Interactions on record — worth a quick check against your medications. Based on 2 of 8 ingredients. Check your meds →
Dietary supplement

Muscle Recovery-Rx Post-Workout And Nighttime Formula Ingredients & Drug Interactions

by Hi-Tech Pharmaceuticals

Muscle Recovery-Rx Post-Workout And Nighttime Formula label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Muscle Recovery-Rx Post-Workout And Nighttime Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Muscle Recovery-Rx Post-Workout And Nighttime Formula is a dietary supplement by Hi-Tech Pharmaceuticals with 8 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 243 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Muscle Recovery-Rx Post-Workout And Nighttime Formula by Hi-Tech Pharmaceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Muscle Recovery-Rx Post-Workout And Nighttime Formula by Hi-Tech Pharmaceuticals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Muscle Recovery-Rx Post-Workout And Nighttime Formula by Hi-Tech Pharmaceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 7 active ingredients.
  • “Muscle Recovery(TM) Proprietary Anabolic/Ant-Catabolic Recovery Aid” is a proprietary blend — the label gives one combined amount (17,000 mg) without saying how much of each component you get.

This 7-ingredient powder contains vitamin B6 and sodium as its documented active ingredients, plus proprietary blend complexes listed on the label: Muscle Recovery(TM) Proprietary Anabolic/Anti-Catabolic Recovery Aid, Hi-Tech Anabolic/Anti-Catabolic Matrix, Hi-Tech Muscle Cell Volumizing and Work Performance Technology, Hi-Tech Growth Hormone Releasing Complex, and Hi-Tech BCAAs and Recovery Rx(TM). The formula also includes inactive ingredients like maltodextrin (a carbohydrate), natural and artificial flavors, stearic acid, and a sweetener.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: muscle recovery and growth post-workout.
  • We looked for evidence on: Muscle protein synthesis, Athletic performance, Muscle strength.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Evidence is established only for vitamin B6 in this formula—it's effective for sideroblastic anemia and vitamin B6 deficiency, likely effective for high homocysteine levels (hyperhomocysteinemia), and possibly effective for pregnancy-related nausea and vomiting. For the other active ingredient, sodium, evidence for its use in cystic fibrosis is likely effective and possibly effective for amphotericin B kidney damage (nephrotoxicity), though it has insufficient evidence for bipolar disorder and heart failure.

We hold no effectiveness data for the proprietary blend ingredients in this product.

The evidence, ingredient by ingredient Vitamin B6 Sodium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses under 100 mg daily and generally considered fine at normal dietary and recommended amounts. However, high doses over time can damage nerves (a condition called sensory neuropathy), especially doses above 1,000 mg daily or total lifetime doses of 1,000 grams or more.

Common side effects at any dose include abdominal pain, headache, heartburn, loss of appetite, nausea, and drowsiness. Sodium is essential in small amounts but excess intake is linked to high blood pressure and heart strain; the safety data advises against sodium supplements or very high intake without medical advice.

Sodium is rated likely safe in pregnancy but possibly unsafe during lactation—talk with your doctor or pharmacist if you're pregnant or breastfeeding before taking this formula.

Side effects, ingredient by ingredient Vitamin B6 Sodium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin B6, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium; Parkinson's medications.
  • For scale: 243 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check any blood pressure medications (antihypertensive drugs) you take—both vitamin B6 and sodium may lower your pressure further. Also confirm any seizure medications (phenobarbital, phenytoin), heart rhythm drugs (amiodarone), Parkinson's medication (levodopa), lithium, corticosteroids, didanosine, sodium phosphate bowel preps, or tolvaptan with your pharmacist before adding this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This post-workout powder is most relevant to people concerned with muscle recovery who don't take blood pressure medications, seizure drugs, lithium, or other sodium-sensitive medications. If you take any prescription medications—especially those for blood pressure, heart rhythm, seizures, mood, or viral infections—check them against the interaction list below or use the search tool before starting.

Talk with your pharmacist about whether this product fits your individual health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Muscle Recovery-Rx Post-Workout And Nighttime Formula, straight from the product label.

Brand Hi-Tech Pharmaceuticals
Barcode (UPC) 857084000460
Net contents 700 Gram(s)
Market status On market
Date entered into DSLD Jun 25, 2012
DSLD ID 10320
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Muscle Recovery-Rx Post-Workout And Nighttime Formula by Hi-Tech Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
17.5 Gram(s)
Maximum serving Sizes:
17.5 Gram(s)
Servings per container
40
UPC/BARCODE
857084000460
IngredientAmount% DV
Calories12 {Calories}--
Total Carbohydrates3 None1%
Sugar0 None--
Vitamin B610 mg500%
Sodium150 mg5%
Phosphorus250 mg25%
Muscle Recovery(TM) Proprietary Anabolic/Ant-Catabolic Recovery Aid17000 mg--
Hi-Tech Anabolic/Anti-Catabolic Matrix0 NP--
Hi-Tech Muscle Cell Volumizing and Work Performance Technology0 NP--
Hi-Tech Growth Hormone Releasing Complex0 NP--
Hi-Tech BCAAs and Recovery Rx(TM)0 NP--

Other ingredients: Maltodextrin, Natural and Artificial flavors, Stearic Acid, Naturally Sweet(TM)

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

DIETARY SUPPLEMENT

General Statements

- Anabolic/Anti-Catabolic Recovery Matrix - Reloads Muscle Cells with Creatine, Glutamine and Branched Chain Amino Acids - Growth Hormone Releasing Complex

Seals/Symbols

HI-TECH PHARMACEUTICALS HTP

Suggested/Recommended/Usage/Directions

Directions: Recommended Use On Training Days Dose #1-Mix 1 scoop with 6 oz of cold water and consume immediately after training. Dose #2-Mix 1 scoop with 6 oz of cold water and consume 6-8 hours after training or immediately before bedtime, whichever is sooner. You may vary the amount of water to achieve your desired flavor and sweetness level. Recommended Use On Non-Training Days Dose #1-Mix 1 scoop with 6 oz of cold water and consume in the morning. Dose #2-Mix 1 scoop with 6 oz of cold water and consume 8 hours after initial dose or before bedtime.

Brand IP Statement(s)

Muscle Recovery-Rx(TM) is a proprietary Anabolic/Anti-Catabolic Recovery formula that incorporates 20 state-of-the-science compounds in an optimally precise, post-workout and nighttime formula for bodybuilders and athletes who wants to gain muscle and strength. This unique formulation is designed to take advantage of the "open windows" at the muscle cell level by placing key anabolic and anti-catabolic compounds in line for shuttling into and within muscle cells. Muscle Recovery-Rx(TM) incorporates into its formulation: - Hi-Tech Anabolic/Anti-Catabolic Matrix - Hi-Tech Muscle Cell Volumizing and Work Performance Technology - Hi-Tech BCAAs and Recovery-Rx(TM) - Hi-Tech Growth Hormone Releasing Complex Muscle Recovery-Rx(TM) saturate your muscles with important recovery and growth compounds and facilitates increased shuttling of amino acids and other key nutrients into muscle cells, which creates catabolic interference (anti-proteolysis) and accelerated anabolism. Muscle Recovery-Rx(TM) means muscle cells transition from a recovery to a growth phase as soon as is metabolically possible. Muscle Recovery-Rx(TM) - When you need optimal, post-workout muscle cell reload!

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, cure, diagnose or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Muscle Recovery-Rx Post-Workout And Nighttime Formula by Hi-Tech Pharmaceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Muscle Recovery-Rx Post-Workout And Nighttime Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Muscle Recovery-Rx Post-Workout And Nighttime Formula by Hi-Tech Pharmaceuticals

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size17.5 Gram(s) Dosage formPowder Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

0 None per serving

Vitamin B6

Interacts with
210 drugs
10 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Sodium

Interacts with
205 drugs
150 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Phosphorus

250 mg per serving

Muscle Recovery(TM) Proprietary Anabolic/Ant-Catabolic Recovery Aid

17000 mg per serving
  • › Hi-Tech Anabolic/Anti-Catabolic Matrix
  • › Hi-Tech Muscle Cell Volumizing and Work Performance Technology
  • › Hi-Tech Growth Hormone Releasing Complex
  • › Hi-Tech BCAAs and Recovery Rx(TM)

Other (inactive) ingredients: Maltodextrin, Natural and Artificial flavors, Stearic Acid, Naturally Sweet(TM). These complete the product’s ingredient list but are not active constituents.

Interaction report

Muscle Recovery-Rx Post-Workout And Nighttime Formula by Hi-Tech Pharmaceuticals Drug Interactions

Want to check YOUR meds against Muscle Recovery-Rx Post-Workout And Nighttime Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
243Drugs
238 Moderate 5 Minor

Ingredients driving the most interactions

Vitamin B6 210
Sodium 205

Individual Drug Interactions

The ingredients in Muscle Recovery-Rx Post-Workout And Nighttime Formula interact with 243 drugs. Click any drug to see the details.

2 of the 8 ingredients in Muscle Recovery-Rx Post-Workout And Nighttime Formula interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in Muscle Recovery-Rx Post-Workout And Nighttime Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Muscle Recovery-Rx Post-Workout And Nighttime Formula, from the product label.

Hi-Tech Pharmaceuticals

See all Hi-Tech Pharmaceuticals products
Name
Hi-Tech Pharmaceuticals, Inc.
Street Address
6015-B Unity Drive
City
Norcross
State
GA
ZipCode
30071
Phone Number
1.888.855.7919
Pharmacist Counseling Corner

Muscle Recovery-Rx Post-Workout And Nighttime Formula by Hi-Tech Pharmaceuticals: Common Questions

Does Muscle Recovery-Rx Post-Workout And Nighttime Formula by Hi-Tech Pharmaceuticals interact with any medications?
Yes. Based on its ingredients, Muscle Recovery-Rx Post-Workout And Nighttime Formula has a known interaction with 243 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Muscle Recovery-Rx Post-Workout And Nighttime Formula contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm taking blood pressure medication?
Both vitamin B6 and sodium in this formula may theoretically add to how much your blood pressure medication lowers your pressure. This is a Moderate-severity interaction, so you should check with your pharmacist or doctor before taking it alongside blood pressure drugs.
What's the sodium content, and is it a problem if I'm on a low-sodium diet?
The product facts don't specify the sodium amount per serving, so you'll need to check the label or contact Hi-Tech Pharmaceuticals directly. If you're on a low-sodium diet or take medications affected by sodium (like lithium or corticosteroids), discuss this product with your pharmacist first.
Can I take this if I'm pregnant or breastfeeding?
Sodium is rated likely safe in pregnancy but possibly unsafe during lactation. Vitamin B6 safety data for pregnancy and breastfeeding isn't on file for this product. Talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.
What are the side effects of vitamin B6 in this product?
At normal doses under 100 mg daily, vitamin B6 is well tolerated. Common side effects include headache, nausea, heartburn, and loss of appetite. High doses over time can cause nerve damage (sensory neuropathy), especially above 1,000 mg daily.
Does this product actually help with muscle recovery?
We have no effectiveness data on file for the proprietary blend ingredients (Hi-Tech's anabolic, volumizing, and growth hormone complexes and BCAAs) in this product. The vitamin B6 and sodium are not established for muscle recovery purposes.
What are the proprietary blends, and why aren't they listed in detail?
The label lists several proprietary blend complexes—their specific ingredient amounts aren't disclosed because they're trade secrets. We can't check most of them for drug interactions because we don't hold data on their exact composition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Muscle Recovery-Rx Post-Workout And Nighttime Formula label
Go deeper

The Full Monographs Behind Muscle Recovery-Rx Post-Workout And Nighttime Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Sources

Sources & How We Checked

Muscle Recovery-Rx Post-Workout And Nighttime Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 70 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Sodium 38 references
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See these in context on the Sodium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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