Acarbose

135 interactions 87 explained in plain English 266 cited references

Also sold as: Prandase® Precose Precose®

About Acarbose

Acarbose is an alpha-glucosidase inhibitor used to help control blood sugar in type 2 diabetes. Read the full Acarbose drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abiraterone Insulin Detemir (Rdna Origin) Injection Acetohexamide Azathioprine Chloroquine Chlorothiazide

70 Major 64 Moderate 1 Minor

All (135) Major (70) Moderate (64) Minor (1)

Major

Acarbose Abiraterone Acetate Abirtega Explained An increased risk of severe hypoglycemia Details Acarbose Abiraterone Acetate, Micronized Abirtega Explained An increased risk of severe hypoglycemia Details Acarbose Acetohexamide Explained An increased risk of hypoglycemia Details Acarbose Azathioprine Azasan Explained An increased risk of hepatotoxicity Details Acarbose Chloroquine Aralen® Hypoglycemia Details Acarbose Chlorothiazide Diuril Explained An increased risk of hyperglycemia and an increased insulin requirement Details Acarbose Chlorpropamide Diabinese® Explained An increased risk of hypoglycemia Details Acarbose Chlorthalidone Hemiclor Explained An increased risk of hyperglycemia and an increased insulin requirement Details Acarbose Ciprofloxacin Explained Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Acarbose Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Acarbose Digoxin Cardoxin® Reduced digoxin exposure Details Acarbose Enoxacin Explained Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Acarbose Furosemide Disal Explained An increased risk of hyperglycemia and an increased insulin requirement Details Acarbose Gatifloxacin Zymaxid Explained Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Acarbose Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Acarbose Gliclazide Explained An increased risk of hypoglycemia Details Acarbose Glipizide Glucotrol An increased risk of hypoglycemia Details Acarbose Glyburide DiaBeta® Explained An increased risk of hypoglycemia Details Acarbose Grepafloxacin Explained Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Acarbose Hydrochlorothiazide Inzirqo Explained An increased risk of hyperglycemia and an increased insulin requirement Details Acarbose Hydroflumethiazide Explained An increased risk of hyperglycemia and an increased insulin requirement Details Acarbose Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Acarbose Indapamide Explained An increased risk of hyperglycemia and an increased insulin requirement Details Acarbose Insulin Afrezza Explained An increased risk of hypoglycemia Details Acarbose Insulin Aspart, Recombinant Fiasp Explained An increased risk of hypoglycemia Details Acarbose Insulin Bovine Explained An increased risk of hypoglycemia Details Acarbose Insulin Degludec Tresiba Explained An increased risk of hypoglycemia Details Acarbose Insulin Detemir Levemir Explained An increased risk of hypoglycemia Details Acarbose Insulin Glargine, Recombinant Basaglar Explained An increased risk of hypoglycemia Details Acarbose Insulin Glulisine Apidra Explained An increased risk of hypoglycemia Details Acarbose Insulin Icodec-Abae Awiqli Explained An increased risk of hypoglycemia Details Acarbose Insulin Lispro, Recombinant Admelog Explained An increased risk of hypoglycemia Details Acarbose Lanreotide Acetate Explained An increased risk of hypoglycemia and impaired glucose regulation Details Acarbose Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Acarbose Levoketoconazole Recorlev Explained Increased risk of serious hepatotoxicity and drug-induced liver injury Details Acarbose Lomefloxacin Explained Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Acarbose Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Acarbose Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Acarbose Metolazone Explained An increased risk of hyperglycemia and an increased insulin requirement Details Acarbose Moxifloxacin Avelox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.