Sleep & GH Formula Peacekeeper Strawberry Kiwi Ingredients & Drug Interactions
by Warrior Labz
What is this page for?
First and foremost: checking Sleep & GH Formula Peacekeeper Strawberry Kiwi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sleep & GH Formula Peacekeeper Strawberry Kiwi is a dietary supplement by Warrior Labz with 6 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, relaxation.Based on those ingredients, 1,520 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Melatonin, Valerian extract, Hops (flower) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sleep & GH Formula Peacekeeper Strawberry Kiwi by Warrior Labz
Ask about any prescription or over-the-counter medication and we check it for interactions with Sleep & GH Formula Peacekeeper Strawberry Kiwi by Warrior Labz — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Sleep & GH Formula Peacekeeper Strawberry Kiwi by Warrior Labz
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This powder contains six active ingredients. GABA is a brain chemical involved in relaxation.
Melatonin is a hormone your body makes naturally to regulate sleep–wake cycles. Hops flower extract comes from the hops plant used in brewing and has traditional calming properties.
Phenibut is a synthetic compound that acts on GABA receptors in the brain. Mucuna pruriens extract (also called cowhage) is a plant source of levodopa, the active compound in Parkinson's medications.
Valerian extract comes from the valerian root plant, used traditionally for sleep support. The inactive ingredients are fillers, binders, and flavoring agents.
Does it work?
Strong evidence
The evidence supporting these ingredients is thin. Melatonin is likely effective for delayed sleep phase disorder and non-24-hour sleep–wake disorder, and possibly effective for pre-procedural anxiety and high blood pressure—so it has the strongest evidence in this formula.
Valerian is possibly effective for insomnia. The rest—GABA, phenibut, hops, and Mucuna pruriens—have insufficient evidence in our data to establish whether they work for any condition, including the sleep and growth-hormone support this product implies.
How safe is it?
Well-documented data
Safety data are incomplete across the board. GABA and melatonin are generally well tolerated short-term, but long-term safety hasn't been well studied.
Common side effects include drowsiness, nausea, and headache; melatonin also carries rare concerns about mood changes and seizure risk. Hops is generally well tolerated short-term and can cause drowsiness.
Phenibut is the troublemaker here—it's regarded as unsafe because it poses a high risk of dependence, severe withdrawal (including seizures and agitation after just three consecutive days of use), and overdose. Valerian is well tolerated short-term but can cause dizziness and mental slowness; stopping it abruptly after chronic use may trigger withdrawal.
Mucuna pruriens contains an active drug-like compound (levodopa) and should be used carefully. None of these ingredients have adequate pregnancy or breastfeeding safety data; most carry warnings to avoid them during these periods.
Meds to double-check
Major interaction found
Check with your pharmacist if you take: methyldopa, non-selective MAOIs, or levodopa (Major risks from Mucuna pruriens). Blood pressure medications (Moderate risk from GABA and melatonin).
Blood thinners like warfarin (Moderate from melatonin). Diabetes medications (Moderate from melatonin and Mucuna pruriens).
Seizure medications (Moderate from melatonin). Any sedating drugs—antihistamines, benzodiazepines, opioids, other sleep aids (Moderate from GABA, phenibut, hops, valerian, and melatonin).
Phenibut itself carries major dependence and withdrawal risks.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This formula is intended for sleep and recovery, but effectiveness isn't well established for most of it, and phenibut's dependence and withdrawal risks are serious red flags. If you take any blood pressure medication, sedating drug, blood thinner, diabetes drug, seizure medication, or MAOI antidepressant, you need to check your exact medications with the tool here before starting.
Talk to your pharmacist or doctor—especially if you're pregnant, breastfeeding, or already taking prescription sleep aids.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sleep & GH Formula Peacekeeper Strawberry Kiwi, straight from the product label.
| Brand | Warrior Labz |
|---|---|
| Barcode (UPC) | 689466847635 |
| Net contents | 150 Gram(s) |
| Market status | Off market |
| Date entered into DSLD | Jan 25, 2017 |
| DSLD ID | 69871 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sleep & GH Formula Peacekeeper Strawberry Kiwi by Warrior Labz, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| GABA | 0 NP | -- |
| Melatonin | 0 NP | -- |
| Hops (flower) extract | 0 NP | -- |
| Peacekeeper Blend | 2000 mg | -- |
| Phenibut | 0 NP | -- |
| Mucuna pruriens extract | 0 NP | -- |
| Valerian extract | 0 NP | -- |
Other ingredients: Maltodextrin, Citric Acid, Erythritol, Natural and Artificial flavors, Sucralose, Silicon Dioxide, Acesulfame K, FD&C Red #40
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Do not use if pregnant or nursing.
To report any adverse event call 1-800-332-1088
Do not use if you are pregnant, or nursing.
Warning: Keep out of reach of children.
Do not use while operating heavy machinery. Seek advice from a health care professional if you have any pre-existing medical condition to ensure it is safe to take this product. In case of accidental overdose seek professional assistance or contact a poison control center immediately. Avoid alcohol and prescription sleep aids while taking this product. Exceeding recommended serving will not improve results and may cause serious adverse health effects. Discontinue use and contact a licensed healthcare professional immediately if you experience an unusually slow heartbeat, dizziness, severe headache, or shortness of breath.
Keep out of reach of children.
Formula
For use by healthy adults only, not recommended for persons under the age of 18.
- 150 Grams
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement mix 1 scoop in 8-10 oz. of water 30 minutes prior to going to bed.
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Made in USA
Quality - purity - potency Promotes muscle growth & recovery Natural GH stimulator Non hangover effect
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sleep & GH Formula Peacekeeper Strawberry Kiwi by Warrior Labz label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sleep & GH Formula Peacekeeper Strawberry Kiwi by Warrior Labz
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size5 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Peacekeeper Blend
Other (inactive) ingredients: Maltodextrin, Citric Acid, Erythritol, Natural and Artificial flavors, Sucralose, Silicon Dioxide, Acesulfame K, FD&C Red #40. These complete the product’s ingredient list but are not active constituents.
Sleep & GH Formula Peacekeeper Strawberry Kiwi by Warrior Labz Drug Interactions
HelloPharmacist Interaction Report
Sleep & GH Formula Peacekeeper by Warrior Labz contains six active ingredients, several of which interact with medications.
The most serious interactions involve Mucuna pruriens extract (which contains levodopa), a compound that carries Major-severity risks with three drug types: it can cause dangerous blood pressure drops with methyldopa, hypertensive crisis with monoamine oxidase inhibitors (MAOIs), and dangerous increases in levodopa-related side effects if you're already taking levodopa itself.
Read the full breakdown — every affected drug type, severity by severity
Melatonin and valerian extract both interact Moderately with a broad range of medication types. Melatonin affects blood thinners like warfarin, blood pressure drugs, diabetes medications, seizure medications, and several others by potentially altering their effectiveness or increasing bleeding risk.
Valerian also has additive sedation with other sedating drugs and can affect how your body metabolizes certain medications. GABA and phenibut add Moderate risks with blood pressure drugs and sedating medications.
Hops extract has Minor interactions with certain metabolized drugs.
We could not check interaction data for Peacekeeper Blend, as it's listed as a proprietary blend whose individual components are the ones reviewed here. Altogether, these interactions span 1,503 individual medications.
Run your exact prescriptions through the medication checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sleep & GH Formula Peacekeeper Strawberry Kiwi?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sleep & GH Formula Peacekeeper Strawberry Kiwi interact with 1,520 drugs. Click any drug to see the details.
6 of the 6 ingredients in Sleep & GH Formula Peacekeeper Strawberry Kiwi interact with drugs. Each result below shows which ingredient is responsible. Melatonin Valerian extract Hops (flower) extract GABA Phenibut Mucuna pruriens extract
AmphetamineAdensys XR-ODT, Adzenys ER, Dyanavel XR, Mydayis
How Amphetamine interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 3 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Amphetamine interactionMelatoninCytochrome P450 2d6 (cyp2d6) Substrates, Seizure Threshold Lowering Drugs Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP2D6.
Read the full Melatonin + Amphetamine interactionValerian ExtractCytochrome P450 2d6 (cyp2d6) Substrates Minor
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian Extract + Amphetamine interactionBenserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 2 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Extract + Benserazide, Levodopa interactionMelatoninSeizure Threshold Lowering Drugs Moderate
Interaction Summary
Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Read the full Melatonin + Benserazide, Levodopa interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 2 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Extract + Carbidopa, Levodopa interactionMelatoninSeizure Threshold Lowering Drugs Moderate
Interaction Summary
Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Read the full Melatonin + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 3 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Extract + Carbidopa, Levodopa, Entacapone interactionValerian ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Extract + Carbidopa, Levodopa, Entacapone interactionMelatoninSeizure Threshold Lowering Drugs Moderate
Interaction Summary
Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Read the full Melatonin + Carbidopa, Levodopa, Entacapone interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 3 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMethyldopa (aldomet) Major
Interaction Summary
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Read the full Mucuna Pruriens Extract + Chlorothiazide, Methyldopa interactionMelatoninAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.
Read the full Melatonin + Chlorothiazide, Methyldopa interactionGabaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Read the full Gaba + Chlorothiazide, Methyldopa interactionHydrochlorothiazide, MethyldopaAldoril 15, Aldoril 25, Aldoril D30, Methazide
How Hydrochlorothiazide, Methyldopa interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 3 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMethyldopa (aldomet) Major
Interaction Summary
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Read the full Mucuna Pruriens Extract + Hydrochlorothiazide, Methyldopa interactionMelatoninAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.
Read the full Melatonin + Hydrochlorothiazide, Methyldopa interactionGabaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Read the full Gaba + Hydrochlorothiazide, Methyldopa interactionIsocarboxazidMarplan
How Isocarboxazid interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Isocarboxazid interactionLevodopaInbrija, Larodopa
How Levodopa interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 2 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Extract + Levodopa interactionMelatoninSeizure Threshold Lowering Drugs Moderate
Interaction Summary
Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Read the full Melatonin + Levodopa interactionLevodopa, CarbidopaDuodopa
How Levodopa, Carbidopa interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 2 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Extract + Levodopa, Carbidopa interactionMelatoninSeizure Threshold Lowering Drugs Moderate
Interaction Summary
Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Read the full Melatonin + Levodopa, Carbidopa interactionMethyldopaAldomet, Methyldopa
How Methyldopa interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 3 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMethyldopa (aldomet) Major
Interaction Summary
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Read the full Mucuna Pruriens Extract + Methyldopa interactionMelatoninAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.
Read the full Melatonin + Methyldopa interactionGabaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Read the full Gaba + Methyldopa interactionMoclobemideManerix, Moclobemide
How Moclobemide interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 2 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Moclobemide interactionMelatoninCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19.
Read the full Melatonin + Moclobemide interactionOzanimod HydrochlorideZeposia
How Ozanimod Hydrochloride interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 2 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Ozanimod Hydrochloride interactionMelatoninImmunosuppressants Moderate
Interaction Summary
Theoretically, melatonin might interfere with immunosuppressive therapy.
Read the full Melatonin + Ozanimod Hydrochloride interactionPhenelzine SulfateNardil
How Phenelzine Sulfate interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 6 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Phenelzine Sulfate interactionPhenibutCns Depressants Moderate
Interaction Summary
Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.
Read the full Phenibut + Phenelzine Sulfate interactionHops (flower) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Read the full Hops (flower) Extract + Phenelzine Sulfate interactionMelatoninCns Depressants Moderate
Interaction Summary
Theoretically, taking melatonin might increase the sedative effects of CNS depressants.
Read the full Melatonin + Phenelzine Sulfate interactionValerian ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Extract + Phenelzine Sulfate interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Phenelzine Sulfate interactionRasagilineAzilect
How Rasagiline interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 3 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Rasagiline interactionMelatoninCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Rasagiline interactionHops (flower) ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
Read the full Hops (flower) Extract + Rasagiline interactionSafinamide MesylateXadago
How Safinamide Mesylate interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Safinamide Mesylate interactionSelegilineCarbex, Eldepryl, Emsam, Zelapar
How Selegiline interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Selegiline interactionTranylcypromineParnate
How Tranylcypromine interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Extract + Tranylcypromine interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 1 ingredient. Tap an ingredient for the detail:
MelatoninImmunosuppressants Moderate
Interaction Summary
Theoretically, melatonin might interfere with immunosuppressive therapy.
Read the full Melatonin + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 1 ingredient. Tap an ingredient for the detail:
MelatoninAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Melatonin + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 1 ingredient. Tap an ingredient for the detail:
MelatoninCytochrome P450 2c19 (cyp2c19) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19.
Read the full Melatonin + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 2 ingredients. Tap an ingredient for the detail:
MelatoninAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Melatonin + Acarbose interactionMucuna Pruriens ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 2 ingredients. Tap an ingredient for the detail:
MelatoninAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.
Read the full Melatonin + Acebutolol interactionGabaAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Read the full Gaba + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 1 ingredient. Tap an ingredient for the detail:
MelatoninAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Melatonin + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 6 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Extract + Acepromazine interactionPhenibutCns Depressants Moderate
Interaction Summary
Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.
Read the full Phenibut + Acepromazine interactionHops (flower) ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Read the full Hops (flower) Extract + Acepromazine interactionValerian ExtractCns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian Extract + Acepromazine interactionMelatoninCns Depressants Moderate
Interaction Summary
Theoretically, taking melatonin might increase the sedative effects of CNS depressants.
Read the full Melatonin + Acepromazine interactionGabaCns Depressants Minor
Interaction Summary
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants.
Read the full Gaba + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 3 ingredients. Tap an ingredient for the detail:
Valerian ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Extract + Acetaminophen interactionMelatoninCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen interactionHops (flower) ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
Read the full Hops (flower) Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 3 ingredients. Tap an ingredient for the detail:
Valerian ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Extract + Acetaminophen, Aspirin interactionMelatoninAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Melatonin + Acetaminophen, Aspirin interactionHops (flower) ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
Read the full Hops (flower) Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 3 ingredients. Tap an ingredient for the detail:
MelatoninCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Aspirin, Caffeine interactionValerian ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Extract + Acetaminophen, Aspirin, Caffeine interactionHops (flower) ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
Read the full Hops (flower) Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 3 ingredients. Tap an ingredient for the detail:
Valerian ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionMelatoninCytochrome P450 1a2 (cyp1a2) Substrates, Seizure Threshold Lowering Drugs Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionHops (flower) ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
Read the full Hops (flower) Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 3 ingredients. Tap an ingredient for the detail:
Valerian ExtractGlucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Extract + Acetaminophen, Butalbital interactionMelatoninCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2.
Read the full Melatonin + Acetaminophen, Butalbital interactionHops (flower) ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
Read the full Hops (flower) Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Sleep & GH Formula Peacekeeper Strawberry Kiwi — through 3 ingredients. Tap an ingredient for the detail:
MelatoninCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.
Read the full Melatonin + Acetaminophen, Butalbital, Caffeine interactionValerian ExtractGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian Extract + Acetaminophen, Butalbital, Caffeine interactionHops (flower) ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
Read the full Hops (flower) Extract + Acetaminophen, Butalbital, Caffeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sleep & GH Formula Peacekeeper Strawberry Kiwi with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Melatonin
Anticoagulant/Antiplatelet Drugs
Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There are isolated case reports of minor bleeding and decreased prothrombin activity in people taking melatonin with warfarin (Coumadin). The mechanism, if any, of this interaction is unknown. Taking melatonin orally seems to decrease coagulation activity within one hour of dosing in healthy men.
Anticonvulsants
Theoretically, melatonin may reduce the effects of anticonvulsants. Some clinical research suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological impairment.
Antidiabetes Drugs
Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that melatonin reduces levels of fasting blood glucose and improves glycemic control. However, other research suggests that melatonin might impair glucose utilization and increase insulin resistance, while other research has found no effect on glucose levels. Until more is known, use melatonin cautiously in combination with antidiabetes drugs.
Antihypertensive Drugs
Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.
Some clinical research suggests that taking melatonin decreases blood pressure in healthy adults. Also, melatonin seems to lower systolic and diastolic blood pressure in individuals with high blood pressure at nighttime or untreated essential hypertension. However, melatonin seems to worsen blood pressure in patients who are taking antihypertensive medications. Immediate-release melatonin 5 mg at night in combination with nifedipine GITS (Procardia XL) increases systolic blood pressure an average of 6.5 mmHg, diastolic blood pressure by an average of 4.9 mmHg, and heart rate by 3.9 bpm. Also, results from animal research suggest that melatonin reduces the effectiveness of certain antihypertensive drugs, including methoxamine and clonidine.
Caffeine
Theoretically, taking caffeine with melatonin might increase levels of melatonin.
Some evidence suggests that caffeine consumption can decrease endogenous melatonin levels, while other evidence suggests that caffeine increases endogenous melatonin levels. When administered in combination with melatonin supplements, caffeine seems to increase melatonin effects and levels. The reason for this discrepancy is not completely clear. Part of the discrepancy may result from the fact that caffeine can inhibit melatonin synthesis as well as inhibit melatonin metabolism. By functioning as an adenosine receptor antagonist, caffeine may indirectly inhibit the synthesis of melatonin. Conversely, because melatonin and caffeine are both metabolized by cytochrome P450 1A2 (CYP1A2) enzyme, concomitant use of melatonin and caffeine may reduce the metabolism of melatonin, resulting in higher serum levels.
Cns Depressants
Theoretically, taking melatonin might increase the sedative effects of CNS depressants.
Melatonin has sedative effects. Theoretically, concomitant use of melatonin with alcohol, benzodiazepines, or other sedative drugs might cause additive sedation.
Contraceptive Drugs
Theoretically, taking contraceptive drugs with melatonin might increase the effects and adverse effects of melatonin.
Contraceptive drugs can increase the levels of endogenous melatonin. Theoretically, these drugs may increase the effects and adverse effects of oral melatonin.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2. Also, other CYP1A2 substrates might decrease the metabolism of melatonin, increasing melatonin levels.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with drugs metabolized by the CYP1A2 enzyme might reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP1A2 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19. Also, other CYP2C19 substrates might decrease the metabolism of melatonin, increasing melatonin levels.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2C19 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP2C19 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Fluvoxamine (Luvox)
Theoretically, taking fluvoxamine with melatonin might increase levels of melatonin.
Fluvoxamine can significantly increase melatonin levels. In some cases, fluvoxamine might increase bioavailability of exogenously administered melatonin by up to 20 times. Some researchers think this might be a beneficial interaction and be potentially useful for cases of refractory insomnia. However, this interaction might also cause unwanted excessive drowsiness and possibly other adverse effects. Fluvoxamine is known to increase endogenous melatonin secretion. It seems to increase serum levels of exogenously administered melatonin possibly by decreasing melatonin metabolism by inhibiting cytochrome P450 (CYP450) 1A2 and 2C19 or by inhibiting melatonin elimination. This effect has been found in healthy people taking fluvoxamine 50-75 mg and melatonin 5 mg.
Immunosuppressants
Theoretically, melatonin might interfere with immunosuppressive therapy.
Melatonin can stimulate immune function. Theoretically, melatonin might interfere with immunosuppressive therapy.
Methamphetamine (Desoxyn)
Theoretically, taking melatonin with methamphetamine may increase the adverse effects of methamphetamine.
Animal research suggests that melatonin exacerbates the adverse effects of methamphetamine, resulting in greater depression of tryptophan hydroxylase (TPH) and tyrosine hydroxylase (TH) activity, as well as a significant reduction in dopamine levels. This has not been shown in humans.
Nifedipine Gits (Procardia Xl)
Theoretically, taking melatonin with extended release nifedipine reduces the effects of nifedipine.
Melatonin can decrease the effectiveness of extended release nifedipine (GITS). Immediate-release melatonin 5 mg at night in combination with nifedipine GITS 30-60 mg daily increases systolic and blood pressure by an average of 6.5 mmHg and 4.9 mmHg, respectively. Concomitant use with melatonin also increases heart rate by 3.9 bpm. The mechanism of this interaction is not known.
Seizure Threshold Lowering Drugs
Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Some clinical evidence suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological disabilities.
Warfarin (Coumadin)
Theoretically, melatonin may have antiplatelet effects and may increase the risk of bleeding with warfarin.
Three cases of increased prothrombin time have been reported for patients aged 48-72 years who took melatonin orally in combination with warfarin. However, three cases of decreased prothrombin time have also been reported for patients aged 51-84 years who took melatonin orally in combination with warfarin. Until more is known, use melatonin cautiously in patients taking warfarin.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, melatonin might increase levels of drugs metabolized by CYP2D6.
Laboratory research suggests that certain lots of melatonin inhibit CYP2D6. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2D6 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that certain lots of melatonin inhibit CYP3A4. Theoretically, combined administration of melatonin with certain drugs metabolized by CYP3A4 may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.
Flumazenil (Romazicon)
Theoretically, taking flumazenil with melatonin might reduce the effects of melatonin.
Animal research shows that flumazenil may inhibit the effect of melatonin.
Valerian extract
Alcohol (Ethanol)
Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.
Alprazolam (Xanax)
Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.
Cns Depressants
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.
Glucuronidated Drugs
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.
Hops (flower) extract
Cns Depressants
Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.
Estrogens
Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.
GABA
Antihypertensive Drugs
Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.
Cns Depressants
Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.
Phenibut
Cns Depressants
Theoretically, phenibut might increase the risk of sedation and respiratory depression when taken with CNS depressants.
Phenibut has been associated with sedation and respiratory depression in several case reports, especially when taken at high doses.
Pregabalin (Lyrica)
Theoretically, phenibut might increase the risk for additive adverse effects, including sedation, when taken with pregabalin.
Phenibut is structurally related to pregabalin, and both chemicals act at GABA receptors in the brain. In a case report, a patient who had experienced tolerance to the effects of pregabalin for treatment of chronic neuropathic pain experienced a reduction in tolerance when phenibut was taken concurrently.
Mucuna pruriens extract
Levodopa
Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.
Methyldopa (Aldomet)
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.
Anesthesia
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.
Antidiabetes Drugs
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.
Antipsychotic Drugs
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.
Guanethidine (Ismelin)
Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.
Tricyclic Antidepressants (Tcas)
Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.
Brand information
Manufacturer and brand details for Sleep & GH Formula Peacekeeper Strawberry Kiwi, from the product label.
Warrior Labz
See all Warrior Labz products- Name
- WARRIOR LABZ
- Street Address
- 1400 Pensacola St
- City
- Honolulu
- State
- HI
- ZipCode
- 96822
- Web Address
- www.WARRIORLABZ.com
Sleep & GH Formula Peacekeeper Strawberry Kiwi by Warrior Labz: Common Questions
Does Sleep & GH Formula Peacekeeper Strawberry Kiwi by Warrior Labz interact with any medications?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sleep & GH Formula Peacekeeper Strawberry Kiwi’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Gamma-aminobutyric Acid (gaba)
Interacts with 419 drugsGABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...
Read the full Gamma-aminobutyric Acid (gaba) monograph → Herb & supplement monographMelatonin
Interacts with 1,461 drugsMelatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with sleep timing problems and jet lag. The evidence is...
Read the full Melatonin monograph → Herb & supplement monographHops
Interacts with 863 drugsHops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...
Read the full Hops monograph → Herb & supplement monographPhenibut
Interacts with 248 drugsPhenibut is a synthetic, lab-made central nervous system depressant—not a natural herb—that some people use for anxiety and sleep, but it carries a serious risk of tolerance, dependence, and...
Read the full Phenibut monograph → Herb & supplement monographCowhage
Interacts with 193 drugsCowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...
Read the full Cowhage monograph → Herb & supplement monographValerian
Interacts with 902 drugsValerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some people sleep but does not work reliably...
Read the full Valerian monograph →Sources & How We Checked
Sleep & GH Formula Peacekeeper Strawberry Kiwi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 217 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Gamma-aminobutyric Acid (gaba) 12 references
- Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
- Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
- Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
- Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
- Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
- ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
- Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
- Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
- Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
- Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
- Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
- de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed
See these in context on the Gamma-aminobutyric Acid (gaba) monograph →
Melatonin 118 references
- Voordouw BC, Euser R, Verdonk RE, et al. Melatonin and melatonin-progestin combinations alter pituitary-ovarian function in women and can inhibit ovulation. J Clin Endocrinol Metab 1992;74:108-17. DOI
- Ellis CM, Lemmens G, Parkes JD. Melatonin and insomnia. J Sleep Res 1996;5:61-5. PubMed
- Petrie K, Dawson AG, Thompson L, Brook R. A double-blind trial of melatonin as a treatment for jet lag in international cabin crew. Biol Psychiatr 1993;33:526-30. PubMed
- Claustrat B, Brun J, David M, et al. Melatonin and jet lag: confirmatory result using a simplified protocol. Biol Psychiatr 1992;32:705-11.
- Fauteck J, Schmidt H, Lerchl A, et al. Melatonin in epilepsy: first results of replacement therapy and first clinical results. Biol Signals Recept 1999;8:105-10. PubMed
- Arangino S, Cagnacci A, Angiolucci M, et al. Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men. Am J Cardiol 1999;83:1417-9. PubMed
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Lancioni GE, O'Reilly MF, Basili G. Review of strategies for treating sleep problems in persons with severe or profound mental retardation or multiple handicaps. Am J Ment Retard 1999;104:170-86. PubMed
- Carman JS, Post RM, Buswell R, et al. Negative effects of melatonin on depression. Am J Psychiatry 1976;133:1181-1186. PubMed
- Hartter S, Grozinger M, Weigmann H, et al. Increased bioavailability of oral melatonin after fluvoxamine coadministration. Clin Pharmacol Ther 2000;67:1-6.
- Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
- Lusardi P, et al. Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. Br J Clin Pharmacol 2000;49:423-7. PubMed
- von Bahr C, Ursing C, Yasui N, et al. Fluvoxamine but not citalopram increases serum melatonin in healthy subjects – an indication that cytochrome P450 CYP1A2 and CYP2C19 hydroxylate melatonin. Eur J Clin Pharmacol 2000;56:123-7.
- Grozinger M, Hartter S, Wang X, et al. Fluvoxamine strongly inhibits melatonin metabolism in a patient with low-amplitude melatonin profile. Arch Gen Psychiatry 2000 Aug;57:812-3. PubMed
- Lissoni P, Barni S, Mandala M, et al. Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solic tumor patients with poor clinical status. Eur J Cancer 1999;35:1688-92.
- Sheldon SH. Pro-convulsant effects of oral melatonin in neurologically disabled children. Lancet 1998;351:1254. PubMed
- Hartter S, Grozinger M, Weigmann H, et al. Increased bioavailability of oral melatonin after fluvoxamine coadministration. Clin Pharmacol Ther 2000;67:1-6.
- Wright KP Jr, Myers BL, Plenzler SC, et al. Acute effects of bright light and caffeine on nighttime melatonin and temperature levels in women taking and not taking oral contraceptives. Brain Res 2000;873:310-7.
- Herxheimer A, Petrie KJ. Melatonin for preventing and treating jet lag. Cochrane Database Syst Rev 2001;(1):CD001520.
- Briggs, Freeman, Yafee. Update Drugs in Pregnancy and Lactation. Lippincott Williams & Wilkins, 2001.
- Suhner A, Schlagenhauf P, Johnson R, et al. Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol Int 1998;15:655-66. PubMed
- Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev 2002;2:CD001520. PubMed
- Munoz-Hoyos A, Sanchez-Forte M, Molina-Carballo A, et al. Melatonin's role as an anticonvulsant and neuronal protector: experimental and clinical evidence. J Child Neurol 1998;13:501-9.. PubMed
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