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Dietary supplement

Mucuna Ingredients & Drug Interactions

by UMZU

Mucuna label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mucuna against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Mucuna is a dietary supplement by UMZU with 1 active ingredient. Its ingredients are commonly taken for parkinson's disease symptoms, male fertility and libido, mood and stress support.Based on those ingredients, 193 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Mucuna pruriens seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mucuna by UMZU

Ask about any prescription or over-the-counter medication and we check it for interactions with Mucuna by UMZU — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mucuna by UMZU

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

UMZU Mucuna contains one active ingredient: Mucuna pruriens seed extract. This extract is the source of levodopa, a compound your body converts to dopamine, a chemical messenger in the brain and body.

The capsules also contain inactive ingredients—rice powder, hydroxypropyl methylcellulose (a binder), purified water, and L-leucine—that help deliver the extract but play no active role.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cowhage's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Cognitive support.
  • We looked for evidence on: Parkinson disease, Memory, Attention, Executive function.
  • The closest evidence on file: Cowhage is rated "Insufficient Reliable Evidence To Rate" for Parkinson disease (Natural Medicines).

The evidence for Mucuna pruriens is not yet established in our data. Studies have looked at its use for anxiety, skin redness (erythema), high prolactin levels (hyperprolactinemia), muscle pain (myalgia), Parkinson's disease, and rheumatoid arthritis, but none of these uses have sufficient reliable evidence to rate.

If you're considering this product for a specific condition, talk with your doctor or pharmacist about what the current research actually supports for your situation.

The evidence, ingredient by ingredient Cowhage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Mucuna pruriens is generally well tolerated when taken by mouth, though adverse effects in real-world use haven't been thoroughly studied. The most commonly reported side effects are digestive—diarrhea, flatulence, and mucosal irritation—along with dry mouth.

Some people taking larger doses have reported nausea, abdominal bloating, vomiting, and headaches; insomnia occurred in a small number of trial participants at higher doses. Because this product contains levodopa and affects dopamine, the safety data advises against use during pregnancy.

During breastfeeding, levodopa can lower prolactin levels and reduce milk supply, so it should be avoided. Since this product is drug-like in its effects, use it only under professional guidance.

Side effects, ingredient by ingredient Cowhage

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cowhage.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; Parkinson's medications.
  • For scale: 193 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking UMZU Mucuna, talk with your doctor or pharmacist if you take methyldopa or other blood pressure drugs, monoamine oxidase inhibitors (MAOIs) for depression or anxiety, levodopa for Parkinson's disease, diabetes medications, antipsychotics, tricyclic antidepressants, or if you have upcoming surgery requiring anesthesia. This product's levodopa content can affect how these medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

UMZU Mucuna is a single-ingredient extract of Mucuna pruriens that contains levodopa, making it more like a potent botanical drug than a typical supplement. It carries significant interactions with blood pressure medications, MAOIs, Parkinson's drugs, diabetes medications, and several other classes—so this is one to clear with your doctor or pharmacist before you start.

If you take any prescription medication or have planned surgery, check first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mucuna, straight from the product label.

Brand UMZU
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 246794
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mucuna by UMZU, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
IngredientAmount% DV
Mucuna pruriens seed extract600 mg--

Other ingredients: Rice powder, Hydroxypropyl Methylcellulose, purified Water, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Cognitive support

General Statements

30 day supply

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Not for use by persons under 18 years old. Keep out of the reach of children.

Consult a healthcare professional prior to use if you are taking any medications or have any medical conditions. Do not use if pregnant or nursing.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Take 2 capsule/1 time per day with a meal.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mucuna by UMZU label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mucuna label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mucuna by UMZU

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Mucuna pruriens seed extract

Interacts with
193 drugs
600 mg per serving

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...

Mucuna pruriens seed extract monograph & interactions

Other (inactive) ingredients: Rice powder, Hydroxypropyl Methylcellulose, Purified Water, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mucuna by UMZU Drug Interactions

Want to check YOUR meds against Mucuna?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
193Drugs
17 Major 176 Moderate

Ingredients driving the most interactions

Mucuna pruriens seed extract 193

Individual Drug Interactions

The ingredients in Mucuna interact with 193 drugs. Click any drug to see the details.

1 of the 1 ingredient in Mucuna interact with drugs. Each result below shows which ingredient is responsible. Mucuna pruriens seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Mucuna with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mucuna pruriens seed extract8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
Mucuna pruriens seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mucuna, from the product label.

UMZU

See all UMZU products
Name
Truth Co, LLC
Street Address
1980 8th st
City
Boulder
State
CO
ZipCode
80302
Pharmacist Counseling Corner

Mucuna by UMZU: Common Questions

Does Mucuna by UMZU interact with any medications?
Yes. Based on its ingredients, Mucuna has a known interaction with 193 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mucuna contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is levodopa and why is it in this product?
Levodopa (or L-dopa) is a compound your body converts into dopamine, a chemical messenger in the brain. Mucuna pruriens naturally contains levodopa, and some products are standardized to deliver 75–400 mg per dose. It's included because levodopa affects dopamine and other neurotransmitters in the body.
Can I take this if I'm pregnant or nursing?
No—the safety data advises against use during pregnancy due to its dopamine effects and lack of safety research. During breastfeeding, levodopa can lower prolactin and reduce milk supply, so avoid it then too. Talk with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
What are the most common side effects?
The most common side effects are digestive: diarrhea, flatulence, and mucosal irritation. Dry mouth, headaches, nausea, and abdominal bloating have also been reported. A small number of people taking higher doses experienced insomnia.
Does it work for Parkinson's disease or anxiety?
The evidence is not yet established in our data. Studies have looked at Mucuna pruriens for Parkinson's disease, anxiety, and other conditions, but none have sufficient reliable evidence to rate its effectiveness. Talk with your doctor about whether it's right for your situation.
Why do I need to check with my doctor before taking this?
Mucuna pruriens contains levodopa, an active compound that interacts with many medications—especially blood pressure drugs, MAOIs, Parkinson's drugs, diabetes medications, and antipsychotics. It also affects how anesthesia works, so tell your doctor if you have surgery planned. Your doctor or pharmacist can check your specific medications against this product.
Is it safe if I'm not on any medications?
Even without medications, this product contains levodopa, which is potent and drug-like, so it should be used only with professional guidance. Digestive side effects are possible, and it's not recommended during pregnancy or breastfeeding. A conversation with your doctor or pharmacist is still a good idea.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mucuna is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mucuna label
Go deeper

The Full Monographs Behind Mucuna’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cowhage

Interacts with 193 drugs

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...

Read the full Cowhage monograph →
Sources

Sources & How We Checked

Mucuna's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cowhage 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Anon. Epidemiological notes and reports: Mucuna pruriens-associated pruritus--New Jersey. MMWR Morb Mortal Wkly Rep 1985;34:732-3.
  4. HP-200 in Parkinson's Disease study group. An alternative medicine treatment for Parkinson's disease: Results of a multicenter clinical trial. J Alt Comp Med 1995;1:249-55. DOI
  5. Infante ME, Perez AM, Simao MR, et al. Outbreak of acute toxic psychosis attributed to Mucuna pruriens. Lancet 1990;336:1129. PubMed
  6. Vaidya AB, Rajagopalan TG, Mankodi NA, et al. Treatment of Parkinson's disease with the cowhage plant-Mucuna pruriens Bak. Neurol India 1978;26:171-6.
  7. Vadivel V, Janardhanan K. Nutritional and anti-nutritional composition of velvet bean: an under-utilized food legume in south India. Int J Food Sci Nutr 2000;51:279-87. PubMed
  8. Akhtar MS, Qureshi AQ, Iqbal J. Antidiabetic evaluation of Mucuna pruriens, Linn seeds. J Pak Med Assoc 1990;40:147-50.
  9. Prakash, D., Niranjan, A., and Tewari, S. K. Some nutritional properties of the seeds of three Mucuna species. Int.J.Food Sci.Nutr. 2001;52(1):79-82.
  10. Vadivel, V. and Janardhanan, K. Nutritional and antinutritional characteristics of seven South Indian wild legumes. Plant Foods Hum.Nutr 2005;60(2):69-75. PubMed
  11. Creapure (Creatine Monohydrate). Toxicological Datasheet. Degussa BioActives. Available at: https://www.fda.gov/ohrms/DOCKETS/.../95s-0316-rpt0154-54-Ref-50-vol112.pdf.
  12. Pulikkalpura H, Kurup R, Mathew PJ, Baby S. Levodopa in Mucuna pruriens and its degradation. Sci Rep 2015;5:11078. PubMed

See these in context on the Cowhage monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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