Norfloxacin

114 interactions 5 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Insulin Glulisine (Rdna Origin) Injection Metronidazole Vaginal Metronidazole Oxaliplatin Injection Metronidazole Topical Entrectinib

85 Major 29 Moderate

All (114) Major (85) Moderate (29)

Major

Norfloxacin Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Norfloxacin Sertraline Explained An increased risk of QT interval prolongation Details Norfloxacin Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Norfloxacin Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Norfloxacin Acarbose Prandase® Explained Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Norfloxacin Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Norfloxacin Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Norfloxacin Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Norfloxacin Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Norfloxacin Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Norfloxacin Azithromycin AzaSite An increased risk of QT interval prolongation Details Norfloxacin Alfuzosin UroXatral An increased risk of QT interval prolongation Details Norfloxacin Alogliptin Nesina Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Norfloxacin Anagrelide Agrylin Increased anagrelide exposure and increased risk of QT interval prolongation Details Norfloxacin Bedaquiline Sirturo Increased risk of QT interval prolongation Details Norfloxacin Budesonide Entocort An increased risk of tendon rupture Details Norfloxacin Budesonide Nasal Spray Rhinocort An increased risk of tendon rupture Details Norfloxacin Budesonide Oral Inhalation Pulmicort An increased risk of tendon rupture Details Norfloxacin Canagliflozin Invokana Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Norfloxacin Chloroquine Aralen® An increased risk of QT interval prolongation Details Norfloxacin Dapagliflozin Farxiga Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Norfloxacin Dasatinib Phyrago An increased risk of QT interval prolongation Details Norfloxacin Deflazacort Emflaza An increased risk of tendon rupture Details Norfloxacin Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Norfloxacin Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Norfloxacin Dexamethasone Injection Decadron An increased risk of tendon rupture Details Norfloxacin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) An increased risk of tendon rupture Details Norfloxacin Disopyramide Norpace An increased risk of QT interval prolongation Details Norfloxacin Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Norfloxacin Dolasetron Anzemet An increased risk of QT interval prolongation Details Norfloxacin Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Norfloxacin Dulaglutide Injection Trulicity Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Norfloxacin Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Norfloxacin Encorafenib Braftovi Increased risk of QT interval prolongation Details Norfloxacin Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Norfloxacin Ertugliflozin Steglatro Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Norfloxacin Exenatide Injection Bydureon Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Norfloxacin Flecainide Tambocor® An increased risk of QT interval prolongation Details Norfloxacin Fludrocortisone Acetate Florinef® An increased risk of tendon rupture Details Norfloxacin Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.