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Dietary supplement

Prodegin Ingredients & Drug Interactions

by Klaire Labs

Prodegin label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Prodegin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Prodegin is a dietary supplement by Klaire Labs with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Prodegin by Klaire Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Prodegin by Klaire Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Prodegin by Klaire Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Probiotic Blend” is a proprietary blend — the label gives one combined amount (164 mg) without saying how much of each component you get.

Prodegin contains five active probiotic ingredients: four Lactobacillus species (salivarius, plantarum, paracasei, and acidophilus) and Lactobacillus rhamnosus, each a live beneficial bacterium meant to support gut health. The product also includes inactive ingredients — stearic acid, cherry and vanilla flavoring, silicon dioxide, magnesium stearate, and licorice extract — which serve as binders, flow agents, and flavor.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Multispecies probiotic supplement.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Rotaviral diarrhea, Lactose intolerance, Travelers' diarrhea.

Lactobacillus acidophilus, one of the five active ingredients, is rated Possibly Effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. It's rated Possibly Ineffective for atopic disease, and there isn't enough reliable evidence to rate it for acute respiratory distress syndrome.

We don't have effectiveness ratings on file for the other four probiotic strains in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. The most common side effects from probiotic combinations are mild gastrointestinal effects — epigastric discomfort, abdominal pain, bloating, flatulence, and diarrhea — but these are uncommon.

In rare cases, live probiotic organisms have been found in serious infections like bacteremia or endocarditis, though this typically occurs when bacteria translocate from areas where they already exist in the body. One trial reported rash and itching, though it's unclear if L. acidophilus was the cause.

Because data are limited, check with your doctor before you start.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Prodegin, double-check any antibiotic drugs you're on — they can reduce how well the Lactobacillus acidophilus in this product works. Timing your doses apart may help.

We couldn't check the other four probiotic strains for interactions, so mention those to your pharmacist too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Prodegin is a five-strain probiotic that may help with IBS, antibiotic-associated diarrhea, and a few other gut and vaginal concerns, though the evidence is still emerging. If you take antibiotics, spacing out your doses from this supplement can help.

Check your medications with our tool before starting, and run it by your doctor or pharmacist — especially if you have any chronic health conditions or a weakened immune system.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Prodegin, straight from the product label.

Brand Klaire Labs
Barcode (UPC) 709616012499
Net contents 60 Chewable Vegetarian Tablet(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 264704
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Prodegin by Klaire Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
709616012499
IngredientAmount% DV
Total Carbohydrate1 Gram(s)1%
Lactobacillus salivarius0 NP--
Lactobacillus plantarum0 NP--
Lactobacillus paracasei0 NP--
Lactobacillus acidophilus0 NP--
Lactobacillus rhamnosus0 NP--
Sugar Alcohol1 Gram(s)--
Probiotic Blend164 mg--

Other ingredients: Stearic Acid, natural Cherry flavor, natural Vanilla flavor, Silicon Dioxide, magnesium stearate, Licorice extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Ships with cool pack

Formula

30 billion CFU

Formulation

Multispecies

Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. Contains no artificial colors, flavors, or preservatives.

Produced under a strict quality management system in compliance with Good Manufacturing Practices (GMPs) and third-party quality certifications.

FDA Statement of Identity

Probiotic Supplement

Precautions

Caution: If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product.

Do not use if shrinkwrap is broken or missing.

Suggested/Recommended/Usage/Directions

Suggested Use: Adults: Chew 1 tablet, 1 to 2 tumes daily preferably 30-60 minutes after meals or as directed by a healthcare professional. Children: As directed by a healthcare professional.

Storage

Keep refrigerated.

Brand IP Statement(s)

SFI

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Prodegin by Klaire Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Prodegin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Prodegin by Klaire Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Probiotic Blend

Interacts with
182 drugs
164 mg per serving Form: Inulin

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Blend monograph & interactions
  • › Lactobacillus salivarius
  • › Lactobacillus plantarum
  • › Lactobacillus paracasei
  • › Lactobacillus acidophilus
  • › Lactobacillus rhamnosus

Other (inactive) ingredients: Stearic Acid, Natural Cherry flavor, Natural Vanilla flavor, Silicon Dioxide, Magnesium stearate, Licorice extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Prodegin by Klaire Labs Drug Interactions

Want to check YOUR meds against Prodegin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Probiotic Blend 182

Individual Drug Interactions

The ingredients in Prodegin interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Prodegin interact with drugs. Each result below shows which ingredient is responsible. Probiotic Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Prodegin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probiotic Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Prodegin, from the product label.

Klaire Labs

See all Klaire Labs products
Name
SFI USA
City
Reno
State
NV
ZipCode
89521
Web Address
Klaire.com
Pharmacist Counseling Corner

Prodegin by Klaire Labs: Common Questions

Does Prodegin by Klaire Labs interact with any medications?
Yes. Based on its ingredients, Prodegin has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Prodegin contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this probiotic work for IBS?
Lactobacillus acidophilus, one of the five strains in Prodegin, is rated Possibly Effective for IBS. That means there's some evidence it may help, but the research is still developing. Results vary person to person, so talk with your doctor about whether to try it for your specific symptoms.
Can I take this while on antibiotics?
Antibiotics can kill the live organisms in Prodegin, making the probiotic less effective. It's best to space them out — ask your pharmacist exactly how many hours apart to take them. Some people wait until they've finished their antibiotic course before starting the probiotic.
What side effects might I notice?
Most people tolerate Prodegin well. Mild bloating, gas, or loose stools can happen at first, especially when you're combining probiotics, but these are uncommon. If you develop a rash, severe abdominal pain, or feel unwell, stop and tell your doctor.
Is it safe to take during pregnancy?
Lactobacillus acidophilus is rated Possibly Safe in pregnancy, but we don't have enough data on the other four probiotic strains for pregnancy. Since safety can vary individually, talk with your OB or midwife before you start it.
What exactly are probiotics?
Probiotics are live beneficial bacteria meant to support your gut. Prodegin contains five Lactobacillus strains that naturally live in a healthy digestive system. They're thought to help restore balance, especially after antibiotics or during gut-related conditions.
Do I need to refrigerate this?
We don't have storage instructions on file for Prodegin. Check the label or contact the manufacturer directly for proper storage to keep the live organisms viable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Prodegin is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Prodegin label
Go deeper

The Full Monographs Behind Prodegin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Prodegin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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