Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Ultimate OmegaChoicePlus Ingredients & Drug Interactions

by OptiChoice

Ultimate OmegaChoicePlus label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultimate OmegaChoicePlus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultimate OmegaChoicePlus is a dietary supplement by OptiChoice with 3 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 743 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3, Astaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultimate OmegaChoicePlus by OptiChoice

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultimate OmegaChoicePlus by OptiChoice — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultimate OmegaChoicePlus by OptiChoice

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Essential Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (840 mg) without saying how much of each component you get.
  • “OmegaChoice TG Omega-3” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Ultimate OmegaChoicePlus contains 5 active ingredients: eicosapentaenoic acid and docosahexaenoic acid (two omega-3 fatty acids from fish oil), vitamin D3, astaxanthin (a carotenoid pigment), and a total omega-3 blend. These are delivered in a softgel capsule with inactive ingredients including fish oil concentrate, gelatin, glycerin, microemulsion technology (VESIsorb), sucrose, and natural color from annatto.

The omega-3 fatty acids support heart and brain health, while vitamin D3 is essential for bone and calcium regulation. Astaxanthin is included as an antioxidant.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: cardiovascular health and omega-3 support.
  • We looked for evidence on: Cardiovascular disease (CVD), Atrial fibrillation, Heart failure, Hyperlipidemia, Hypertension, coronary heart disease — and 2 related terms.
  • The strongest evidence on file: Vitamin D is rated "Possibly Effective" for Heart failure (Natural Medicines).
  • Also on file: Vitamin D is rated "Possibly Ineffective" for Cardiovascular disease (CVD).
  • Also on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Atrial fibrillation, Hyperlipidemia, Pregnancy-induced hypertension.

Vitamin D3 is effective for treating bone and mineral disorders: familial hypophosphatemia, osteomalacia (soft bones), renal bone disease, rickets, and hypoparathyroidism. For astaxanthin, the evidence we hold is insufficient to rate it for age-related cognitive decline, macular degeneration, aging skin, Alzheimer's disease, athletic performance, or carpal tunnel syndrome.

We have no effectiveness ratings on file for the omega-3 fatty acids in this product.

The evidence, ingredient by ingredient Vitamin D Astaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D3 is generally well tolerated at recommended doses, but very high doses over time can cause vitamin D toxicity with symptoms of high blood calcium, bone loss, vision problems, and in rare cases anemia. Astaxanthin is generally well tolerated in short-term studies, though long-term safety data are limited; common side effects in trials include belly pain, diarrhea, and red-colored stools.

Vitamin D3 is likely safe during pregnancy and lactation at recommended amounts, but only under your doctor's guidance. The safety data for astaxanthin in pregnancy and breastfeeding are not sufficient—the facts advise against use during both.

Talk with your doctor or pharmacist about whether this product is right for you before you start.

Side effects, ingredient by ingredient Vitamin D Astaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin D, Astaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 744 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor if you take thiazide diuretics (water pills for blood pressure), heart rhythm medications like verapamil or diltiazem, digoxin, cholesterol drugs like atorvastatin, or the psoriasis medication calcipotriene. Additionally, if you take medications broken down by your liver (especially those metabolized through the CYP3A4 or CYP2B6 pathways), verify they're not affected before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ultimate OmegaChoicePlus may help support bone health and provide omega-3 fatty acids, but it carries moderate interactions with several common medications, especially those for the heart and blood pressure. If you take a thiazide diuretic, heart rhythm drug, statin, or psoriasis medication, you need to check with your own doctor or pharmacist before starting this product.

Pregnant or breastfeeding individuals should discuss this with their healthcare provider beforehand.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultimate OmegaChoicePlus, straight from the product label.

Brand OptiChoice
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD May 22, 2020
DSLD ID 217041
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Qualified Health, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultimate OmegaChoicePlus by OptiChoice, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
IngredientAmount% DV
Calories8 Calorie(s)--
Calories from Fat8 Calorie(s)--
Eicosapentaenoic Acid80 mg--
Docosahexaenoic Acid480 mg--
Vitamin D32000 IU--
Total Omega-3 Fatty Acids620 mg--
Trans Fat0 Gram(s)--
Total Fat0.8 Gram(s)--
Saturated Fat0 Gram(s)2%
Essential Fatty Acids840 mg--
Astaxanthin600 mcg--
OmegaChoice TG Omega-30 NP--

Other ingredients: VESIsorb Microemulsion preconcentrate, Gelatin, Glycerin, Fish Oil concentrate, Sucrose, natural Annatto color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

VESIsorb

6x better absorption

Astaxanthin is a super antioxidant 500 times more powerful than vitamin E. Vitamin D3 is essential for promoting bone health. Recent scientific discoveries show every cell in your body needs vitamin D for your optimal well-being.

The patented VESIsorb colloidal droplet delivery system dramatically improves absorption and bioavailability of DHA Omega-3, astaxanthin and vitamin D3 in the body. Higher absorption translates into optimal support for the cardiovascular system, healthy lipid metabolism, joint function, skin health, and vital antioxidant defense against oxidative stress.

Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease.

Superior Triglyceride form New advanced formula

Optimal absorption and bioavailability

Formula

Ultimate OmegaChoice Plus is formulated with supercritical CO2 extracted fish oil concentrate providing 480 mg DHA per serving.

vitamin D3 plus astaxanthin

General Statements

The American Heart Association recommends omega-3 to help support cardiovascular health.

VESIsorb is green technology.

800 mg

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 2 softgels daily with food or as directed by your health care professional or pharmacist.

Storage

Storage: Keep tightly closed in a cool, dry place in the original container. Do not expose to excessive heat.

Precautions

Keep out of the reach of children.

Caution: Do not use if seal is broken.

As with all dietary supplements, please consult a medical professional before using if you are pregnant, lactating, or have any existing medical condition.

Brand IP Statement(s)

VESIsorb and OmegaChoice are registered trademarks of SourceOne Global Partners. For more information, please visit www.source-1-global.com.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultimate OmegaChoicePlus by OptiChoice label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultimate OmegaChoicePlus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultimate OmegaChoicePlus by OptiChoice

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D3

Interacts with
715 drugs
2000 IU per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D3 monograph & interactions

Astaxanthin

Interacts with
671 drugs
600 mcg per serving

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise...

Astaxanthin monograph & interactions

OmegaChoice TG Omega-3

0 NP per serving
  • › Essential Fatty Acids

Other (inactive) ingredients: VESIsorb Microemulsion preconcentrate, Gelatin, Glycerin, Fish Oil concentrate, Sucrose, Natural Annatto color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultimate OmegaChoicePlus by OptiChoice Drug Interactions

Want to check YOUR meds against Ultimate OmegaChoicePlus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
743Drugs
743 Moderate

Ingredients driving the most interactions

Vitamin D3 715
Astaxanthin 671

Individual Drug Interactions

The ingredients in Ultimate OmegaChoicePlus interact with 743 drugs. Click any drug to see the details.

2 of the 3 ingredients in Ultimate OmegaChoicePlus interact with drugs. Each result below shows which ingredient is responsible. Vitamin D3 Astaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultimate OmegaChoicePlus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D38 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D3 full monograph & interactions

Astaxanthin2 drug types · 671 drugs

Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP2B6.
In vitro research shows that astaxanthin induces cytochrome CYP2B6 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.
In vitro research shows that astaxanthin induces CYP3A4 enzyme activity in human hepatocytes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Astaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultimate OmegaChoicePlus, from the product label.

OptiChoice

See all OptiChoice products
Name
OptiChoice The Natural Choice for Optimal Health
Street Address
445 E. Illinois ST.
City
Chicago
State
IL
ZipCode
60611
Phone Number
1-800-755-4996
Pharmacist Counseling Corner

Ultimate OmegaChoicePlus by OptiChoice: Common Questions

Does Ultimate OmegaChoicePlus by OptiChoice interact with any medications?
Yes. Based on its ingredients, Ultimate OmegaChoicePlus has a known interaction with 743 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultimate OmegaChoicePlus contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does vitamin D3 do in this product?
Vitamin D3 helps your body absorb and regulate calcium for bone and mineral health. It's effective for treating conditions like rickets, osteomalacia (soft bones), and disorders of calcium metabolism—but it works best under medical supervision, especially at higher doses.
What are the omega-3 fatty acids in this product?
The product contains eicosapentaenoic acid and docosahexaenoic acid, two omega-3 fatty acids from fish oil that support heart and brain health. We have no effectiveness ratings on file for them specifically, but they're well-established nutrients from fish.
Can I take this while I'm pregnant?
Vitamin D3 is likely safe during pregnancy at recommended doses, but only under your doctor's guidance. Astaxanthin does not have enough safety data for pregnancy, so you'll need to talk with your doctor about whether this product is right for you.
Can I take this while breastfeeding?
Vitamin D3 is likely safe while breastfeeding at recommended doses. Astaxanthin does not have enough safety data for breastfeeding, so check with your doctor or pharmacist before taking it.
What are the common side effects of astaxanthin?
In studies, astaxanthin caused belly pain, diarrhea, and red-colored stools in a small number of trial participants. Higher doses have also caused severe stomach pain in rare cases.
Is vitamin D3 safe at any dose?
Vitamin D3 is generally well tolerated at recommended doses. Very high doses over time can cause toxicity with symptoms like high blood calcium, bone loss, and vision problems. Your doctor can advise on the right dose for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultimate OmegaChoicePlus label
Go deeper

The Full Monographs Behind Ultimate OmegaChoicePlus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Astaxanthin

Interacts with 671 drugs

Astaxanthin is a reddish carotenoid pigment with strong antioxidant activity in the lab, and it is widely promoted for skin, eye, heart, and exercise benefits. Early human studies are promis...

Read the full Astaxanthin monograph →
Sources

Sources & How We Checked

Ultimate OmegaChoicePlus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 29 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Astaxanthin 3 references
  1. Kupcinskas L, Lafolie P, Lignell A, et al. Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled
  2. Kistler, A., Liechti, H., Pichard, L., Wolz, E., Oesterhelt, G., Hayes, A., and Maurel, P. Metabolism and CYP-inducer properties of astaxanthin in man and primary human hepatocytes. Arch.Toxicol. 2002;75(11-12):665-675. PubMed
  3. Choi HD, Youn YK, Shin WG. Positive effects of astaxanthin on lipid profiles and oxidative stress in overweight subjects. Plant Foods Hum Nutr. 2011;66:363-369. PubMed

See these in context on the Astaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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