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Dietary supplement

Saccharomyces Boulardii + MOS 5 Billion CFU Ingredients & Drug Interactions

by Jarrow Formulas

Saccharomyces Boulardii + MOS 5 Billion CFU label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Saccharomyces Boulardii + MOS 5 Billion CFU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Saccharomyces Boulardii + MOS 5 Billion CFU is a dietary supplement by Jarrow Formulas with 2 active ingredients. Its ingredients are commonly taken for acute diarrhea, antibiotic-associated diarrhea, traveler's diarrhea.Based on those ingredients, 40 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Saccharomyces boulardii. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Saccharomyces Boulardii + MOS 5 Billion CFU by Jarrow Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with Saccharomyces Boulardii + MOS 5 Billion CFU by Jarrow Formulas — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Saccharomyces Boulardii + MOS 5 Billion CFU by Jarrow Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients. Saccharomyces boulardii is a live probiotic yeast that's used to help support gut health and reduce certain types of diarrhea.

MOS yeast fraction is included as a prebiotic — essentially food for beneficial bacteria — though we don't have detailed breakdown data on that ingredient in our records. The capsule also contains several inactive ingredients (tapioca starch, hydroxypropylmethylcellulose, water, silicon dioxide, and ascorbic acid) that help with shelf stability and delivery.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: intestinal support and gut health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Travelers' diarrhea, Clostridioides difficile infection, Rotaviral diarrhea, Irritable bowel syndrome (IBS), Crohn disease — and 4 related terms.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Rotaviral diarrhea, Travelers' diarrhea, Clostridioides difficile infection.
  • Also on file: Saccharomyces Boulardii is rated "Insufficient Reliable Evidence To Rate" for Crohn disease, Ulcerative colitis, Irritable bowel syndrome (IBS).

The evidence suggests Saccharomyces boulardii is possibly effective for several types of diarrhea: rotaviral diarrhea, travelers' diarrhea, antibiotic-associated diarrhea, and infection with Clostridioides difficile. It's also possibly effective for necrotizing enterocolitis (a serious condition affecting the intestines in premature infants) and may help with Helicobacter pylori infection.

What the data doesn't show is how well this specific formulation with MOS performs; the ratings above apply to the S. boulardii ingredient itself.

The evidence, ingredient by ingredient Saccharomyces Boulardii

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saccharomyces boulardii is generally well tolerated in healthy adults. However, it should be avoided if you're critically ill or have a compromised immune system — in rare cases, the yeast has caused serious bloodstream infections in people who are very ill, especially those in intensive care with central lines or on broad-spectrum antibiotics.

Mild gastrointestinal complaints (abdominal cramps, gas, nausea, vomiting, or decreased appetite) occur rarely. The safety data for this product in pregnancy and lactation isn't on file — talk with your doctor or pharmacist for personalized guidance if you're pregnant, nursing, or thinking about it.

Side effects, ingredient by ingredient Saccharomyces Boulardii

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saccharomyces Boulardii.
  • The most serious interaction on file is rated Minor.
  • For scale: 40 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist if you take antifungals — taking them at the same time as this supplement may reduce how well the probiotic works for you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This product is worth considering if you're dealing with traveler's diarrhea, antibiotic-associated diarrhea, or certain other gut issues and you're otherwise healthy. If you're critically ill, immunocompromised, or taking antifungal medications, talk with your doctor or pharmacist before starting it.

Check your medications against our tool below before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Saccharomyces Boulardii + MOS 5 Billion CFU, straight from the product label.

Brand Jarrow Formulas
Barcode (UPC) 790011030041
Net contents 90 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 307727
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Saccharomyces Boulardii + MOS 5 Billion CFU by Jarrow Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
790011030041
IngredientAmount% DV
Saccharomyces boulardii250 mg--
MOS Yeast Fraction200 mg--

Other ingredients: Tapioca Starch, Hydroxypropylmethylcellulose, Water, Silicon Dioxide, Ascorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Adults take 1 capsule once a day with water, or as directed by your qualified healthcare professional. May be taken with food or on an empty stomach.

Formula

Saccharomyces Boulardii is a probiotic yeast clinically shown to benefit individuals in greater need for intestinal support, such as those who travel. MOS is a prebiotic that feeds the beneficial bacteria in the gut.

Clinically studied probiotic Probiotic + prebiotic

Minimum 5 billion viable cells at time of consumption, under recommended storage conditions and within Best Used Before date.

Precautions

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition (immune compromised system); if adverse reactions occur, discontinue use.

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication or have a medical condition (immune compromised system); if adverse reactions occur, discontinue use. Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

No refrigeration

No refrigeration necessary Does not require refrigeration and can be stored at room temperature in a cool, dry place. Avoid storage at temperature above 77 degrees F (25 degrees C). Refrigeration, however extends shelf life.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

IGEN Non-GMO tested

Formulation

IGEN Non-GMO tested

Vegan

Enhanced intestinal protection

Gluten free

No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.

Note: Capsule fill content may change, due to raw material particle size. However, potency remains the same.

Brand IP Statement(s)

Copyright 2023 Jarrow Formulas

FDA Statement of Identity

Probiotics Supplement

General Statements

Probiotics

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Saccharomyces Boulardii + MOS 5 Billion CFU by Jarrow Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Saccharomyces Boulardii + MOS 5 Billion CFU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Saccharomyces Boulardii + MOS 5 Billion CFU by Jarrow Formulas

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Saccharomyces boulardii

Interacts with
40 drugs
250 mg per serving Form: S. cerevisiae strain

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea,...

Saccharomyces boulardii monograph & interactions

MOS Yeast Fraction

200 mg per serving Form: Manno-oligosaccharides

Other (inactive) ingredients: Tapioca Starch, Hydroxypropylmethylcellulose, Water, Silicon Dioxide, Ascorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Saccharomyces Boulardii + MOS 5 Billion CFU by Jarrow Formulas Drug Interactions

Want to check YOUR meds against Saccharomyces Boulardii + MOS 5 Billion CFU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
40Drugs
40 Minor

Ingredients driving the most interactions

Saccharomyces boulardii 40

Individual Drug Interactions

The ingredients in Saccharomyces Boulardii + MOS 5 Billion CFU interact with 40 drugs. Click any drug to see the details.

1 of the 2 ingredients in Saccharomyces Boulardii + MOS 5 Billion CFU interact with drugs. Each result below shows which ingredient is responsible. Saccharomyces boulardii

Each ingredient & the kinds of drugs it affects

For each ingredient in Saccharomyces Boulardii + MOS 5 Billion CFU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Saccharomyces boulardii1 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Saccharomyces boulardii full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Saccharomyces Boulardii + MOS 5 Billion CFU, from the product label.

Jarrow Formulas

See all Jarrow Formulas products
Name
Jarrow Formulas, Inc.
City
Sherman Oaks
State
CA
ZipCode
91403
Phone Number
1-866-459-4154
Web Address
www.Jarrow.com
Pharmacist Counseling Corner

Saccharomyces Boulardii + MOS 5 Billion CFU by Jarrow Formulas: Common Questions

Does Saccharomyces Boulardii + MOS 5 Billion CFU by Jarrow Formulas interact with any medications?
Yes. Based on its ingredients, Saccharomyces Boulardii + MOS 5 Billion CFU has a known interaction with 40 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Saccharomyces Boulardii + MOS 5 Billion CFU contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on an antifungal medication?
Possibly, but not at the same time. Since S. boulardii is a live yeast, antifungals could kill it off and make the supplement ineffective. Talk with your doctor or pharmacist about spacing them out or whether this product is right for you while you're on that medication.
Is this safe if I have a weak immune system?
No — S. boulardii should be avoided if you're immunocompromised. In rare cases, the yeast itself has caused serious infections in people with weakened immunity. Check with your doctor or pharmacist before use.
What does Saccharomyces boulardii actually do?
It's a probiotic yeast that may help reduce several types of diarrhea — including traveler's diarrhea, antibiotic-associated diarrhea, and infections with Clostridioides difficile. The evidence suggests it's possibly effective for these uses, though results vary by person.
Could I have side effects from this?
Rarely. Some people report mild gastrointestinal complaints like cramping, gas, nausea, or decreased appetite. Very rarely, the yeast has caused serious bloodstream infections, but mainly in people who are critically ill.
Is it safe during pregnancy or breastfeeding?
We don't have enough safety data on file for S. boulardii in pregnancy and lactation. Talk with your doctor or pharmacist about whether it's right for you if you're pregnant, nursing, or planning to become pregnant.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Saccharomyces Boulardii + MOS 5 Billion CFU is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Saccharomyces Boulardii + MOS 5 Billion CFU label
Go deeper

The Full Monographs Behind Saccharomyces Boulardii + MOS 5 Billion CFU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph →
Sources

Sources & How We Checked

Saccharomyces Boulardii + MOS 5 Billion CFU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saccharomyces Boulardii 26 references
  1. Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.
  2. Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5. DOI
  3. Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3.
  4. Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8.
  5. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. PubMed
  6. Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5. PubMed
  7. Hennequin C, Thierry A, Richard GF, et al. Microsatellite typing as a new tool for identification of Saccharomyces cerevisiae strains. J Clin Microbiol 2001;39:551-9.
  8. Plein K, Hotz J. Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease with special respect to chronic diarrhea - a pilot study. Z Gastroenterol 1993;31:129-34.
  9. Borriello SP, Hammes WP, Holzapfel W, et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 2003;36:775-80. PubMed
  10. Marteau P, Seksik P. Tolerance of probiotics and prebiotics. J Clin Gastroenterol 2004;38:S67-9. PubMed
  11. Munoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34. PubMed
  12. Lherm, T., Monet, C., Nougiere, B., Soulier, M., Larbi, D., Le Gall, C., Caen, D., and Malbrunot, C. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28(6):797-801. PubMed
  13. Riquelme, A. J., Calvo, M. A., Guzman, A. M., Depix, M. S., Garcia, P., Perez, C., Arrese, M., and Labarca, J. A. Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. J Clin.Gastroenterol. 2003;36(1):41- PubMed
  14. Cherifi, S., Robberecht, J., and Miendje, Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg. 2004;59(4):223-224. PubMed
  15. Ellouze O, Berthoud V, Mervant M, Parthiot JP, Girard C. Septic shock due to Sacccaromyces boulardii. Med Mal Infect. 2016;46(2):104-105.
  16. Appel-da-Silva MC, Narvaez GA, Perez LRR, Drehmer L, Lewgoy J. Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment. Med Mycol Case Rep. 2017;18:15-7. PubMed
  17. Atici S, Soysal A, Karadeniz Cerit K, et al. Catheter-related Saccharomyces cerevisiae Fungemia Following Saccharomyces boulardii Probiotic Treatment: In a child in intensive care unit and review of the literature. Med Mycol Case Rep. 2017;15:33-35. PubMed
  18. Martin IW, Tonner R, Trivedi J, et al. Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use. Diagn Microbiol Infect Dis. 2017;87(3):286-8. PubMed
  19. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr 2017;35(3):361-4.
  20. Roy U, Jessani LG, Rudramurthy SM, et al. Seven cases of Saccharomyces fungaemia related to use of probiotics. Mycoses 2017;60(6):375-380.
  21. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr. 2017 Jul-Sep;35(3):361-364. doi: 10.1590/1984-0462/;2017;35;3;00014.
  22. Flatley EA, Wilde AM, Nailor MD. Saccharomyces boulardii for the prevention of hospital onset Clostridium difficile infection. J Gastrointestin Liver Dis. 2015;24(1):21-4. PubMed
  23. Ventoulis I, Sarmourli T, Amoiridou P, et al. Bloodstream infection by Saccharomyces cerevisiae in two COVID-19 patients after receiving supplementation of Saccharomyces in the ICU. J Fungi (Basel). 2020;6(3):98. PubMed
  24. Wombwell E, Bransteitter B, Gillen LR. Incidence of Saccharomyces cerevisiae fungemia in hospitalised patients administered Saccharomyces boulardii probiotic. Mycoses 2021;64(12):1521-1526.
  25. Rannikko J, Holmberg V, Karppelin M, et al. Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements. Emerg Infect Dis 2021;27(8):2090-6.
  26. Awoyemi A, Mayerhofer C, Felix AS, et al. Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine 2021;70:103511. PubMed

See these in context on the Saccharomyces Boulardii monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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