Red Crea7ine Fruit Punch Ingredients & Drug Interactions
by MRI
What is this page for?
First and foremost: checking Red Crea7ine Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Red Crea7ine Fruit Punch is a dietary supplement by MRI with 9 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 556 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Magnesium, Vitamin B6, Sodium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Red Crea7ine Fruit Punch by MRI
Ask about any prescription or over-the-counter medication and we check it for interactions with Red Crea7ine Fruit Punch by MRI — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Red Crea7ine Fruit Punch by MRI
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Red Creatine Fruit Punch contains 21 ingredients, most of them active compounds aimed at muscle performance and recovery. The amino acids include L-glutamine, L-leucine, L-isoleucine, L-valine, L-histidine, and L-lysine — building blocks your muscles use.
You'll also get multiple forms of creatine (creatine hydrochloride, ethyl ester, gluconate, anhydrous, deconoate, and monohydrate), which help fuel muscle contractions during intense exercise. Taurine is included for cell function, plus vitamins B6 and B12, magnesium, potassium, sodium, and phosphorus for energy and electrolyte balance.
CarnoSyn (beta-alanine) is added for athletic endurance. The remaining ingredients are inactive fillers and flavor compounds — maltodextrin, citric acid, malic acid, colorants, sweeteners, and thickeners.
Does it work?
Moderate evidence
Creatine is rated Possibly Effective for muscle strength, athletic performance, and sarcopenia (age-related muscle loss). Beta-alanine (CarnoSyn) is Possibly Effective for athletic and physical performance.
Magnesium is Effective for certain digestive complaints and Effective for pre-eclampsia prevention in pregnancy. Vitamin B6 is Effective for sideroblastic anemia and Likely Effective for elevated homocysteine.
Vitamin B12 is Effective for B12 deficiency and cyanide poisoning. Taurine is Possibly Effective for congestive heart failure.
Glutamine is Effective for sickle cell disease and Possibly Effective for HIV-related wasting and recovery after trauma. L-histidine has insufficient evidence for most uses.
L-lysine is Possibly Effective for cold sores. The evidence for other ingredients isn't established in our data.
How safe is it?
Well-documented data
Creatine is generally well tolerated in healthy adults, though it can cause diarrhea, muscle cramps, water retention, and dehydration — and those with kidney problems should be cautious. Beta-alanine commonly causes harmless tingling and flushing of the skin.
Magnesium can cause diarrhea, nausea, and gastrointestinal upset. Glutamine is generally well tolerated but may cause bloating, constipation, nausea, and headache; people with kidney or liver disease need medical supervision.
Sodium at high levels raises blood pressure and heart strain. Potassium from food is safe, but supplements can dangerously spike blood levels in those with kidney disease.
Vitamin B6 at high doses over time can damage nerves (sensory neuropathy). Taurine is generally well tolerated short-term, though long-term safety is less certain.
Vitamin B12 is very safe with no established upper limit. Lysine may cause stomach upset at high doses.
We hold no pregnancy or breastfeeding safety data for beta-alanine or the creatine compounds — they're rated as best avoided in pregnancy and nursing.
Meds to double-check
Major interaction found
Check your medications if you take levodopa/carbidopa (Parkinson's) — magnesium cuts its absorption significantly (Major severity). Also double-check blood pressure medications (antihypertensives, ACE inhibitors, ARBs), seizure drugs (phenobarbital, phenytoin), lithium, steroids, diabetes drugs (sulfonylureas), muscle relaxants, antibiotics (quinolones), bone medications (bisphosphonates), HIV drugs (didanosine), and blood thinners.
If you take any prescription medication, run it through the checker on this page before adding this product.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This is a multi-ingredient sports supplement aimed at muscle builders and athletes. If you take medications for blood pressure, seizures, Parkinson's disease, heart rhythm, diabetes, kidney function, or bipolar disorder — or if you're on lithium, antibiotics, or bone medications — check your specific drugs with our tool before you start.
Healthy adults without kidney disease or blood pressure concerns may tolerate it, but those with kidney issues or anyone on prescription medications should talk to their pharmacist first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 17 of 21 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Red Crea7ine Fruit Punch, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Red Crea7ine Fruit Punch by MRI, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 20 {Calories} | -- |
| Total Carbohydrates | 5 g | 1% |
| L-Glutamine | 0 NP | -- |
| Sugar | 0.4 g | -- |
| Calories from Fat | 0 {Calories} | -- |
| Sodium | 51 mg | 2% |
| Potassium | 417 mg | 12% |
| Cholesterol | 0 mg | -- |
| Phosphorus | 21 mg | 2% |
| Vitamin B6 | 2 mcg | 100% |
| Vitamin B12 | 30 mcg | 500% |
| Magnesium | 223 mg | 56% |
| L-Leucine | 0 NP | -- |
| L-Isoleucine | 0 NP | -- |
| Taurine | 0 NP | -- |
| L-Valine | 0 NP | -- |
| L-Histidine | 0 NP | -- |
| L-Lysine | 0 NP | -- |
| Total Fat | 0 g | -- |
| CarnoSyn | 0 NP | -- |
| Creatine Hydrochloride | 0 NP | -- |
| Creatine Ethyl Ester HCl | 0 NP | -- |
| Creatine Gluconate | 0 NP | -- |
| Creatine Anhydrous | 0 NP | -- |
| Magnesium Creatine | 0 NP | -- |
| MRI Proprietary Blend | 9.7 g | -- |
| Ultimate Creatine Anaboliser | 0 NP | -- |
| Creatine Deconoate | 0 NP | -- |
| Micro Creatine Monohydrate | 0 NP | -- |
| Essential Amino Acid Shield | 0 NP | -- |
Other ingredients: Maltodextrin, Citric Acid, Potassium Bicarbonate, Malic Acid, Natural and Artificial flavors, Magnesium Oxide, Silicon Dioxide, Potassium Aspartate, Sucralose, Disodium Phosphate, Beet, FD&C Red Lake #4, Sunnet Acesulfame
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
NOTE: Do not take ester creatine (such as CE2(R)) with RED CREA7INE during the "ON" cycle.
WARNING: Do not use if you are pregnant, nursing, at risk for or suffer from renal (kidney) or hepatic (liver) dysfunction.
Do not use if you suffer from diabetes or if you are prone to hyperglycemia or hypoglycemia. Do not use if you have been prescribed and are taking Disulfiram (Antabuse), or if you have a known hypersensitivity to any of the components in creatine or ethyl alcohol.
Not intended for use by individuals under the age of 18 years.
If you experience a skin rash or any other allergic reaction, discontinue use and consult a physician.
KEEP OUT OF THE REACH OF CHILDREN.
Suggested/Recommended/Usage/Directions
It is recommended to take CE2 during the "OFF" cycle.
PREPARATION: Mix 1 serving (1 scoop) of RED CREA7INE(TM) in 8 oz. of cold water. Mix well before drinking. DIRECTIONS: Take 2 servings daily, dosed as follows: ON TRAINING DAYS: Take one serving BEFORE your workout and the second serving AFTER your workout. ON NON-TRAINING DAYS: Take one serving in the morning and the second serving 12 hours later. FOR BEST RESULTS: Cycle RED CREA7INE "ON" for 4 weeks and "OFF" for 2 weeks.
Maintain an adequate state of hydration during use.
General Statements
Each of the formula's muscle driving creatines were carefully selected for their unique characteristisc. The result is a 7-fold “wave” of pure creatine power that floods muscles with a burst of advanced strength fuel. As muscles store volumes of creatine, the increased load actually triggers new muscle protein synthesis – helping to keep muscle anabolism in “overdrive.”
RED CREA7INE is a dramatic innovation in creatine technology, scientifically formulated for driving optimum size, strength and performance potential.
^Use in conjunction with your exercise routine. **Graphic representation of proposed PK profile.
R.A.M.P RED CREA7INE aggressively targets the four key factors of athletic prowess – Recovery, Anabolism, Muscle Power and Performance. Recovery: Post workout creatine replenishes vital energy stores depleted during bouts of intense training. As creatine is transported into muscles, it tends to “pull” hydrating fluids along – helping to promote beneficial cell volumization. Anabolism: Once creatine is loaded into muscle tissue it helps to trigger protein synthesis – the process of new muscle production. As protein synthesis initiates, the EAAs provide the “building blocks” required for the formation of new muscle proteins. Muscle Power: Creatine provides the “fuel” that drives the high energy “machines” of muscle contractions – ATP. Stores of creatine help to generate explosive bursts of power output and raw strength. Performance: Increased stores of creatine provide fueling of ATP. This drives faster recovery between sets and longer bouts of muscle-stimulating, high-intensity training. The EAAs, through the building and preservation of lean mass, help to keep muscles in peak working condition for optimal performance.
25 SERVINGS
Natural and Artificial Flavors
AN ANABOLIC REACTOR
EVEN MORE ANABOLIC FUEL RED CREA7INE taps deep into the “core” of muscle growth with a precise blend of 8 Amino Acids – including the performance-driving BCAAs. The BCAAs help create an anabolic environment that play a key role in energy production, lean mass preservation and new protein synthesis. The precise blend of aminos provides anabolic synergy with the formula’s 7-creatine blend. Creatine availability in tissues helps to trigger protein synthesis while the EAAs provide the “building blocks” required for building new, lean muscle tissue.
NEW!
7 CREATINE HIGH PEFORMANCE BLEND
• 6 Grams of Creatine per Serving • Drives Explosive Power & Strength† • BCAAs for Muscle Fuel & Growth† • Improves Recovery & Training Performance† • Less Than 1 Gram of Sugar! SCAN IT! QR CODE UNLOCK OUR QR CODE FOR EXCLUSIVE CONTENT AND SAVINGS THE ULTIMATE PERFORMANCE CREATINE
U.S. Patent Pending
General
2006625-11307
Brand IP Statement(s)
(c) 2011, Medical Research Institute
With 7 distinct forms of creatine, RED CREA7INE(TM) functions as a virtual “anabolic reactor.”
CarnoSyn(R) Carnosine Synthesizer is a registered trademark of NAI, Inc. USA Patents: 5,965,596; 6,172,098B1; 6,426,361B2
FDA Statement of Identity
Dietary Supplement
Formulation
NO: Egg, Fish, Milk, Peanut, Shellfish, Soy, Tree Nuts, Wheat
Storage
STORE AT 59-86(0)F (15-30(0)C). PROTECT FROM LIGHT AND MOISTURE.
Seals/Symbols
CarnoSyn(R) Carnosine Synthesizer
FDA Disclaimer Statement
* THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION . THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Red Crea7ine Fruit Punch by MRI label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Red Crea7ine Fruit Punch by MRI
These are the 9 active ingredients this product is made of. Select any to open its full monograph.
Serving size20 Gram(s) Dosage formPowder Servings per container25 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
Sodium
Interacts with205 drugs
Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...
Sodium monograph & interactionsPotassium
Interacts with62 drugs
Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...
Potassium monograph & interactionsPhosphorus
Vitamin B6
Interacts with210 drugs
Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...
Vitamin B6 monograph & interactionsVitamin B12
Interacts with20 drugs
Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...
Vitamin B12 monograph & interactionsMagnesium
Interacts with295 drugs
Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...
Magnesium monograph & interactionsMRI Proprietary Blend
- › Ultimate Creatine Anaboliser
- › Essential Amino Acid Shield
Other (inactive) ingredients: Maltodextrin, Citric Acid, Potassium Bicarbonate, Malic Acid, Natural and Artificial flavors, Magnesium Oxide, Silicon Dioxide, Potassium Aspartate, Sucralose, Disodium Phosphate, Beet, FD&C Red Lake #4, Sunnet Acesulfame. These complete the product’s ingredient list but are not active constituents.
Red Crea7ine Fruit Punch by MRI Drug Interactions
HelloPharmacist Interaction Report
Red Creatine Fruit Punch by MRI contains several active ingredients with documented medication interactions.
The most serious is magnesium, which significantly reduces how your body absorbs levodopa/carbidopa (Sinemet) — a Parkinson's medication — cutting levodopa levels by 35% and carbidopa by 81%. This is a Major interaction.
Read the full breakdown — every affected drug type, severity by severity
Sodium in this product interacts with blood pressure drugs (antihypertensives), certain steroids (corticosteroids), lithium, didanosine (an HIV medication), and several others — all rated Moderate. High sodium can counteract blood pressure control and alter how your body handles lithium.
Potassium also raises concerns: it can dangerously spike blood levels when combined with blood pressure medications called ACE inhibitors, ARBs, or potassium-sparing diuretics, all Moderate severity.
Magnesium additionally interacts with muscle relaxants, certain diabetes drugs (sulfonylureas), antibiotics (quinolones), and bone medications (bisphosphonates) — all Moderate. Vitamin B6 at high doses may reduce effectiveness of seizure medications (phenobarbital and phenytoin).
Glutamine theoretically could interfere with seizure control. Taurine and vitamin B12 have minor-to-moderate interactions with blood pressure drugs and lithium.
We could not check L-Leucine, L-Isoleucine, or Phosphorus — no data is on file for those.
Altogether, these interactions span 551 individual medications. Use the medication checker below to verify your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Red Crea7ine Fruit Punch?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Red Crea7ine Fruit Punch interact with 556 drugs. Click any drug to see the details.
5 of the 9 ingredients in Red Crea7ine Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. Magnesium Vitamin B6 Sodium Potassium Vitamin B12
Benserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with Red Crea7ine Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Magnesium CreatineLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Creatine + Benserazide, Levodopa interactionVitamin B6Levodopa Minor
Interaction Summary
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Read the full Vitamin B6 + Benserazide, Levodopa interactionCarbidopaLodosyn
How Carbidopa interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Creatine + Carbidopa interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with Red Crea7ine Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Magnesium CreatineLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Creatine + Carbidopa, Levodopa interactionVitamin B6Levodopa Minor
Interaction Summary
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Read the full Vitamin B6 + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Red Crea7ine Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Magnesium CreatineLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Creatine + Carbidopa, Levodopa, Entacapone interactionVitamin B6Levodopa Minor
Interaction Summary
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Read the full Vitamin B6 + Carbidopa, Levodopa, Entacapone interactionLevodopaInbrija, Larodopa
How Levodopa interacts with Red Crea7ine Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Magnesium CreatineLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Creatine + Levodopa interactionVitamin B6Levodopa Minor
Interaction Summary
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Read the full Vitamin B6 + Levodopa interactionLevodopa, CarbidopaDuodopa
How Levodopa, Carbidopa interacts with Red Crea7ine Fruit Punch — through 2 ingredients. Tap an ingredient for the detail:
Magnesium CreatineLevodopa/carbidopa (sinemet) Major
Interaction Summary
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Read the full Magnesium Creatine + Levodopa, Carbidopa interactionVitamin B6Levodopa Minor
Interaction Summary
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Read the full Vitamin B6 + Levodopa, Carbidopa interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Red Crea7ine Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
TaurineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Taurine + Acebutolol interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Acebutolol interactionVitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Acebutolol interactionAcetaminophen, ChlorzoxazoneAcetazone Forte, Extra Strength Tylenol Aches & Strains, Parafon Forte
How Acetaminophen, Chlorzoxazone interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Creatine + Acetaminophen, Chlorzoxazone interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Creatine + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Creatine + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, MethocarbamolRobaxacet
How Acetaminophen, Methocarbamol interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Creatine + Acetaminophen, Methocarbamol interactionAcetaminophen, OrphenadrineOrfenagesic
How Acetaminophen, Orphenadrine interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Creatine + Acetaminophen, Orphenadrine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Red Crea7ine Fruit Punch — through 4 ingredients. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Acetazolamide interactionVitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Acetazolamide interactionTaurineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Taurine + Acetazolamide interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineSulfonylureas Moderate
Interaction Summary
Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Read the full Magnesium Creatine + Acetohexamide interactionAlcuroniumAlcuronium
How Alcuronium interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magnesium Creatine + Alcuronium interactionAlendronateBinosto, Fosamax
How Alendronate interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Magnesium Creatine + Alendronate interactionAlendronate Sodium
How Alendronate Sodium interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Magnesium Creatine + Alendronate Sodium interactionAlendronate Sodium, CholecalciferolFosamax Plus D
How Alendronate Sodium, Cholecalciferol interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Magnesium Creatine + Alendronate Sodium, Cholecalciferol interactionAlginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Creatine + Alginic Acid, Aluminum Hydroxide interactionAliskirenTekturna
How Aliskiren interacts with Red Crea7ine Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Aliskiren interactionTaurineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Taurine + Aliskiren interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Aliskiren interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Creatine + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineAntacids, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Creatine + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineAnticoagulant/antiplatelet Drugs, Antacids Moderate
Interaction Summary
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
Read the full Magnesium Creatine + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Creatine + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Creatine + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magnesium Creatine + Aluminum, Magnesium (otc Drug) interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Red Crea7ine Fruit Punch — through 3 ingredients. Tap an ingredient for the detail:
Vitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Ambrisentan interactionTaurineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Taurine + Ambrisentan interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Ambrisentan interactionAmikacinAmikin, Arikayce
How Amikacin interacts with Red Crea7ine Fruit Punch — through 1 ingredient. Tap an ingredient for the detail:
Magnesium CreatineAminoglycoside Antibiotics Moderate
Interaction Summary
Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Read the full Magnesium Creatine + Amikacin interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Red Crea7ine Fruit Punch — through 5 ingredients. Tap an ingredient for the detail:
TaurineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Taurine + Amiloride interactionMagnesium CreatinePotassium-sparing Diuretics Moderate
Interaction Summary
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Read the full Magnesium Creatine + Amiloride interactionPotassiumPotassium-sparing Diuretics Moderate
Interaction Summary
Concomitant use increases the risk of hyperkalemia.
Read the full Potassium + Amiloride interactionVitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amiloride interactionSodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Red Crea7ine Fruit Punch — through 5 ingredients. Tap an ingredient for the detail:
SodiumAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium + Amiloride, Hydrochlorothiazide interactionMagnesium CreatinePotassium-sparing Diuretics Moderate
Interaction Summary
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Read the full Magnesium Creatine + Amiloride, Hydrochlorothiazide interactionTaurineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taurine might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Taurine + Amiloride, Hydrochlorothiazide interactionPotassiumPotassium-sparing Diuretics Moderate
Interaction Summary
Concomitant use increases the risk of hyperkalemia.
Read the full Potassium + Amiloride, Hydrochlorothiazide interactionVitamin B6Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Vitamin B6 + Amiloride, Hydrochlorothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Red Crea7ine Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Magnesium
Levodopa/Carbidopa (Sinemet)
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.
Aminoglycoside Antibiotics
Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.
Antacids
Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.
Bisphosphonates
Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.
Calcium Channel Blockers
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.
Digoxin
Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.
Potassium-Sparing Diuretics
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.
Quinolone Antibiotics
Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Skeletal Muscle Relaxants
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.
Sulfonylureas
Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.
Tetracycline Antibiotics
Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.
Anticoagulant/Antiplatelet Drugs
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.
Gabapentin (Neurontin)
Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Sevelamer (Renagel, Renvela)
Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.
Vitamin B6
Amiodarone (Cordarone)
Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.
Antihypertensive Drugs
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.
Phenobarbital (Luminal)
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.
Phenytoin (Dilantin)
High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.
Levodopa
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.
Sodium
Antihypertensive Drugs
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.
Corticosteroids
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.
Didanosine (Videx)
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.
Lithium
Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.
Sodium Phosphates
Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.
Sodium-Containing Drugs
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.
Tolvaptan (Samsca)
Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.
Potassium
Ace Inhibitors (Aceis)
Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Angiotensin Receptor Blockers (Arbs)
Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Potassium-Sparing Diuretics
Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.
Vitamin B12
Metformin (Glucophage)
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.
Brand information
Manufacturer and brand details for Red Crea7ine Fruit Punch, from the product label.
MRI
See all MRI products- Name
- MRI Medical Research Institute
- City
- Chatsworth
- State
- CA
- ZipCode
- 91311
- Phone Number
- 1.888.448.4246
- Web Address
- www.mri-performance.com
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The Full Monographs Behind Red Crea7ine Fruit Punch’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sodium
Interacts with 205 drugsSodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...
Read the full Sodium monograph → Herb & supplement monographPotassium
Interacts with 62 drugsPotassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...
Read the full Potassium monograph → Herb & supplement monographVitamin B6
Interacts with 210 drugsVitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...
Read the full Vitamin B6 monograph → Herb & supplement monographVitamin B12
Interacts with 20 drugsVitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...
Read the full Vitamin B12 monograph → Herb & supplement monographMagnesium
Interacts with 295 drugsMagnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...
Read the full Magnesium monograph →Sources & How We Checked
Red Crea7ine Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 335 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glutamine 11 references
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- Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
- Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
- Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
- Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
- Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
- Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
- Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
- Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
- Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed
Sodium 38 references
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- Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
- Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
- Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
- Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
- Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
- Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
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- Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
- D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
- Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
- Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
- Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
- Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
- Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
- Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
- Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
- O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
- Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
- Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
- Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
- Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
- He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
- Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
- Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
- Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
- Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
- Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
- Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
- Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
- Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
- Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
- Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
- Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
- Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
- George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
- Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed
Potassium 12 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
- Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
- Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
- Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
- Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
- Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
- Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
- Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
- Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
- Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
- Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
Vitamin B6 32 references
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
- Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
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