild digestive upset — very high doses raise concerns about kidney stones and prostate cancer risk.

For pregnancy and breastfeeding: zinc is likely safe in pregnancy but has conflicting safety data; melatonin is possibly unsafe in pregnancy, and safety while breastfeeding is not established; L-carnitine has insufficient pregnancy data but is possibly safe while breastfeeding; and calcium is likely safe in both pregnancy and breastfeeding when used at recommended amounts.

Side effects, ingredient by ingredient Zinc Melatonin L-carnitine Calcium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Calcium, Melatonin, Zinc, L-carnitine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,526 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood thinners (anticoagulants) like warfarin — melatonin and carnitine may increase bleeding risk. Also confirm before starting if you take HIV integrase inhibitors (dolutegravir, elvitegravir, raltegravir), because calcium sharply reduces how well they work.

Check too if you take antibiotics (quinolones, tetracyclines, cephalexin), thyroid hormone (levothyroxine), blood pressure medications, seizure drugs (anticonvulsants), diabetes medications, or immunosuppressants — zinc and melatonin interact with several of these. Altogether, these interactions span 1,526 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with graded evidence leaning against its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Leukic Pro Series is aimed at people looking to support muscle protein synthesis and recovery, mainly through its L-leucine content. If you take blood thinners, HIV medications, antibiotics, thyroid hormone, blood pressure drugs, or seizure medications, you need to check this product with your doctor or pharmacist before starting — several ingredients interact with these drug types and may need careful timing or dose adjustment.

Otherwise, in recommended doses it's generally well tolerated, though nausea, stomach upset, and a metallic taste are possible. Talk it over with your own healthcare provider before adding it to your routine, especially if you're pregnant, breastfeeding, or managing a chronic condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Leukic Pro Series, straight from the product label.

Brand MuscleTech
Barcode (UPC) 631656602319
Net contents 180 Caplet(s)
Market status On market
Date entered into DSLD Mar 23, 2012
DSLD ID 6505
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Women (not pregnant or lactating), Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Leukic Pro Series by MuscleTech, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Caplet(s)
Maximum serving Sizes:
4 Caplet(s)
Servings per container
45
UPC/BARCODE
631656602319
IngredientAmount% DV
L-Leucine0 NP--
Zinc15 mg100%
Melatonin0 NP--
Carnitine Fumarate0 NP--
Leukic Pro Series Proprietary Blend3768 mg--
Calcium Alpha-Ketoisocaproate Dihydrate0 NP--

Other ingredients: Microcrystalline Cellulose, Hydroxypropylcellulose, Croscarmellose Sodium, Crospovidone, Stearic Acid, Silica, Magnesium Stearate, Coating, Acesulfame-Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Scientific Study Shows Key Compound Able to Amplify Androgen NR3C4 Receptor Concentration? ² In a journal-published, cross-over design study on another key compound in LEUKIC(R) Pro Series, 10 resistance-trained subjects increased androgen NR3C4 receptor concentration by significantly more than when taking a placebo in just 21 days. Researchers in this study theorized that this led to greater cellular uptake of testosterone.? MuscleTech(R) researchers have added the exact dose of this university-tested compound to LEUKIC(R) Pro Series to increase androgen NR3C4 receptor concentration.?

Test Subjects Increased the Output of One of the Body's Primary Anabolic Growth Factors? ¹ In a study conducted at Baylor University, 10 physically active males who combined a single serving of one of the key compounds in LEUKIC(R) Pro Series with training significantly increased production of one of their body's most anabolic growth factors post-workout.? When you take LEUKIC(R) Pro Series, you're getting a state-of-the-art supplement that supplies a key compound capable of driving up an important growth factor!?

What Is LEUKIC(R) Pro Series? LEUKIC(R) Pro Series is a mega-dosed, supercharged formula that delivers leucine to hard-training muscles. Leucine is an essential amino acid that you need to supply your body with from external sources since your body can't produce it on its own. Leucine plays a crucial role in the biological process of building muscle (protein synthesis). Not only does LEUKIC(R) Pro Series supply leucine, it also delivers additional advanced compounds that have been added to this supercharged formula.

(C)2010.

??The MuscleTech(R) brand of supplements is America's #1 selling bodybuilding supplement brand based on cumulative wholesale dollar sales 2006-present.

LEUKIC(R) Pro Series: An Ultra-Powerful New Formula! MuscleTech(R) researchers have created a truly remarkable formula with LEUKIC(R) Pro Series. With an evolved formula loaded with scientifically advanced compounds, LEUKIC(R) Pro Series represents the next generation of MuscleTech(R) supplements.

MEGA-DOSED SUPERCHARGED FORMULA

MICRO-DIFFUSE(TM) TECHNOLOGY

Precautions

CONTAINS SOY INGREDIENTS.

Discontinue use and consult a medical doctor if you experience unusual symptoms. Consult a medical doctor before use if you have been treated for, diagnosed with or have a family history of any medical condition, or if you are using any prescription or over-the-counter drug(s), including blood thinners. Consult a medical doctor before starting a diet or exercise program. Do not exceed recommend serving. Improper use of this product will not improve results and is not advised. Use only as directed.

Do not use if packaging has been tampered with.

WARNING: Not intended for use by persons under 18.

KEEP OUT OF REACH OF CHILDREN.

Do not use if you are pregnant or nursing.

Seals/Symbols

AMERICA'S #1 SELLING BODYBUILDING SUPPLEMENT BRAND??

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take 1 serving (4 caplets) with a glass of water two times daily. On days of your workout, take 1 serving LEUKIC(R) Pro Series with breakfast and 1 serving immediately before your workout. On non-workout days, take one serving with breakfast and one serving with lunch. To ensure maximum results, combine LEUKIC(R) Pro Series with a hardcore diet and training program. Do not exceed 2 servings (8 caplets) in a 24-hour period. Consume 10 glasses of water daily for general good health. Read the entire label before use and follow directions provided.

FDA Disclaimer Statement

?These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place (60(0)F to 80(0)F).

General Statements

• Delivers Ultra-Pure Leucine and Other Key Compounds to Hard-Training Muscles • Test Subjects Increased the Output of One of the Body's Primary Anabolic Growth Factors?,¹ • Scientific Study Shows Key Compound Able to Amplify Androgen NR3C4 Receptor Concentration?,²

Caplet shown not actual size.

For lot no. and expiry date: See bottle.

Made in the U.S.A. from international and domestic ingredients.

NEW FORMULA

Patent Pending.

Research and development

Results based on core ingredient testing.

SCIENTIFICALLY DEVELOPED BASED ON RESEARCH FROM UNIVERSITY STUDIES

See side panel for study details.

General

7110US 0810

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Leukic Pro Series by MuscleTech label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Leukic Pro Series label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Leukic Pro Series by MuscleTech

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zinc

Interacts with
67 drugs
15 mg per serving Form: Zinc Oxide

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Leukic Pro Series Proprietary Blend

3768 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropylcellulose, Croscarmellose Sodium, Crospovidone, Stearic Acid, Silica, Magnesium Stearate, Coating, Acesulfame-Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Leukic Pro Series by MuscleTech Drug Interactions

Want to check YOUR meds against Leukic Pro Series?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,525Drugs
7 Major 1,193 Moderate 325 Minor

Ingredients driving the most interactions

Melatonin 1,461
Calcium Alpha-Ketoisocaproate Dihydrate 168
Zinc 67
Carnitine Fumarate 19

Individual Drug Interactions

The ingredients in Leukic Pro Series interact with 1,525 drugs. Click any drug to see the details.

4 of the 5 ingredients in Leukic Pro Series interact with drugs. Each result below shows which ingredient is responsible. Melatonin Calcium Alpha-Ketoisocaproate Dihydrate Zinc Carnitine Fumarate

Each ingredient & the kinds of drugs it affects

For each ingredient in Leukic Pro Series with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Melatonin18 drug types · 1,461 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There are isolated case reports of minor bleeding and decreased prothrombin activity in people taking melatonin with warfarin (Coumadin). The mechanism, if any, of this interaction is unknown. Taking melatonin orally seems to decrease coagulation activity within one hour of dosing in healthy men.

Likelihood Possible Evidence B
Anticonvulsants

Theoretically, melatonin may reduce the effects of anticonvulsants. Some clinical research suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological impairment.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that melatonin reduces levels of fasting blood glucose and improves glycemic control. However, other research suggests that melatonin might impair glucose utilization and increase insulin resistance, while other research has found no effect on glucose levels. Until more is known, use melatonin cautiously in combination with antidiabetes drugs.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.
Some clinical research suggests that taking melatonin decreases blood pressure in healthy adults. Also, melatonin seems to lower systolic and diastolic blood pressure in individuals with high blood pressure at nighttime or untreated essential hypertension. However, melatonin seems to worsen blood pressure in patients who are taking antihypertensive medications. Immediate-release melatonin 5 mg at night in combination with nifedipine GITS (Procardia XL) increases systolic blood pressure an average of 6.5 mmHg, diastolic blood pressure by an average of 4.9 mmHg, and heart rate by 3.9 bpm. Also, results from animal research suggest that melatonin reduces the effectiveness of certain antihypertensive drugs, including methoxamine and clonidine.

Likelihood Possible Evidence A
Caffeine

Theoretically, taking caffeine with melatonin might increase levels of melatonin.
Some evidence suggests that caffeine consumption can decrease endogenous melatonin levels, while other evidence suggests that caffeine increases endogenous melatonin levels. When administered in combination with melatonin supplements, caffeine seems to increase melatonin effects and levels. The reason for this discrepancy is not completely clear. Part of the discrepancy may result from the fact that caffeine can inhibit melatonin synthesis as well as inhibit melatonin metabolism. By functioning as an adenosine receptor antagonist, caffeine may indirectly inhibit the synthesis of melatonin. Conversely, because melatonin and caffeine are both metabolized by cytochrome P450 1A2 (CYP1A2) enzyme, concomitant use of melatonin and caffeine may reduce the metabolism of melatonin, resulting in higher serum levels.

Likelihood Probable Evidence B
Cns Depressants

Theoretically, taking melatonin might increase the sedative effects of CNS depressants.
Melatonin has sedative effects. Theoretically, concomitant use of melatonin with alcohol, benzodiazepines, or other sedative drugs might cause additive sedation.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, taking contraceptive drugs with melatonin might increase the effects and adverse effects of melatonin.
Contraceptive drugs can increase the levels of endogenous melatonin. Theoretically, these drugs may increase the effects and adverse effects of oral melatonin.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2. Also, other CYP1A2 substrates might decrease the metabolism of melatonin, increasing melatonin levels.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with drugs metabolized by the CYP1A2 enzyme might reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP1A2 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Probable Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19. Also, other CYP2C19 substrates might decrease the metabolism of melatonin, increasing melatonin levels.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2C19 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP2C19 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, taking fluvoxamine with melatonin might increase levels of melatonin.
Fluvoxamine can significantly increase melatonin levels. In some cases, fluvoxamine might increase bioavailability of exogenously administered melatonin by up to 20 times. Some researchers think this might be a beneficial interaction and be potentially useful for cases of refractory insomnia. However, this interaction might also cause unwanted excessive drowsiness and possibly other adverse effects. Fluvoxamine is known to increase endogenous melatonin secretion. It seems to increase serum levels of exogenously administered melatonin possibly by decreasing melatonin metabolism by inhibiting cytochrome P450 (CYP450) 1A2 and 2C19 or by inhibiting melatonin elimination. This effect has been found in healthy people taking fluvoxamine 50-75 mg and melatonin 5 mg.

Likelihood Probable Evidence B
Immunosuppressants

Theoretically, melatonin might interfere with immunosuppressive therapy.
Melatonin can stimulate immune function. Theoretically, melatonin might interfere with immunosuppressive therapy.

Likelihood Possible Evidence B
Methamphetamine (Desoxyn)

Theoretically, taking melatonin with methamphetamine may increase the adverse effects of methamphetamine.
Animal research suggests that melatonin exacerbates the adverse effects of methamphetamine, resulting in greater depression of tryptophan hydroxylase (TPH) and tyrosine hydroxylase (TH) activity, as well as a significant reduction in dopamine levels. This has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine Gits (Procardia Xl)

Theoretically, taking melatonin with extended release nifedipine reduces the effects of nifedipine.
Melatonin can decrease the effectiveness of extended release nifedipine (GITS). Immediate-release melatonin 5 mg at night in combination with nifedipine GITS 30-60 mg daily increases systolic and blood pressure by an average of 6.5 mmHg and 4.9 mmHg, respectively. Concomitant use with melatonin also increases heart rate by 3.9 bpm. The mechanism of this interaction is not known.

Likelihood Probable Evidence B
Seizure Threshold Lowering Drugs

Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Some clinical evidence suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological disabilities.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, melatonin may have antiplatelet effects and may increase the risk of bleeding with warfarin.
Three cases of increased prothrombin time have been reported for patients aged 48-72 years who took melatonin orally in combination with warfarin. However, three cases of decreased prothrombin time have also been reported for patients aged 51-84 years who took melatonin orally in combination with warfarin. Until more is known, use melatonin cautiously in patients taking warfarin.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP2D6.
Laboratory research suggests that certain lots of melatonin inhibit CYP2D6. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2D6 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that certain lots of melatonin inhibit CYP3A4. Theoretically, combined administration of melatonin with certain drugs metabolized by CYP3A4 may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Possible Evidence D
Flumazenil (Romazicon)

Theoretically, taking flumazenil with melatonin might reduce the effects of melatonin.
Animal research shows that flumazenil may inhibit the effect of melatonin.

Likelihood Possible Evidence D
Melatonin full monograph & interactions

Calcium Alpha-Ketoisocaproate Dihydrate18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium Alpha-Ketoisocaproate Dihydrate full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions

Carnitine Fumarate3 drug types · 19 drugs

Acenocoumarol (Sintrom)

Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.

Likelihood Possible Evidence D
Carnitine Fumarate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Leukic Pro Series, from the product label.

MuscleTech

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Phone Number
1-877-502-2021
Pharmacist Counseling Corner

Leukic Pro Series by MuscleTech: Common Questions

Does Leukic Pro Series by MuscleTech interact with any medications?
Yes. Based on its ingredients, Leukic Pro Series has a known interaction with 1,525 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Leukic Pro Series contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take Leukic Pro Series if I'm pregnant or breastfeeding?
The safety data varies by ingredient. Zinc is likely safe in pregnancy but has conflicting data for breastfeeding. Melatonin is possibly unsafe in pregnancy and safety while breastfeeding hasn't been established — you should avoid it unless your doctor advises otherwise. L-carnitine has no pregnancy data on file, but is possibly safe while breastfeeding. Calcium is likely safe during both. Talk with your doctor or pharmacist about your specific situation before taking this product.
What side effects might I experience from this product?
The most common side effects come from zinc and melatonin — you might notice nausea, diarrhea, abdominal cramps, or a metallic taste from zinc, and drowsiness, headache, or dizziness from melatonin. L-carnitine can cause stomach upset, diarrhea, and a fishy body odor at higher doses. Calcium typically causes mild digestive upset like constipation or bloating. Serious side effects are rare but can include seizures (with L-carnitine or melatonin).
Does this product actually work for building muscle?
Leukic Pro Series relies mainly on L-leucine, an amino acid that supports muscle protein building, but we don't have effectiveness data on file for L-leucine itself. The product also contains melatonin and carnitine, which aren't muscle-building ingredients. If you're looking for evidence-based support for muscle recovery, talk with your doctor or a registered dietitian about whether this is the right choice for you.
Can I take this if I'm on antibiotics?
It depends on which antibiotic. Zinc in this product can reduce how well quinolones, tetracyclines, and cephalexin are absorbed — you'd need to separate doses by at least 2–6 hours. Check with your pharmacist or doctor about your specific antibiotic before starting this product, because timing matters for treatment to work properly.
What's the difference between the L-leucine and L-carnitine in this product?
L-leucine is an amino acid that directly supports muscle protein synthesis — your muscles use it to build and repair tissue. L-carnitine (as carnitine fumarate) is a different amino acid that helps your cells produce energy by shuttling fatty acids into mitochondria. They play different roles in your body, and we have effectiveness data for carnitine but not for leucine supplementation.
Is there any ingredient in this product we haven't checked for drug interactions?
Yes — we could not check L-leucine for interactions because we don't have data on file for it. The other checked ingredients (zinc, melatonin, L-carnitine, and calcium) do have documented interactions with numerous medications, so review those carefully with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Leukic Pro Series label
Go deeper

The Full Monographs Behind Leukic Pro Series’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Melatonin

Interacts with 1,461 drugs

Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with sleep timing problems and jet lag. The evidence is...

Read the full Melatonin monograph → Herb & supplement monograph

L-carnitine

Interacts with 19 drugs

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...

Read the full L-carnitine monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph →
Sources

Sources & How We Checked

Leukic Pro Series's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 309 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zinc 88 references
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See these in context on the Zinc monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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