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Dietary supplement

Mucuna Supreme Ingredients & Drug Interactions

by Supreme Nutrition Products

Mucuna Supreme label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mucuna Supreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Mucuna Supreme is a dietary supplement by Supreme Nutrition Products with 1 active ingredient. Its ingredients are commonly taken for parkinson's disease symptoms, male fertility and libido, mood and stress support.Based on those ingredients, 193 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Cowhage. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Mucuna Supreme by Supreme Nutrition Products

Ask about any prescription or over-the-counter medication and we check it for interactions with Mucuna Supreme by Supreme Nutrition Products — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mucuna Supreme by Supreme Nutrition Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Mucuna Supreme contains one active ingredient: cowhage, a plant material that naturally contains levodopa, the same compound used in Parkinson's disease medications. Each capsule is enclosed in vegetable cellulose.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Cowhage product and its label doesn't state a use — see Cowhage's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that cowhage works for the uses listed—anxiety, skin redness (erythema), high prolactin levels, muscle pain, Parkinson disease, or rheumatoid arthritis. All are rated insufficient reliable evidence to rate, meaning the research hasn't been thorough enough to say whether it's effective for these purposes.

The evidence, ingredient by ingredient Cowhage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cowhage is generally well tolerated when taken by mouth, though a complete safety evaluation hasn't been done. The most commonly reported side effects are diarrhea, flatulence, and mouth irritation; headaches and insomnia (in about 3% of people in one study) have also been reported.

Some users report nausea, abdominal bloating, vomiting, or dry mouth. The safety data advises against taking cowhage during pregnancy because it lacks robust safety information and its dopamine effects are a concern.

While breastfeeding, cowhage should be avoided—levodopa can lower prolactin levels and reduce milk supply. Talk with your doctor or pharmacist before taking this product if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Cowhage

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cowhage.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; Parkinson's medications.
  • For scale: 193 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Mucuna Supreme, double-check with your own doctor or pharmacist if you take blood pressure medications (especially methyldopa or guanethidine), non-selective monoamine oxidase inhibitors (MAOIs), prescription levodopa, antipsychotic drugs, tricyclic antidepressants, blood sugar or diabetes medications, or if you're scheduled for surgery. No interactions are documented for MAO-B selective inhibitors such as selegiline, but all other Major and Moderate interactions should be reviewed before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Mucuna Supreme is a single-ingredient product of cowhage, which naturally contains levodopa. If you take blood pressure medications, MAOIs, diabetes drugs, antipsychotics, tricyclic antidepressants, or are scheduled for surgery, you need to check with your own doctor or pharmacist before starting this product—the interactions are serious.

Effectiveness for its listed uses hasn't been established in the data we hold.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mucuna Supreme, straight from the product label.

Brand Supreme Nutrition Products
Net contents 90 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 252089
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mucuna Supreme by Supreme Nutrition Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
IngredientAmount% DV
Cowhage509 mg--

Other ingredients: Vegetable Cellulose Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: 1 capsule on awakening, at least 30 minutes before food.

Precautions

Warning: Don't take Mucuna if you have a history of melanoma, have been diagnosed with liver or cardiovascular disease, or suffer from diabetes/low blood sugar. Consult your physician before taking this if you have been diagnosed with a mental issue.

Don't take if pregnant or nursing.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to treat, diagnose, prevent or cure any disease or illness.

FDA Statement of Identity

Dietary Supplement

General Statements

90 509 mg vegetable capsules

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mucuna Supreme by Supreme Nutrition Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mucuna Supreme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mucuna Supreme by Supreme Nutrition Products

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Cowhage

Interacts with
193 drugs
509 mg per serving

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...

Cowhage monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mucuna Supreme by Supreme Nutrition Products Drug Interactions

Want to check YOUR meds against Mucuna Supreme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
193Drugs
17 Major 176 Moderate

Ingredients driving the most interactions

Cowhage 193

Individual Drug Interactions

The ingredients in Mucuna Supreme interact with 193 drugs. Click any drug to see the details.

1 of the 1 ingredient in Mucuna Supreme interact with drugs. Each result below shows which ingredient is responsible. Cowhage

Each ingredient & the kinds of drugs it affects

For each ingredient in Mucuna Supreme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cowhage8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
Cowhage full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mucuna Supreme, from the product label.

Supreme Nutrition Products

See all Supreme Nutrition Products products
Name
Supreme Nutrition Products
Street Address
1019 Regents Blvd #203
City
Tacoma
State
WA
ZipCode
98466
Web Address
www.SupremeNutritionProducts.com
Pharmacist Counseling Corner

Mucuna Supreme by Supreme Nutrition Products: Common Questions

Does Mucuna Supreme by Supreme Nutrition Products interact with any medications?
Yes. Based on its ingredients, Mucuna Supreme has a known interaction with 193 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mucuna Supreme contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is cowhage?
Cowhage is a plant material that naturally contains levodopa, the active compound used in some Parkinson's disease medications. It's the sole active ingredient in Mucuna Supreme.
How much levodopa does each dose contain?
The product facts don't specify the levodopa content per capsule in Mucuna Supreme. Different cowhage products have been standardized to contain anywhere from 75 to 400 mg of levodopa per dose, so check the label or contact the manufacturer for this product's exact amount.
Can I take this while breastfeeding?
No. Levodopa can lower prolactin and reduce milk supply, so the safety data advises against it. Talk with your doctor or pharmacist if you're breastfeeding and considering this product.
Is it safe in pregnancy?
The safety data advises against cowhage during pregnancy because there isn't enough safety information and its dopamine effects are a concern. If you're pregnant or planning to become pregnant, discuss it with your own doctor or pharmacist before taking it.
What side effects might I experience?
The most common side effects reported are diarrhea, flatulence, and mouth irritation. Some people also experience headaches, nausea, abdominal bloating, vomiting, dry mouth, or insomnia. Adverse effects seem to be rare overall, but a thorough safety evaluation hasn't been completed.
Does it work for Parkinson's disease?
The evidence we hold is insufficient to say whether cowhage is effective for Parkinson disease. If you're considering it for this or any other condition, talk with your own doctor or pharmacist about whether it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mucuna Supreme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mucuna Supreme label
Go deeper

The Full Monographs Behind Mucuna Supreme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cowhage

Interacts with 193 drugs

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...

Read the full Cowhage monograph →
Sources

Sources & How We Checked

Mucuna Supreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cowhage 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Anon. Epidemiological notes and reports: Mucuna pruriens-associated pruritus--New Jersey. MMWR Morb Mortal Wkly Rep 1985;34:732-3.
  4. HP-200 in Parkinson's Disease study group. An alternative medicine treatment for Parkinson's disease: Results of a multicenter clinical trial. J Alt Comp Med 1995;1:249-55. DOI
  5. Infante ME, Perez AM, Simao MR, et al. Outbreak of acute toxic psychosis attributed to Mucuna pruriens. Lancet 1990;336:1129. PubMed
  6. Vaidya AB, Rajagopalan TG, Mankodi NA, et al. Treatment of Parkinson's disease with the cowhage plant-Mucuna pruriens Bak. Neurol India 1978;26:171-6.
  7. Vadivel V, Janardhanan K. Nutritional and anti-nutritional composition of velvet bean: an under-utilized food legume in south India. Int J Food Sci Nutr 2000;51:279-87. PubMed
  8. Akhtar MS, Qureshi AQ, Iqbal J. Antidiabetic evaluation of Mucuna pruriens, Linn seeds. J Pak Med Assoc 1990;40:147-50.
  9. Prakash, D., Niranjan, A., and Tewari, S. K. Some nutritional properties of the seeds of three Mucuna species. Int.J.Food Sci.Nutr. 2001;52(1):79-82.
  10. Vadivel, V. and Janardhanan, K. Nutritional and antinutritional characteristics of seven South Indian wild legumes. Plant Foods Hum.Nutr 2005;60(2):69-75. PubMed
  11. Creapure (Creatine Monohydrate). Toxicological Datasheet. Degussa BioActives. Available at: https://www.fda.gov/ohrms/DOCKETS/.../95s-0316-rpt0154-54-Ref-50-vol112.pdf.
  12. Pulikkalpura H, Kurup R, Mathew PJ, Baby S. Levodopa in Mucuna pruriens and its degradation. Sci Rep 2015;5:11078. PubMed

See these in context on the Cowhage monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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