Sleep Support Mint Flavor Ingredients & Drug Interactions
by TerraVita
What is this page for?
First and foremost: checking Sleep Support Mint Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sleep Support Mint Flavor is a dietary supplement by TerraVita with 7 active ingredients. Its ingredients are commonly taken for digestive upset and indigestion, nausea, hormonal acne and unwanted hair (pcos-related).Based on those ingredients, 1,233 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Chamomile Glycerite Liquid Extract, Passion Flower Glycerite Liquid Extract, Spearmint Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sleep Support Mint Flavor by TerraVita
Ask about any prescription or over-the-counter medication and we check it for interactions with Sleep Support Mint Flavor by TerraVita — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Sleep Support Mint Flavor by TerraVita
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 7 active ingredients in liquid form. Spearmint, linden, poppy seed, chamomile, orange tree, passion flower, and blueberry extracts are blended to support sleep.
These are herbal glycerites—plant extracts suspended in glycerin—rather than powders or capsules. The liquid also contains glycerin and mint flavor as inactive ingredients.
Does it work?
Moderate evidence
Passion flower is rated Possibly Effective for insomnia and pre-procedural anxiety—the two sleep and relaxation outcomes with the best evidence. Poppy seed has insufficient evidence to support its use for insomnia.
Spearmint, linden, chamomile, orange tree, and blueberry lack established effectiveness ratings for sleep or sleep-related conditions in our data, meaning the evidence for their sleep benefits isn't established here. If you're looking for a sleep aid, passion flower is the ingredient in this formula with some research backing.
How safe is it?
Well-documented data
Passion flower, spearmint, blueberry, and poppy seed are generally well tolerated orally when used short-term. The most common side effects are drowsiness, dizziness, and mild gastrointestinal complaints (nausea, constipation, or diarrhea with blueberry).
Allergic reactions are rare but possible—spearmint can trigger allergic swelling of the soft palate, and poppy seed allergies may cause breathing difficulty or mouth swelling. Passion flower carries a caution for drowsiness and should be avoided during pregnancy due to lack of safety data and possible effects on the uterus; breastfeeding safety is also not established.
Linden safety is limited in humans and its use during pregnancy or breastfeeding is not well studied—talk with your doctor. Spearmint and blueberry as food amounts are likely safe in pregnancy, but concentrated supplements are not well studied.
We have no pregnancy or breastfeeding data on file for chamomile or orange tree extracts.
Meds to double-check
Major interaction found
Before you take this, check whether you're on CNS depressants like sleeping pills, anti-anxiety drugs, or opioids—spearmint and passion flower may add to their effects. If you take lithium (a mood stabilizer), hepatotoxic drugs (medications that stress the liver), diabetes medications, buspirone, flurbiprofen, or any CYP3A4 or OATP substrates, run them through the tool below.
These ingredients may change how those drugs work or raise their levels in your blood.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This product is built around passion flower, which has some research for insomnia and anxiety. It's generally well tolerated short-term, but it will make you drowsy—that's the point, though it means no driving or heavy machinery.
The biggest caution is medications: if you take anything for sleep, anxiety, blood pressure, diabetes, liver conditions, or certain psychiatric drugs, check your exact medications on this page first. Pregnant or breastfeeding?
Talk with your pharmacist or doctor before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sleep Support Mint Flavor, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sleep Support Mint Flavor by TerraVita, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 0.13 mL | -- |
| Spearmint Glycerite Liquid Extract | 0 NP | -- |
| Linden Glycerite Liquid Extract | 0 NP | -- |
| Poppy Seed Glycerite Liquid Extract | 0 NP | -- |
| Chamomile Glycerite Liquid Extract | 0 NP | -- |
| Orange Tree Glycerite Liquid Extract | 0 NP | -- |
| Passion Flower Glycerite Liquid Extract | 0 NP | -- |
| Blueberry Glycerite Liquid Extract | 0 NP | -- |
Other ingredients: Glycerin, Mint Flavor
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Copyright 2018 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.
Formula
Glycerite liquid extract (1:5)
Formulation
Alcohol free
Suggested/Recommended/Usage/Directions
Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.
Precautions
Keep away from children.
Do not use if safety seal around cap is broken or missing.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sleep Support Mint Flavor by TerraVita label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sleep Support Mint Flavor by TerraVita
These are the 7 active ingredients this product is made of. Select any to open its full monograph.
Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Glycerin, Mint Flavor. These complete the product’s ingredient list but are not active constituents.
Sleep Support Mint Flavor by TerraVita Drug Interactions
HelloPharmacist Interaction Report
Sleep Support Mint Flavor by TerraVita contains several active ingredients with documented interactions affecting over 1,000 individual medications.
The most serious concern is spearmint, which has a Moderate interaction with CNS depressants (sedatives, sleeping pills, tranquilizers). Spearmint may alter how sedative drugs work in your body—animal research suggests it has its own sedative effects, though human data are mixed, making the result unpredictable.
Read the full breakdown — every affected drug type, severity by severity
Passion flower also interacts Moderately with CNS depressants and may add to their drowsiness and other side effects. Spearmint has a second Moderate interaction with hepatotoxic drugs (medications that can stress the liver).
High doses of spearmint might raise your risk of liver damage if taken alongside these drugs. Linden interacts Moderately with lithium; because linden may have diuretic properties (making you urinate more), it could increase lithium levels and side effects, possibly requiring a dose adjustment.
Blueberry has three Minor interactions: it may increase the risk of low blood sugar (hypoglycemia) with diabetes medications, raise blood levels of the anti-anxiety drug buspirone, and increase blood levels of the anti-inflammatory flurbiprofen. Passion flower also has Minor interactions with certain drug-transport and liver-enzyme pathways that may affect how some medications work.
We could not check the interaction data for chamomile and orange tree extracts. Use the medication search tool on this page to check your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sleep Support Mint Flavor?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sleep Support Mint Flavor interact with 1,233 drugs. Click any drug to see the details.
6 of the 7 ingredients in Sleep Support Mint Flavor interact with drugs. Each result below shows which ingredient is responsible. Chamomile Glycerite Liquid Extract Passion Flower Glycerite Liquid Extract Spearmint Glycerite Liquid Extract Orange Tree Glycerite Liquid Extract Blueberry Glycerite Liquid Extract Linden Glycerite Liquid Extract
AtorvastatinAtorvaliq
How Atorvastatin interacts with Sleep Support Mint Flavor — through 4 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Atorvastatin interactionChamomile Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Atorvastatin interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Atorvastatin interactionPassion Flower Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Sleep Support Mint Flavor — through 4 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Atorvastatin Calcium interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Atorvastatin Calcium interactionChamomile Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Atorvastatin Calcium interactionPassion Flower Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Atorvastatin Calcium interactionBosentanTracleer
How Bosentan interacts with Sleep Support Mint Flavor — through 4 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Bosentan interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Bosentan interactionChamomile Glycerite Liquid ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Bosentan interactionPassion Flower Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Bosentan interactionBrincidofovirTembexa
How Brincidofovir interacts with Sleep Support Mint Flavor — through 2 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Brincidofovir interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Brincidofovir interactionCeliprololCelicard
How Celiprolol interacts with Sleep Support Mint Flavor — through 2 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractP-glycoprotein Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) +1 Major
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Orange Tree Glycerite Liquid Extract + Celiprolol interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Celiprolol interactionCerivastatin SodiumBaycol
How Cerivastatin Sodium interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Cerivastatin Sodium interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Cerivastatin Sodium interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Cerivastatin Sodium interactionCinoxacinCinobac
How Cinoxacin interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Cinoxacin interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Cinoxacin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractQuinolone Antibiotics, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Read the full Orange Tree Glycerite Liquid Extract + Ciprofloxacin interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Ciprofloxacin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Ciprofloxacin interactionCiprofloxacin, HydrocortisoneCipro HC Otic
How Ciprofloxacin, Hydrocortisone interacts with Sleep Support Mint Flavor — through 2 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Ciprofloxacin, Hydrocortisone interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Ciprofloxacin, Hydrocortisone interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with Sleep Support Mint Flavor — through 2 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractQuinolone Antibiotics, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Read the full Orange Tree Glycerite Liquid Extract + Clinafloxacin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Clinafloxacin interactionEnoxacinPenetrex
How Enoxacin interacts with Sleep Support Mint Flavor — through 2 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractQuinolone Antibiotics, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Read the full Orange Tree Glycerite Liquid Extract + Enoxacin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Enoxacin interactionEtoposideEtopophos, VePesid, VP16
How Etoposide interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), P-glycoprotein Substrates Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Etoposide interactionChamomile Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Etoposide interactionPassion Flower Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Etoposide interactionEzetimibe, AtorvastatinLiptruzet
How Ezetimibe, Atorvastatin interacts with Sleep Support Mint Flavor — through 4 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Ezetimibe, Atorvastatin interactionChamomile Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Ezetimibe, Atorvastatin interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Ezetimibe, Atorvastatin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Ezetimibe, Atorvastatin interactionFexofenadineAllegra
How Fexofenadine interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractFexofenadine (allegra), P-glycoprotein Substrates +1 Major
Interaction Summary
Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Read the full Orange Tree Glycerite Liquid Extract + Fexofenadine interactionChamomile Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Fexofenadine interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Fexofenadine interactionFexofenadine, PseudoephedrineAllegra D
How Fexofenadine, Pseudoephedrine interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractFexofenadine (allegra), P-glycoprotein Substrates +1 Major
Interaction Summary
Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Read the full Orange Tree Glycerite Liquid Extract + Fexofenadine, Pseudoephedrine interactionChamomile Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Fexofenadine, Pseudoephedrine interactionPassion Flower Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Fexofenadine, Pseudoephedrine interactionFluvastatinLescol, Lescol XL
How Fluvastatin interacts with Sleep Support Mint Flavor — through 4 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Fluvastatin interactionChamomile Glycerite Liquid ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Fluvastatin interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Fluvastatin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Fluvastatin interactionGatifloxacinTequin, Tequin Injection
How Gatifloxacin interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractQuinolone Antibiotics, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Read the full Orange Tree Glycerite Liquid Extract + Gatifloxacin interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Gatifloxacin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Gatifloxacin interactionGemifloxacinFactive
How Gemifloxacin interacts with Sleep Support Mint Flavor — through 2 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Gemifloxacin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Gemifloxacin interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with Sleep Support Mint Flavor — through 5 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Glyburide interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Glyburide interactionChamomile Glycerite Liquid ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Glyburide interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Glyburide interactionBlueberry Glycerite Liquid ExtractAntidiabetes Drugs Minor
Interaction Summary
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Blueberry Glycerite Liquid Extract + Glyburide interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Sleep Support Mint Flavor — through 5 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Glyburide, Metformin interactionChamomile Glycerite Liquid ExtractCytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Glyburide, Metformin interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Glyburide, Metformin interactionBlueberry Glycerite Liquid ExtractAntidiabetes Drugs Minor
Interaction Summary
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Blueberry Glycerite Liquid Extract + Glyburide, Metformin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Glyburide, Metformin interactionGrepafloxacinRaxar
How Grepafloxacin interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Grepafloxacin interactionChamomile Glycerite Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Grepafloxacin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Grepafloxacin interactionIrinotecanCamptosar, Onivyde
How Irinotecan interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Irinotecan interactionChamomile Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Irinotecan interactionPassion Flower Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Irinotecan interactionIrinotecan Hydrochloride
How Irinotecan Hydrochloride interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Irinotecan Hydrochloride interactionChamomile Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Irinotecan Hydrochloride interactionPassion Flower Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Irinotecan Hydrochloride interactionIsoniazid, Pyrazinamide, RifampinRifater
How Isoniazid, Pyrazinamide, Rifampin interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Isoniazid, Pyrazinamide, Rifampin interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Isoniazid, Pyrazinamide, Rifampin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Isoniazid, Pyrazinamide, Rifampin interactionIsoniazid, RifampinRifamate
How Isoniazid, Rifampin interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Isoniazid, Rifampin interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Isoniazid, Rifampin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Isoniazid, Rifampin interactionIvermectinMectizan, Sklice, Soolantra, Stromectol
How Ivermectin interacts with Sleep Support Mint Flavor — through 1 ingredient. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractP-glycoprotein Substrates, Ivermectin (stromectol, Others) Major
Interaction Summary
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Read the full Orange Tree Glycerite Liquid Extract + Ivermectin interactionLevofloxacinLeva-pak, Levaquin, Levaquin Injection
How Levofloxacin interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Levofloxacin interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Levofloxacin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Levofloxacin interactionLevofloxacin (ophthalmic)Levofloxacin
How Levofloxacin (ophthalmic) interacts with Sleep Support Mint Flavor — through 2 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp), Quinolone Antibiotics Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Levofloxacin (ophthalmic) interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Levofloxacin (ophthalmic) interactionLomefloxacinMaxaquin
How Lomefloxacin interacts with Sleep Support Mint Flavor — through 3 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractQuinolone Antibiotics, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Read the full Orange Tree Glycerite Liquid Extract + Lomefloxacin interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Lomefloxacin interactionPassion Flower Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Lomefloxacin interactionLovastatinAltocor, Mevacor
How Lovastatin interacts with Sleep Support Mint Flavor — through 4 ingredients. Tap an ingredient for the detail:
Orange Tree Glycerite Liquid ExtractOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming sweet orange juice can decrease oral absorption of OATP substrates.
Read the full Orange Tree Glycerite Liquid Extract + Lovastatin interactionChamomile Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
Read the full Chamomile Glycerite Liquid Extract + Lovastatin interactionSpearmint Glycerite Liquid ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Spearmint Glycerite Liquid Extract + Lovastatin interactionPassion Flower Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Organic Anion-transporting Polypeptide Substrates (oatp) Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passion Flower Glycerite Liquid Extract + Lovastatin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sleep Support Mint Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Chamomile Glycerite Liquid Extract
Cns Depressants
Theoretically, German chamomile might have additive effects when used with CNS depressants.
German chamomile has mild sedative effects. Theoretically, concomitant use with drugs with sedative properties can cause additive effects and side effects.
Contraceptive Drugs
Theoretically, large amounts of German chamomile might reduce the effectiveness of oral contraceptives.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, concomitant use of large amounts of German chamomile might interfere with contraceptive drugs through competition for estrogen receptors.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2C9. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2C9 in patients taking German chamomile.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2D6. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2D6 in patients taking German chamomile.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP3A4. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP3A4 in patients taking German chamomile.
Estrogens
Theoretically, large amounts of German chamomile might reduce the effectiveness of estrogens.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, large amounts of German chamomile might interfere with hormone replacement therapy through competition for estrogen receptors.
Tamoxifen (Nolvadex)
Theoretically, large amounts of German chamomile might interfere with the activity of tamoxifen.
In vitro, German chamomile has demonstrated antiestrogenic activity.
Warfarin (Coumadin)
German chamomile might increase the effects of warfarin and increase the risk of bleeding.
In one case, a 70-year-old female taking warfarin developed retroperitoneal hematoma and bilateral recti muscle bleeding along with an INR of 7.9 following ingestion of German chamomile tea 4-5 cups daily and use of a topical chamomile-based lotion applied 4-5 times daily.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
In vitro and animal research shows that German chamomile might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP1A2 in patients taking German chamomile.
Passion Flower Glycerite Liquid Extract
Cns Depressants
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.
Spearmint Glycerite Liquid Extract
Cns Depressants
Theoretically, spearmint might alter the sedative effects of CNS depressants.
Animal research suggests that (-)-carvone, a major constituent of spearmint, has sedative effects. However, in humans, chewing spearmint-flavored gum induced arousal effects.
Hepatotoxic Drugs
Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Animal research suggests that drinking spearmint tea for 30 days can increase markers of liver damage, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and cause liver degeneration and necrosis, in a dose-dependent manner. This effect has not been reported in humans.
Orange Tree Glycerite Liquid Extract
Celiprolol (Celicard)
Consuming sweet orange with celiprolol can decrease oral absorption of celiprolol.
A pharmacokinetic study in healthy volunteers shows that celiprolol levels, after a single dose of 100 mg, are decreased by up to 90% in people who drink sweet orange juice 200 mL three times daily. It's not known if lower consumption of sweet orange juice will have the same effect. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.
Ivermectin (Stromectol, Others)
Consuming sweet orange juice with ivermectin can decrease the oral absorption of ivermectin.
A pharmacokinetic study in healthy volunteers shows that taking ivermectin orally with sweet orange juice 750 mL over 4 hours reduces the bioavailability of ivermectin. This effect does not seem to be related to effects on P-glycoprotein. The effect on ivermectin is more pronounced in males compared to females.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Consuming sweet orange juice can decrease oral absorption of OATP substrates. Separate administration by at least 4 hours.
Clinical research shows that consuming sweet orange juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. For example, sweet orange juice decreases bioavailability of fexofenadine, a substrate of OATP, by about 72% and of celiprolol, another OATP substrate, by up to 90%. Since sweet orange juice seems to affect OATP for a short time, recommend separating drug administration and consumption of sweet orange juice by at least 4 hours.
Pravastatin (Pravachol)
Consuming sweet orange juice with pravastatin can increase the absorption of pravastatin.
A small pharmacokinetic study in healthy volunteers shows that consuming sweet orange juice 800 mL over 3 hours, including before, during, and after taking pravastatin 10 mg, increases pravastatin levels by about 149%, without affecting pravastatin elimination. Theoretically this effect might be due to modulation of organic anion transporting polypeptides (OATPs) by sweet orange juice. Sweet orange juice does not seem to affect simvastatin levels, but it is not known if sweet orange affects any of the other statins.
Fexofenadine (Allegra)
Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Clinical research shows that coadministration of sweet orange juice 1200 mL decreases bioavailability of fexofenadine by about 72%. In an animal model, sweet orange juice decreased bioavailability of fexofenadine by 31%. Fexofenadine manufacturer data indicates that concomitant administration of sweet orange juice and fexofenadine results in larger wheal and flare sizes in research models. This suggests that sweet orange reduces the clinical response to fexofenadine. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.
P-Glycoprotein Substrates
Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Animal and in vitro research suggest that orange juice extract inhibits drug efflux by P-gp, increasing absorption and levels of P-gp substrates. In contrast, pharmacokinetic research in humans shows that drinking large amounts of sweet orange juice decreases absorption and levels of the P-gp substrate celiprolol. This suggests that orange juice actually induces drug efflux by P-gp or affects drug levels by another mechanism such as inhibiting the gut drug transporter called organic anion transporting polypeptide (OATP). Until more is known, sweet orange juice should be used cautiously in people taking P-gp substrates.
Quinolone Antibiotics
Calcium-fortified sweet orange juice might reduce quinolone absorption.
Calcium binds to quinolones in the gut. Theoretically, the calcium in certain fortified orange juices can also bind to quinolone antibiotics and reduce their absorption and levels.
Blueberry Glycerite Liquid Extract
Antidiabetes Drugs
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggests that blueberry and/or blueberry leaf extracts can lower blood glucose levels.
Buspirone (Buspar)
Theoretically, blueberry juice might increase blood levels of buspirone.
In vitro research shows that blueberry juice can inhibit the metabolism of buspirone, possibly by inhibiting cytochrome P450 3A (CYP3A) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking buspirone hydrochloride 10 mg does not significantly affect the concentration or clearance of buspirone.
Flurbiprofen (Ansaid, Others)
Theoretically, blueberry juice might increase blood levels of flurbiprofen.
In vitro research shows that blueberry juice can inhibit the metabolism of flurbiprofen, possibly by inhibiting cytochrome P450 2C9 (CYP2C9) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking flurbiprofen 100 mg does not significantly affect the concentration or clearance of flurbiprofen.
Linden Glycerite Liquid Extract
Lithium
Theoretically, due to its potential diuretic effects, linden might increase the effects and adverse effects of lithium.
Linden is thought to have diuretic properties. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Sleep Support Mint Flavor, from the product label.
TerraVita
See all TerraVita products- Name
- ZooScape LLC
- Phone Number
- 844-449-0444
- Web Address
- www.ZooScape.com
Sleep Support Mint Flavor by TerraVita: Common Questions
Does Sleep Support Mint Flavor by TerraVita interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this make me drowsy during the day?
Is this safe to take if I'm pregnant?
Can I take this while breastfeeding?
What does passion flower do in this formula?
Could this cause an allergic reaction?
Is this okay to take long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Sleep Support Mint Flavor is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sleep Support Mint Flavor’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Spearmint
Interacts with 579 drugsSpearmint is a common culinary mint that is generally safe in food and tea amounts. Early research suggests possible benefits for digestion, mild hormone-related issues (such as excess facia...
Read the full Spearmint monograph → Herb & supplement monographLinden
Interacts with 1 drugLinden (also called lime flower) is a traditional herbal tea long used to calm nerves, ease cold symptoms, and support restful sleep. Strong human evidence for these uses is lacking, but the...
Read the full Linden monograph → Herb & supplement monographPoppy Seed
Poppy seeds are a common food ingredient harvested from the opium poppy, and the seeds themselves contain very little of the plant's opium compounds. They are generally safe as food, but eat...
Read the full Poppy Seed monograph → Herb & supplement monographGerman Chamomile
Interacts with 960 drugsGerman chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible benefits for mild anxiety and some skin o...
Read the full German Chamomile monograph → Herb & supplement monographSweet Orange
Interacts with 246 drugsSweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and...
Read the full Sweet Orange monograph → Herb & supplement monographPassion Flower
Interacts with 836 drugsPassion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...
Read the full Passion Flower monograph → Herb & supplement monographBlueberry
Interacts with 88 drugsBlueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most people. Concentrated supplements are mark...
Read the full Blueberry monograph →Sources & How We Checked
Sleep Support Mint Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 93 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Spearmint 20 references
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Akdogan M, Ozguner M, Aydin G, Gokalp O. Investigation of biochemical and histopathological effects of Mentha piperita Labiatae and Mentha spicata Labiatae on liver tissue in rats. Hum Exp Toxicol 2004;23:21-8.
- Poon, T. S. and Freeman, S. Cheilitis caused by contact allergy to anethole in spearmint flavoured toothpaste. Australas.J Dermatol. 2006;47(4):300-301. PubMed
- Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
- de Sousa, D. P., Farias Nobrega, F. F., and de Almeida, R. N. Influence of the chirality of (R)-(-)- and (S)-(+)-carvone in the central nervous system: a comparative study. Chirality 5-5-2007;19(4):264-268.
- Larsen, W., Nakayama, H., Fischer, T., Elsner, P., Frosch, P., Burrows, D., Jordan, W., Shaw, S., Wilkinson, J., Marks, J., Jr., Sugawara, M., Nethercott, M., and Nethercott, J. Fragrance contact dermatitis: a worldwide multicenter investigation (Part II PubMed
- Guney, M., Oral, B., Karahanli, N., Mungan, T., and Akdogan, M. The effect of Mentha spicata Labiatae on uterine tissue in rats. Toxicol.Ind.Health 2006;22(8):343-348.
- Masumoto, Y., Morinushi, T., Kawasaki, H., Ogura, T., and Takigawa, M. Effects of three principal constituents in chewing gum on electroencephalographic activity. Psychiatry Clin.Neurosci. 1999;53(1):17-23. PubMed
- Bulat, R., Fachnie, E., Chauhan, U., Chen, Y., and Tougas, G. Lack of effect of spearmint on lower oesophageal sphincter function and acid reflux in healthy volunteers. Aliment.Pharmacol Ther. 1999;13(6):805-812. PubMed
- Francalanci, S., Sertoli, A., Giorgini, S., Pigatto, P., Santucci, B., and Valsecchi, R. Multicentre study of allergic contact cheilitis from toothpastes. Contact Dermatitis 2000;43(4):216-222. PubMed
- Bonamonte, D., Mundo, L., Daddabbo, M., and Foti, C. Allergic contact dermatitis from Mentha spicata (spearmint). Contact Dermatitis 2001;45(5):298.
- Tomson, N., Murdoch, S., and Finch, T. M. The dangers of making mint sauce. Contact Dermatitis 2004;51(2):92-93. PubMed
- Clayton, R. and Orton, D. Contact allergy to spearmint oil in a patient with oral lichen planus. Contact Dermatitis 2004;51(5-6):314-315. PubMed
- Dal Sacco, D., Gibelli, D., and Gallo, R. Contact allergy in the burning mouth syndrome: a retrospective study on 38 patients. Acta Derm.Venereol. 2005;85(1):63-64. PubMed
- Goncalves, J. C., Oliveira, Fde S., Benedito, R. B., de Sousa, D. P., de Almeida, R. N., and de Araujo, D. A. Antinociceptive activity of (-)-carvone: evidence of association with decreased peripheral nerve excitability. Biol Pharm Bull. 2008;31(5):1017- PubMed
- Ormerod, A. D. and Main, R. A. Sensitisation to "sensitive teeth" toothpaste. Contact Dermatitis 1985;13(3):192-193. PubMed
- Skrebova, N., Brocks, K., and Karlsmark, T. Allergic contact cheilitis from spearmint oil. Contact Dermatitis 1998;39(1):35. PubMed
- Damiani E, Aloia AM, Priore MG, et al. Allergy to mint (Mentha spicata). J Investig Allergol Clin Immunol 2012;22:309-10.
- Connelly AE, Tucker AJ, Tulk H, et al. High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms. J Med Food 2014;17:1361-7. PubMed
- Lasrado JA, Nieman KM, Fonseca BA, et al. Safety and tolerability of a dried aqueous spearmint extract. Regul Toxicol Pharmacol 2017;86:167-176. PubMed
Linden 2 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Poppy Seed 13 references
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Meneely KD. Poppy seed ingestion: the Oregon perspective. J Forensic Sci 1992;37(4):1158-1162. DOI
- Kaplan, R. Poppy seed dependence. Med J Aust 1994;161(2):176. PubMed
- Braye, K., Harwood, T., Inder, R., Beasley, R., and Robinson, G. Poppy seed tea and opiate abuse in New Zealand. Drug Alcohol Rev 2007;26(2):215-219. PubMed
- Lloyd-Jones, D. M. and Bonomo, Y. Unusual presentations for pharmacotherapy-poppy seed dependence. Drug Alcohol Rev 2006;25(4):375-376. PubMed
- Braun, W. and Kovary, P. M. [Poppy seed allergy]. Z.Hautkr 1988;63(4):344.
- Pettitt BC Jr, Dyszel SM, Hood LV. Opiates in poppy seed: effect on urinalysis results after consumption of poppy seed cake-filling. Clin Chem 1987;33(7):1251-2. DOI
- Bjerver K, Jonsson J, Kilsson A. Morphine intake from poppy seed food. J Pharma Pharmacol 2011;34(12):798-801. DOI
- Facchini PJ, De Luca V. Phloem-Specific Expression of Tyrosine/Dopa Decarboxylase Genes and the Biosynthesis of Isoquinoline Alkaloids in Opium Poppy. The Plant Cell 1995;7(11):1811-1821. PubMed
- Powers D, Erickson S, Swortwood MJ. Quantification of morphine, codeine, and thebaine in home-brewed poppy seed tea by LC-MS/MS. J Forensic Sci. 2018;63(4):1229-1235.
- Schuppener LM, Corliss RF. Death due to complications of bowel obstruction following raw poppy seed ingestion. J Forensic Sci. 2018;63(2):614-618. PubMed
- Poponea N, Kashlan MT, Vollstaedt J. Opium poppy seed tea: A lesser known but deadly cocktail. Am J Respir Crit Care Med. 2018;197:A6895.
- Tan YPA, Alexander PDG, Knowles S. Acute cardiotoxicity following 'poppy seed tea' consumption. Anaesth Rep 2021;9(2):e12130. PubMed
German Chamomile 15 references
- Subiza J, Subiza JL, Hinojosa M, et al. Anaphylactic reaction after the ingestion of chamomile tea; a study of cross-reactivity with other composite pollens. J Allergy Clin Immunol 1989;84:353-8. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- Viola H, Wasowski C, Levi de Stein M, et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med 1995;61:213-6.
- van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1982;8:143. PubMed
- van Ketel WG. Allergy to Matricaria chamomilla. Contact Dermatitis 1987;16:50-1. PubMed
- Hormann HP, Korting HC. Evidence for the efficacy and safety of topical herbal drugs in dermatology: part I: anti-inflammatory agents. Phytomedicine 1994;1:161-71. PubMed
- Avallone R, Zanoli P, Puia G, et al. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol 2000;59:1387-94. PubMed
- Kassi E, Papoutsi Z, Fokialakis N, et al. Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties. J Agric Food Chem 2004;52:6956-61. PubMed
- Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
- Segal R, Pilote L. Warfarin interaction with Matricaria chamomilla. CMAJ 2006;174:1281-2. PubMed
- Loggia RD, Traversa U, Scarcia V, et al. Depressive effects of Chamomilla recutita (L.) Rausch, tubular flowers, on central nervous system in mice. Pharmacol Res Commun 1982;14(2):153-162. PubMed
- Ganzera M, Schneider P, Stuppner H. Inhibitory effects of the essential oil of chamomile (Matricaria recutita L.) and its major constituents on human cytochrome P450 enzymes. Life Sci 2006;78(8):856-861. PubMed
- Benito P, Rodríguez-Perez R, García F, Juste S, Moneo I, Caballero ML. Occupational allergic rhinoconjunctivitis induced by Matricaria chamomilla with tolerance of chamomile tea. J Investig Allergol Clin Immunol. 2014;24(5):369-70. No abstract available.
- Braga FT, Santos AC, Bueno PC, et al. Use of Chamomilla recutita in the prevention and treatment of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a randomized, controlled, phase II clinical trial. Cancer Nurs 2015;38(4):32 PubMed
- Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety T
Sweet Orange 17 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- FDA, CFSAN. FDA-approved potassium health claim notification for potassium containing foods. 2000. Available at: www.cfsan.fda.gov/~dms/hclm-k.html.
- Kurowska EM, Spence JD, Jordan J, et al. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 2000;72:1095-100. PubMed
- Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
- Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
- Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
- Lilja JJ, Juntti-Patinen L, Neuvonen PJ. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther 2004;75:184-90.
- Tian R, Koyabu N, Takanaga H, et al. Effects of grapefruit juice and orange juice on the intestinal efflux of P-glycoprotein substrates. Pharm Res 2002;19:802-9. PubMed
- Vanapalli SR, Chen Y, Ellingrod VL, et al. Orange juice decreases the oral bioavailability of ivermectin in health volunteers. Clin Pharmacol Ther 2003;73 (Abstract PDII-A-10):P94.
- Huang SM, Lesko LJ. Drug-drug, drug-dietary supplement, and drug-citrus fruit and other food interactions: what have we learned? J Clin Pharmacol 2004;44:559-69. PubMed
- Koitabashi Y, Kumai T, Matsumoto N, et al. Orange juice increased the bioavailability of pravastatin, 3-hydroxy-3-methylglutaryl CoA reductase inhibitor, in rats and healthy human subjects. Life Sci 2006;78:2852-9. PubMed
- Takanaga H, Ohnishi A, Yamada S, et al. Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4. J Pharmacol Exp Ther 2000;293:230-6. DOI
- Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49:1403-7. PubMed
- Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55. PubMed
- Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94:233-9. PubMed
- Kays MB, Overholser BR, Mueller BA, et al. Effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin. Am J Kidney Dis. 2003;42(6):1253-9. PubMed
- Neuhofel, A. L., Wilton, J. H., Victory, J. M., Hejmanowsk, L. G., and Amsden, G. W. Lack of bioequivalence of ciprofloxacin when administered with calcium-fortified orange juice: a new twist on an old interaction. J Clin Pharmacol. 2002;42(4):461-466. DOI
Passion Flower 19 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6.
- Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. PubMed
- Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. DOI
- Mori A, Hasegawa K, Murasaki M, et al. Clinical evaluation of Passiflamin (passiflora extract) on neurosis - multicenter double blind study in comparison with mexazolam. Rinsho Hyoka (Clinical Evaluation) 1993;21:383-440.
- Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518. DOI
- Speroni E., Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med. 1988;54:488-91.
- Capasso A., Sorrentino L. Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine. 2005;12:39-45. PubMed
- Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
- Smith, G. W., Chalmers, T. M., and Nuki, G. Vasculitis associated with herbal preparation containing Passiflora extract. Br J Rheumatol. 1993;32(1):87-88.
- Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R., and Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20. PubMed
- Nojoumi M, Ghaeli P, Salimi S, Sharifi A, Raisi F. Effects of Passion Flower Extract, as an Add-On Treatment to Sertraline, on Reaction Time in Patients ?with Generalized Anxiety Disorder: A Double-Blind Placebo-Controlled Study. Iran J Psychiatry. 2016;1
- Rokhtabnak F, Ghodraty MR, Kholdebarin A, et al. Comparing the Effect of Preoperative Administration of Melatonin and Passiflora incarnata on Postoperative Cognitive Disorders in Adult Patients Undergoing Elective Surgery. Anesth Pain Med. 2016;7(1):e4123 PubMed
- Dantas LP, de Oliveira-Ribeiro A, de Almeida-Souza LM, Groppo FC. Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Med Oral Patol Oral Cir Bucal. 2017;22(1):e95-e101. PubMed
- Ozturk Z, Kalayci CC. Pregnancy outcomes in psychiatric patients treated with passiflora incarnata. Complement Ther Med. 2018 Feb;36:30-32. PubMed
- da Cunha RS, Amorim KS, Gercina AC, et al. Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial. Clin Oral Investig. 2020. PubMed
- Schäfer AM, Gilgen PM, Spirgi C, et al. Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. Planta Med. 2021. PubMed
- Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed
Blueberry 7 references
- Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
- Wang SY, Lin HS. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 2000;48:140-6.. PubMed
- Martineau, L. C., Couture, A., Spoor, D., Benhaddou-Andaloussi, A., Harris, C., Meddah, B., Leduc, C., Burt, A., Vuong, T., Mai, Le P., Prentki, M., Bennett, S. A., Arnason, J. T., and Haddad, P. S. Anti-diabetic properties of the Canadian lowbush bluebe
- Vuong, T., Martineau, L. C., Ramassamy, C., Matar, C., and Haddad, P. S. Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. Can J Physiol Pharma
- Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolnikowski GG, Court MH, Greenblatt DJ. Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. Br J Clin Pharmacol. 2013 Apr;75(4):1041-52. PubMed
- Basu A, Du M, Leyva MJ, et al. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 2010;140(9):1582-7. PubMed
- Basu A, Feng D, Planinic P, Ebersole JL, Lyons TJ, Alexander JM. Dietary blueberry and soluble fiber supplementation reduces risk of gestational diabetes in women with obesity in a randomized controlled trial. J Nutr 2021;151(5):1128-38. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC