7-alpha-hydroxy-dhea + Methadone
Methadone brand name: Dolophine.
We found no known interaction between 7-alpha-hydroxy-dhea and Methadone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
7-alpha-hydroxy-dhea and Methadone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Methadone and 7-alpha-hydroxy-dhea in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for 7-alpha-hydroxy-dhea at all — not against Methadone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
7-alpha-hydroxy-dhea safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Questions About 7-alpha-hydroxy-dhea or Methadone
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers 7-alpha-hydroxy-dhea or Methadone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Can Benadryl Cause A Positive Drug Test Result For Tramadol? ›
- Took More Methadone And Now I'm Short ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Methadone
This page covers 7-alpha-hydroxy-dhea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methadone page lists 223 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).
By severity: 10 major · 174 moderate · 39 minor.
From our pharmacist’s overview on the Methadone page
“If you take methadone, choose your supplements with genuine care. Of the 223 ingredients on this page, most either add to methadone's sedating effect or change how fast your body clears it, which can push its blood level up or down.”
Reviewed by 2 · Jul 18, 2026
Taking 7-alpha-hydroxy-dhea as Part of a Dietary Supplement Product? Check It for Interactions
We hold 2 real supplement products containing 7-alpha-hydroxy-dhea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 7-alpha-hydroxy-dhea. Even though 7-alpha-hydroxy-dhea itself has no known interaction with Methadone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where 7-alpha-hydroxy-dhea and Methadone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,006 of 1,452 supplements looked up here in the last 7 days
#744 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. 7-alpha-hydroxy-dhea is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 7-alpha-hydroxy-dhea reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The 7-alpha-hydroxy-dhea and Methadone records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About 7-alpha-hydroxy-dhea
What is 7-alpha-hydroxy-dhea?
- Anti-aging support
- Immune support
- Weight management
- Energy and vitality
- Hormone metabolism support
7-alpha-hydroxy-DHEA is a natural breakdown product (metabolite) of the adrenal hormone DHEA, and very little reliable human research exists on taking it as a supplement. Because it is hormone-related and poorly studied, the safest approach is to avoid it unless a knowledgeable doctor or pharmacist advises otherwise.
Not a plant; this is a hormone metabolite (made in the body or made synthetically for supplements) · Capsules, tablets, sublingual products (often marketed as part of DHEA-related supplements)
An interaction check asks whether these two react with each other — it does not ask whether 7-alpha-hydroxy-dhea is a good idea for someone in your situation. Here is what our 7-alpha-hydroxy-dhea record says about it on its own.
7-alpha-hydroxy-dhea: dosing
There is no established or standardized dose for 7-alpha-hydroxy-DHEA. Reliable studies that would tell us a safe and effective amount are lacking.If a product is used, follow the directions on the label and do not exceed them.
From our 7-alpha-hydroxy-dhea monograph — the full record covers uses, side effects and every documented interaction.
About Methadone
What Is Methadone Used For?
Brand name: Dolophine
Methadone treats two main problems. Some products are used for severe, persistent pain that needs daily, around-the-clock opioid treatment when other options are not adequate. Some products are used for opioid addiction (heroin or other morphine-like drugs), as detoxification or as maintenance treatment along with social and medical services.
Not every product is approved for every use. Methadone tablets, oral solution and oral concentrate (Intensol) list both pain and opioid addiction. Diskets, Methadose Dispersible tablets and the Methadose and Methadone Hydrocloride oral concentrates are labeled only for opioid addiction. Methadone injection is for severe pain, and for short-term treatment of opioid dependence in people who cannot take medicine by mouth, such as hospitalized patients. It is not approved for outpatient opioid dependence treatment. Methadone is not meant to be used as an as-needed pain reliever.
Other Drugs & 7-alpha-hydroxy-dhea
Browse every other medication we’ve checked against 7-alpha-hydroxy-dhea — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked 7-alpha-hydroxy-dhea against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Sertraline ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Isotretinoin ›
- Warfarin Sodium ›
- Tirzepatide ›
- Amlodipine Besylate ›
- Ibuprofen ›
- Methamphetamine ›
- Docusate ›
- Tadalafil ›
- Hydroxyurea ›
- Metformin ›
- Valacyclovir ›
- Sumatriptan ›
- Prednisone ›
- Semaglutide ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Amphetamine ›
- Levothyroxine, Liothyronine ›
- Propranolol ›
- Methotrexate ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Bendamustine ›
- Pregabalin ›
- Doxycycline ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Acyclovir ›
- Acetaminophen, Aspirin, Caffeine ›
- Naproxen ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full 7-alpha-hydroxy-dhea list.
7-alpha-hydroxy-dhea References
The 2 sources that drive our 7-alpha-hydroxy-dhea monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. 7-alpha-hydroxy-dhea is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- DHEA — MedlinePlus Source
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking 7-alpha-hydroxy-dhea and Methadone Together: Common Questions
Is it safe to take 7-alpha-hydroxy-dhea with Methadone?
Does Methadone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Methadone and 7-alpha-hydroxy-dhea?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.