Interactions on record — worth a quick check against your medications. Based on 3 of 11 ingredients. Check your meds →
Dietary supplement

N.O. Overload Pre-Workout Formula Pounding Punch Flavor Ingredients & Drug Interactions

by Hi-Tech Pharmaceuticals

N.O. Overload Pre-Workout Formula Pounding Punch Flavor label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking N.O. Overload Pre-Workout Formula Pounding Punch Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

N.O. Overload Pre-Workout Formula Pounding Punch Flavor is a dietary supplement by Hi-Tech Pharmaceuticals with 11 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 263 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Sodium, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against N.O. Overload Pre-Workout Formula Pounding Punch Flavor by Hi-Tech Pharmaceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with N.O. Overload Pre-Workout Formula Pounding Punch Flavor by Hi-Tech Pharmaceuticals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of N.O. Overload Pre-Workout Formula Pounding Punch Flavor by Hi-Tech Pharmaceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 5 of its 10 active ingredients.
  • “Proprietary Precision Growth Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This powder contains 10 ingredients, but only a few are active compounds we have data for. Vitamin B6 supports nerve and brain function, and vitamin B12 is essential for energy and red blood cell formation.

Sodium is included as an electrolyte for muscle function and hydration during intense exercise. The other ingredients—labeled as proprietary blends and branded technologies (NO Overload, Nitric Oxide Blend with Micro-Rx and Extend-Rx, Arginase Inhibitors, Muscle Cell Volumizing and Performance Technology, Thermo-Rx and Energy Complex, and Recovery-Rx)—are not individually detailed in the facts we hold.

The product also contains inactive ingredients: sweetener, fruit punch flavors, citric acid, Red #40, and silicon dioxide.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: muscular size, vascularity, strength and endurance.
  • We looked for evidence on: athletic performance, muscle hypertrophy, exercise capacity, blood flow.
  • The closest evidence on file: Vitamin B12 is rated "Possibly Ineffective" for Physical performance (Natural Medicines).

Vitamin B6 in this formula is effective for treating sideroblastic anemia and vitamin B6 deficiency, and likely effective for high homocysteine levels (a cardiovascular risk factor). It's possibly effective for pregnancy-related nausea and vomiting.

Vitamin B12 is effective for B12 deficiency and a rare genetic condition (Imerslund-Grasbeck disease), and likely effective against cyanide poisoning. For the other ingredients in this pre-workout formula—including the proprietary blends and the sodium content—we don't hold effectiveness data for their intended pre-workout purposes.

The evidence, ingredient by ingredient Vitamin B6 Sodium Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is generally well tolerated at doses under 100 mg daily, but high doses over time can damage nerves (sensory neuropathy). Common mild side effects include headache, nausea, and heartburn.

Vitamin B12 is very safe—it's generally well tolerated orally and intramuscularly with no established upper limit, since excess is removed in urine. The most common injection-site reaction is mild.

Sodium is fine in normal dietary amounts but too much is linked to high blood pressure and heart strain; the safety notes advise against sodium supplements or very high intake without medical guidance. For pregnancy: vitamin B6 is likely safe but also possibly unsafe (talk with your doctor), while B6 and B12 are generally considered safe at recommended amounts during breastfeeding.

Side effects, ingredient by ingredient Vitamin B6 Sodium Vitamin B12

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Vitamin B12, Vitamin B6, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium; Parkinson's medications.
  • For scale: 263 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your pharmacist or doctor if you use seizure medications (phenobarbital or phenytoin), blood pressure drugs, the heart medication amiodarone, lithium, or any sodium-containing medication. If you take levodopa for Parkinson's disease without carbidopa, ask your provider first.

The product contains several proprietary ingredients we cannot assess for drug interactions, so full transparency about your current medications is essential.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This pre-workout powder is aimed at people looking for a stimulant boost before exercise, but it carries real interactions with blood pressure medications, seizure drugs, lithium, and several others. If you take any prescription medication—especially for the heart, brain, or blood pressure—check your exact medications with the tool on this page before taking it.

The vitamin B6 at high doses can harm nerves over time, and excess sodium isn't ideal if you have heart or kidney concerns. Talk it over with your own doctor or pharmacist to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about N.O. Overload Pre-Workout Formula Pounding Punch Flavor, straight from the product label.

Brand Hi-Tech Pharmaceuticals
Barcode (UPC) 857084000453
Net contents 310 Gram(s)
Market status On market
Date entered into DSLD Jun 25, 2012
DSLD ID 10324
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for N.O. Overload Pre-Workout Formula Pounding Punch Flavor by Hi-Tech Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8 Gram(s)
Maximum serving Sizes:
24 Gram(s)
Servings per container
39
UPC/BARCODE
857084000453
IngredientAmount% DV
Calories8 {Calories}0.6%
Total Carbohydrates2 None2%
Sugar0 None--
Vitamin B610 mg500%
Sodium70 mg3%
Phosphorus150 mg15%
Vitamin B1240 mcg666%
NO Overload(TM)8000 mg--
Proprietary Precision Growth Blend0 NP--
Nitric Oxide Blend with Micro-Rx(TM) and Extend-Rx(TM) Technology0 NP--
Hi-Tech Arginase Inhibitors0 NP--
Hi-Tech Muscle Cell Volumizing and Performance Technology0 NP--
Thermo-Rx and Hi-Tech Energy Complex0 NP--
Hi-Tech Recovery-Rx(TM)0 NP--

Other ingredients: Naturally Sweet(TM), Nat/Art Fruit Punch Flavors, Citric Acid, Red #40, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

HI-TECH PHARMACEUTICALS HTP

FDA Statement of Identity

Dietary Supplement

General Statements

- World's Strongest Anabolic Nitric Oxide Injection System - For Rapid Muscular Size, Vascularity, Strength and Endurance - Revolutionary Arginase Inhibiton - Explosive Strength/Train Insane!

Suggested/Recommended/Usage/Directions

Directions: Recommended Use On Training Days: Once your tolerance has been established, mix 1-3 scoops with 6-8 oz of cold water and consume 30-45 minutes before training. Use approximately 6 oz of water per 1 scoop of powder. Recommended Use On Non-Training Days: Mix 1 scoop with 6 oz of cold water.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, cure, diagnose or prevent any disease.

Brand IP Statement(s)

N.O. Overload(TM) is a proprietary Precision Growth Blend that incorporates 23 state-of-the-science compounds in an optimally precise, pre-workout formula for bodybuilders and athletes who want to gain muscle and enhance performance, strength and training intensity! Muscle N.O. Overload(TM) incorporates into its formulation: - Hi-Tech Arginase Inhibitors - Hi-Tech Muscle Cell Volumizing and Work Performance Technology - Nitric Oxide Blend – Micro-Rx(TM)/Extend-Rx(TM) Technology - Thermo-Rx(R) and Hi-Tech Energy Complex This unique, multi-directional formulation is designed to facilitate an optimal pre-workout metabolic environment, by creating a staging area in the bloodstream of key compounds that act synergistically to enhance nitric oxide (NO) production and vasodilation, primarily through the unrivaled use of novel arginase inhibitors. This allows for more intense and longer muscular contraction across a spectrum of various resistance and endurance to perform high intensity training, from start to finish, beyond your normal threshold limits. Hi-Tech’s revolutionary arginase inhibition approach is truly novel to the supplement industry. N.O. Overload(TM) has the ability to generate and maintain substantially more NO than ordinary AAKG-based NO products. N.O. Overload(TM)'s arginine inhibitors, ABH, BEC and L-Norvaline, ensure safe delivery of the high dosage of arginine in N.O. Overload(TM) directly into muscle fibers, resulting in a significant increase in the availability of arginine for NO production. This translates to an incredible perpetual pump, which results in continuous muscle fullness, hardness and vascularity. N.O. Overload(TM), by utilizing arginase inhibition, has raised the bar in the nitric oxide sports nutrition category.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

N.O. Overload Pre-Workout Formula Pounding Punch Flavor by Hi-Tech Pharmaceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

N.O. Overload Pre-Workout Formula Pounding Punch Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in N.O. Overload Pre-Workout Formula Pounding Punch Flavor by Hi-Tech Pharmaceuticals

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size8 Gram(s) Dosage formPowder Servings per container39 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

0 None per serving

Vitamin B6

Interacts with
210 drugs
10 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Sodium

Interacts with
205 drugs
70 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Phosphorus

150 mg per serving

Vitamin B12

Interacts with
20 drugs
40 mcg per serving Form: Cyanocobalamin, Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

NO Overload(TM)

8000 mg per serving

Proprietary Precision Growth Blend

0 NP per serving
  • › Nitric Oxide Blend with Micro-Rx(TM) and Extend-Rx(TM) Technology
  • › Hi-Tech Arginase Inhibitors
  • › Hi-Tech Muscle Cell Volumizing and Performance Technology
  • › Thermo-Rx and Hi-Tech Energy Complex
  • › Hi-Tech Recovery-Rx(TM)

Other (inactive) ingredients: Naturally Sweet(TM), Nat/Art Fruit Punch Flavors, Citric Acid, Red #40, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

N.O. Overload Pre-Workout Formula Pounding Punch Flavor by Hi-Tech Pharmaceuticals Drug Interactions

Want to check YOUR meds against N.O. Overload Pre-Workout Formula Pounding Punch Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
263Drugs
238 Moderate 25 Minor

Ingredients driving the most interactions

Vitamin B6 210
Sodium 205
Vitamin B12 20

Individual Drug Interactions

The ingredients in N.O. Overload Pre-Workout Formula Pounding Punch Flavor interact with 263 drugs. Click any drug to see the details.

3 of the 11 ingredients in N.O. Overload Pre-Workout Formula Pounding Punch Flavor interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Sodium Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in N.O. Overload Pre-Workout Formula Pounding Punch Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for N.O. Overload Pre-Workout Formula Pounding Punch Flavor, from the product label.

Hi-Tech Pharmaceuticals

See all Hi-Tech Pharmaceuticals products
Name
Hi-Tech Pharmaceuticals, Inc.
Street Address
6015-B Unity Drive
City
Norcross
State
GA
ZipCode
30071
Phone Number
1.888.855.7919
Pharmacist Counseling Corner

N.O. Overload Pre-Workout Formula Pounding Punch Flavor by Hi-Tech Pharmaceuticals: Common Questions

Does N.O. Overload Pre-Workout Formula Pounding Punch Flavor by Hi-Tech Pharmaceuticals interact with any medications?
Yes. Based on its ingredients, N.O. Overload Pre-Workout Formula Pounding Punch Flavor has a known interaction with 263 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
N.O. Overload Pre-Workout Formula Pounding Punch Flavor contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this pre-workout work if I take blood pressure medication?
The vitamin B6 and sodium in this formula may interfere with how well your blood pressure drugs work. High sodium can raise your blood pressure, working against your medication, and B6 may add extra blood-pressure-lowering effects. Check with your doctor or pharmacist about your specific medications before taking this product.
Is it safe to take if I'm on seizure medication?
No, not without checking first. Vitamin B6 in this product may reduce blood levels of phenobarbital and phenytoin, potentially making your seizure control weaker. Talk to your doctor or pharmacist before using it.
Can I take this if I'm pregnant?
The vitamin B6 in this product is rated likely safe but also possibly unsafe in pregnancy—the data is mixed. There isn't enough reliable information to say it's definitely okay. Talk with your doctor about whether this product is right for you during pregnancy.
What are the common side effects of the vitamins in here?
Vitamin B6 at normal doses (under 100 mg daily) is usually well tolerated, though some people report headache, nausea, heartburn, or loss of appetite. Vitamin B12 is very safe with almost no reported side effects except rare mild injection-site reactions. At very high doses over time, B6 can damage nerves.
How much sodium is in one serving?
The product facts don't give the exact amount of sodium per serving, so check the nutrition label on the package. Because sodium can affect blood pressure and interact with several medications, it's worth knowing the dose before you take it.
What are all those proprietary blends actually made of?
The product uses branded formulas like NO Overload, Nitric Oxide Blend with Micro-Rx and Extend-Rx Technology, and others, but the exact ingredient list for each blend isn't provided in the facts we hold. You'd need to contact the manufacturer for a full breakdown of what's in each one.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

N.O. Overload Pre-Workout Formula Pounding Punch Flavor label
Go deeper

The Full Monographs Behind N.O. Overload Pre-Workout Formula Pounding Punch Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

N.O. Overload Pre-Workout Formula Pounding Punch Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 100 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
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Vitamin B12 30 references
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  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
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  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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