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Dietary supplement

Lion's Mane Powder Ingredients & Drug Interactions

by Real Mushrooms

Lion's Mane Powder label
See full label image
Powder Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane Powder is a dietary supplement by Real Mushrooms with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 494 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Mushroom Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane Powder by Real Mushrooms

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane Powder by Real Mushrooms — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lion's Mane Powder by Real Mushrooms

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Lion's Mane Mushroom Extract” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

This product is a single-ingredient powder: it contains beta-glucans from Lion's Mane mushroom. Beta-glucans are naturally occurring carbohydrates found in mushrooms and other fungi.

They're the active compound responsible for the mushroom's effects on heart health and cholesterol.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Memory and cognitive support.
  • We looked for evidence on: Memory, Cognitive function, Cognitive impairment, Alzheimer disease, Dementia, Brain health — and 1 related terms.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Beta-glucans in this product are rated Likely Effective for two conditions: helping lower cholesterol (dyslipidemia) and supporting heart health in coronary heart disease. The evidence shows real benefit for these uses, though as always, a supplement works best alongside the lifestyle and medication changes your doctor recommends.

The evidence, ingredient by ingredient Lion's Mane Mushroom Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-glucans from food sources are generally well tolerated by most people. When concentrated into supplements, though, safety data is limited, so it's wise to use caution and start at a low dose if you're new to it.

Most reported side effects are mild and occur with topical application (skin reactions like contact dermatitis), not with oral powder. One trial participant developed temporary liver enzyme elevations after starting a very high dose; this is rare and resolved on its own.

There isn't much research on supplement doses during breastfeeding, so talk it over with your doctor or pharmacist if you're nursing.

Side effects, ingredient by ingredient Lion's Mane Mushroom Beta-glucans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your doctor or pharmacist if you take blood pressure medicines (antihypertensive drugs) — beta-glucans may lower blood pressure further. Also flag any immune-suppressing drugs (immunosuppressants), which beta-glucans might interfere with.

Altogether, these interactions span 293 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking to support cholesterol and heart health, beta-glucans have solid evidence behind them. Anyone on blood pressure medication or immune-suppressing drugs should check with their own doctor or pharmacist before adding this product — there's a real interaction risk.

Start with a small amount and see how you feel, and loop in your healthcare provider if you have questions about whether it fits your personal health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane Powder, straight from the product label.

Brand Real Mushrooms
Barcode (UPC) 627843438731
Net contents 60 Gram(s); 2.12 Ounce(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 312722
Product type Botanical With Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane Powder by Real Mushrooms, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gram(s)
Maximum serving Sizes:
1 Gram(s)
Servings per container
60
UPC/BARCODE
627843438731
IngredientAmount% DV
Beta-1,3-1,6-Glucan300 mg--
Lion's Mane Mushroom Extract1000 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

100% pure + organic

100% pure + organic

Cognition Quality grown

Scientifically verified for active compounds

No grain No starch No fillers

Vegan

Non-GMO Gluten free

USDA Organic

Bulk powder

Certified organic and sustainably produced

Our guarantee: This product is scientifically verified for active compounds. There are no added fillers, starch, grains or mycelium.

Our guarantee: This product is scientifically verified for active compounds.

Certified Organic by Quality Assurance International

Gluten free Non GMO

Formula

Organic mushroom extract powder

Our quality commitment to you Extracts are made from 100% pure lion's mane mushrooms Guaranteed potency: greater than 25% beta-glucans

Seals/Symbols

USDA Organic

Quality Assurance International Certified Organic

Vegan

FDA Statement of Identity

Dietary Supplement

General Statements

Purity. Potency. History. Get deals become a VIP customer realmushrooms.com/VIP

NPN# 80091136

Suggested/Recommended/Usage/Directions

Great with tea, coffee & smoothies

Suggested use: Adults take 1 gram per day.

Storage

Storage: Store in a cool dry place with zip lock securely closed.

Precautions

Warning: Keep out of reach of children.

Consult a physician if you are pregnant or nursing; have or had a medical condition; or are taking prescription drugs.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane Powder by Real Mushrooms label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane Powder by Real Mushrooms

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Gram(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

Lion's Mane Mushroom Extract

Interacts with
327 drugs
1000 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Mushroom Extract monograph & interactions
Interaction report

Lion's Mane Powder by Real Mushrooms Drug Interactions

Want to check YOUR meds against Lion's Mane Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
494Drugs
494 Moderate

Ingredients driving the most interactions

Lion's Mane Mushroom Extract 327

Individual Drug Interactions

The ingredients in Lion's Mane Powder interact with 494 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane Powder interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Mushroom Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Mushroom Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Mushroom Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane Powder, from the product label.

Real Mushrooms

See all Real Mushrooms products
Name
Real Mushrooms Inc.
Street Address
908 17 Ave SW, Suite 303
City
Calgary
ZipCode
AB T2T 0A3
Phone Number
1-800-263-4387
Web Address
realmushrooms.com
Pharmacist Counseling Corner

Lion's Mane Powder by Real Mushrooms: Common Questions

Does Lion's Mane Powder by Real Mushrooms interact with any medications?
Yes. Based on its ingredients, Lion's Mane Powder has a known interaction with 494 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Lion's Mane actually work?
The beta-glucans in this product are rated Likely Effective for lowering cholesterol and supporting heart health in coronary heart disease. That's real evidence, not just a claim. It works best as part of a full plan with diet and any medications your doctor prescribes.
What are beta-glucans?
They're natural carbohydrates found in mushrooms and fungi. In this powder, they're the active ingredient doing the work on cholesterol and heart health.
Are there any common side effects?
Beta-glucans are generally well tolerated when you take them by mouth. The main side effects reported in trials are skin reactions (contact dermatitis) when applied topically, not with powder you swallow. One trial participant had temporary liver enzyme changes on a very high dose, but that's rare and resolved on its own.
Is it safe to take while breastfeeding?
There isn't much research on supplement doses during breastfeeding, so caution is advised. Talk with your doctor or pharmacist for personalized guidance on whether it's right for you.
Does the product have any fillers or other inactive ingredients?
No — this is a pure powder with no inactive ingredients listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane Powder label
Go deeper

The Full Monographs Behind Lion's Mane Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph →
Sources

Sources & How We Checked

Lion's Mane Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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