Drug & supplement interaction

7-alpha-hydroxy-dhea + Metformin

Metformin brand names: Glucophage, Metformin.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between 7-alpha-hydroxy-dhea and Metformin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

7-alpha-hydroxy-dhea and Metformin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Metformin and 7-alpha-hydroxy-dhea in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for 7-alpha-hydroxy-dhea at all — not against Metformin, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

7-alpha-hydroxy-dhea safety at a glance

7-alpha-hydroxy-dh... overall Not established Human safety data for 7-alpha-hydroxy-DHEA as a supplement is very limited.
Pregnancy Avoid Hormone-related products should be avoided during pregnancy due to unknown risks.
Breastfeeding Avoid Not enough safety information; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Metformin and 7-alpha-hydroxy-dhea? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Metformin’s Own FDA Label Lists

This is not an interaction — none of it involves 7-alpha-hydroxy-dhea. These are the most notable effects listed in the ADVERSE REACTIONS section of Metformin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • Low blood sugar Worth acting on
  • High blood sugar Worth acting on
  • Chest pain Worth acting on
  • Shortness of breath Worth acting on
  • Liver problems Worth acting on
  • A change in taste
  • Chills
  • Flushing
  • Bloating or gas
  • Sweating

Showing the 10 most notable of 19 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Metformin. Read the label on DailyMed › 7-alpha-hydroxy-dhea’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no 7-alpha-hydroxy-dhea side to compare — that is a limit of the record, not a statement that 7-alpha-hydroxy-dhea has no side effects.

From our Q&A

Questions About 7-alpha-hydroxy-dhea or Metformin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers 7-alpha-hydroxy-dhea or Metformin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Metformin

This page covers 7-alpha-hydroxy-dhea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metformin page lists 258 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 217 moderate · 39 minor.

From our pharmacist’s overview on the Metformin page

“Siberian cocklebur is the ingredient I most want anyone taking metformin (Glucophage) to know about. It has caused severe low blood sugar in people, documented in humans, and it should not be combined with any glucose-lowering medication.”

Reviewed by 2 · Jul 18, 2026

Open the Metformin interaction page

One more smart check

Taking 7-alpha-hydroxy-dhea as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing 7-alpha-hydroxy-dhea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 7-alpha-hydroxy-dhea. Even though 7-alpha-hydroxy-dhea itself has no known interaction with Metformin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 7-alpha-hydroxy-dhea and Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 7-alpha-hydroxy-dhea
Steady interest

#833 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Metformin
Top 1%

#29 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. 7-alpha-hydroxy-dhea is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 7-alpha-hydroxy-dhea reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The 7-alpha-hydroxy-dhea and Metformin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 7-alpha-hydroxy-dhea

What is 7-alpha-hydroxy-dhea?

  • Anti-aging support
  • Immune support
  • Weight management
  • Energy and vitality
  • Hormone metabolism support

7-alpha-hydroxy-DHEA is a natural breakdown product (metabolite) of the adrenal hormone DHEA, and very little reliable human research exists on taking it as a supplement. Because it is hormone-related and poorly studied, the safest approach is to avoid it unless a knowledgeable doctor or pharmacist advises otherwise.

Not a plant; this is a hormone metabolite (made in the body or made synthetically for supplements) · Capsules, tablets, sublingual products (often marketed as part of DHEA-related supplements)

An interaction check asks whether these two react with each other — it does not ask whether 7-alpha-hydroxy-dhea is a good idea for someone in your situation. Here is what our 7-alpha-hydroxy-dhea record says about it on its own.

7-alpha-hydroxy-dhea: dosing

There is no established or standardized dose for 7-alpha-hydroxy-DHEA. Reliable studies that would tell us a safe and effective amount are lacking.If a product is used, follow the directions on the label and do not exceed them.

From our 7-alpha-hydroxy-dhea monograph — the full record covers uses, side effects and every documented interaction.

Read the full 7-alpha-hydroxy-dhea monograph & all interactions
Medication

About Metformin

What Is Metformin Used For?

Brand names: Glucophage, Metformin

Metformin is used to improve blood sugar (glucose) control in people with type 2 diabetes mellitus. It is always used together with diet and exercise, not instead of them.

Metformin hydrochloride tablets and oral solution are approved for adults and children 10 years and older. Metformin hydrochloride extended-release tablets — including brands such as Fortamet, Glumetza, and Metformin Hydrochloride Extended Release — are approved for adults only.

See full Metformin drug information
Keep checking

Other Drugs & 7-alpha-hydroxy-dhea

Browse every other medication we’ve checked against 7-alpha-hydroxy-dhea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked 7-alpha-hydroxy-dhea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full 7-alpha-hydroxy-dhea list.

See the full 7-alpha-hydroxy-dhea interactions page
See every supplement checked against Metformin, ranked by severity
Evidence & sources

7-alpha-hydroxy-dhea References

The 2 sources that drive our 7-alpha-hydroxy-dhea monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. 7-alpha-hydroxy-dhea is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. DHEA — MedlinePlus Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 7-alpha-hydroxy-dhea and Metformin Together: Common Questions

Is it safe to take 7-alpha-hydroxy-dhea with Metformin?
We do not list a known interaction between 7-alpha-hydroxy-dhea and Metformin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Metformin interact with any supplements?
Yes. Metformin has documented interactions with 258 supplements in our database — 7-alpha-hydroxy-dhea is not one of them. The Metformin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

7-alpha-hydroxy-dhea monograph Uses, safety profile, and every drug interaction in one place Metformin drug information The full plain-English guide to this medication Metformin supplement interactions Every supplement checked against Metformin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Metformin and 7-alpha-hydroxy-dhea?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.