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Dietary supplement

Nopal Cactus Powder Ingredients & Drug Interactions

by BareOrganics

Nopal Cactus Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nopal Cactus Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nopal Cactus Powder is a dietary supplement by BareOrganics with 1 active ingredient. Its ingredients are commonly taken for blood sugar control, high cholesterol, hangover symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Nopal Cactus powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nopal Cactus Powder by BareOrganics

Ask about any prescription or over-the-counter medication and we check it for interactions with Nopal Cactus Powder by BareOrganics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nopal Cactus Powder by BareOrganics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This powder is made from a single active ingredient: organic nopal cactus (also called prickly pear cactus). There are no other active ingredients or fillers listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Prickly Pear Cactus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Prickly Pear Cactus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Diabetes — rated "Possibly Effective" (Natural Medicines).

Prickly pear cactus is possibly effective for diabetes—meaning there's some evidence it may help, though more research would strengthen the case. For age-related cognitive decline, benign prostatic hyperplasia (enlarged prostate), indigestion, and high cholesterol, the evidence isn't established enough in our data to rate it.

The evidence, ingredient by ingredient Prickly Pear Cactus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, prickly pear cactus is generally well tolerated as a food, though supplement safety is less studied. The most common side effects are mild stomach upset—abdominal fullness, indigestion, nausea, and mild diarrhea.

Rare cases of headache, insomnia, and dizziness have been reported in clinical studies. Very rarely, the dried powder can swell inside the colon and cause blockage, especially if consumed in large amounts with seeds.

During pregnancy and breastfeeding, there isn't enough safety data on supplement amounts, so the safety data advises against it. Talk with your doctor or pharmacist about whether this is right for you if you're pregnant or nursing.

Side effects, ingredient by ingredient Prickly Pear Cactus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Prickly Pear Cactus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this powder, check with your doctor or pharmacist if you take any diabetes medications. There's a moderate risk of low blood sugar when you combine prickly pear cactus with drugs like metformin, glyburide, glipizide, or chlorpropamide.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you have type 2 diabetes and take medication, check with your doctor or pharmacist before starting this product—it may lower your blood sugar further. For other uses, evidence is limited.

Side effects are usually mild stomach symptoms. Pregnancy and breastfeeding safety data is thin; discuss it with your healthcare provider if either applies to you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nopal Cactus Powder, straight from the product label.

Brand BareOrganics
Barcode (UPC) 818423029948
Net contents 8 Ounce(s); 227 Gram(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 254899
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nopal Cactus Powder by BareOrganics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Gram(s)
Maximum serving Sizes:
3 Gram(s)
Servings per container
76
UPC/BARCODE
818423029948
IngredientAmount% DV
organic Nopal Cactus powder3 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Easy peel label

Visit www.bareorganics.com for great recipes and ideas.

Superfoods to nourish your life.

BPA Free Reusable Container

Let's reduce landfill waste! How do you repurpose your BareOrganics containers? #BarelyUsedBareO Instagram Facebook @BareOrganicsSuperfoods This container is reusable, BPA free, 100% recyclable, microwave and top shelf dishwasher safe.

Formula

Organic Nopal Cactus Powder

Desert super fruit

Keto & Paleo Friendly

Formulation

Commonly referred to as a prickly pear cactus, the Nopal Cactus has traditionally been used in the southwest to support good health. Its cactus "pad" is regarded around the world as a nutritional superfood.

Benefits: Health and vitality.

Organic

Vegan

Gluten Free Non-GMO

USDA Organic

Certified Organic by: A bee organic

Suggested/Recommended/Usage/Directions

Suggested Use: Mix 1 scoop with juice, yogurt, or your favorite smoothie.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

USDA Organic

FDA Statement of Identity

Dietary Supplement

Precautions

Note: Silica packet included to help maintain freshness. Do not consume.

Warning: If you are pregnant or lactating, consult a health care professional before using this product.

Keep out of reach of children.

Store in a cool, dry place away from sunlight and moisture.

Do not use this product if tamper-evident seal has been removed or is broken.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nopal Cactus Powder by BareOrganics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nopal Cactus Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nopal Cactus Powder by BareOrganics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Gram(s) Dosage formPowder Servings per container76 Amounts shown are per serving.

Organic Nopal Cactus powder

Interacts with
86 drugs
3 Gram(s) per serving

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hango...

Organic Nopal Cactus powder monograph & interactions
Interaction report

Nopal Cactus Powder by BareOrganics Drug Interactions

Want to check YOUR meds against Nopal Cactus Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

organic Nopal Cactus powder 86

Individual Drug Interactions

The ingredients in Nopal Cactus Powder interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nopal Cactus Powder interact with drugs. Each result below shows which ingredient is responsible. organic Nopal Cactus powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Nopal Cactus Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Nopal Cactus powder1 drug type · 86 drugs

Antidiabetes Drugs

Combining prickly pear cactus with antidiabetes drugs might increase the risk of hypoglycemia.
Case reports show that combining prickly pear cactus with antidiabetes drugs such as chlorpropamide, glyburide, glipizide, and metformin can increase the risk of hypoglycemia in patients with type 2 diabetes. Advise patients to monitor glucose levels closely. Dose adjustments may be necessary.

Likelihood Probable Evidence D
organic Nopal Cactus powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nopal Cactus Powder, from the product label.

BareOrganics

See all BareOrganics products
Name
BareOrganics
Street Address
9160 E. Bahia Dr.
City
Scottsdale
State
AZ
ZipCode
85260
Web Address
www.bareorganics.com
Pharmacist Counseling Corner

Nopal Cactus Powder by BareOrganics: Common Questions

Does Nopal Cactus Powder by BareOrganics interact with any medications?
Yes. Based on its ingredients, Nopal Cactus Powder has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nopal Cactus Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on metformin or another diabetes drug?
Not without checking first. Prickly pear cactus can increase the risk of low blood sugar when combined with diabetes medications like metformin, glyburide, glipizide, or chlorpropamide. Talk with your doctor or pharmacist before starting it—they can advise you on whether it's safe for you and whether you need to monitor your blood sugar more often.
What are the most common side effects?
Mild stomach problems: abdominal fullness, indigestion, nausea, and mild diarrhea. Rare cases of headache, insomnia, and dizziness have been reported. Side effects are generally mild and go away on their own.
Is prickly pear cactus safe to take while pregnant?
There isn't enough safety data on supplement amounts during pregnancy. The safety data advises against it. Talk with your doctor or pharmacist about whether it's right for you if you're pregnant.
Is prickly pear cactus safe to take while breastfeeding?
There isn't enough safety data on supplement amounts while breastfeeding. The safety data advises against it. Talk with your doctor or pharmacist about whether it's right for you if you're nursing.
Does this really help with diabetes?
Prickly pear cactus is possibly effective for diabetes—meaning there's some evidence it may help. But it's not a replacement for your medication. Always talk with your doctor about how to manage your blood sugar.
Will this help with high cholesterol?
The evidence isn't established enough in our data to say whether it works for cholesterol. More research is needed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nopal Cactus Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nopal Cactus Powder label
Go deeper

The Full Monographs Behind Nopal Cactus Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Prickly Pear Cactus

Interacts with 86 drugs

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hangover symptoms. Some small studies suggest...

Read the full Prickly Pear Cactus monograph →
Sources

Sources & How We Checked

Nopal Cactus Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Prickly Pear Cactus 9 references
  1. Meckes-Lozyoa M, Roman-Ramos R. Opuntia streptacantha; a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14:116-8.
  2. Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.
  3. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  4. Sobieraj DM, Freyer CW. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 2010;44:1334-7. PubMed
  5. Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607.
  6. Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. PubMed
  7. Meckes-Lozyoa, M. and Roman-Ramos, R. Opuntia streptacantha: a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14(3-4):116-118.
  8. Onakpoya IJ, O'Sullivan J, Heneghan CJ. The effect of cactus pear (Opuntia ficus-indica) on body weight and cardiovascular risk factors: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2015;31(5):640-6. PubMed
  9. Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11

See these in context on the Prickly Pear Cactus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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