Ol' Number 11 Ingredients & Drug Interactions
by Pure Herbs
What is this page for?
First and foremost: checking Ol' Number 11 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ol' Number 11 is a dietary supplement by Pure Herbs with 8 active ingredients. Its ingredients are commonly taken for cough and chest congestion, sore throat, bronchitis and respiratory irritation.Based on those ingredients, 2,055 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Marshmallow Root Extract, Skullcap aerial parts extract, Mullein Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ol' Number 11 by Pure Herbs
Ask about any prescription or over-the-counter medication and we check it for interactions with Ol' Number 11 by Pure Herbs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Ol' Number 11 by Pure Herbs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Ol' Number 11 contains 8 ingredients, most of them herbal extracts: mullein leaf, marshmallow root, lobelia aerial parts, skullcap aerial parts, white oak bark, stoneroot root, wormwood aerial part, and black walnut hull. The product lists them within a proprietary blend, so the exact amount of each isn't disclosed on the label.
There are no inactive ingredients listed.
Does it work?
Not established
The evidence for what this blend does is not established in the data we hold. Most of the individual herbal ingredients—mullein, marshmallow, skullcap, white oak, wormwood, and black walnut—have insufficient reliable evidence to rate their effectiveness for any of their traditional uses, whether that's cough, respiratory infections, skin conditions, or digestive support.
Lobelia is rated possibly ineffective for smoking cessation. Because the product is a blend with undisclosed proportions and the individual herbs lack proven benefit in published studies, we can't say whether it works for any particular purpose.
How safe is it?
Well-documented data
Most of these herbs are generally well tolerated for short-term use, but human safety data are limited for several. Lobelia carries the strongest caution: it can cause serious toxicity at higher doses, with symptoms including nausea, vomiting, tremors, rapid heartbeat, low blood pressure, and in severe cases, death.
Wormwood contains thujone, a neurotoxin that can cause muscle pain, nausea, kidney damage, and seizures when used in medicinal amounts. White oak bark has a high tannin content that may irritate your digestive tract.
Black walnut hull may cause digestive upset from tannins; tree nuts (including black walnut) are also a major food allergen. A small number of people using skullcap reported digestive disturbances, and higher doses may cause sedation or vivid dreams.
Meds to double-check
Moderate interaction found
If you take anticonvulsants (seizure medications), check with your doctor or pharmacist before using this product—wormwood may reduce their effectiveness. Also double-check if you're on blood thinners (like warfarin), lithium, or CNS depressants (sleep aids, benzodiazepines, sedating pain relievers)—this product's ingredients interact with all three.
General oral medications may also be affected by the marshmallow's mucilage if taken at the same time.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This is a multi-herb blend with limited proven effectiveness and multiple documented drug interactions—most notably with seizure medications, blood thinners, lithium, and sedating drugs. Most of its ingredients are not well studied in humans, and lobelia and wormwood carry serious toxicity warnings.
Before you start Ol' Number 11, talk it over with your doctor or pharmacist, especially if you take any prescription medications or have liver or kidney concerns.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 7 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ol' Number 11, straight from the product label.
| Brand | Pure Herbs |
|---|---|
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2023 |
| DSLD ID | 281368 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ol' Number 11 by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 1873 mg | -- |
| Mullein Leaf Extract | 0 NP | -- |
| Marshmallow Root Extract | 0 NP | -- |
| Lobelia Aerial Parts Extract | 0 NP | -- |
| Skullcap aerial parts extract | 0 NP | -- |
| White Oak Bark extract | 0 NP | -- |
| Stoneroot Root Extract | 0 NP | -- |
| Wormwood Aerial Part Extract | 0 NP | -- |
| Black Walnut Hull Extract | 0 NP | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.
Shake well before use
Formulation
Beneficial for maintaining gastrointestinal health.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.
Discontinue use and consult with your doctor if any adverse reactions occur.
Keep out of reach of children
Contains: Walnuts
Brand IP Statement(s)
Pure Herbs, Ltd. Natural Herbal Extracts
FDA Statement of Identity
Dietary Supplement
General Statements
"No expense has been spared to provide the finest nature has to offer."
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ol' Number 11 by Pure Herbs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ol' Number 11 by Pure Herbs
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Mullein Leaf Extract
- › Marshmallow Root Extract
- › Lobelia Aerial Parts Extract
- › Skullcap aerial parts extract
- › White Oak Bark extract
- › Stoneroot Root Extract
- › Wormwood Aerial Part Extract
- › Black Walnut Hull Extract
Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
Ol' Number 11 by Pure Herbs Drug Interactions
HelloPharmacist Interaction Report
Ol' Number 11 by Pure Herbs has interactions documented for several of its ingredients: mullein leaf extract, marshmallow root extract, lobelia aerial parts extract, skullcap aerial parts extract, and wormwood aerial part extract.
The most serious interaction is with anticonvulsant drugs (seizure medications) through the wormwood content—wormwood contains thujone, which has convulsant effects and may interfere with how these medications work.
Read the full breakdown — every affected drug type, severity by severity
Multiple ingredients affect blood thinners (anticoagulants/antiplatelet drugs) with Minor severity: mullein leaf extract increases clotting time mildly, and marshmallow flower extract has theoretical antiplatelet effects (though the root is more commonly used in supplements). Marshmallow root and lobelia both have Moderate interactions with lithium—both may reduce how your kidneys clear lithium, potentially raising it to unsafe levels.
Marshmallow also contains mucilage that may slow oral drug absorption (Minor).
Skullcap has a Moderate interaction with CNS depressants (sedating drugs like benzodiazepines, sleep aids, pain relievers)—it can add to their drowsy or impairing effects. White oak bark extract and black walnut hull extract show no interactions in our data.
We could not check stoneroot root extract because we hold no data for it.
Altogether, these interactions span 2,056 individual medications. Use the search tool below to check your exact prescriptions before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ol' Number 11?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ol' Number 11 interact with 2,055 drugs. Click any drug to see the details.
5 of the 8 ingredients in Ol' Number 11 interact with drugs. Each result below shows which ingredient is responsible. Marshmallow Root Extract Skullcap aerial parts extract Mullein Leaf Extract Wormwood Aerial Part Extract Lobelia Aerial Parts Extract
AcepromazineAtravet
How Acepromazine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acepromazine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acepromazine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Butalbital, Codeine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Caffeine, Codeine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Chlorzoxazone, Codeine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Codeine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Codeine, Doxylamine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Codeine, Methocarbamol interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Dichloralantipyrine, Isometheptene interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Dichloralphenazone, Isometheptene interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Dichlorophenazone, Isometheptane interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Diphenhydramine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Hydrocodone interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Hydrocodone interactionAcetaminophen, MeperidineDemerol APAP
How Acetaminophen, Meperidine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Meperidine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Meperidine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Oxycodone interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Oxycodone interactionAcetaminophen, PentazocineTalacen
How Acetaminophen, Pentazocine interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Pentazocine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Pentazocine interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetaminophen, Propoxyphene interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetaminophen, Propoxyphene interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Ol' Number 11 — through 3 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Acetazolamide interactionWormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Acetazolamide interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Acetazolamide interactionAlfentanilAlfenta
How Alfentanil interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Alfentanil interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Alfentanil interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Alprazolam interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Alprazolam interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Ol' Number 11 — through 3 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionMarshmallow Root ExtractOral Drugs, Anticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionMullein Leaf ExtractAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot.
Read the full Mullein Leaf Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAminoglutethimideCytadren
How Aminoglutethimide interacts with Ol' Number 11 — through 2 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Aminoglutethimide interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Aminoglutethimide interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Ol' Number 11 — through 3 ingredients. Tap an ingredient for the detail:
Skullcap Aerial Parts ExtractCns Depressants Moderate
Interaction Summary
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Read the full Skullcap Aerial Parts Extract + Aminophylline, Amobarbital, Ephedrine interactionWormwood Aerial Part ExtractAnticonvulsants Moderate
Interaction Summary
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Read the full Wormwood Aerial Part Extract + Aminophylline, Amobarbital, Ephedrine interactionMarshmallow Root ExtractOral Drugs Minor
Interaction Summary
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Read the full Marshmallow Root Extract + Aminophylline, Amobarbital, Ephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ol' Number 11 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Marshmallow Root Extract
Lithium
Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.
Anticoagulant/Antiplatelet Drugs
Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.
Oral Drugs
Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.
Skullcap aerial parts extract
Cns Depressants
Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.
Mullein Leaf Extract
Anticoagulant/Antiplatelet Drugs
Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot. This is likely due to at least one of the known constituents of muellein, triterpenoid saponins. However, the effects appear to be mild and results have been inconsistent. Extracts from different plant parts have been show to have varying anticoagulant strengths, with water-based ones being more potent than alcohol-based extracts.
Wormwood Aerial Part Extract
Anticonvulsants
Theoretically, taking wormwood might interfere with the effects of anticonvulsant drugs.
Thujone, a constituent of wormwood, has convulsant effects.
Lobelia Aerial Parts Extract
Lithium
Lobelia is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, lobelia might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Ol' Number 11, from the product label.
Pure Herbs
See all Pure Herbs products- Name
- Pure Herbs, Ltd.
- City
- Sterling Heights
- State
- MI
- Phone Number
- (800) 860-4372
- Web Address
- www.pureherbs.com
Ol' Number 11 by Pure Herbs: Common Questions
Does Ol' Number 11 by Pure Herbs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is it safe to use while pregnant or breastfeeding?
What does lobelia do in this blend, and why the toxicity warnings?
What's the concern with wormwood?
Does this product have fillers or 'other ingredients'?
What if I take this 30–60 minutes after my other pills to avoid the marshmallow interaction?
Can I use this if I'm on lithium?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ol' Number 11’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Mullein
Interacts with 122 drugsMullein is a traditional herbal remedy most often used as a tea or syrup to soothe coughs, sore throats, and respiratory irritation. High-quality human studies are lacking, so its benefits a...
Read the full Mullein monograph → Herb & supplement monographMarshmallow
Interacts with 2,040 drugsMarshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...
Read the full Marshmallow monograph → Herb & supplement monographLobelia
Interacts with 1 drugLobelia is a traditional herb once used for breathing problems and to help people quit smoking, but reliable evidence supporting these uses is lacking. It can be toxic in higher amounts, cau...
Read the full Lobelia monograph → Herb & supplement monographSkullcap
Interacts with 248 drugsAmerican skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...
Read the full Skullcap monograph → Herb & supplement monographWhite Oak
White oak bark is a traditional herbal remedy rich in tannins, used mostly as a tea or skin wash for diarrhea, sore throat, and minor skin problems. Solid human evidence is very limited, and...
Read the full White Oak monograph → Herb & supplement monographWormwood
Interacts with 50 drugsWormwood is a very bitter herb traditionally used to stimulate appetite and ease digestion, and it has early research interest in Crohn's disease. It contains thujone, which can be toxic in...
Read the full Wormwood monograph → Herb & supplement monographBlack Walnut
Black walnut is a tree whose green hulls are traditionally used as a natural antiparasitic and digestive remedy, but solid human evidence for these uses is lacking. It contains a compound ca...
Read the full Black Walnut monograph →Sources & How We Checked
Ol' Number 11's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Mullein 2 references
- Castro AI, Carmona JB, Gonzales FG, Nestar OB. Occupational airborne dermatitis from gordolobo (Verbascum densiflorum). Contact Dermatitis 2006;55(5):301.
- Flores Echaiz C, Al Ali A, Cao AQ, Sasseville D. Simultaneous contact dermatitis caused by Asteraceae and Verbascum thapsus. Contact Dermatitis 2017;76(5):316-8.
Marshmallow 5 references
- Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Hage-Sleiman R, Mroueh M, Daher CF. Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon. Pharm Biol 2011;49(3):327-33.
Lobelia 6 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- McChargue DE, Collins FL Jr, Cohen LM. Effect of non-nicotinic moist snuff replacement and lobeline on withdrawal symptoms during 48-h smokeless tobacco deprivation. Nicotine Tob Res 2002;4:195-200. PubMed
- Stead LF, Hughes JR. Lobeline for smoking cessation. Cochrane Database Syst Rev 2000;2:CD000124. PubMed
- Plakun, A. L., Ambrus, J., Bross, I., Graham, S., Levin, M. L., and Ross, C. A. Clinical factors in smoking withdrawal: preliminary report. Am J Public Health Nations.Health 1966;56(3):434-441. PubMed
Skullcap 3 references
- Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
- Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
- Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.
White Oak 2 references
Wormwood 10 references
- Weisbord SD, Soule JB, Kimmel PL. Poison on line-acute renal failure caused by oil of wormwood purchased through the internet. N Engl J Med 1997;337:825-7. PubMed
- Gambelunghe C, Melai P. Absinthe: enjoying a new popularity among young people? Forensic Sci Int 2002;130:183-6.
- Hold KM, Sirisoma NS, Casida JE. Detoxification of alpha- and beta-Thujones (the active ingredients of absinthe): site specificity and species differences in cytochrome P450 oxidation in vitro and in vivo. Chem Res Toxicol 2001;14:589-95.
- Lachenmeier DW, Walch SG, Padosch SA, Kroner LU. Absinthe--a review. Crit Rev Food Sci Nutr 2006;46:365-77.
- Padosch SA, Lachenmeier DW, Kroner LU. Absinthism: a fictitious 19th century syndrome with present impact. Subst Abuse Treat Prev Policy 2006;1:14. PubMed
- Lachenmeier DW, Emmert J, Kuballa T, Sartor G. Thujone--cause of absinthism? Forensic Sci Int 2006;158:1-8. PubMed
- Dettling, A., Grass, H., Schuff, A., Skopp, G., Strohbeck-Kuehner, P., and Haffner, H. T. Absinthe: attention performance and mood under the influence of thujone. J Stud.Alcohol 2004;65(5):573-581. PubMed
- Benezet-Mazuecos, J. and de la Fuente, A. Electrocardiographic findings after acute absinthe intoxication. Int J Cardiol. 11-10-2006;113(2):e48-e50. PubMed
- El Makrini NI, Hassam B. Artemisia absinthium: burning plant! Pan Afr Med J. 2016 Jan 22;23:10. PubMed
- Kocaoglu C, Ozel A. Persistent metabolic acidosis and severe diarrhoea due to Artemisia absinthium poisoning. J Pak Med Assoc. 2014 Sep;64(9):1081-3.
Black Walnut 3 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC