Liver Kidney Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Liver Kidney against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Liver Kidney is a dietary supplement by Organic India with 3 active ingredients. Its ingredients are commonly taken for liver support, digestive complaints, asthma and breathing problems.Based on those ingredients, 1,113 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Bhumyamalaki, Katuki. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Liver Kidney by Organic India
Ask about any prescription or over-the-counter medication and we check it for interactions with Liver Kidney by Organic India — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Liver Kidney by Organic India
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Liver Kidney contains 3 active ingredients: katuki (the traditional Ayurvedic herb picrorhiza), organic bhumyamalaki (chanca piedra, also called stone root), and organic punarnava. These herbs have been used in traditional medicine to support liver and kidney function, though the evidence for their effectiveness varies.
The capsule also contains pullulan, an inactive ingredient that forms the capsule shell.
Does it work?
Moderate evidence
Katuki shows possibly effective evidence for vitiligo, but possibly ineffective for asthma. For chronic obstructive pulmonary disease (COPD) and hepatitis, the evidence isn't established enough to rate it.
Organic bhumyamalaki is possibly effective for kidney stones but likely ineffective for hepatitis B; for anemia of chronic disease and benign prostatic hyperplasia (enlarged prostate), the data aren't sufficient to say. We hold no effectiveness data for organic punarnava.
How safe is it?
Well-documented data
Katuki is generally used in traditional medicine, but human safety data are limited, so use with care. It may cause vomiting, rash, loss of appetite, diarrhea, itching, and dizziness.
The safety data advise against use during pregnancy and while breastfeeding. Organic bhumyamalaki is often well tolerated short-term, but high-quality safety data are limited.
It may cause abdominal pain, nausea, vomiting, and fatigue in some people. The safety data advise against use during pregnancy and while breastfeeding.
We hold no safety information on file for organic punarnava.
Meds to double-check
Moderate interaction found
Before taking Liver Kidney, check with your doctor or pharmacist if you take immunosuppressants, antidiabetes drugs, blood thinners or antiplatelet drugs (like warfarin or aspirin), blood pressure medications, lithium, or any drug that your liver metabolizes heavily (ask your pharmacist if you're unsure). These are the medication types with documented interactions.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may help with kidney stones or vitiligo, though the evidence is mixed. If you take immunosuppressants, diabetes medication, blood thinners, blood pressure drugs, or lithium, you should talk with your doctor or pharmacist before starting it — the interactions are real and may need dose adjustments or closer monitoring.
Don't take it in pregnancy or while breastfeeding without checking with your doctor or pharmacist first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Liver Kidney, straight from the product label.
| Brand | Organic India |
|---|---|
| Barcode (UPC) | 851469000915 |
| Net contents | 90 Vegetarian Cap(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2023 |
| DSLD ID | 300139 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Halal |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Liver Kidney by Organic India, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Katuki | 200 mg | -- |
| organic Bhumyamalaki | 250 mg | -- |
| organic Punarnava | 200 mg | -- |
Other ingredients: Pullulan
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Love & Consciousness In Action: Whole herb solutions for healthy conscious living, grown sustainably by small family farmers using regenerative organic agriculture.
Mfg. Lic. No. A-2755
Formulation
Vegan Vegetarian
Gluten free
Liver Kidney promotes normal healthy liver & kidney function - a powerful detoxification team.
Detoxify & Rejuvenate
USDA Organic
Non GMO Project Verified nongmoproject.org
Certified Organic by Control Union- CU 801983. Product produced and processed according to NPOP standard of India & USDA-NOP www.controlunion.com
Product of India For Export to USA Only
Suggested/Recommended/Usage/Directions
Suggested Use: 2 caps twice daily with food and water.
Precautions
Do not use if pregnant or nursing without consulting a physician.
Warning: Reproductive Harm - www.P65Warnings.ca.gov
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
USDA Organic Non GMO Project Verified nongmoproject.org Certified B Corporations
Control Union Certified NPOP/NAB/0010
Control Union Certified NPOP/NAB/0010 Jamiat Ulama Halal Foundation Mumbai India 0854 OU (Kosher)
Formula
Jamiat Ulama Halal Foundation Mumbai India 0854
OU (Kosher)
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Liver Kidney by Organic India label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Liver Kidney by Organic India
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Katuki
Interacts with207 drugs
Picrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small h...
Katuki monograph & interactionsOrganic Bhumyamalaki
Interacts with1,020 drugs
Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health. Human evidence f...
Organic Bhumyamalaki monograph & interactionsOrganic Punarnava
Other (inactive) ingredients: Pullulan. These complete the product’s ingredient list but are not active constituents.
Liver Kidney by Organic India Drug Interactions
HelloPharmacist Interaction Report
Liver Kidney by Organic India interacts with medications through its katuki and organic bhumyamalaki content.
The most serious interaction is with immunosuppressants (drugs that prevent your immune system from attacking a transplanted organ or controlling an autoimmune condition): katuki appears to stimulate immune activity, which may interfere with how these drugs work. You'd need to monitor this closely with your doctor if you take azathioprine, cyclosporine, tacrolimus, or similar medications.
Read the full breakdown — every affected drug type, severity by severity
Katuki also interacts with antidiabetes drugs (insulin and oral blood sugar medications) — animal evidence suggests it may lower blood sugar further, raising the risk of low blood sugar (hypoglycemia). Both ingredients may affect blood sugar, so if you take diabetes medication, your dose might need adjusting.
Organic bhumyamalaki carries several Moderate interactions: it may increase bleeding risk with blood thinners and antiplatelet drugs like warfarin or aspirin; it could amplify the effects of certain blood pressure medications or affect how your liver processes many common drugs (including some antidepressants, statins, and immunosuppressants through CYP3A4 pathways); and it may interfere with lithium levels or reduce the blood pressure-raising effects of norepinephrine. It also carries a Minor interaction with antidiabetes drugs.
We could not check organic punarnava for interactions. Altogether, these interactions span 1,114 individual medications.
Before you start this product, run your exact prescriptions through the interaction checker on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Liver Kidney?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Liver Kidney interact with 1,113 drugs. Click any drug to see the details.
2 of the 3 ingredients in Liver Kidney interact with drugs. Each result below shows which ingredient is responsible. organic Bhumyamalaki Katuki
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
KatukiImmunosuppressants Moderate
Interaction Summary
Picrorhiza seems to have immunostimulating activity.
Read the full Katuki + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Bhumyamalaki + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Organic Bhumyamalaki + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Bhumyamalaki + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Bhumyamalaki + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Bhumyamalaki + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Liver Kidney — through 2 ingredients. Tap an ingredient for the detail:
Organic BhumyamalakiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Organic Bhumyamalaki + Abrocitinib interactionKatukiImmunosuppressants Moderate
Interaction Summary
Picrorhiza seems to have immunostimulating activity.
Read the full Katuki + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Bhumyamalaki + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Liver Kidney — through 2 ingredients. Tap an ingredient for the detail:
KatukiAntidiabetes Drugs Moderate
Interaction Summary
Evidence from animal research suggests that an extract of picrorhiza can reduce fasting and non-fasting blood sugar levels.
Read the full Katuki + Acarbose interactionOrganic BhumyamalakiAntidiabetes Drugs Minor
Interaction Summary
Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.
Read the full Organic Bhumyamalaki + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Organic Bhumyamalaki + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Organic Bhumyamalaki + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Liver Kidney — through 1 ingredient. Tap an ingredient for the detail:
Organic BhumyamalakiCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Organic Bhumyamalaki + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Liver Kidney with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
organic Bhumyamalaki
Anticoagulant/Antiplatelet Drugs
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In vitro research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can inhibit platelet aggregation. This effect has not been reported in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that chanca piedra extract increases CYP1A2 activity. Theoretically, chanca piedra might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that chanca piedra extract inhibits CYP3A4. Theoretically, chanca piedra might increase the levels of CYP3A4 substrates. This interaction has not been reported in humans.
Diuretic Drugs
Theoretically, concomitant use of chanca piedra with diuretics might increase diuresis.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking diuretic drugs.
Lithium
Theoretically, chanca piedra might reduce excretion and increase levels of lithium.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows that taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking lithium. The dose of lithium might need to be decreased.
Norepinephrine (Levophed)
Theoretically, chanca piedra may reduce the effects of norepinephrine.
Animal research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can reverse blood vessel contraction caused by norepinephrine.
Antidiabetes Drugs
Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.
Animal research suggests that chanca piedra can have hypoglycemic effects. However, a small clinical study in adults with diabetes shows that chanca piedra extract 25 grams orally daily for 1 week does not lower fasting or postprandial blood glucose levels.
Antihypertensive Drugs
Theoretically, concomitant use of chanca piedra with antihypertensive drugs might have additive blood pressure lowering effects.
Animal research suggests that chanca piedra can decrease blood pressure. However, this effect was not observed in most hypertensive patients treated with chanca piedra for 10 days.
Katuki
Antidiabetes Drugs
Evidence from animal research suggests that an extract of picrorhiza can reduce fasting and non-fasting blood sugar levels. Theoretically, picrorhiza might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia. Monitor blood glucose levels closely. Dose adjustments might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Immunosuppressants
Picrorhiza seems to have immunostimulating activity. Theoretically, picrorhiza may interfere with immunosuppressant therapy. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).
Brand information
Manufacturer and brand details for Liver Kidney, from the product label.
Organic India
See all Organic India products- Name
- Organic India USA
- City
- Boulder
- State
- CO
- ZipCode
- 80302
- Phone Number
- 1-888-550-8332
- Web Address
- organicindiaUSA.com
Liver Kidney by Organic India: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Liver Kidney’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Picrorhiza
Interacts with 207 drugsPicrorhiza (Picrorhiza kurroa) is a bitter Himalayan herb used in Ayurvedic medicine, mainly for liver and digestive complaints. Early lab and small human studies suggest possible liver-prot...
Read the full Picrorhiza monograph → Herb & supplement monographChanca Piedra
Interacts with 1,020 drugsChanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health. Human evidence for these uses is limited and mostly smal...
Read the full Chanca Piedra monograph →Sources & How We Checked
Liver Kidney's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Picrorhiza 7 references
- Sharma ML, Rao CS, Duda PL. Immunostimulatory activity of Picrorhiza kurroa leaf extract. J Ethnopharmacol 1994;41:185-92. PubMed
- Bedi KL, Zutshi U, Chopra CL, Amla V. Picrorhiza kurroa, an ayurvedic herb, may potentiate photochemotherapy in vitiligo. J Ethnopharmacol 1989;27:347-52. PubMed
- Vaidya AB, Antarkar DS, Doshi JC, et al. Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent--experimental & clinical studies. J Postgrad Med 1996;42:105-8.
- Baruah CC, Gupta PP, Nath A, et al. Anti-allergic and anti-anaphylactic activity of picroliv--a standardised iridoid glycoside fraction of Picrorhiza kurroa. Pharmacol Res 1998;38:487-92.
- Doshi VB, Shetye VM, Mahashur AA, Kamat SR. Picrorrhiza kurroa in bronchial asthma. J Postgrad Med 1983;29:89-95.
- Joy, K. L. and Kuttan, R. Anti-diabetic activity of Picrorrhiza kurroa extract. J Ethnopharmacol 11-1-1999;67(2):143-148. PubMed
- Brockwell C, Ampikaipakan S, Sexton DW, Price D, Freeman D, Thomas M, Ali M, Wilson AM. Adjunctive treatment with oral AKL1, a botanical nutraceutical, in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2014;9:715-21. PubMed
Chanca Piedra 18 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Srividya N, Periwal S. Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus amarus. Indian J Exp Biol 1995; 33:861-4.
- Rao, M. V. and Alice, K. M. Contraceptive effects of Phyllanthus amarus in female mice. Phytother.Res 2001;15(3):265-267.
- Moshi, M. J., Lutale, J. J., Rimoy, G. H., Abbas, Z. G., Josiah, R. M., and Swai, A. B. The effect of Phyllanthus amarus aqueous extract on blood glucose in non-insulin dependent diabetic patients. Phytother.Res 2001;15(7):577-580.
- Nishiura, J. L., Campos, A. H., Boim, M. A., Heilberg, I. P., and Schor, N. Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients. Urol.Res 2004;32(5):362-366. PubMed
- Iizuka, T., Moriyama, H., and Nagai, M. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol.Pharm.Bull. 2006;29(1):177-179. PubMed
- Adeneye, A. A., Amole, O. O., and Adeneye, A. K. Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice. Fitoterapia 2006;77(7-8):511-514. PubMed
- Iizuka, T., Nagai, M., Taniguchi, A., Moriyama, H., and Hoshi, K. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol.Pharm.Bull. 2007;30(2):382-384. PubMed
- Amaechina, F. C. and Omogbai, E. K. Hypotensive effect of aqueous extract of the leaves of Phyllanthus amarus Schum and Thonn (Euphorbiaceae). Acta Pol.Pharm. 2007;64(6):547-552.
- Okoli, C. O., Obidike, I. C., Ezike, A. C., Akah, P. A., and Salawu, O. A. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Pharm.Biol. 2011;49(3):248-255.
- Moshi MJ, Uiso FC Mahunnah RL et al. A study of the effect of Phyllanthus amarus extracts on blood glucose in rabbits. International Journal of Pharmacognosy 1997;35(3):167-173. DOI
- Kumar NG, Nair AN Raghunandanan VR et al. Hypoglycaemic effect of Phyllanthus niruri leaves in rabbits. Kerala Journal of Veterinary Science 1989;20(1):77-80.
- Navarro M, Coussio J Hnatyszyn O et al. Hypoglycemic Effect of an Aqueous Extract of Phyllanthus sellowianus ("sarandi blanco") in C57BL/Ks mice. Acta Farmaceutica Bonaerense 2004;23:520-523.
- Etta HE, Udoh PB Asuquo BO et al. Effect of Phyllanthus amarus on breeding efficiency of female albino rats. Global Journal of Agricultural Sciences 2007;215-217. DOI
- Etta H. Effects of Phyllanthus amarus on litter traits in albino rats. Scientific Research and Essays 2008;370-372.
- Pucci ND, Marchini GS, Mazzucchi E, et al. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. Int Braz J Urol 2018;44(4):758-64. PubMed
- Sowjanya K, Girish C, Bammigatti C, Prasanna Lakshmi NC. Efficacy of Phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis: A double-blind randomized controlled trial. Indian J Pharmacol 2021;53(6):448-456. PubMed
- Husain I, Abdulrahman B, Dale OR, et al. Interaction of Phyllanthus amarus extract and its lignans with human xenobiotic receptors, drug metabolizing enzymes and drug transporters. J Ethnopharmacol 2025;339:119142. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC