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Dietary supplement

White Mulberry Leaf Extract Ingredients & Drug Interactions

by NusaPure

White Mulberry Leaf Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking White Mulberry Leaf Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

White Mulberry Leaf Extract is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, weight management.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are White Mulberry Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against White Mulberry Leaf Extract by NusaPure

Ask about any prescription or over-the-counter medication and we check it for interactions with White Mulberry Leaf Extract by NusaPure — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of White Mulberry Leaf Extract by NusaPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: white mulberry leaf extract. The capsules also contain inactive ingredients — cellulose, silica, magnesium stearate, and rice powder — which serve as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see White Mulberry's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Blood sugar and cholesterol support.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Hyperlipidemia, Hypertension, Metabolic health, Cardiovascular health.
  • The closest evidence on file: White Mulberry is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: White Mulberry is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Hypertension, Impaired glucose tolerance (prediabetes).

The evidence we hold doesn't establish that white mulberry leaf is effective for any of the conditions it's marketed for — androgenic alopecia (hair loss), osteoporosis, common cold, diabetes, and high cholesterol all show insufficient reliable evidence to rate. That doesn't mean it won't work for you; it means the clinical trials we have aren't solid enough yet to say one way or the other.

The evidence, ingredient by ingredient White Mulberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

White mulberry leaf is generally well tolerated when taken by mouth. The most common side effects are transient bloating, constipation, flatulence, and loose stools — and notably, these tend to ease up over time as your body adjusts.

In one clinical study, about half the participants experienced bloating and gas, a quarter had loose stools, and a fifth had constipation in the first few weeks, but the rate dropped over 12 weeks. During pregnancy and breastfeeding, there isn't enough safety data to know whether medicinal amounts are safe, so the data advises against using this supplement in those situations.

Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient White Mulberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — White Mulberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 87 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, double-check any antidiabetes medications you take — there's a moderate risk of low blood sugar. Also check any OCT2 substrate medications (like metformin) with your pharmacist, as white mulberry leaf may slow how your body clears them.

Altogether, these interactions span 86 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

White Mulberry Leaf Extract is worth considering if you're interested in its traditional uses and want to try it — but be aware the clinical evidence for its effectiveness isn't firm yet. If you take any diabetes medication or kidney-clearing drugs like metformin, you need to check with your pharmacist first.

Always monitor your blood sugar closely if you go ahead.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about White Mulberry Leaf Extract, straight from the product label.

Brand NusaPure
Barcode (UPC) X001O7YOQP
Net contents 200 Veg Cap(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 307405
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for White Mulberry Leaf Extract by NusaPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
Servings per container
200
UPC/BARCODE
X001O7YOQP
IngredientAmount% DV
White Mulberry Leaf Extract500 mg--

Other ingredients: Cellulose, Silica, Magnesium Stearate, Rice, Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

White Mulberry Leaf 500mg 5:1 Concentrated Extract

White Mulberry Leaf Extract 2500mg Equivalent per capsule

General Statements

New

Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule once daily, preferably with a meal.

Precautions

Warning: if you are pregnant, nursing or taking any medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not eat freshness packet. Keep in bottle.

Allergen information: not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nuts ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

GMO Free Made with non-GMO ingredients Gluten Free FDA Registered Facility

Assembled in USA Tested Supports normal nutritional supplementation Made under strict GMP guidelines Max strength

Allergen information: not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nuts ingredients.

Storage

Store in a cool, dry place after.

Seals/Symbols

Premium Quality Assembled in USA Gluten Free FDA Registered Facility

Manufactured in a cGMP Inspected Facility

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

White Mulberry Leaf Extract by NusaPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

White Mulberry Leaf Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in White Mulberry Leaf Extract by NusaPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container200 Amounts shown are per serving.

White Mulberry Leaf Extract

Interacts with
87 drugs
500 mg per serving

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is gen...

White Mulberry Leaf Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Magnesium Stearate, Rice, Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

White Mulberry Leaf Extract by NusaPure Drug Interactions

Want to check YOUR meds against White Mulberry Leaf Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

White Mulberry Leaf Extract 87

Individual Drug Interactions

The ingredients in White Mulberry Leaf Extract interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in White Mulberry Leaf Extract interact with drugs. Each result below shows which ingredient is responsible. White Mulberry Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in White Mulberry Leaf Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

White Mulberry Leaf Extract2 drug types · 87 drugs

Antidiabetes Drugs

Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that white mulberry leaf can lower blood glucose levels. Advise patients to monitor glucose levels closely.

Likelihood Possible Evidence D
Organic Cation Transporter 2 (Oct2) Substrates

Theoretically, white mulberry leaf might slow the elimination and increase the adverse effects of drugs which are OCT2 substrates.
Animal research shows that coadministration of white mulberry leaf extract with metformin, an OCT2 substrate, slows the renal elimination of metformin via inhibition of OCT2 activity. OCT2 is expressed in the kidneys and is responsible for transporting cationic drugs into tubular epithelial cells in order to be excreted in the urine.

Likelihood Possible Evidence D
White Mulberry Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for White Mulberry Leaf Extract, from the product label.

NusaPure

See all NusaPure products
Name
Gmax Central, LLC
Street Address
500 Westover Dr. #92909
City
Sanford
State
NC
ZipCode
27330
Pharmacist Counseling Corner

White Mulberry Leaf Extract by NusaPure: Common Questions

Does White Mulberry Leaf Extract by NusaPure interact with any medications?
Yes. Based on its ingredients, White Mulberry Leaf Extract has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
White Mulberry Leaf Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will white mulberry leaf actually help with blood sugar or cholesterol?
The evidence we have isn't established enough to say yet. All the conditions this product is marketed for — diabetes, high cholesterol, and others — show insufficient reliable evidence in our data. That's not a no; it just means we need better clinical trials.
What side effects should I watch for?
The main ones are bloating, constipation, flatulence, and loose stools. The good news is these tend to be temporary — in one study, about half of people experienced bloating or gas early on, but those numbers dropped over the following weeks as their body adjusted.
Is it safe to use while I'm pregnant or breastfeeding?
There isn't enough safety data to know either way with medicinal amounts, so the recommendation is to avoid it during pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're in one of those situations.
How much of this did people take in the studies?
In the clinical study we have data for, participants took 4.6 grams of white mulberry leaf powder three times daily. This product is a capsule extract, so the amount per dose will differ — check your label for the exact dosing.
Does white mulberry leaf interact with common medications?
Yes — it interacts with antidiabetes drugs (increasing low blood sugar risk) and certain kidney-clearing medications like metformin. Before you start, run your exact medications through the checker on this page or ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if White Mulberry Leaf Extract is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

White Mulberry Leaf Extract label
Go deeper

The Full Monographs Behind White Mulberry Leaf Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

White Mulberry

Interacts with 87 drugs

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is generally well tolerated as a food and tea,...

Read the full White Mulberry monograph →
Sources

Sources & How We Checked

White Mulberry Leaf Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

White Mulberry 6 references
  1. Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. PubMed
  2. Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. PubMed
  3. Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. PubMed
  4. Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. 2020;12(1):49. PubMed
  5. Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292. PubMed
  6. Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 2021;18(1):41. PubMed

See these in context on the White Mulberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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