Pancreatin Select Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Pancreatin Select against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pancreatin Select is a dietary supplement by Moss Nutrition with 8 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.Based on those ingredients, 385 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artichoke whole herb extract, Gentian root extract, Betaine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pancreatin Select by Moss Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with Pancreatin Select by Moss Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pancreatin Select by Moss Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
Pancreatin Select contains 8 active ingredients—pancreatic enzymes and herbal extracts designed to support digestion. The pancreatic enzymes are lipase, amylase, and protease, which break down fats, carbohydrates, and proteins respectively.
You'll also find lipase on its own, plus three herbal digestive aids: betaine hydrochloride (which increases stomach acid), artichoke whole herb extract, and gentian root extract. Ox bile extract supports fat digestion.
The product also contains inactive ingredients—hypromellose, microcrystalline cellulose, and silicon dioxide—which are common capsule and tablet fillers.
Does it work?
Moderate evidence
The evidence for how well Pancreatin Select works is limited. Artichoke shows possibly effective ratings for high cholesterol (hyperlipidemia) and indigestion (dyspepsia), with study data suggesting modest benefits for cholesterol and some digestive support.
For the other active ingredients—the pancreatic enzymes lipase, amylase, and protease, plus betaine hydrochloride and gentian root—the data we hold shows insufficient reliable evidence to rate their effectiveness for the conditions they're marketed for. That doesn't mean they don't work; it means large, well-designed human studies haven't firmly established their benefit yet.
How safe is it?
Well-documented data
Most of these ingredients are generally well tolerated by healthy adults. Artichoke is well tolerated overall, though it can cause mild digestive upset—abdominal pain, diarrhea, flatulence, nausea—in some people.
If you're allergic to ragweed or plants in the daisy family, be cautious with artichoke because of cross-sensitivity risk. Betaine hydrochloride may irritate the stomach and is not safe if you have ulcers, gastritis, or true acid reflux.
The pancreatic enzymes are generally well tolerated but should only be used under medical guidance if you have serious digestive conditions. For pregnancy: safety data for all these ingredients is sparse or absent.
Betaine hydrochloride is best avoided in pregnancy due to insufficient safety information. Artichoke, gentian root extract, and the pancreatic enzymes are also best avoided unless your doctor advises otherwise.
For breastfeeding, the same caution applies—check with your healthcare provider first before using this product, as safety hasn't been well studied.
Meds to double-check
Moderate interaction found
Before taking Pancreatin Select, double-check with your doctor or pharmacist if you take diabetes medications, blood pressure medications, acid-reducing drugs (H2-blockers, antacids, or PPIs), or any medications metabolized by the liver enzymes CYP2C19 or CYP2B6. Moderate-severity interactions are documented with diabetes and blood pressure drugs; minor interactions apply to acid reducers.
These ingredients may decrease how well your medications work or cause your blood pressure or blood sugar to drop too far.
The bottom line
Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This is a digestive enzyme and herbal supplement meant to support digestion, and artichoke within it may offer some benefit for cholesterol and indigestion. However, if you take diabetes medications, blood pressure medications, or acid reducers, you'll need to check your specific drugs against the interaction tool before starting, because this product may interfere with how they work.
Pregnant or breastfeeding? Talk with your doctor or pharmacist first—the safety data just isn't there yet.
If you have serious digestive issues or are allergic to plants in the ragweed family, discuss this product with your healthcare provider before you use it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pancreatin Select, straight from the product label.
| Brand | Moss Nutrition |
|---|---|
| Barcode (UPC) | M147 |
| Net contents | 120 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2021 |
| DSLD ID | 247282 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pancreatin Select by Moss Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lipase | 50 mg | -- |
| Betaine HCl | 150 mg | -- |
| Artichoke whole herb extract | 50 mg | -- |
| Ox Bile extract | 60 mg | -- |
| Amylase, Pancreatic | 0 NP | -- |
| Protease, Pancreatic | 0 NP | -- |
| Lipase, Pancreatic | 0 NP | -- |
| Pancreatin 8X | 200 mg | -- |
| Gentian root extract | 50 mg | -- |
Other ingredients: Hypromellose, Microcrystalline Cellulose, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: 1 capsule per meal or as directed by your healthcare professional.
Precautions
Warning: If you are taking medication, have a medical condition or an upcoming medical procedure, or are pregnant or nursing, consult a physician before using.
If adverse reactions occur, discontinue use & consult your healthcare practitioner.
Keep out of reach of children.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
M Professional Supplements Est. 1991
Formulation
Comprehensive Digestive Support
Does not contain gluten.
FDA Statement of Identity
Dietary Supplement
Storage
Store sealed in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pancreatin Select by Moss Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pancreatin Select by Moss Nutrition
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Lipase
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase monograph & interactionsBetaine HCl
Interacts with36 drugs
Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...
Betaine HCl monograph & interactionsArtichoke whole herb extract
Interacts with363 drugs
Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...
Artichoke whole herb extract monograph & interactionsOx Bile extract
Pancreatin 8X
- › Amylase, Pancreatic
- › Protease, Pancreatic
- › Lipase, Pancreatic
Gentian root extract
Interacts with172 drugs
Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. Th...
Gentian root extract monograph & interactionsOther (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Pancreatin Select by Moss Nutrition Drug Interactions
HelloPharmacist Interaction Report
Pancreatin Select by Moss Nutrition contains several ingredients with documented interactions.
Through its betaine hydrochloride, artichoke whole herb extract, and gentian root extract, this product may interact with medications. The most serious concern is a moderate-severity interaction: artichoke may increase the risk of low blood sugar (hypoglycemia) when taken with diabetes medications, as studies show it can modestly reduce blood sugar levels.
Read the full breakdown — every affected drug type, severity by severity
Betaine hydrochloride poses minor interactions with three acid-reducing medication types—H2-blockers, antacids, and proton pump inhibitors (PPIs)—because it increases stomach acid and could counteract their effects. Artichoke also carries moderate-severity interactions with blood pressure medications (antihypertensive drugs), as it may lower blood pressure further and raise the risk of dangerously low blood pressure (hypotension).
Additionally, artichoke may theoretically increase levels of certain medications metabolized by the liver enzymes CYP2C19 and CYP2B6, though this hasn't been confirmed in humans.
Gentian root extract presents a moderate-severity interaction with blood pressure medications for the same reason—it may increase hypotension risk. We were unable to check two ingredients: ox bile extract and pancreatic amylase.
Altogether, these interactions span 385 individual medications. Before you start this product, use the search tool below to check your exact medications, especially if you take diabetes drugs, blood pressure medications, or acid reducers.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pancreatin Select?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pancreatin Select interact with 385 drugs. Click any drug to see the details.
3 of the 8 ingredients in Pancreatin Select interact with drugs. Each result below shows which ingredient is responsible. Artichoke whole herb extract Gentian root extract Betaine HCl
AbrocitinibCibinqo
How Abrocitinib interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Whole Herb Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Whole Herb Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Acebutolol interactionArtichoke Whole Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Whole Herb Extract + Acebutolol interactionAcetaminophen, OrphenadrineOrfenagesic
How Acetaminophen, Orphenadrine interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractCytochrome P450 2b6 (cyp2b6) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
Read the full Artichoke Whole Herb Extract + Acetaminophen, Orphenadrine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Acetazolamide interactionArtichoke Whole Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Whole Herb Extract + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Whole Herb Extract + Acetohexamide interactionAerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Whole Herb Extract + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionAgomelatineValdoxan
How Agomelatine interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Whole Herb Extract + Agomelatine interactionAlbiglutideTanzeum
How Albiglutide interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Whole Herb Extract + Albiglutide interactionAliskirenTekturna
How Aliskiren interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Aliskiren interactionArtichoke Whole Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Whole Herb Extract + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Whole Herb Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Whole Herb Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Whole Herb Extract + Alogliptin, Pioglitazone interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Ambrisentan interactionArtichoke Whole Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Whole Herb Extract + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Whole Herb Extract + Amiloride interactionGentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amiloride, Hydrochlorothiazide interactionArtichoke Whole Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Whole Herb Extract + Amiloride, Hydrochlorothiazide interactionAmitriptylineElavil
How Amitriptyline interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Whole Herb Extract + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Whole Herb Extract + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Whole Herb Extract + Amitriptyline, Perphenazine interactionAmlodipineNorliqva
How Amlodipine interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Whole Herb Extract + Amlodipine interactionGentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amlodipine Benzoate interactionArtichoke Whole Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Whole Herb Extract + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Whole Herb Extract + Amlodipine Besilate interactionGentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amlodipine Besylate interactionArtichoke Whole Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Whole Herb Extract + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Whole Herb Extract + Amlodipine Besylate, Benazepril interactionGentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Gentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Amlodipine, Celecoxib interactionArtichoke Whole Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Whole Herb Extract + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Whole Herb Extract + Ammonium Chloride interactionGentian Root ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
Read the full Gentian Root Extract + Ammonium Chloride interactionAmobarbital, SecobarbitalTuinal
How Amobarbital, Secobarbital interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractCytochrome P450 2b6 (cyp2b6) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
Read the full Artichoke Whole Herb Extract + Amobarbital, Secobarbital interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Pancreatin Select — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Whole Herb Extract + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionBetaine HclProton Pump Inhibitors (ppis) Minor
Interaction Summary
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
Read the full Betaine Hcl + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Whole Herb Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with Pancreatin Select — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Whole Herb ExtractCytochrome P450 2b6 (cyp2b6) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
Read the full Artichoke Whole Herb Extract + Aprobarbital, Butabarbital, Phenobarbital interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pancreatin Select with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Artichoke whole herb extract
Antidiabetes Drugs
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.
Antihypertensive Drugs
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.
Gentian root extract
Antihypertensive Drugs
Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.
Betaine HCl
Antacids
Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.
H2-Blockers
Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.
Proton Pump Inhibitors (Ppis)
Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs
Brand information
Manufacturer and brand details for Pancreatin Select, from the product label.
Moss Nutrition
See all Moss Nutrition products- Name
- Moss Nutrition Products, Inc.
- Street Address
- 380 Russell Street
- City
- Hadley
- State
- MA
- ZipCode
- 01035
- Phone Number
- 800-851-5444
- Web Address
- www.mossnutrition.com
Pancreatin Select by Moss Nutrition: Common Questions
Does Pancreatin Select by Moss Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this supplement help with indigestion?
Can I take this if I'm allergic to ragweed?
Is it safe to use during pregnancy or breastfeeding?
Can this supplement cause side effects?
What do the pancreatic enzymes in this product do?
Can I take this with my acid reflux or ulcer medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pancreatin Select is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pancreatin Select’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographBetaine Hydrochloride
Interacts with 36 drugsBetaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...
Read the full Betaine Hydrochloride monograph → Herb & supplement monographArtichoke
Interacts with 363 drugsArtichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...
Read the full Artichoke monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographGentian
Interacts with 172 drugsGentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...
Read the full Gentian monograph →Sources & How We Checked
Pancreatin Select's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Betaine Hydrochloride 2 references
- Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
- Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed
See these in context on the Betaine Hydrochloride monograph →
Artichoke 16 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
- Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
- Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
- Miralles, J. C., Garcia-Sells, J., Bartolome, B., and Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95. PubMed
- Franck, P., Moneret-Vautrin, D. A., Morisset, M., Kanny, G., Megret-Gabeaux, M. L., and Olivier, J. L. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 2005;136(2):155-158. PubMed
- Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Contact Dermatitis 1983;9(4):314.
- Quirce, S., Tabar, A. I., Olaguibel, J. M., and Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke (Cynara scolymus). J Allergy Clin Immunol. 1996;97(2):710-711. PubMed
- Held C. Von der 1. Deutsche-Ungarischen Phytopharmakon-Konferenz, Budapest, 20. November 1991. Z Klin Med 1992;47:92-93.
- Barrat E, Zaïr Y, Ogier N, et al. A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial. Int J Food Sci Nutr. 2013;64(7):882-9. PubMed
- Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C - a pilot study. Phytomedicine. 2009 Sep;16(9):801-4. PubMed
- Caputo F, Barranco R, Bonsignore A, Fraternali Orcioni G, Ventura F. A rare case of fatal bowel obstruction secondary to a colonic bezoar. Am J Forensic Med Pathol. 2018;39(1):38-40. PubMed
- Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-16. PubMed
- Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed
- Jalili C, Moradi S, Babaei A, et al. Effects of Cynara scolymus L. on glycemic indices: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020;52:102496. PubMed
- Gallo R, Oddenino G, Trave I, Gasparini G, Guadagno A, Parodi A. Contact sensitivity to sesquiterpene lactone mix and artichoke in a patient with severe recurrent dermatitis: A puzzling case. Contact Dermatitis 2023;88(2):156-158. PubMed
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Gentian 5 references
- Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
- Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
- Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
- Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
- Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC