Liver Kidney Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Liver Kidney against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Liver Kidney is a dietary supplement by Organic India with 3 active ingredients. Its ingredients are commonly taken for kidney stones, gallstones, liver support.Based on those ingredients, 1,113 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phyllanthus, Picrorhiza. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Liver Kidney by Organic India
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Liver Kidney by Organic India
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Liver Kidney contains three active ingredients: boerhavia, phyllanthus (also called chanca piedra), and picrorhiza. These are traditional herbal ingredients used in Ayurvedic medicine to support liver and kidney function.
The capsules also contain pullulan, an inactive ingredient that forms the capsule shell.
Does it work?
Moderate evidence
The evidence varies by ingredient. Phyllanthus is possibly effective for kidney stones, but likely ineffective for hepatitis B.
The data for phyllanthus in anemia and benign prostatic hyperplasia (enlarged prostate) is insufficient. Picrorhiza is possibly effective for vitiligo (a patchy skin pigmentation condition) but possibly ineffective for asthma; evidence for COPD and hepatitis is insufficient.
We hold no effectiveness data for boerhavia.
How safe is it?
Well-documented data
Phyllanthus is generally well tolerated in the short term, though high-quality long-term safety information is limited. It can cause abdominal pain, nausea, vomiting, and fatigue in some people.
The safety data advise against use during pregnancy and breastfeeding. Picrorhiza is used in traditional medicine but has limited human safety data, so use with care.
It may cause vomiting, rash, loss of appetite, diarrhea, itching, and dizziness. Safety data advise against use during pregnancy and breastfeeding.
We hold no pregnancy or breastfeeding safety information for boerhavia.
Meds to double-check
Moderate interaction found
Before starting, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin), water pills (diuretics), lithium, blood pressure medications, diabetes drugs, immunosuppressants, or any medication processed by your liver. These are the drug types with the strongest documented interaction concerns.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is marketed for liver and kidney support using traditional herbal ingredients, but the evidence for effectiveness is mixed or limited. Because it interacts with a large number of medications—especially blood thinners, diabetes drugs, blood pressure medications, immunosuppressants, and certain other prescriptions—you should check your exact medications against the interaction tool on this page before taking it.
Talk with your doctor or pharmacist about whether it's right for you, especially if you're pregnant, breastfeeding, or managing a chronic condition.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Liver Kidney, straight from the product label.
| Brand | Organic India |
|---|---|
| Net contents | 30 Daily Pack(s); 30 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2023 |
| DSLD ID | 300178 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Halal |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Liver Kidney by Organic India, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Boerhavia | 100 mg | -- |
| Phyllanthus | 125 mg | -- |
| Picrorhiza | 100 mg | -- |
Other ingredients: Pullulan
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
30 day supply New Easy open dispenser
Capsules shown actual size
Meet the farmers Beginning with a single farmer in 1999, the Organic India farmer partner community has grown to over 3,000 farms throughout India. Scan me Scan QR code to learn more
Formulation
Whole-herb Ayurvedic formulations, backed by science, for daily digestive support Healthy conscious living Holistic Convenient Simple Economical Sustainable
USDA Organic
Non GMO Project Verified nongmoproject.org
Take the guesswork out of your supplement routine. Optimize digestive function with this convenient daily pack of ancient Ayurvedic herbs. Detoxification
Certified Organic by Control Union-CU 801983 Product produced and processed according to NPOP standard of India USDA-NOP NPOP/NAB/0010
Product of India For export in the USA Ayurvedic Medicine Mfg. Lic. No. A-2755
Vegan Vegetarian
Gluten free
FDA Statement of Identity
Herbal Supplement
Formula
Katuki (Boerhavia) Liver Kidney's powerhouse three-herb blend gets an added boost from Andrographis to provide ultimate liver cleansing support.
OU (Kosher)
Halal Jamiat Ulama Halal Foundation Mumbai India 0884
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Suggested/Recommended/Usage/Directions
Suggested use: 1 pack daily with food and water.
Seals/Symbols
Certified Organic by Control Union-CU 801983 Product produced and processed according to NPOP standard of India USDA-NOP NPOP/NAB/0010
USDA Organic OU (Kosher) Halal Jamiat Ulama Halal Foundation Mumbai India 0884
Precautions
If pregnant or nursing consult your health physician prior to use. Warning: Reproductive harm - www.P65Warnings.ca.gov
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Liver Kidney by Organic India label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Liver Kidney by Organic India
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Boerhavia
Phyllanthus
Interacts with1,020 drugs
Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health. Human evidence f...
Phyllanthus monograph & interactionsPicrorhiza
Interacts with207 drugs
Picrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small h...
Picrorhiza monograph & interactionsOther (inactive) ingredients: Pullulan. These complete the product’s ingredient list but are not active constituents.
Liver Kidney by Organic India Drug Interactions
HelloPharmacist Interaction Report
Liver Kidney by Organic India contains phyllanthus and picrorhiza, both of which interact with medications.
The most serious interactions are Moderate in severity, affecting multiple drug categories.
Read the full breakdown — every affected drug type, severity by severity
Phyllanthus carries Moderate-severity interactions with blood thinners and antiplatelet drugs (theoretically increasing bleeding risk), water pills and lithium (potentially affecting how your kidneys handle these drugs), blood pressure medications, diabetes drugs, certain heart medications, and drugs processed through liver pathways CYP1A2 and CYP3A4 (theoretically altering their levels). It also has Minor interactions with blood pressure and diabetes medications.
Picrorhiza adds Moderate interactions with immunosuppressants (theoretically interfering with transplant rejection prevention) and diabetes drugs (theoretically raising low blood sugar risk).
We could not check boerhavia — we hold no safety data for it. Altogether, these interactions span 1,114 individual medications.
Check your exact prescriptions with the tool on this page before starting, and discuss the results with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Liver Kidney?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Liver Kidney interact with 1,113 drugs. Click any drug to see the details.
2 of the 3 ingredients in Liver Kidney interact with drugs. Each result below shows which ingredient is responsible. Phyllanthus Picrorhiza
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PicrorhizaImmunosuppressants Moderate
Interaction Summary
Picrorhiza seems to have immunostimulating activity.
Read the full Picrorhiza + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Phyllanthus + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Liver Kidney — through 2 ingredients. Tap an ingredient for the detail:
PhyllanthusAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Phyllanthus + Abrocitinib interactionPicrorhizaImmunosuppressants Moderate
Interaction Summary
Picrorhiza seems to have immunostimulating activity.
Read the full Picrorhiza + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Liver Kidney — through 2 ingredients. Tap an ingredient for the detail:
PicrorhizaAntidiabetes Drugs Moderate
Interaction Summary
Evidence from animal research suggests that an extract of picrorhiza can reduce fasting and non-fasting blood sugar levels.
Read the full Picrorhiza + Acarbose interactionPhyllanthusAntidiabetes Drugs Minor
Interaction Summary
Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.
Read the full Phyllanthus + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Phyllanthus + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Phyllanthus + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Phyllanthus + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
PhyllanthusCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Phyllanthus + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Liver Kidney with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Phyllanthus
Anticoagulant/Antiplatelet Drugs
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In vitro research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can inhibit platelet aggregation. This effect has not been reported in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that chanca piedra extract increases CYP1A2 activity. Theoretically, chanca piedra might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that chanca piedra extract inhibits CYP3A4. Theoretically, chanca piedra might increase the levels of CYP3A4 substrates. This interaction has not been reported in humans.
Diuretic Drugs
Theoretically, concomitant use of chanca piedra with diuretics might increase diuresis.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking diuretic drugs.
Lithium
Theoretically, chanca piedra might reduce excretion and increase levels of lithium.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows that taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking lithium. The dose of lithium might need to be decreased.
Norepinephrine (Levophed)
Theoretically, chanca piedra may reduce the effects of norepinephrine.
Animal research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can reverse blood vessel contraction caused by norepinephrine.
Antidiabetes Drugs
Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.
Animal research suggests that chanca piedra can have hypoglycemic effects. However, a small clinical study in adults with diabetes shows that chanca piedra extract 25 grams orally daily for 1 week does not lower fasting or postprandial blood glucose levels.
Antihypertensive Drugs
Theoretically, concomitant use of chanca piedra with antihypertensive drugs might have additive blood pressure lowering effects.
Animal research suggests that chanca piedra can decrease blood pressure. However, this effect was not observed in most hypertensive patients treated with chanca piedra for 10 days.
Picrorhiza
Antidiabetes Drugs
Evidence from animal research suggests that an extract of picrorhiza can reduce fasting and non-fasting blood sugar levels. Theoretically, picrorhiza might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia. Monitor blood glucose levels closely. Dose adjustments might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Immunosuppressants
Picrorhiza seems to have immunostimulating activity. Theoretically, picrorhiza may interfere with immunosuppressant therapy. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).
Brand information
Manufacturer and brand details for Liver Kidney, from the product label.
Organic India
See all Organic India products- Name
- Organic India Pvt. Ltd.
- Street Address
- C-5/10, Agro Park Phase-II UPSIDC Industrial Area, Kursi Road
- City
- Barabanki
- State
- U.P.
- ZipCode
- 225302
Liver Kidney by Organic India: Common Questions
Does Liver Kidney by Organic India interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
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The Full Monographs Behind Liver Kidney’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Chanca Piedra
Interacts with 1,020 drugsChanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health. Human evidence for these uses is limited and mostly smal...
Read the full Chanca Piedra monograph → Herb & supplement monographPicrorhiza
Interacts with 207 drugsPicrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small human studies suggest possible liver-prot...
Read the full Picrorhiza monograph →Sources & How We Checked
Liver Kidney's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Chanca Piedra 18 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Srividya N, Periwal S. Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus amarus. Indian J Exp Biol 1995; 33:861-4.
- Rao, M. V. and Alice, K. M. Contraceptive effects of Phyllanthus amarus in female mice. Phytother.Res 2001;15(3):265-267.
- Moshi, M. J., Lutale, J. J., Rimoy, G. H., Abbas, Z. G., Josiah, R. M., and Swai, A. B. The effect of Phyllanthus amarus aqueous extract on blood glucose in non-insulin dependent diabetic patients. Phytother.Res 2001;15(7):577-580.
- Nishiura, J. L., Campos, A. H., Boim, M. A., Heilberg, I. P., and Schor, N. Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients. Urol.Res 2004;32(5):362-366. PubMed
- Iizuka, T., Moriyama, H., and Nagai, M. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol.Pharm.Bull. 2006;29(1):177-179. PubMed
- Adeneye, A. A., Amole, O. O., and Adeneye, A. K. Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice. Fitoterapia 2006;77(7-8):511-514. PubMed
- Iizuka, T., Nagai, M., Taniguchi, A., Moriyama, H., and Hoshi, K. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol.Pharm.Bull. 2007;30(2):382-384. PubMed
- Amaechina, F. C. and Omogbai, E. K. Hypotensive effect of aqueous extract of the leaves of Phyllanthus amarus Schum and Thonn (Euphorbiaceae). Acta Pol.Pharm. 2007;64(6):547-552.
- Okoli, C. O., Obidike, I. C., Ezike, A. C., Akah, P. A., and Salawu, O. A. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Pharm.Biol. 2011;49(3):248-255.
- Moshi MJ, Uiso FC Mahunnah RL et al. A study of the effect of Phyllanthus amarus extracts on blood glucose in rabbits. International Journal of Pharmacognosy 1997;35(3):167-173. DOI
- Kumar NG, Nair AN Raghunandanan VR et al. Hypoglycaemic effect of Phyllanthus niruri leaves in rabbits. Kerala Journal of Veterinary Science 1989;20(1):77-80.
- Navarro M, Coussio J Hnatyszyn O et al. Hypoglycemic Effect of an Aqueous Extract of Phyllanthus sellowianus ("sarandi blanco") in C57BL/Ks mice. Acta Farmaceutica Bonaerense 2004;23:520-523.
- Etta HE, Udoh PB Asuquo BO et al. Effect of Phyllanthus amarus on breeding efficiency of female albino rats. Global Journal of Agricultural Sciences 2007;215-217. DOI
- Etta H. Effects of Phyllanthus amarus on litter traits in albino rats. Scientific Research and Essays 2008;370-372.
- Pucci ND, Marchini GS, Mazzucchi E, et al. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. Int Braz J Urol 2018;44(4):758-64. PubMed
- Sowjanya K, Girish C, Bammigatti C, Prasanna Lakshmi NC. Efficacy of Phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis: A double-blind randomized controlled trial. Indian J Pharmacol 2021;53(6):448-456. PubMed
- Husain I, Abdulrahman B, Dale OR, et al. Interaction of Phyllanthus amarus extract and its lignans with human xenobiotic receptors, drug metabolizing enzymes and drug transporters. J Ethnopharmacol 2025;339:119142. PubMed
Picrorhiza 7 references
- Sharma ML, Rao CS, Duda PL. Immunostimulatory activity of Picrorhiza kurroa leaf extract. J Ethnopharmacol 1994;41:185-92. PubMed
- Bedi KL, Zutshi U, Chopra CL, Amla V. Picrorhiza kurroa, an ayurvedic herb, may potentiate photochemotherapy in vitiligo. J Ethnopharmacol 1989;27:347-52. PubMed
- Vaidya AB, Antarkar DS, Doshi JC, et al. Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent--experimental & clinical studies. J Postgrad Med 1996;42:105-8.
- Baruah CC, Gupta PP, Nath A, et al. Anti-allergic and anti-anaphylactic activity of picroliv--a standardised iridoid glycoside fraction of Picrorhiza kurroa. Pharmacol Res 1998;38:487-92.
- Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.
- Joy, K. L. and Kuttan, R. Anti-diabetic activity of Picrorrhiza kurroa extract. J Ethnopharmacol 11-1-1999;67(2):143-148. PubMed
- Brockwell C, Ampikaipakan S, Sexton DW, Price D, Freeman D, Thomas M, Ali M, Wilson AM. Adjunctive treatment with oral AKL1, a botanical nutraceutical, in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2014;9:715-21. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC