Trospium

14 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Buprenorphine Fentanyl Transdermal Patch Glucagon Injection Glucagon Injection / Solution Glucagon Nasal Powder
11 Major 3 Moderate
All (14) Major (11) Moderate (3)

Major

Trospium Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of paralytic ileus Details Trospium Buprenorphine Belbuca Explained An increased risk of paralytic ileus Details Trospium Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Trospium Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Trospium Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Trospium Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Trospium Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Trospium Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Trospium Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Trospium Hydroxychloroquine Plaquenil An increased risk of seizures Details Trospium Morphine Injection Astramorph® PF Increased morphine exposure, increased trospium exposure and an increased risk of urinary retention, constipation and paralytic il... Details

Moderate

Trospium Aclidinium Oral Inhalation Tudorza An increased risk of anticholinergic adverse reactions (eg, dry mouth, constipation) Details Trospium Atropine Ophthalmic Atropine Care 1% An increased risk of anticholinergic adverse reactions (eg, dry mouth, constipation) Details Trospium Cyclopentolate Ophthalmic Akpentolate® An increased risk of anticholinergic adverse reactions (eg, dry mouth, constipation) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.