Major interaction on record — check this product against your medications before combining. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Wellstra Advanced Ingredients & Drug Interactions

by NewtonEverett

Wellstra Advanced label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wellstra Advanced against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Wellstra Advanced is a dietary supplement by NewtonEverett with 6 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 497 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Borage Oil powder, Vitamin B6, Dong Quai. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Wellstra Advanced by NewtonEverett

Ask about any prescription or over-the-counter medication and we check it for interactions with Wellstra Advanced by NewtonEverett — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wellstra Advanced by NewtonEverett

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Borage Oil powder” is listed as a grouped ingredient — the label gives one combined amount (100 mg) without saying how much of each component you get.

Wellstra Advanced contains six active ingredients. Vitamin B6 is a B vitamin with roles in nerve function and metabolism.

Gamma-linolenic acid is a fatty acid sourced from borage oil. Folate is a B vitamin that supports cell division and DNA.

Dong quai is a traditional plant used in women's health formulations. Wild yam extract comes from the tuber and is included for its plant compounds.

Chaste berry tree extract (vitex) is derived from the berry of the vitex plant and is commonly used in hormone-related formulations. The product also contains inactive ingredients — gelatin, rice flour, magnesium stearate, silica, and black cohosh (a capsule filler).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: women's health support.
  • We looked for evidence on: Dysmenorrhea, Mastalgia, Menopausal symptoms, Amenorrhea, Infertility, Atopic dermatitis (eczema) — and 3 related terms.
  • The strongest evidence on file: Vitamin B6 is rated "Possibly Effective" for Premenstrual syndrome (PMS) (Natural Medicines).
  • Also on file: Vitex Agnus-castus is rated "Possibly Effective" for Mastalgia, Premenstrual syndrome (PMS).
  • Also on file: Wild Yam is rated "Possibly Ineffective" for Menopausal symptoms.

Evidence for Wellstra Advanced's ingredients is mixed. Vitamin B6 is effective for sideroblastic anemia and B6 deficiency, likely effective for high homocysteine levels, and possibly effective for pregnancy-related nausea.

Chaste berry (vitex) is possibly effective for premenstrual syndrome and breast tenderness (mastalgia). For the other conditions listed — osteoporosis, migraines, heart disease, menopausal symptoms, and sexual function — the evidence we hold is insufficient to rate these ingredients as effective.

Wild yam is actually rated possibly ineffective for menopausal symptoms.

The evidence, ingredient by ingredient Vitamin B6 Dong Quai Borage Wild Yam Vitex Agnus-castus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses under 100 mg daily, though high doses over time can harm nerves (sensory neuropathy), especially above 1,000 mg daily. Common side effects are mild — nausea, headache, loss of appetite.

Dong quai is generally well tolerated but can cause burping and flatulence; it may increase skin sensitivity to sunlight and bleeding risk. Wild yam is generally well tolerated short-term with mild side effects like headache or upset stomach, though anaphylaxis is rare.

Vitex is well tolerated but may affect menstruation and cause diarrhea, fatigue, headache, or skin irritation. Pregnancy and breastfeeding data are limited across these ingredients — vitamin B6 is likely safe in pregnancy but possibly unsafe at high doses, and should only be used under a doctor's guidance for morning sickness; dong quai, wild yam, and vitex should be avoided in pregnancy and breastfeeding due to insufficient safety data and possible hormonal effects.

Side effects, ingredient by ingredient Vitamin B6 Dong Quai Borage Wild Yam Vitex Agnus-castus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Vitamin B6, Dong Quai, Vitex Agnus-castus, Wild Yam.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; Parkinson's medications.
  • For scale: 442 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Wellstra Advanced, check with your doctor or pharmacist if you take blood thinners like warfarin or antiplatelet drugs like aspirin or clopidogrel (Major and Moderate risk from dong quai). Double-check if you're on seizure medications (phenytoin, phenobarbital), heart rhythm drugs (amiodarone), or Parkinson's medication (levodopa) — vitamin B6, especially at higher doses, can interfere with these.

If you take oral contraceptives, estrogen therapy, hormone replacement therapy, metoclopramide (nausea medication), antipsychotics, or dopamine agonists, confirm with your healthcare provider — wild yam and vitex may reduce their effectiveness. If you take blood pressure medications, vitamin B6 may add to their effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Wellstra Advanced may appeal to people seeking support for premenstrual symptoms or certain deficiencies, but the ingredient mix carries real medication interactions — especially with blood thinners, seizure drugs, heart medications, and hormone therapies. If you take any prescription medications, run them through the tool on this page or talk with your doctor or pharmacist before starting.

Pregnant or breastfeeding people should skip this product and consult their healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wellstra Advanced, straight from the product label.

Brand NewtonEverett
Barcode (UPC) 689076033794
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2016
DSLD ID 66819
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Women (not pregnant or lactating), Adult Female (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wellstra Advanced by NewtonEverett, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
689076033794
IngredientAmount% DV
Vitamin B617 mg850%
Gamma-Linolenic Acid15 mg--
Folate133 mcg33%
Dong Quai100 mg--
Borage Oil powder100 mg--
Wild Yam extract75 mg--
Chaste Berry tree (Vitex) extract50 mg--

Other ingredients: Gelatin, Rice Flour, Magnesium Stearate, Silica, Black Cohosh

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Not intended for pregnant or nursing women.

Warning: For adults only.

Consult physician if taking medication or have a medical condition. This product should not be consumed during the first week of the menstrual period.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Suggested/Recommended/Usage/Directions

Suggested Use: As dietary supplement for women, take 1 capsule 3 times daily with food.

Storage

Store in a cool, dry place after opening.

Formulation

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

General

J15

General Statements

Daily herbal formula

Formula

Women's health support

Complete formula including Wild Yam Borage Oil Dong Quai

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wellstra Advanced by NewtonEverett label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wellstra Advanced label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wellstra Advanced by NewtonEverett

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
17 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Folate

133 mcg per serving Form: Folic Acid

Dong Quai

Interacts with
163 drugs
100 mg per serving

Dong Quai is a traditional Chinese herb often called "female ginseng" and is mostly used for menstrual and menopausal complaints. High-quality scienti...

Dong Quai monograph & interactions

Borage Oil powder

Interacts with
226 drugs
100 mg per serving

Borage is a Mediterranean herb whose seed oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid studied mostly for skin conditions and arth...

Borage Oil powder monograph & interactions
  • › Gamma-Linolenic Acid

Wild Yam extract

Interacts with
41 drugs
75 mg per serving Form: Diosgenin

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Wild Yam extract monograph & interactions

Chaste Berry tree (Vitex) extract

Interacts with
121 drugs
50 mg per serving Form: Agnusides

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS sympto...

Chaste Berry tree (Vitex) extract monograph & interactions

Other (inactive) ingredients: Gelatin, Rice Flour, Magnesium Stearate, Silica, Black Cohosh. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wellstra Advanced by NewtonEverett Drug Interactions

Want to check YOUR meds against Wellstra Advanced?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
497Drugs
2 Major 495 Moderate

Ingredients driving the most interactions

Borage Oil powder 226
Vitamin B6 210
Dong Quai 163
Chaste Berry tree (Vitex) extract 121
Wild Yam extract 41

Individual Drug Interactions

The ingredients in Wellstra Advanced interact with 497 drugs. Click any drug to see the details.

5 of the 6 ingredients in Wellstra Advanced interact with drugs. Each result below shows which ingredient is responsible. Borage Oil powder Vitamin B6 Dong Quai Chaste Berry tree (Vitex) extract Wild Yam extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Wellstra Advanced with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Borage Oil powder3 drug types · 226 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In healthy individuals, borage seed oil supplementation does not seem to affect platelet aggregation. However, gamma-linolenic acid, a constituent of borage seed oil, seems to decrease platelet aggregation by 45% and increase the risk of bleeding by 40% in animal and clinical research.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Although borage seed oil contains little to no PAs, some borage plant parts, such as the leaf, flower, and seed, can contain hepatotoxic PAs. Hepatotoxic PAs are substrates of CYP3A4, which converts these chemicals into toxic metabolites. Tell patients to avoid borage preparations that are not certified and labeled as hepatotoxic PA-free.

Likelihood Possible Evidence D
Phenothiazines

Theoretically, taking borage sed oil with phenothiazines might increase the risk of seizures.
Borage seed oil contains gamma-linolenic acid (GLA). There is concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines. This is based on limited data from two reports published in the 1980s. In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with evening primrose, another source of GLA. However, none experienced an actual seizure. In the other report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose 4 grams daily was added. One of these patients had a prior history of seizures. It is unclear whether evening primrose had any additive epileptogenic effects with the phenothiazines, but there is no evidence that taking GLA-containing supplements alone can cause seizures.

Likelihood Possible Evidence D
Borage Oil powder full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Dong Quai3 drug types · 163 drugs

Warfarin (Coumadin)

Dong quai may increase the risk of bleeding when used with warfarin.
Case reports suggest that concomitant use of dong quai with warfarin can increase the anticoagulant effects of warfarin and increase the risk of bleeding. In one case, after 4 weeks of taking dong quai 565 mg once or twice daily, the international normalized ratio (INR) increased to 4.9. The INR normalized 4 weeks after discontinuation of dong quai.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, dong quai may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Animal studies suggest that dong quai has antithrombin activity and inhibits platelet aggregation due to its coumarin components. Additionally, some case reports in humans suggest that dong quai can increase the anticoagulant effects of warfarin. However, clinical research in healthy adults shows that taking 1 gram of dong quai root daily for 3 weeks does not significantly inhibit platelet aggregation or cause bleeding. Until more is known, use dong quai with caution in patients taking antiplatelet/anticoagulant drugs.

Likelihood Possible Evidence D
Estrogens

Theoretically, dong quai may reduce the effects of estrogens.
Dong quai has estrogenic effects. Theoretically, concomitant use of large amounts of dong quai might interfere with hormone replacement therapy due to competition for estrogen receptors.

Likelihood Possible Evidence D
Dong Quai full monograph & interactions

Chaste Berry tree (Vitex) extract5 drug types · 121 drugs

Antipsychotic Drugs

Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as antipsychotic drugs due to its dopamine agonist effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Vitex agnus-castus might interfere with the efficacy of oral contraceptives due to possible hormone modulating activity.

Likelihood Possible Evidence B
Dopamine Agonists

Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Vitex agnus-castus might potentiate the actions of dopaminergic agonists due to possible dopaminergic effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Vitex agnus-castus has hormone modulating activity that can interfere with the efficacy of hormone replacement therapy.

Likelihood Probable Evidence D
Metoclopramide (Reglan)

Theoretically, dopaminergic effects of vitex agnus-castus could interfere with metoclopramide.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as metoclopramide due to its possible dopaminergic effects.

Likelihood Possible Evidence D
Chaste Berry tree (Vitex) extract full monograph & interactions

Wild Yam extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wellstra Advanced, from the product label.

NewtonEverett

See all NewtonEverett products
Name
Newton-Everett Biotech
City
Scottsdale
State
AZ
ZipCode
85255
Phone Number
866.593.3424
Web Address
www.newton-everett.com
Pharmacist Counseling Corner

Wellstra Advanced by NewtonEverett: Common Questions

Does Wellstra Advanced by NewtonEverett interact with any medications?
Yes. Based on its ingredients, Wellstra Advanced has a known interaction with 497 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wellstra Advanced contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is vitamin B6 in this product safe for morning sickness?
Vitamin B6 is often used for pregnancy-related nausea and is rated likely safe in pregnancy, but only under a doctor's guidance. Your doctor can confirm the right dose for you, since high doses over time can cause nerve damage.
Will this product interfere with my birth control?
Yes — vitex (chaste berry) in this product may theoretically reduce the effectiveness of oral contraceptives due to its hormone-modulating activity. Talk with your doctor or pharmacist before taking it alongside birth control.
Can I take this if I'm on a blood thinner like warfarin?
No — dong quai in this product has a Major interaction with warfarin and may significantly increase your bleeding risk. This product is not safe to combine with warfarin. Speak with your doctor or pharmacist about whether this supplement is appropriate for you.
What does vitex actually do?
Vitex (chaste berry) is possibly effective for premenstrual syndrome and breast tenderness. The evidence is limited for other uses listed on the package, and the product is not recommended during pregnancy or breastfeeding.
Are there any serious side effects from the ingredients?
Most side effects are mild — nausea, headache, diarrhea, or flatulence. At very high doses, vitamin B6 can cause nerve damage (sensory neuropathy). Wild yam carries a rare risk of anaphylaxis. If you experience unusual symptoms, stop and contact your healthcare provider.
Is it safe to take this long-term?
Long-term safety isn't well studied for most of these ingredients, especially wild yam. Vitamin B6 is safe at normal dietary amounts but risky at high doses over time. Talk with your doctor about how long it's appropriate for you to take this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wellstra Advanced label
Go deeper

The Full Monographs Behind Wellstra Advanced’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Dong Quai

Interacts with 163 drugs

Dong Quai is a traditional Chinese herb often called "female ginseng" and is mostly used for menstrual and menopausal complaints. High-quality scientific evidence that it works for these use...

Read the full Dong Quai monograph → Herb & supplement monograph

Borage

Interacts with 226 drugs

Borage is a Mediterranean herb whose seed oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid studied mostly for skin conditions and arthritis with mixed results. The plant's le...

Read the full Borage monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph → Herb & supplement monograph

Vitex Agnus-castus

Interacts with 121 drugs

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS symptoms. It is generally well tolerated by ma...

Read the full Vitex Agnus-castus monograph →
Sources

Sources & How We Checked

Wellstra Advanced's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 92 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
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Dong Quai 19 references
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Borage 11 references
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Wild Yam 7 references
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Vitex Agnus-castus 23 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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