Interactions on record — worth a quick check against your medications. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

Pro-Sculpt Blue Raspberry Ingredients & Drug Interactions

by GNC GenetixHD

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Pro-Sculpt Blue Raspberry is a dietary supplement by GNC GenetixHD with 4 active ingredients. Its ingredients are commonly taken for high cholesterol, vitamin b3 deficiency (pellagra), heart health support.Based on those ingredients, 727 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Niacin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Pro-Sculpt Blue Raspberry by GNC GenetixHD

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

GNC GenetixHD Pro-Sculpt Blue Raspberry is a powder with four active ingredients. Niacin (also called vitamin B3) is included to support cellular energy and metabolism.

The other three—Lipo-Thermo Trigger Blend, ROS & Catabolism Combating Blend, and Multi-Action Amino Acid Blend—are proprietary blends; the product facts don't break down their individual components or doses. The powder also contains inactive ingredients for taste and texture, including citric acid, malic acid, artificial flavors, sweeteners (acesulfame potassium and sucralose), silica, and blue food coloring.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Niacin's overall clinical evidence instead.

Strong

Strong clinical evidence supports Niacin for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Pellagra — rated "Likely Effective" (Natural Medicines).
  • On file: HIV/AIDS-related dyslipidemia — rated "Possibly Effective" (Natural Medicines).
  • On file: Metabolic syndrome — rated "Possibly Effective" (Natural Medicines).

Niacin is likely effective for pellagra (a serious deficiency disease). It's possibly effective for improving abnormal cholesterol and triglyceride levels in people with HIV/AIDS-related dyslipidemia, and possibly effective for metabolic syndrome.

Evidence for the three proprietary blends—Lipo-Thermo Trigger Blend, ROS & Catabolism Combating Blend, and Multi-Action Amino Acid Blend—is not established in the data we hold.

The evidence, ingredient by ingredient Niacin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

At normal dietary amounts, niacin is well tolerated. In high supplemental doses, it commonly causes flushing (affecting up to 70% of people), gastrointestinal upset (nausea, vomiting, heartburn, abdominal pain, constipation, or diarrhea), and elevated liver enzymes.

Rare but serious effects include liver damage, muscle damage, low platelet counts, and vision changes. The product facts caution that high-dose niacin should be avoided unless prescribed by your doctor.

Normal amounts from food and standard prenatal vitamins are fine, but high-dose supplements in pregnancy require medical direction. Normal dietary intake during breastfeeding is fine; high-dose supplements should be directed by a doctor.

Side effects, ingredient by ingredient Niacin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Niacin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 728 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take GNC GenetixHD Pro-Sculpt Blue Raspberry, double-check with your pharmacist or doctor if you take blood thinners or antiplatelet drugs (the most serious concern), blood pressure medications, diabetes medications, cholesterol-lowering statins, gout medications like allopurinol or probenecid, bile acid sequestrants (cholesterol drugs that bind in the gut), or any drugs known to stress the liver.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product's niacin content can help with energy metabolism, but it interacts with many common medications—blood thinners, blood pressure drugs, diabetes medications, and statins among them. If you take any prescription drugs, check your exact medications with the tool on this page before starting.

Talk with your doctor or pharmacist about whether this product is right for you and your current health plan.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pro-Sculpt Blue Raspberry, straight from the product label.

Brand GNC GenetixHD
Barcode (UPC) 048107114220
Net contents 13.8 oz.; 390 g
Market status On market
Date entered into DSLD Oct 25, 2012
DSLD ID 14803
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pro-Sculpt Blue Raspberry by GNC GenetixHD, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
13 Gram(s)
Maximum serving Sizes:
13 Gram(s)
Servings per container
30
UPC/BARCODE
048107114220
IngredientAmount% DV
Calories30 {Calories}--
Total Carbohydrates3 g1%
Calories from Fat20 {Calories}--
Total Fat2 g3%
Niacin20 mg100%
Lipo-Thermo Trigger Blend2000 mg--
ROS & Catabolism Combating Blend1150 mg--
Multi-Action Amino Acid Blend6150 mg--

Other ingredients: Citric Acid, Malic Acid, Natural and Artificial flavors, Acesulfame Potassium, Silica, Sucralose, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Each serving supplies 200 mg of Caffeine.

Precautions

WARNING: Do not use if pregnant, nursing or are allergic or contraindicated to aspirin.

If you are taking aspirin or blood thinning or other medication, or have a medical condition, consult your health care professional before using this product.

Discontinue use two weeks prior to surgery, or if upset stomach occurs.

KEEP OUT OF REACH OF CHILDREN.

General Statements

NOTICE: Significant product settling may occur.

E6133901

The ROS & Catabolism Combating Blend is designed to protect vital muscle from harmful free radicals that are induced during your training. This scientific formula is no accident. It's the latest creating from a team of GNC Scientists who uncovered the multi-faceted formula for activating the cellular signals that trigger fat oxidation and maximize thermogenesis while simultaneously fueling and protecting muscle cells. Combined with a fat-slashing diet and exercise program, it works in three distinct phases.

PHASE 3: ROS & Catabolism Combating Blend When you push your body beyond its limits, to promote protein synthesis & build lean muscle, you need to protect against harmful ROS (reactive oxygen species) that damage your cells. Powered by the antioxidant quercetin, this blend targets ROS free radicals, to protect your muscle cells from oxidative damage triggered by intense exercise. Another key element to this blend, glutamine, one of the most abundant amino acids in muscle tissue, works to promote protein synthesis and muscle cell hydration. The ROS & Catabolism Combating Blend offers unrivaled free radiacal protection to the vital processes that promote energy and fatty acid metabolism.

In a double-blind, randomized, placebo-controlled cross-over study, 25 subjects exercised on a treadmill on two occasions. On one occasion subjects took the proprietary module within the Lipo-Thermo Trigger Blend 60 minutes before exercise and on the second occasion, they took a placebo. When the subjects took the proprietary module within the Lipo-Thermo Trigger Blend, they burned 300% more calories before starting their exercises compared to the placebo group. The amount of calories burned was higher in the proprietary module in the Lipo-Thermo Trigger Blend before, during and up to one hour after exercise relative to placebo.

PHASE 1: Lipo-Thermo Trigger Blend An extreme thermogenic blend ignites pre-training calorie burning by an astounding 300%. Ingredients such as caffeine, EGCG, capsicum and piperine directly impact fat metabolism, while white willow, a natural source of salicin, influences metabolic pathways in the body to amplify caffeine's powerful thermogenic effects. The daily two-serving dose features 3.4 grams of clinically backed CLA to promote a lean, healthy body composition. PHASE 2: Mult-Action Amino Acid Blend A special blend of micronized amino acids and ingredients engineered for rapid, efficient uptake. This formula features leucine, a fundamental branched-chain amino acid for triggering protein synthesis and supporting lean muscle. Also featured are several other co-factors, such as beta-alanine, to prime your muscles and stimulate a key fatigue-controlling factor for maximal muscle toning workouts.

The key to GNX Science(TM) is its multi-pronged genomic approach to leveraging every last ounce of your true potential. It targets multiple metabolic pathways from every direction for unparalleled results.

EXTREME MUSCLE DEFINITION SYSTEM - Revolutionary Thermogenic Amplifier Ignites Calorie Burning by 300% - Multi-Action Amino Acid Blend Fuels Lean Muscle & Clinically Studied CLA Supports a Healthy Body Composition - Activates Cellular Signals to Trigger Fatty Acid Metabolism While Fueling & Protecting Muscle Cells

NATURAL & ARTIFICIAL FLAVOR

REACH YOUR TRUE PHYSICAL POTENTIAL For the first time, GNC combines a clinically studied thermogenic formula with rapidly absorbed micronized amino acids to target fatty acid metabolism and fuel lean, sculpted muscles. You have a purpose every time you work out. Your training and diet are precise. You train for results and you expect them to be extraordinary. The body you expect is lean and defined.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Pro-Sculpt(TM) is the premier supplement needed to fuel your workouts as you strive for that next level of detail and definition. Taken daily in the morning or before workouts, Pro-Sculpt(TM) provides a blast of thermogenic amplifiers to push calorie burning to extreme levels, while micronized amino acids prime your body and fuel lean, toned muscles.

PRO-SCULPT(TM) WORKS

Powered by GNX Science(TM)

Capsimax(TM) is a trademark of OmniActive Health Technologies. Licensed under one or more of U.S. Pat. Nos. 5,965,596, 6,426,361, 7,504,376 and 8,064,381, each of which is owned by Natural Alternatives International, Inc. (NAI). NAI is also the owner of the registered trademark CarnoSyn(R). Clarinol(R) CLA is a registered trademark of Stepan Specialty Products LLC.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

GNX

(QR CODE) SCAN & LEARN MORE

FDA Statement of Identity

DIETARY SUPPLEMENT

General

CODE 933394 BNG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, add one level scoop (13 g) to 10 oz of cold water and mix well. To avoid settling, consume immediately after mixing and continue to stir product while drinking. For maximum results use two servings daily.

For maximum results, take two servings daily in combination with regular exercise.

See for yourself

Pro-Sculpt Blue Raspberry by GNC GenetixHD label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Pro-Sculpt Blue Raspberry by GNC GenetixHD

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size13 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Niacin

Interacts with
727 drugs
20 mg per serving

Niacin (vitamin B3) is an essential nutrient your body needs for energy and metabolism, and deficiency is uncommon in most developed countries. Prescr...

Niacin monograph & interactions

Lipo-Thermo Trigger Blend

2000 mg per serving Form: Caffeine Blend, Capsimax Capsicum fruit extract, Conjugated Linoleic Acid, Powder, Green Tea extract, White WIllow bark extract

ROS & Catabolism Combating Blend

1150 mg per serving Form: L-Glutamine, Quercetin Dihydrate, Rhodiola Root Extract

Multi-Action Amino Acid Blend

6150 mg per serving Form: CarnoSyn, L-Arginine, Micronized, L-Citrulline, Micronized, L-Isoleucine, Micronized, L-Leucine, Micronized, L-Valine, Micronized, micronized L-Carnitine, micronized Taurine

Other (inactive) ingredients: Citric Acid, Malic Acid, Natural and Artificial flavors, Acesulfame Potassium, Silica, Sucralose, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pro-Sculpt Blue Raspberry by GNC GenetixHD Drug Interactions

Want to check YOUR meds against Pro-Sculpt Blue Raspberry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
727Drugs
727 Moderate

Ingredients driving the most interactions

Niacin 727

Each ingredient & the kinds of drugs it affects

For each ingredient in Pro-Sculpt Blue Raspberry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Niacin15 drug types · 727 drugs

Alcohol (Ethanol)

Concomitant use of alcohol and niacin might increase the risk of flushing and hepatotoxicity.
Alcohol can exacerbate the flushing and pruritus associated with niacin. Large doses of niacin might also exacerbate liver dysfunction associated with chronic alcohol use. A case report describes delirium and lactic acidosis in a patient taking niacin 3 grams daily who ingested 1 liter of wine. Advise patients to avoid large amounts of alcohol while taking niacin.

Likelihood Probable Evidence D
Allopurinol (Zyloprim)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as allopurinol.
Large doses of niacin can reduce urinary excretion of uric acid, potentially resulting in hyperuricemia. Doses of uricosurics such as allopurinol might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Anticoagulant/Antiplatelet Drugs

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.
Several cases of clotting factor synthesis deficiency and coagulopathy have been reported in patients taking sustained-release niacin. Also, thrombocytopenia has been reported in patients treated with niacin or niacin plus lovastatin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Niacin can increase blood glucose levels and may diminish the effects of antidiabetes drugs.
Niacin impairs glucose tolerance in a dose-dependent manner, probably by causing or aggravating insulin resistance and increasing hepatic production of glucose. In diabetes patients, niacin 4.5 grams daily for 5 weeks can increase plasma glucose by an average of 16% and glycated hemoglobin (HbA1c) by 21%. However, lower doses of 1.5 grams daily or less appear to have minimal effects on blood glucose. In some patients, glucose levels increase when niacin is started, but then return to baseline when a stable dose is reached. Up to 35% of patients with diabetes may need adjustments in hypoglycemic therapy when niacin is added.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, niacin may increase the risk of hypotension when used with antihypertensive drugs.
The vasodilating effects of niacin can cause hypotension. Furthermore, some clinical evidence suggests that a one-hour infusion of niacin can reduce systolic, diastolic, and mean blood pressure in hypertensive patients. This effect is not observed in normotensive patients.

Likelihood Possible Evidence B
Bile Acid Sequestrants

Bile acid sequestrants can bind niacin and decrease absorption. Separate administration by 4-6 hours to avoid an interaction.
In vitro studies show that colestipol (Colestid) binds about 98% of available niacin and cholestyramine (Questran) binds 10% to 30%.

Likelihood Possible Evidence D
Gemfibrozil (Lopid)

Theoretically, concomitant use of niacin and gemfibrozil might increase the risk of myopathy in some patients.
A case of myopathy from concomitant use of niacin and gemfibrozil has been reported. Niacin alone has also been associated with cases of myopathy. Using gemfibrozil with niacin might further increase the risk of developing myopathy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.
Niacin has been associated with cases of liver toxicity, especially when used in pharmacologic doses. Sustained-release niacin preparations appear to be associated with a higher risk of hepatotoxicity than immediate-release niacin.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, concomitant use of niacin and statins might increase the risk of myopathy and rhabdomyolysis in some patients.
Some case reports have raised concerns that niacin might increase the risk of myopathy and rhabdomyolysis when combined with statins. However, a significantly increased risk of myopathy has not been demonstrated in clinical trials, including those using an FDA-approved combination of lovastatin and niacin (Advicor).

Likelihood Possible Evidence D
Probenecid (Benemid)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as probenecid.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as probenecid might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Sulfinpyrazone (Anturane)

Theoretically, niacin might antagonize the therapeutic effects of uricosurics such as sulfinpyrazone.
Large doses of niacin reduce urinary excretion of uric acid, potentially causing hyperuricemia. Doses of uricosurics such as sulfinpyrazone might need to be increased to maintain control of gout in patients who start taking niacin. People who have frequent attacks of gout despite uricosuric therapy should avoid niacin.

Likelihood Probable Evidence C
Thyroid Hormone

Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.
Clinical research and case reports suggests that taking niacin can reduce serum levels of thyroxine-binding globulin by up to 25% and moderately reduce levels of thyroxine (T4). Patients taking thyroid hormone for hypothyroidism might need dose adjustments when using niacin.

Likelihood Probable Evidence D
Transdermal Nicotine (Nicoderm)

Theoretically, concomitant use of niacin and transdermal nicotine might increase the risk of flushing and dizziness.
Niacin and nicotine can both cause flushing and dizziness.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacin may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 3.9 after taking niacin for two weeks. The patient's INR was previously stable, ranging between 2 and 3 in recent months, and no other medication changes were identified. The elevated INR returned to therapeutic range within 4 days following the discontinuation of niacin.

Likelihood Possible Evidence D
Aspirin

Large doses of aspirin might alter the clearance of niacin.
Aspirin is often used with niacin to reduce niacin-induced flushing. Doses of 80-975 mg aspirin have been used, but 325 mg appears to be optimal. Aspirin also seems to reduce the clearance of niacin by competing for glycine conjugation. Taking aspirin 1 gram seems to reduce niacin clearance by 45%. This is probably a dose-related effect and not clinically significant with the more common aspirin dose of 325 mg.

Likelihood Likely Evidence B
The maker

Brand information

Manufacturer and brand details for Pro-Sculpt Blue Raspberry, from the product label.

GNC GenetixHD

See all GNC GenetixHD products
Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Pro-Sculpt Blue Raspberry by GNC GenetixHD: Common Questions

Does Pro-Sculpt Blue Raspberry by GNC GenetixHD interact with any medications?
Yes. Based on its ingredients, Pro-Sculpt Blue Raspberry has a known interaction with 727 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pro-Sculpt Blue Raspberry contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does niacin do in this product?
Niacin is a B vitamin that supports cellular energy and metabolism. It's also been studied for its effects on cholesterol and triglyceride levels, especially in people with HIV-related dyslipidemia or metabolic syndrome. At normal dietary doses it's well tolerated; high supplemental doses are where interactions and side effects become a concern.
What are the most common side effects of niacin?
Flushing (a warm, tingling feeling in the face and upper body) is very common, affecting up to 70% of people taking niacin doses used for health purposes. Gastrointestinal upset—nausea, heartburn, abdominal pain, constipation, or diarrhea—is also typical. These effects are usually dose-related and may improve with continued use or if you take it with food.
Is high-dose niacin safe in pregnancy?
Normal amounts from food and standard prenatal vitamins are safe. High-dose niacin supplements, however, should be avoided in pregnancy unless your doctor prescribes it. Talk with your doctor or pharmacist before taking this product if you're pregnant or planning to become pregnant.
Can I take this if I'm on a blood pressure medication?
Niacin can theoretically lower blood pressure further when combined with blood pressure drugs, which could be a problem. Don't start this product on your own—check with your doctor or pharmacist first, especially if you're already on antihypertensive drugs. They can advise whether it's safe for you.
What are the three blends in this product for?
The product includes a Lipo-Thermo Trigger Blend, ROS & Catabolism Combating Blend, and Multi-Action Amino Acid Blend, but we don't have the specific ingredient breakdown or dosing for those blends. The product label or manufacturer's website should have more detail on their intended roles.
Does this contain fillers or artificial ingredients?
Yes. Beyond the active ingredients, the powder contains citric acid, malic acid, natural and artificial flavors, acesulfame potassium, silica, sucralose, and FD&C Blue #1 for taste, sweetness, and color.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pro-Sculpt Blue Raspberry label
Go deeper

The Full Monographs Behind Pro-Sculpt Blue Raspberry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Pro-Sculpt Blue Raspberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 66 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Niacin 66 references
  1. Garg R, Malinow MR, Pettinger M, et al. Niacin treatment increases plasma homocysteine levels. Am Heart J 1999;138:1082-7.
  2. Anon. Inositol hexaniacinate. Altern Med Rev 1998;3:222-3.
  3. Knodel LC, Talbert RL. Adverse effects of hypolipidaemic drugs. Med Toxicol 1987;2:10-32. PubMed
  4. Guyton JR, Blazing MA, Hagar J, et al. Extended-release niacin vs gemfibrozil for the treatment of low levels of high-density lipoprotein cholesterol. Niaspan-Gemfibrozil Study Group. Arch Intern Med 2000;160:1177-84. PubMed
  5. Gibbons LW, Gonzalez V, Gordon N, Grundy S. The prevalence of side effects with regular and sustained-release nicotinic acid. Am J Med 1995;99:378-85. PubMed
  6. Whelan AM, Price SO, Fowler SF, Hainer BL. The effect of aspirin on niacin-induced cutaneous reactions. J Fam Pract 1992;34:165-8.
  7. Jungnickel PW, Maloley PA, Vander Tuin EL, et al. Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions. J Gen Intern Med 1997;12:591-6. PubMed
  8. Capuzzi DM, Guyton JR, Morgan JM, et al. Efficacy and safety of an extended-release niacin (Niaspan): a long-term study. Am J Cardiol 1998;82:74-81;disc. 85U-6U. PubMed
  9. Gray DR, Morgan T, Chretien SD, Kashyap ML. Efficacy and safety of controlled-release niacin in dyslipoproteinemic veterans. Ann Intern Med 1994;121:252-8. PubMed
  10. McKenney JM, Proctor JD, Harris S, Chinchili VM. A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients. JAMA 1994;271:672-7. DOI
  11. Knopp RH, Alagona P, Davidson M, et al. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia. Metabolism 1998;47:1097-104. PubMed
  12. Knopp RH. Clinical profiles of plain versus sustained-release niacin (Niaspan) and the physiologic rationale for nighttime dosing. Am J Cardiol 1998;82:24U-28U;discussion 39U-41U. PubMed
  13. Garg A, Grundy SM. Nicotinic acid as therapy for dyslipidemia in non-insulin-dependent diabetes mellitus. JAMA 1990;264:723-6. DOI
  14. Leighton RF, Gordon NF, Small GS, et al. Dental and gingival pain as side effects of niacin therapy. Chest 1998;114:1472-4. PubMed
  15. American Society of Health-System Pharmacists. ASHP Therapeutic Position Statement on the safe use of niacin in the management of dyslipidemias. Am J Health Syst Pharm 1997;54:2815-9. DOI
  16. Vega GL, Grundy SM. Lipoprotein responses to treatment with lovastatin, gemfibrozil, and nicotinic acid in normolipidemic patients with hypoalphalipoproteinemia. Arch Intern Med 1994;154:73-82. DOI
  17. Guyton JR, Goldberg AC, Kreisberg RA, et al. Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia. Am J Cardiol 1998;82:737-43.
  18. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  19. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  20. Bays HE, Dujovne CA. Drug interactions of lipid-altering drugs. Drug Saf 1998;19:355-71. PubMed
  21. Rader JI, Calvert RJ, Hathcock JN. Hepatic toxicity of unmodified and time-release preparations of niacin. Am J Med 1992;92:77-81. PubMed
  22. Kahn SE, Beard JC, Schwartz MW, et al. Increased B-cell secretory capacity as mechanism for islet adaptation to nicotinic acid-induced insulin resistance. Diabetes 1989;38:562-8.
  23. Schwartz ML. Severe reversible hyperglycemia as a consequence of niacin therapy. Arch Int Med 1993;153:2050-2. DOI
  24. Raising HDL and Niacin Use. Pharmacist's Letter/Prescriber's Letter 2004;20(5):200504.
  25. McKenney J. New perspectives on the use of niacin in the treatment of lipid disorders. Arch Intern Med 2004;164:697-705. PubMed
  26. Reaven P, Witztum JL. Lovastatin, nicotinic acid and rhabdomyolysis (letter). Ann Int Med 1988;109:597-8. PubMed
  27. Ito MK. Advances in the understanding and management of dyslipidemia: using niacin-based therapies. Am J Health-Syst Pharm 2003;60(suppl 2):s15-21. PubMed
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Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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