Pentoxifylline

33 interactions
Also sold as: Pentoxil® Trental®
About Pentoxifylline

Pentoxifylline is used to improve blood flow in patients with circulation problems to reduce aching, cramping, and tiredness in the hands and feet. It works by decreasing the thickness (viscosity) of blood. This change allows your blood to flow more easily, especially in the small blood vessels of the hands and feet. T… Read the full Pentoxifylline drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Pentoxifylline Aspirin Acuprin® An increased risk of bleeding Details Pentoxifylline Aspirin Rectal Aspirin An increased risk of bleeding Details Pentoxifylline Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Pentoxifylline Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Pentoxifylline Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Pentoxifylline Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Pentoxifylline Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Pentoxifylline Etodolac Lodine An increased risk of bleeding Details Pentoxifylline Fenoprofen Fenopron An increased risk of bleeding Details Pentoxifylline Flurbiprofen Ansaid An increased risk of bleeding Details Pentoxifylline Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Pentoxifylline Ibuprofen Addaprin An increased risk of bleeding Details Pentoxifylline Ketoprofen Actron® An increased risk of bleeding Details Pentoxifylline Meclofenamate Meclodium® An increased risk of bleeding Details Pentoxifylline Mefenamic Acid Ponstel® An increased risk of bleeding Details Pentoxifylline Meloxicam Alloxate An increased risk of bleeding Details Pentoxifylline Meloxicam Injection Alloxate An increased risk of bleeding Details Pentoxifylline Nabumetone Relafen An increased risk of bleeding Details Pentoxifylline Naproxen Aleve An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.