Whole and Complete Pomegranate Ingredients & Drug Interactions
by Solgar
What is this page for?
First and foremost: checking Whole and Complete Pomegranate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Whole and Complete Pomegranate is a dietary supplement by Solgar with 1 active ingredient. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, high blood pressure.Based on those ingredients, 922 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are standardized Pomegranate whole fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Whole and Complete Pomegranate by Solgar
Ask about any prescription or over-the-counter medication and we check it for interactions with Whole and Complete Pomegranate by Solgar — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Whole and Complete Pomegranate by Solgar
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains a single active ingredient: a standardized extract made from the whole pomegranate fruit. The capsule itself is filled with inactive ingredients — vegetable cellulose, microcrystalline cellulose, vegetable magnesium stearate, and silica — which are standard binders and fillers.
Does it work?
Moderate evidence
Pomegranate extract is possibly effective for high blood pressure; some research shows it may help lower it modestly. For cholesterol and diabetes, the evidence leans toward possibly ineffective — studies haven't shown meaningful benefit.
For nonalcoholic fatty liver disease, we don't have enough reliable evidence yet to say whether it works.
How safe is it?
Well-documented data
Pomegranate fruit and juice are generally well tolerated as food. When taken as a concentrated extract supplement, the main side effects are mild digestive ones: diarrhea and flatulence happen in a small number of people, and at higher doses, nausea, abdominal pain, or constipation have been reported.
The safety data on concentrated supplements isn't as complete as it is for food amounts, so use caution. One clinical trial noted that 2% of people taking pomegranate juice experienced high blood pressure or high cholesterol, though most research suggests the opposite.
For pregnancy and breastfeeding, pomegranate is rated possibly safe, but the data is limited — talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before taking this product, check with your pharmacist if you're on blood pressure medications (especially ACE inhibitors), warfarin or other blood thinners, cholesterol drugs like rosuvastatin, or any drug metabolized by liver enzymes — which includes hundreds of common medications. The most serious risk is with blood pressure and blood-thinning drugs.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
If you're dealing with high blood pressure and aren't on other medications that lower it, this extract may be worth discussing with your pharmacist. If you take blood thinners, blood pressure meds, cholesterol drugs, or anything metabolized by the liver, check your medications first — the interaction list is long.
Start with a normal dose and watch for digestive upset.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Whole and Complete Pomegranate, straight from the product label.
| Brand | Solgar |
|---|---|
| Barcode (UPC) | 033984022447 |
| Net contents | 60 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 24, 2020 |
| DSLD ID | 214789 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Whole and Complete Pomegranate by Solgar, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Carbohydrates | 1 Gram(s) | 1% |
| standardized Pomegranate whole fruit extract | 800 mg | -- |
Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Solgar's Whole and Complete Pomegranate Vegetable Capsules are free of corn, yeast, wheat, soy, dairy products and gluten and are formulated without the use of artificial preservatives, flavors, or colors.
Suitable for vegetarians
Sugar, salt and starch free
Storage
To assure freshness and potency, store at room temperature 59 degrees-86 degrees F (15 degrees-30 degrees C). Store away from heat, light and moisture.
Formula
Solgar's KOF-K certification #K-1250
Precautions
Do not use if outer bottle seal is missing, torn or damaged in any way.
If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.
Keep out of reach of children.
General Statements
Solgar since 1947
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
K Parve (Kosher)
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement for adults, take two (2) vegetable capsules daily, preferably at mealtime, or as directed by a healthcare practitioner.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Whole and Complete Pomegranate by Solgar label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Whole and Complete Pomegranate by Solgar
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Standardized Pomegranate whole fruit extract
Interacts with922 drugs
Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...
Standardized Pomegranate whole fruit extract monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Whole and Complete Pomegranate by Solgar Drug Interactions
HelloPharmacist Interaction Report
Solgar's Whole and Complete Pomegranate contains one active ingredient — a standardized pomegranate extract — that interacts with several medication types.
The most serious documented concern involves blood pressure medications. Pomegranate can lower blood pressure on its own, so taking it alongside antihypertensive drugs (like ACE inhibitors) could push your pressure too low.
Read the full breakdown — every affected drug type, severity by severity
Pomegranate also affects how your body processes warfarin (a blood thinner), potentially increasing bleeding risk, and it may raise levels of certain cholesterol medications like rosuvastatin. Additionally, it can theoretically increase levels of drugs broken down by the liver enzymes CYP2D6, CYP2C9, and CYP3A4 — a large group that includes many common prescriptions.
Altogether, these interactions span 911 individual medications. We'd strongly recommend checking your exact medications with the search tool on this page before starting this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Whole and Complete Pomegranate?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Whole and Complete Pomegranate interact with 922 drugs. Click any drug to see the details.
1 of the 1 ingredient in Whole and Complete Pomegranate interact with drugs. Each result below shows which ingredient is responsible. standardized Pomegranate whole fruit extract
DolasetronAnzemet
How Dolasetron interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Dolasetron interactionDonepezilAricept
How Donepezil interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Donepezil interactionDonepezil (patch)Adlarity
How Donepezil (patch) interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Donepezil (patch) interactionDorzolamide Hydrochloride, Timolol MaleateCosopt PF
How Dorzolamide Hydrochloride, Timolol Maleate interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Dorzolamide Hydrochloride, Timolol Maleate interactionDorzolamide, TimololCosopt
How Dorzolamide, Timolol interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Dorzolamide, Timolol interactionDoxazosin MesylateCardura
How Doxazosin Mesylate interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Standardized Pomegranate Whole Fruit Extract + Doxazosin Mesylate interactionDoxepinDoxepin, Sinequan, Zonalon
How Doxepin interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Doxepin interactionDuloxetineCymbalta, Drizalma Sprinkle, Irenka
How Duloxetine interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Duloxetine interactionEnalapril MaleateEpaned, Vasotec
How Enalapril Maleate interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractAntihypertensive Drugs, Ace Inhibitors (aceis) Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Standardized Pomegranate Whole Fruit Extract + Enalapril Maleate interactionEnalapril Maleate, FelodipineLexxel
How Enalapril Maleate, Felodipine interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractAce Inhibitors (aceis), Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Read the full Standardized Pomegranate Whole Fruit Extract + Enalapril Maleate, Felodipine interactionEnalapril Maleate, HydrochlorothiazideVaseretic
How Enalapril Maleate, Hydrochlorothiazide interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractAntihypertensive Drugs, Ace Inhibitors (aceis) Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Standardized Pomegranate Whole Fruit Extract + Enalapril Maleate, Hydrochlorothiazide interactionEnasidenibIdhifa
How Enasidenib interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Enasidenib interactionEncainideEnkaid
How Encainide interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Encainide interactionEplerenoneInspra
How Eplerenone interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Standardized Pomegranate Whole Fruit Extract + Eplerenone interactionEpoprostenolFlolan
How Epoprostenol interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Standardized Pomegranate Whole Fruit Extract + Epoprostenol interactionEprosartanTeveten
How Eprosartan interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Standardized Pomegranate Whole Fruit Extract + Eprosartan interactionEsmololBrevibloc
How Esmolol interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Standardized Pomegranate Whole Fruit Extract + Esmolol interactionEthacrynic AcidEdecrin
How Ethacrynic Acid interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Standardized Pomegranate Whole Fruit Extract + Ethacrynic Acid interactionFelodipinePlendil, Renedil
How Felodipine interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Standardized Pomegranate Whole Fruit Extract + Felodipine interactionFenfluraminePondimin
How Fenfluramine interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Fenfluramine interactionFenoldopamCorlopam
How Fenoldopam interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Standardized Pomegranate Whole Fruit Extract + Fenoldopam interactionFentanylAbstral, Duragesic, Fentora, Lazanda, Sublimaze, Subsys
How Fentanyl interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Fentanyl interactionFentanyl Citrate, Oral Transmucosal Fentanyl CitrateActiq
How Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Standardized Pomegranate Whole Fruit Extract + Fentanyl Citrate, Oral Transmucosal Fentanyl Citrate interactionFentanyl CitrateInnovar
How Fentanyl Citrate interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Fentanyl Citrate interactionFlecainideTambocor
How Flecainide interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Flecainide interactionFluoxetineProzac, Sarafem
How Fluoxetine interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Fluoxetine interactionFlupenthixolFluanxol
How Flupenthixol interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Flupenthixol interactionFluphenazineFluphenazine, Permitil, Prolixin
How Fluphenazine interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Fluphenazine interactionFluvoxamineLuvox
How Fluvoxamine interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Fluvoxamine interactionFomoterolForadil
How Fomoterol interacts with Whole and Complete Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Standardized Pomegranate Whole Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Standardized Pomegranate Whole Fruit Extract + Fomoterol interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Whole and Complete Pomegranate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
standardized Pomegranate whole fruit extract
Ace Inhibitors (Aceis)
Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.
Antihypertensive Drugs
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.
Rosuvastatin (Crestor)
Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.
Warfarin (Coumadin)
Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.
Carbamazepine (Tegretol)
Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.
Tolbutamide (Orinase)
Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.
Brand information
Manufacturer and brand details for Whole and Complete Pomegranate, from the product label.
Solgar
See all Solgar products- Name
- Solgar Vitamin and Herb
- City
- Leonia
- State
- N.J.
- ZipCode
- 07605
- Phone Number
- 1-877-765-4274
- Web Address
- www.solgar.com
Whole and Complete Pomegranate by Solgar: Common Questions
Does Whole and Complete Pomegranate by Solgar interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this pomegranate extract actually help my blood pressure?
What side effects should I watch for?
Is this safe to take while I'm pregnant or breastfeeding?
Why does this have so many ingredient names if there's only one active ingredient?
Can I take this with cholesterol medication?
Does pomegranate actually help with cholesterol or diabetes?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Whole and Complete Pomegranate is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Whole and Complete Pomegranate’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Whole and Complete Pomegranate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Pomegranate 27 references
- Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
- Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
- Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. PubMed
- Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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