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Dietary supplement

S.B.C. Saccharomyces Boulardii Capsules Ingredients & Drug Interactions

by Douglas Laboratories

S.B.C. Saccharomyces Boulardii Capsules label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking S.B.C. Saccharomyces Boulardii Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

S.B.C. Saccharomyces Boulardii Capsules is a dietary supplement by Douglas Laboratories with 1 active ingredient. Its ingredients are commonly taken for acute diarrhea, antibiotic-associated diarrhea, traveler's diarrhea.Based on those ingredients, 40 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Saccharomyces boulardii. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against S.B.C. Saccharomyces Boulardii Capsules by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with S.B.C. Saccharomyces Boulardii Capsules by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of S.B.C. Saccharomyces Boulardii Capsules by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: Saccharomyces boulardii, a live yeast strain used as a probiotic. The capsule itself is made from gelatin and contains microcrystalline cellulose and vegetable stearate as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Saccharomyces Boulardii's overall clinical evidence instead.

Moderate

Some clinical evidence supports Saccharomyces Boulardii for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Antibiotic-associated diarrhea — rated "Possibly Effective" (Natural Medicines).
  • On file: Helicobacter pylori — rated "Possibly Effective" (Natural Medicines).
  • On file: Necrotizing enterocolitis (NEC) — rated "Possibly Effective" (Natural Medicines).
  • On file: Rotaviral diarrhea — rated "Possibly Effective" (Natural Medicines).
  • On file: Travelers' diarrhea — rated "Possibly Effective" (Natural Medicines).

Saccharomyces boulardii is possibly effective for several types of diarrhea — including rotaviral diarrhea, travelers' diarrhea, antibiotic-associated diarrhea, and diarrhea from Clostridioides difficile infection. It's also possibly effective for helping prevent necrotizing enterocolitis (NEC, a serious intestinal condition in premature newborns) and may help with Helicobacter pylori infection.

The evidence supporting these uses exists, but it's not definitive — more research is ongoing.

The evidence, ingredient by ingredient Saccharomyces Boulardii

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saccharomyces boulardii is generally well tolerated in healthy adults, but it should be avoided if you're critically ill or have a weakened immune system. There's limited safety data overall, so talk with your doctor before starting it.

In rare cases, people have reported mild gastrointestinal complaints like abdominal cramps, flatulence, nausea, vomiting, or decreased appetite. Very rarely, the live yeast has caused a bloodstream infection (fungemia) — this has occurred almost exclusively in critically ill ICU patients with central lines, feeding tubes, or those on broad-spectrum antibiotics, and usually when capsules were opened or powder packets were used directly.

Side effects, ingredient by ingredient Saccharomyces Boulardii

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saccharomyces Boulardii.
  • The most serious interaction on file is rated Minor.
  • For scale: 40 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antifungal medication (Minor severity), double-check with your doctor or pharmacist before using this product. Antifungals can reduce the effectiveness of the live yeast in this supplement.

No other medication interactions are documented for this ingredient in our data, but that doesn't mean none exist — your pharmacist can search your full medication list using the tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Only minor medication interactions are documented, and safety information is well characterized.

This probiotic may help with certain types of diarrhea if you're generally healthy. It's not for people who are severely ill or immunocompromised.

If you're on an antifungal medication, you'll need to check with your doctor or pharmacist about whether to take this product and when. Always talk it over with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about S.B.C. Saccharomyces Boulardii Capsules, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539003183
Net contents 50 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232002
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for S.B.C. Saccharomyces Boulardii Capsules by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
50
UPC/BARCODE
310539003183
IngredientAmount% DV
Saccharomyces boulardii0 NP--

Other ingredients: Microcrystalline Cellulose, Gelatin, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 capsule with each meal (3 times daily) or as directed by your health professional.

Precautions

Warning: If you are pregnant, nursing, have any health condition or taking any medication, consult your health professional before using this product.

Caution: If you are immunocompromised, consult your health professional before using probiotic-containing products.

Keep out of the reach of children.

Use only if safety seal is intact.

Storage

Store in a cool, dry place.

Formulation

Gluten-free, Non-GMO

Gastrointestinal health

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Scan to learn about our manufacturing excellence Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

S.B.C. Saccharomyces Boulardii Capsules by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

S.B.C. Saccharomyces Boulardii Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in S.B.C. Saccharomyces Boulardii Capsules by Douglas Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Saccharomyces boulardii

Interacts with
40 drugs
0 NP per serving

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea,...

Saccharomyces boulardii monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

S.B.C. Saccharomyces Boulardii Capsules by Douglas Laboratories Drug Interactions

Want to check YOUR meds against S.B.C. Saccharomyces Boulardii Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
40Drugs
40 Minor

Ingredients driving the most interactions

Saccharomyces boulardii 40

Individual Drug Interactions

The ingredients in S.B.C. Saccharomyces Boulardii Capsules interact with 40 drugs. Click any drug to see the details.

1 of the 1 ingredient in S.B.C. Saccharomyces Boulardii Capsules interact with drugs. Each result below shows which ingredient is responsible. Saccharomyces boulardii

Each ingredient & the kinds of drugs it affects

For each ingredient in S.B.C. Saccharomyces Boulardii Capsules with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Saccharomyces boulardii1 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Saccharomyces boulardii full monograph & interactions
The maker

Brand information

Manufacturer and brand details for S.B.C. Saccharomyces Boulardii Capsules, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Phone Number
1.800.245.4440
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

S.B.C. Saccharomyces Boulardii Capsules by Douglas Laboratories: Common Questions

Does S.B.C. Saccharomyces Boulardii Capsules by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, S.B.C. Saccharomyces Boulardii Capsules has a known interaction with 40 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
S.B.C. Saccharomyces Boulardii Capsules contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Saccharomyces boulardii safe if I'm on antibiotics?
For most healthy people on regular antibiotics, it's generally considered safe. However, if you're critically ill and on broad-spectrum antibiotics in an ICU setting, there's a rare risk of infection, so talk with your doctor. If you're immunocompromised, avoid it altogether.
Can I take this alongside my antifungal medication?
Not at the same time — antifungals kill the yeast in this supplement, making it ineffective. Your doctor or pharmacist can help you figure out whether to space them out or skip the probiotic while you're on the antifungal.
What does this supplement actually do?
It may help reduce diarrhea from several causes: viral infection (rotavirus), traveler's diarrhea, diarrhea triggered by antibiotics, and Clostridioides difficile infection. It's also possibly helpful for Helicobacter pylori and for preventing a serious intestinal condition in premature infants. The evidence suggests it works, but more research is still needed.
Are there any side effects?
Most people tolerate it well. Rarely, some experience mild gut symptoms like stomach cramps, gas, nausea, or decreased appetite. Very rarely, a bloodstream infection from the yeast has occurred, almost only in critically ill hospitalized patients.
Is it safe to use if I'm pregnant or breastfeeding?
We don't have enough safety data on file to say whether this product is safe during pregnancy or breastfeeding. Talk with your doctor or pharmacist before taking it if you're pregnant or nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if S.B.C. Saccharomyces Boulardii Capsules is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

S.B.C. Saccharomyces Boulardii Capsules label
Go deeper

The Full Monographs Behind S.B.C. Saccharomyces Boulardii Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph →
Sources

Sources & How We Checked

S.B.C. Saccharomyces Boulardii Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saccharomyces Boulardii 26 references
  1. Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.
  2. Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5. DOI
  3. Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3.
  4. Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8.
  5. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. PubMed
  6. Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5. PubMed
  7. Hennequin C, Thierry A, Richard GF, et al. Microsatellite typing as a new tool for identification of Saccharomyces cerevisiae strains. J Clin Microbiol 2001;39:551-9.
  8. Plein K, Hotz J. Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease with special respect to chronic diarrhea - a pilot study. Z Gastroenterol 1993;31:129-34.
  9. Borriello SP, Hammes WP, Holzapfel W, et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 2003;36:775-80. PubMed
  10. Marteau P, Seksik P. Tolerance of probiotics and prebiotics. J Clin Gastroenterol 2004;38:S67-9. PubMed
  11. Munoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34. PubMed
  12. Lherm, T., Monet, C., Nougiere, B., Soulier, M., Larbi, D., Le Gall, C., Caen, D., and Malbrunot, C. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28(6):797-801. PubMed
  13. Riquelme, A. J., Calvo, M. A., Guzman, A. M., Depix, M. S., Garcia, P., Perez, C., Arrese, M., and Labarca, J. A. Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. J Clin.Gastroenterol. 2003;36(1):41- PubMed
  14. Cherifi, S., Robberecht, J., and Miendje, Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg. 2004;59(4):223-224. PubMed
  15. Ellouze O, Berthoud V, Mervant M, Parthiot JP, Girard C. Septic shock due to Sacccaromyces boulardii. Med Mal Infect. 2016;46(2):104-105.
  16. Appel-da-Silva MC, Narvaez GA, Perez LRR, Drehmer L, Lewgoy J. Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment. Med Mycol Case Rep. 2017;18:15-7. PubMed
  17. Atici S, Soysal A, Karadeniz Cerit K, et al. Catheter-related Saccharomyces cerevisiae Fungemia Following Saccharomyces boulardii Probiotic Treatment: In a child in intensive care unit and review of the literature. Med Mycol Case Rep. 2017;15:33-35. PubMed
  18. Martin IW, Tonner R, Trivedi J, et al. Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use. Diagn Microbiol Infect Dis. 2017;87(3):286-8. PubMed
  19. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr 2017;35(3):361-4.
  20. Roy U, Jessani LG, Rudramurthy SM, et al. Seven cases of Saccharomyces fungaemia related to use of probiotics. Mycoses 2017;60(6):375-380.
  21. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr. 2017 Jul-Sep;35(3):361-364. doi: 10.1590/1984-0462/;2017;35;3;00014.
  22. Flatley EA, Wilde AM, Nailor MD. Saccharomyces boulardii for the prevention of hospital onset Clostridium difficile infection. J Gastrointestin Liver Dis. 2015;24(1):21-4. PubMed
  23. Ventoulis I, Sarmourli T, Amoiridou P, et al. Bloodstream infection by Saccharomyces cerevisiae in two COVID-19 patients after receiving supplementation of Saccharomyces in the ICU. J Fungi (Basel). 2020;6(3):98. PubMed
  24. Wombwell E, Bransteitter B, Gillen LR. Incidence of Saccharomyces cerevisiae fungemia in hospitalised patients administered Saccharomyces boulardii probiotic. Mycoses 2021;64(12):1521-1526.
  25. Rannikko J, Holmberg V, Karppelin M, et al. Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements. Emerg Infect Dis 2021;27(8):2090-6.
  26. Awoyemi A, Mayerhofer C, Felix AS, et al. Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine 2021;70:103511. PubMed

See these in context on the Saccharomyces Boulardii monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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