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Dietary supplement

Saccharomycin DF Ingredients & Drug Interactions

by XYMOGEN

Saccharomycin DF label
See full label image
Capsule Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Saccharomycin DF against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Saccharomycin DF is a dietary supplement by XYMOGEN with 1 active ingredient. Its ingredients are commonly taken for acute diarrhea, antibiotic-associated diarrhea, traveler's diarrhea.Based on those ingredients, 40 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Saccharomyces boulardii. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Saccharomycin DF by XYMOGEN

Ask about any prescription or over-the-counter medication and we check it for interactions with Saccharomycin DF by XYMOGEN — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Saccharomycin DF by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Saccharomycin DF is a single-ingredient probiotic supplement built around Saccharomyces boulardii, a beneficial yeast strain. This one active ingredient is the entire formula.

The capsule itself is made up of inactive ingredients — hypromellose, water, stearic acid, microcrystalline cellulose, magnesium stearate, silica, and medium-chain triglyceride oil — that help deliver the probiotic and hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports intestinal barrier and probiotic organisms.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Travelers' diarrhea, Rotaviral diarrhea, HIV/AIDS-related diarrhea, Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Rotaviral diarrhea, Travelers' diarrhea, Clostridioides difficile infection.
  • Also on file: Saccharomyces Boulardii is rated "Insufficient Reliable Evidence To Rate" for HIV/AIDS-related diarrhea, Crohn disease, Ulcerative colitis.

Saccharomyces boulardii shows possibly effective evidence for several types of diarrhea: rotaviral diarrhea (the kind some infants and young children get), travelers' diarrhea, and diarrhea that develops after taking antibiotics. The research also suggests it may be possibly effective for necrotizing enterocolitis (a serious gut inflammation in premature infants), Clostridioides difficile infection (a severe bacterial infection), and Helicobacter pylori (a stomach bacterium linked to ulcers).

That said, 'possibly effective' means the evidence exists but isn't yet conclusive — you're looking at promising early data, not proven cures.

The evidence, ingredient by ingredient Saccharomyces Boulardii

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saccharomycin DF is generally well tolerated in healthy adults. However, it should be avoided by anyone who is critically ill or immunocompromised (has a weakened immune system), because there's a rare but documented risk of the live yeast spreading into the bloodstream in those populations — particularly in people in intensive care units with central lines, feeding tubes, or on broad-spectrum antibiotics.

Rarely, the product has caused gastrointestinal complaints like abdominal cramps, bloating, nausea, vomiting, and loss of appetite. The safety data overall isn't extensive, so use it only under medical advice.

There isn't enough information on file about safety during pregnancy or breastfeeding — talk it over with your doctor or pharmacist before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Saccharomyces Boulardii

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saccharomyces Boulardii.
  • The most serious interaction on file is rated Minor.
  • For scale: 40 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antifungal medication (a drug used to treat fungal infections), double-check with your pharmacist or doctor before starting this product — the antifungal may reduce how well the probiotic works. The two can be taken, but timing matters.

No other medication interactions are documented for the ingredient we checked.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Saccharomycin DF may be worth considering if you have rotaviral diarrhea, travelers' diarrhea, antibiotic-associated diarrhea, or certain bacterial gut infections and want to explore a probiotic approach. Steer clear if you're critically ill, immunocompromised, or in an intensive care setting.

Check your medications — especially antifungals — with your doctor or pharmacist before starting, and talk it over if you're pregnant, breastfeeding, or have any gut concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Saccharomycin DF, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 871149002619
Net contents 20 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 303842
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Saccharomycin DF by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
10
UPC/BARCODE
871149002619
IngredientAmount% DV
Saccharomyces boulardii500 mg--

Other ingredients: Hypromellose, Water, Stearic Acid, Microcrystalline Cellulose, Magnesium Stearate, Silica, Medium-Chain Triglyceride Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one to two capsules per day, or as directed by your healthcare professional.

Precautions

Consult your healthcare professional prior to use.

Do not use if you have severe immune suppression or are taking antifungal medication.

Do not use if tamper seal is damaged.

Not for use by infants under three months of age. Storage: Keep closed in a cool, dry place out of reach of children.

Formula

Saccharomycin DF is a lactose-free, stomach acid-resistant, stable, European patent-pending formula containing DNA-verified Saccharomyces boulardii. This probiotic yeast supports other probiotic organisms in addition to intestinal barrier function and integrity. Research also suggests that Saccharomyces boulardii supports normal immune responses.

DNA-Verified Saccharomyces boulardii

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Storage: Keep closed in a cool, dry place out of reach of children.

Formulation

Formulated to exclude: Wheat, gluten, corn, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically-modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

Colony-Forming Units

Vegetarian Caps

Brand IP Statement(s)

Europe Patent Pending #05425084.0 Copyright 2021 XYMOGEN

XYMOGEN Exclusive Professional Formulas

Seals/Symbols

ePV (ePedigree Verification)

Third-Party Verified GMP Compliant

FDA Statement of Identity

Dietary Supplement

General Statements

Scan to learn more! This package is completely recyclable

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See for yourself

Saccharomycin DF by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Saccharomycin DF label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Saccharomycin DF by XYMOGEN

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container10 Amounts shown are per serving.

Saccharomyces boulardii

Interacts with
40 drugs
500 mg per serving

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea,...

Saccharomyces boulardii monograph & interactions

Other (inactive) ingredients: Hypromellose, Water, Stearic Acid, Microcrystalline Cellulose, Magnesium Stearate, Silica, Medium-Chain Triglyceride Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Saccharomycin DF by XYMOGEN Drug Interactions

Want to check YOUR meds against Saccharomycin DF?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
40Drugs
40 Minor

Ingredients driving the most interactions

Saccharomyces boulardii 40

Individual Drug Interactions

The ingredients in Saccharomycin DF interact with 40 drugs. Click any drug to see the details.

1 of the 1 ingredient in Saccharomycin DF interact with drugs. Each result below shows which ingredient is responsible. Saccharomyces boulardii

Each ingredient & the kinds of drugs it affects

For each ingredient in Saccharomycin DF with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Saccharomyces boulardii1 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Saccharomyces boulardii full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Saccharomycin DF, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

Saccharomycin DF by XYMOGEN: Common Questions

Does Saccharomycin DF by XYMOGEN interact with any medications?
Yes. Based on its ingredients, Saccharomycin DF has a known interaction with 40 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Saccharomycin DF contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Saccharomyces boulardii and why is it in this supplement?
It's a beneficial yeast strain — a live microorganism that acts as a probiotic. It's included because research suggests it may help restore balance to your gut during or after diarrhea, particularly diarrhea from travel, viral infection, or antibiotics.
Can I take this if I'm on an antifungal medication?
Technically yes, but antifungals may reduce how well this probiotic works because they kill yeast and fungi. Space them several hours apart if you can, and ask your pharmacist or doctor about the best timing for your situation.
Is this safe if I have a weak immune system?
No — the product should be avoided by people who are immunocompromised or critically ill. There's a rare risk that the live yeast could spread into your bloodstream. Talk with your doctor before use if your immune system is compromised.
What side effects might I notice?
Most people tolerate it well, but rarely it can cause bloating, abdominal cramps, nausea, vomiting, or loss of appetite. These are digestive complaints and not common, but they're worth knowing about.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data on file to say either way. Talk with your doctor or pharmacist for personalized advice before use if you're pregnant or nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Saccharomycin DF label
Go deeper

The Full Monographs Behind Saccharomycin DF’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph →
Sources

Sources & How We Checked

Saccharomycin DF's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saccharomyces Boulardii 26 references
  1. Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.
  2. Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5. DOI
  3. Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3.
  4. Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8.
  5. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. PubMed
  6. Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5. PubMed
  7. Hennequin C, Thierry A, Richard GF, et al. Microsatellite typing as a new tool for identification of Saccharomyces cerevisiae strains. J Clin Microbiol 2001;39:551-9.
  8. Plein K, Hotz J. Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease with special respect to chronic diarrhea - a pilot study. Z Gastroenterol 1993;31:129-34.
  9. Borriello SP, Hammes WP, Holzapfel W, et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 2003;36:775-80. PubMed
  10. Marteau P, Seksik P. Tolerance of probiotics and prebiotics. J Clin Gastroenterol 2004;38:S67-9. PubMed
  11. Munoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34. PubMed
  12. Lherm, T., Monet, C., Nougiere, B., Soulier, M., Larbi, D., Le Gall, C., Caen, D., and Malbrunot, C. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28(6):797-801. PubMed
  13. Riquelme, A. J., Calvo, M. A., Guzman, A. M., Depix, M. S., Garcia, P., Perez, C., Arrese, M., and Labarca, J. A. Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. J Clin.Gastroenterol. 2003;36(1):41- PubMed
  14. Cherifi, S., Robberecht, J., and Miendje, Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg. 2004;59(4):223-224. PubMed
  15. Ellouze O, Berthoud V, Mervant M, Parthiot JP, Girard C. Septic shock due to Sacccaromyces boulardii. Med Mal Infect. 2016;46(2):104-105.
  16. Appel-da-Silva MC, Narvaez GA, Perez LRR, Drehmer L, Lewgoy J. Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment. Med Mycol Case Rep. 2017;18:15-7. PubMed
  17. Atici S, Soysal A, Karadeniz Cerit K, et al. Catheter-related Saccharomyces cerevisiae Fungemia Following Saccharomyces boulardii Probiotic Treatment: In a child in intensive care unit and review of the literature. Med Mycol Case Rep. 2017;15:33-35. PubMed
  18. Martin IW, Tonner R, Trivedi J, et al. Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use. Diagn Microbiol Infect Dis. 2017;87(3):286-8. PubMed
  19. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr 2017;35(3):361-4.
  20. Roy U, Jessani LG, Rudramurthy SM, et al. Seven cases of Saccharomyces fungaemia related to use of probiotics. Mycoses 2017;60(6):375-380.
  21. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr. 2017 Jul-Sep;35(3):361-364. doi: 10.1590/1984-0462/;2017;35;3;00014.
  22. Flatley EA, Wilde AM, Nailor MD. Saccharomyces boulardii for the prevention of hospital onset Clostridium difficile infection. J Gastrointestin Liver Dis. 2015;24(1):21-4. PubMed
  23. Ventoulis I, Sarmourli T, Amoiridou P, et al. Bloodstream infection by Saccharomyces cerevisiae in two COVID-19 patients after receiving supplementation of Saccharomyces in the ICU. J Fungi (Basel). 2020;6(3):98. PubMed
  24. Wombwell E, Bransteitter B, Gillen LR. Incidence of Saccharomyces cerevisiae fungemia in hospitalised patients administered Saccharomyces boulardii probiotic. Mycoses 2021;64(12):1521-1526.
  25. Rannikko J, Holmberg V, Karppelin M, et al. Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements. Emerg Infect Dis 2021;27(8):2090-6.
  26. Awoyemi A, Mayerhofer C, Felix AS, et al. Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine 2021;70:103511. PubMed

See these in context on the Saccharomyces Boulardii monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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