Oxcarbazepine
39 interactions 6 explained in plain English
Also sold as:
Oxtellar
Trileptal
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Contraindicated
Oxcarbazepine Cabotegravir Apretude Decreased cabotegravir plasma concentrations with possible loss of virologic response Details Oxcarbazepine Doravirine Pifeltro Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance DetailsMajor
Oxcarbazepine Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Oxcarbazepine Sertraline Explained An increased risk of serotonin syndrome Details Oxcarbazepine Buprenorphine Belbuca Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Oxcarbazepine Apixaban Eliquis Explained Decreased apixaban exposure and possible subtherapeutic anticoagulation which could lead to a thrombotic event Details Oxcarbazepine Atogepant Qulipta Reduced atogepant exposure Details Oxcarbazepine Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Oxcarbazepine Amlodipine Amvaz® Reduced amLODIPine exposure Details Oxcarbazepine Calcifediol Rayaldee Altered serum levels of calcifediol Details Oxcarbazepine Cyclosporine Injection Atopica Reduced cycloSPORINE exposure Details Oxcarbazepine Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure Details Oxcarbazepine Dolutegravir Juluca® (as a combination product containing dolutegravir, rilpivirine) Reduced dolutegravir exposure and reduced efficacy of dolutegravir Details Oxcarbazepine Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Oxcarbazepine Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of contraceptive failure Details Oxcarbazepine Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of contraceptive failure Details Oxcarbazepine Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of contraceptive failure Details Oxcarbazepine Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Oxcarbazepine Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Oxcarbazepine Ifosfamide Injection Ifex Increased neurotoxic and nephrotoxic effects Details Oxcarbazepine Lenacapavir Injection Sunlenca Reduced lenacapavir exposure and reduced efficacy of lenacapavir Details Oxcarbazepine Lenacapavir Oral Sunlenca Reduced lenacapavir exposure and reduced efficacy of lenacapavir Details Oxcarbazepine Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Oxcarbazepine Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Oxcarbazepine Linagliptin Tradjenta Reduced linagliptin exposure Details Oxcarbazepine Lumateperone Caplyta Reduced lumateperone exposure Details Oxcarbazepine Medroxyprogesterone Amen® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of contraceptive failure Details Oxcarbazepine Medroxyprogesterone Injection Depo-Provera Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of contraceptive failure Details Oxcarbazepine Naloxegol Movantik Reduced naloxegol exposure and reduced efficacy of naloxegol Details Oxcarbazepine Nifedipine Adalat® Reduced NIFEdipine exposure Details Oxcarbazepine Orlistat Alli Reduced efficacy of anticonvulsant DetailsModerate
Oxcarbazepine Simvastatin Flolipid Explained Reduced simvastatin exposure Details Oxcarbazepine Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Oxcarbazepine Felodipine Plendil® Decreased felodipine exposure Details Oxcarbazepine Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Oxcarbazepine Hydrocortisone Ala-Cort Reduced hydrocortisone exposure Details Oxcarbazepine Hydrocortisone Injection A-Hydrocort® Reduced hydrocortisone exposure Details Oxcarbazepine Nimodipine Nimotop Reduced nimodipine plasma concentrations and lack of nimodipine efficacy Details Oxcarbazepine Ospemifene Osphena Decreased ospemifene exposure and efficacy DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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