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Dietary supplement

Tribulus Max Ingredients & Drug Interactions

by MET-Rx

Tribulus Max label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus Max against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus Max is a dietary supplement by MET-Rx with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus Max by MET-Rx

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus Max by MET-Rx — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tribulus Max by MET-Rx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Tribulus Max contains a single active ingredient: tribulus extract, derived from the tribulus terrestris plant. The tablet also includes inactive ingredients — cellulose and croscarmellose — which are fillers and binders that help form and hold the tablet together.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: athletic performance and training support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, muscle strength, endurance, recovery.
  • The closest evidence on file: Tribulus is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

Tribulus extract is possibly effective for sexual dysfunction based on the evidence we hold. For athletic performance, the data suggests it's possibly ineffective.

For benign prostatic hyperplasia (an enlarged prostate), there isn't enough reliable evidence to rate whether it works.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated short-term in healthy adults, though long-term safety data are limited and quality varies between products. Rare serious effects like liver or kidney injury and seizures have been reported.

More common mild side effects include abdominal pain, cramping, nausea, vomiting, diarrhea, and constipation — though in one study these occurred at similar rates in people taking tribulus and those taking placebo. Do not use tribulus during pregnancy because it may affect hormones and safety is not established.

Avoid it while breastfeeding due to lack of reliable safety information.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Tribulus Max, double-check with your doctor or pharmacist if you take blood pressure medications, diabetes medications, or lithium. All three drug types can have moderate interactions with tribulus extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus Max may be worth considering if you're interested in sexual function support and you don't take blood pressure medications, diabetes medications, or lithium. If you do take any of those, or if you're pregnant or breastfeeding, talk with your doctor or pharmacist before starting.

Long-term safety data are limited, so this is best used short-term under professional guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus Max, straight from the product label.

Brand MET-Rx
Barcode (UPC) 786560579681
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Nov 21, 2016
DSLD ID 66319
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus Max by MET-Rx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
786560579681
IngredientAmount% DV
Tribulus extract1200 mg--

Other ingredients: Cellulose, Croscarmellose, Contains <2% of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

SPECIALTY SUPPLEMENT

1200 MG IN ONE SINGLE TABLET...QUALITY INGREDIENTS FOR A QUALITY PRODUCT! THE PERFECT COMPLEMENT TO YOUR HARDCORE TRAINING REGIMEN.

SPECIALTY SUPPLEMENT

Formula

TRIBULUS TERRESTRIS IS ONE OF THE HOTTEST SUPPLEMENTS ON THE MARKET, USED BY BODYBUILDERS AND ATHLETES DURING THE TOUGHEST OF TRAINING CYCLES.

>> 1200 MG PER TABLET >> STANDARDIZED FOR 40% SAPONINS

Brand IP Statement(s)

MET-Rx HAS PACKED 1200 MG OF ACTIVE INGREDIENT INTO ONE POWERFUL TABLET MAKING THIS ONE OF THE MOST UNIQUE TRIBULUS PRODUCTS ON THE MARKET!

YOU CAN’T FAKE STRONG

2016

Precautions

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT: DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Storage

STORE AT ROOM TEMPERATURE AND AVOID EXCESSIVE HEAT.

FDA Statement of Identity

DIETARY SUPPLEMENT

General

57968 01A B57643

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) tablet daily, preferably with a meal.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus Max by MET-Rx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus Max label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus Max by MET-Rx

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Tribulus extract

Interacts with
259 drugs
1200 mg per serving Form: Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus extract monograph & interactions

Other (inactive) ingredients: Cellulose, Croscarmellose, Contains <2% of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus Max by MET-Rx Drug Interactions

Want to check YOUR meds against Tribulus Max?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus extract 259

Individual Drug Interactions

The ingredients in Tribulus Max interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus Max interact with drugs. Each result below shows which ingredient is responsible. Tribulus extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus Max with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus Max, from the product label.

MET-Rx

See all MET-Rx products
Name
MET-Rx Nutrition, Inc.
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-800-556-3879
Web Address
www.MET-Rx.com
Pharmacist Counseling Corner

Tribulus Max by MET-Rx: Common Questions

Does Tribulus Max by MET-Rx interact with any medications?
Yes. Based on its ingredients, Tribulus Max has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus Max contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does tribulus really help with sexual function?
The evidence we have rates tribulus as possibly effective for sexual dysfunction, meaning there's some support but it's not definitive. Results vary, and more research would help clarify how well it actually works.
Can I take this if I'm trying to improve athletic performance?
The data suggests tribulus is possibly ineffective for athletic performance. If that's your main goal, this product likely won't deliver what you're looking for.
What are the most common side effects?
Mild gastrointestinal upset — abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation — can occur, though in one study these happened at similar rates in people taking tribulus and those taking placebo. Serious side effects are rare but have included liver or kidney injury and seizures.
Is it safe to take long-term?
Long-term safety data are limited. Tribulus seems generally well tolerated over the short term in healthy adults, but we don't have solid evidence for long-term use. Talk with your doctor or pharmacist about how long it's safe for you to use.
Can I take this while pregnant or breastfeeding?
No — tribulus may affect hormones during pregnancy and safety is not established, so it should be avoided. It should also be avoided while breastfeeding due to lack of reliable safety information. Talk with your doctor or pharmacist if you're considering it during either time.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus Max is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus Max label
Go deeper

The Full Monographs Behind Tribulus Max’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus Max's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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