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Dietary supplement

True Food Superpotency Soyagen Ingredients & Drug Interactions

by Higher Nature

True Food Superpotency Soyagen label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking True Food Superpotency Soyagen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

True Food Superpotency Soyagen is a dietary supplement by Higher Nature with 1 active ingredient. Its ingredients are commonly taken for menopause symptoms (hot flashes), heart and cholesterol health, bone health.Based on those ingredients, 1,233 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are fermentation-activated organically grown whole Soya. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against True Food Superpotency Soyagen by Higher Nature

Ask about any prescription or over-the-counter medication and we check it for interactions with True Food Superpotency Soyagen by Higher Nature — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of True Food Superpotency Soyagen by Higher Nature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Total Isoflavones” is listed as a grouped ingredient — the label gives one combined amount (40 mg) without saying how much of each component you get.
  • “fermentation-activated organically grown whole Soya” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

True Food Superpotency Soyagen contains 3 active ingredients: total isoflavones (a blend), genistein, and diadzein and glycetein (also isoflavones from fermented soya). Isoflavones are plant compounds with estrogen-like properties.

The product also contains inactive ingredients — enzyme pre-digested soya, stearic acid, silicon dioxide, magnesium stearate, and a coating — that are excipients (fillers and binders).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Red Clover's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Fermented soy nutrition and wholefood supplement.
  • We looked for evidence on: Menopausal symptoms, Postmenopausal conditions, Hyperlipidemia, Cardiovascular disease (CVD), Osteoporosis, General nutritional support — and 1 related terms.
  • The closest evidence on file: Red Clover is rated "Insufficient Reliable Evidence To Rate" for Osteoporosis (Natural Medicines).
  • Also on file: Red Clover is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Menopausal symptoms.

The data we hold shows insufficient reliable evidence to rate this product for any condition — including menopausal symptoms, osteoporosis, osteoarthritis, and androgenic alopecia (male-pattern hair loss). That means the evidence isn't established enough in our records to say whether it works or doesn't.

If you're considering it for a specific health concern, ask your pharmacist or doctor what the current research says.

The evidence, ingredient by ingredient Soy

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Genistein is generally well tolerated short-term in healthy adults, though its estrogen-like effects mean some people need to be cautious. The most common side effects reported are muscle aches, nausea, and vaginal spotting.

Because of its estrogenic activity, there's been concern about whether it might increase breast or uterine cancer risk; a meta-analysis suggests it may modestly increase breast density on mammograms in premenopausal women, but not in postmenopausal ones. Avoid this product during pregnancy because of its estrogen-like effects and lack of safety data.

There's not enough safety information for breastfeeding, so it's best avoided then too. We hold no safety data on diadzein and glycetein.

Side effects, ingredient by ingredient Soy

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Red Clover.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 868 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting, check if you take tamoxifen, estrogens or hormone therapy, or methotrexate — all Moderate-severity concerns. Also double-check any drugs metabolized by your liver (the CYP1A2, CYP2C9, CYP2C19, or CYP3A4 systems) and blood thinners or antiplatelet drugs like warfarin or aspirin, though the real-world risk for these is lower.

Use the medication checker on this page for your specific prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take tamoxifen, estrogen therapy, or methotrexate, talk to your pharmacist before starting this. If you're pregnant or breastfeeding, skip it.

The evidence for what it treats isn't established in our data, so be clear on why you're taking it and what you expect. Check your exact medications with the tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about True Food Superpotency Soyagen, straight from the product label.

Brand Higher Nature
Barcode (UPC) 5031013101458
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 223087
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for True Food Superpotency Soyagen by Higher Nature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
5031013101458
IngredientAmount% DV
Total Isoflavones40 mg--
Genistein900 mcg--
Diadzein3200 mcg--
Glycetein2700 mcg--
fermentation-activated organically grown whole Soya1000 mg--

Other ingredients: enzyme pre-digested whole Soya, Stearic Acid, Silicon Dioxide, Magnesium Stearate, Coating

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

NRV = Nutrient Reference Value

This product is not tested on animals.

Life Stage True Food Fermented nutrition Wholefood Goodness

Formula

All True Food nutrients also contain B vitamins, beta glucans, glutathione, choline, inositol, amino acids and other phytonutrients naturally found in fermented food cultures.

Fermented soy isoflavones

Fermented whole soya Fully activated soya isoflavones

Formulation

Free from: Artificial colours, flavourings or preservatives, corn, dairy products, gluten, lactose, maize, salt, starch, wheat.

Vegetarian and vegan

FDA Statement of Identity

Food Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults take 1 tablet a day. Do not exceed recommended daily intake.

Precautions

Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Storage: Store in a cool, dry place out of reach of children.

Storage

Storage: Store in a cool, dry place out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

True Food Superpotency Soyagen by Higher Nature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

True Food Superpotency Soyagen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in True Food Superpotency Soyagen by Higher Nature

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Fermentation-activated organically grown whole Soya

Interacts with
611 drugs
1000 mg per serving

Soy is a nutritious bean that is a staple food and a popular source of plant protein and isoflavones. Eating soy foods as part of a balanced diet is g...

Fermentation-activated organically grown whole Soya monograph & interactions
  • › Total Isoflavones

Other (inactive) ingredients: Enzyme pre-digested whole Soya, Stearic Acid, Silicon Dioxide, Magnesium Stearate, Coating. These complete the product’s ingredient list but are not active constituents.

Interaction report

True Food Superpotency Soyagen by Higher Nature Drug Interactions

Want to check YOUR meds against True Food Superpotency Soyagen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,233Drugs
9 Major 345 Moderate 879 Minor

Ingredients driving the most interactions

fermentation-activated organically grown whole Soya 611

Individual Drug Interactions

The ingredients in True Food Superpotency Soyagen interact with 1,233 drugs. Click any drug to see the details.

1 of the 1 ingredient in True Food Superpotency Soyagen interact with drugs. Each result below shows which ingredient is responsible. fermentation-activated organically grown whole Soya

Each ingredient & the kinds of drugs it affects

For each ingredient in True Food Superpotency Soyagen with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

fermentation-activated organically grown whole Soya12 drug types · 611 drugs

Monoamine Oxidase Inhibitors (Maois)

Taking soy products containing high amounts of tyramine along with MAOIs can increase the risk of hypertensive crisis.
Fermented soy products such as tofu and soy sauce contain tyramine, a naturally occurring chemical that affects blood pressure regulation. The metabolism of tyramine is decreased by MAOIs. Consuming more than 6 mg of tyramine while taking an MAOI can increase the risk of hypertensive crisis. The amount of tyramine in fermented soy products is usually less than 0.6 mg per serving; however, there can be significant variation depending on the specific product used, storage conditions, and length of storage. Storing one brand of tofu for a week can increase tyramine content from 0.23 mg to 4.8 mg per serving. Advise patients taking MAOIs to avoid fermented soy products that contain high amounts of tyramine.

Likelihood Likely Evidence C
Antidiabetes Drugs

Soy can lower blood glucose and have additive effects with antidiabetes drugs.
Clinical research shows that whole soy diets and soy-based meals reduce fasting glucose levels in diabetic and non-diabetic individuals. Also, individuals following a soy-based meal replacement plan seem to require lower doses of sulfonylureas and metformin to manage blood glucose levels when compared with individuals following a diet plan recommended by the American Diabetes Association.

Likelihood Possible Evidence A
Antihypertensive Drugs

Theoretically soy protein may have additive effects with antihypertensive drugs and increase the risk of hypotension.
Although some contradictory research exists, most clinical evidence suggests that consuming soy protein modestly reduces systolic and diastolic blood pressure in individuals with prehypertension or hypertension.

Likelihood Possible Evidence A
Caffeine

Theoretically, soy might reduce the clearance of caffeine.
Soy contains genistein. Taking genistein 1 gram daily for 14 days seems to inhibit caffeine clearance and metabolism in healthy females. This effect has been attributed to inhibition of the cytochrome P450 1A2 (CYP1A2) enzyme, which is involved in caffeine metabolism. It is unclear if this effect occurs with the lower amounts of genistein found in soy.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, soy might have additive effects when used with diuretic drugs.
Animal research suggests that genistein, a soy isoflavone, increases diuresis within 6 hours of subcutaneous administration in rats. The effects seem to be similar to those of furosemide. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, soy might competitively inhibit the effects of estrogen replacement therapy.
Soy contains phytoestrogens and has been shown to have estrogenic activity in some patients. Although this has not been demonstrated in humans, theoretically, concomitant use of soy with estrogen replacement therapy might reduce the effects of the estrogen replacement therapy.

Likelihood Possible Evidence D
Levothyroxine (Synthroid, Others)

Soy products might reduce the absorption of levothyroxine in some patients.
Preliminary clinical research and a case report suggest that soy-based formulas inhibit the absorption of levothyroxine in infants with congenital hypothyroidism. A levothyroxine dosage increase may be needed for infants with congenital hypothyroidism while using soy-based formulas, and the dose may need to be reduced when soy-based formulas are no longer administered. However, in postmenopausal adults, clinical research shows that taking a single dose of soy extract containing isoflavones 60 mg along with levothyroxine does not affect the oral bioavailability of levothyroxine.

Likelihood Possible Evidence B
Progesterone

Theoretically, combining soy isoflavones with transdermal progesterone may worsen bone density.
Clinical research suggests that significant bone loss may occur in females with osteoporosis who receive a combination of transdermal progesterone with soy milk containing isoflavones when compared with placebo, soy milk alone, or progesterone alone.

Likelihood Possible Evidence A
Tamoxifen (Nolvadex)

Theoretically, estrogenic soy isoflavones might alter the effects of tamoxifen.
Laboratory research suggests that genistein and daidzen, isoflavones from soy, can antagonize the antitumor effects of tamoxifen under some circumstances; however, soy isoflavones might have different effects when used at different doses. A relatively low in vitro concentration of soy isoflavones such as 1 microM/L seems to interfere with tamoxifen, whereas high in vitro concentrations such as those >10 microM/L might actually enhance tamoxifen effects. People on a high-soy diet have soy isoflavones levels ranging from 0.1-6 microM/L. Until more is known, advise patients taking tamoxifen to avoid therapeutic use of soy products.

Likelihood Possible Evidence B
Warfarin (Coumadin)

Theoretically, soy might interfere with the effects of warfarin.
Soy milk has been reported to decrease the international normalized ratio (INR) in a patient taking warfarin. The mechanism of this interaction is not known. However, animal and in vitro research suggests that soy may also inhibit platelet aggregation. Dosing adjustments for warfarin may be necessary.

Likelihood Possible Evidence D
Antibiotic Drugs

Theoretically, antibiotics may decrease the activity of soy isoflavones.
Intestinal bacteria are responsible in part for converting soy isoflavones into their active forms. Antibiotics may decrease the amount of intestinal bacteria and decrease its ability to convert isoflavones.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Soy might modestly induce CYP2C9 enzymes. However, this effect does not seem to be clinically significant.
In vitro research suggests that an unhydrolyzed soy extract might induce CYP2C9. However, the significance of this interaction is likely minimal. In healthy females taking a specific extract of soy (Genistein Soy Complex, Source Naturals), blood levels of losartan, a CYP2C9 substrate, were not significantly affected.

Likelihood Unlikely Evidence D
fermentation-activated organically grown whole Soya full monograph & interactions
The maker

Brand information

Manufacturer and brand details for True Food Superpotency Soyagen, from the product label.

Higher Nature

See all Higher Nature products
Name
Higher Nature Ltd
Street Address
10 Discovery Way
City
Horam TN21 0GE
State
East Sussex
Web Address
highernature.com
Pharmacist Counseling Corner

True Food Superpotency Soyagen by Higher Nature: Common Questions

Does True Food Superpotency Soyagen by Higher Nature interact with any medications?
Yes. Based on its ingredients, True Food Superpotency Soyagen has a known interaction with 1,233 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
True Food Superpotency Soyagen contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against it during pregnancy because of genistein's estrogen-like effects and lack of safety data. There's also not enough information to say it's safe while breastfeeding. Talk with your doctor or pharmacist about your specific situation.
What are the common side effects?
Most commonly, people report muscle aches, nausea, and vaginal spotting. A specific red clover isoflavone product has been associated with headache, though at rates similar to placebo. Most people tolerate it well short-term.
Does it really work for hot flashes and night sweats?
The evidence we have isn't established enough to say. We rate it as insufficient reliable evidence for menopausal symptoms, so we can't confirm it helps. Your pharmacist or doctor can tell you what current research shows.
Why can't I take this with tamoxifen?
Genistein, one of the isoflavones in this product, might theoretically interfere with how tamoxifen works to fight breast cancer. Lab and animal evidence is mixed, but it's serious enough to avoid without your doctor's approval.
What's the difference between the isoflavones in here?
This product contains genistein, diadzein, and glycetein — all plant compounds with estrogen-like activity. We have interaction data for genistein, but we couldn't check diadzein and glycetein, so we hold no data on how they interact with your medications.
Is there any filler in this product?
Yes — it contains enzyme pre-digested soya, stearic acid, silicon dioxide, magnesium stearate, and a coating, which are inactive ingredients (excipients) used as binders and fillers.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if True Food Superpotency Soyagen is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

True Food Superpotency Soyagen label
Go deeper

The Full Monographs Behind True Food Superpotency Soyagen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Soy

Interacts with 611 drugs

Soy is a nutritious bean that is a staple food and a popular source of plant protein and isoflavones. Eating soy foods as part of a balanced diet is generally considered safe for most people...

Read the full Soy monograph →
Sources

Sources & How We Checked

True Food Superpotency Soyagen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 112 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Red Clover 24 references
  1. Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  4. This P, De La Rochefordiere A, Clough K, et al. Phytoestrogens after breast cancer. Endocr Relat Cancer 2001;8:129-34. PubMed
  5. Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.
  6. Ingram DM, Hickling C, West L, et al. A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. The Breast 2002;11:170-4. PubMed
  7. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  8. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  9. Geller SE, Shulman LP, van Breemen RB, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause 2009;16:1156-66. PubMed
  10. Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed
  11. Campbell MJ, Woodside JV, Honour JW, et al. Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. Eur J Clin Nutr 2004;58(1):173-179. PubMed
  12. Guerrero JA, Lozano ML, Castillo J, et al. Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. J Thromb Haemost 2005;3(2):369-376. PubMed
  13. Kondo K, Suzuki Y, Ikeda Y, Umemura K. Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation. Eur J Pharmacol 2002;455(1):53-57. PubMed
  14. Polini N, Rauschemberger MB, Mendiberri J, et al. Effect of genistein and raloxifene on vascular dependent platelet aggregation. Mol Cell Endocrinol 2007;267(1-2):55-62. PubMed
  15. Wuttke W, Jarry H, Seidlova-Wuttke D. Plant-derived alternative treatments for the aging male: facts and myths. Aging Male 2010;13(2):75-81. PubMed
  16. Villaseca P. Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice. Climacteric 2012;15(2):115-124. PubMed
  17. Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. PubMed
  18. Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
  19. Hooper, L., Madhavan, G., Tice, J. A., Leinster, S. J., and Cassidy, A. Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials. Hum.Reprod.Update. 2010;16(6):745-7 PubMed
  20. Orr A and Parker R. Red clover causing symptoms suggestive of methotrexate toxicity in a patient on high-dose methotrexate. Menopause Int. 2013;19(3):133-134. PubMed
  21. Clifton-Bligh PB, et al. Red cover isoflavones enriched with formononetin lower serum LDL cholesterol- a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2015;69(1):134-142.
  22. Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). 2015. DOI
  23. Ferraris C, Ballestra B, Listorti C, et al. Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen. Breast Cancer Res Treat 2020;180(1):157-65. doi: 10.1007/s1054 PubMed
  24. Chen L, Choi J, Leonard SW, et al. No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women. J Agric Food Chem. 2020;68(47):13929-13939. PubMed

See these in context on the Red Clover monograph →

Soy 88 references
  1. Franke AA, Custer LJ, Tanaka Y. Isoflavones in human breast milk and other biological fluids. Am J Clin Nutr 1998;68:1466-73. PubMed
  2. Albertazzi P, Pansini F, Bonaccorsi G, et al. The effect of dietary soy supplementation on hot flushes. Obstet Gynecol 1998;91:6-11. PubMed
  3. Lu LJ, Anderson KE, Grady JJ, et al. Decreased ovarian hormones during a soya diet: implications for breast cancer prevention. Cancer Res 2000;60:4112-21.
  4. Pino AM, Valladares LE, Palma MA, et al. Dietary isoflavones affect sex hormone-binding globulin levels in postmenopausal women. J Clin Endocrinol Metab 2000;85:2797-800. DOI
  5. Nisley N, Klepser T. Phytoestrogens for the prevention and treatment of osteoporosis. Alt Med Alert 1999 Dec;138-42.
  6. McMichael-Phillips DF, Harding C, Morton M, et al. Effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast. Am J Clin Nutr 1998;68:1431S-5S. PubMed
  7. Petrakis NL, Barnes S, King EB, et al. Stimulatory influence of soy protein isolate on breast secretion in pre- and postmenopausal women. Cancer Epidemiol Biomarkers Prev 1996;5:785-94.
  8. Baird DD, Umbach DM, Lansdell L, et al. Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. J Clin Endocrinol Metab 1995;80:1685-90. DOI
  9. Duncan AM, Underhill KE, Xu X, et al. Modest hormonal effects of soy isoflavones in postmenopausal women. J Clin Endocrinol Metab 1999;84:3479-84. PubMed
  10. Ginsburg J, Prelevic GM. Lack of significant hormonal effects and controlled trials of phyto-oestrogens. Lancet 2000;355:163-4. PubMed
  11. Anthony MS. Soy and cardiovascular disease: Cholesterol lowering and beyond. J Nutr 2000;130:662S-3S. PubMed
  12. Hargreaves DF, Potten CS, Harding C, et al. Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast. J Clin Endocrinol Metab 1999;84:4017-24. DOI
  13. Lamartiniere CA. Protection against breast cancer with genistein: a component of soy. Am J Clin Nutr 2000;71:1705S-7S. PubMed
  14. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  15. Codina R, Ardusso L, Lockey RF, et al. Sensitization to soybean hull allergens in subjects exposed to different levels of soybean dust inhalation in Argentina. J Allergy Clin Immunol 2000;105:570-6. PubMed
  16. Anto JM, Sunyer J, Rodriguez-Roisin R, et al. Community outbreaks of asthma associated with inhalation of soybean dust. Toxicoepidemiological Committee. N Engl J Med 1989;320:1097-1102. PubMed
  17. White MC, Etzel RA, Olson DR, Goldstein IF. Re-examination of epidemic asthma in New Orleans, Louisianna, in relation to the presence of soy at the harbor. Am J Epidemiol 1997;145:432-8.
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