Drug & supplement interaction

Agmatine + Diclofenac

Diclofenac brand name: Zorvolex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Agmatine and Diclofenac in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Agmatine and Diclofenac

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diclofenac and Agmatine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Agmatine safety at a glance

Agmatine overall Use caution Short-term use appears generally well tolerated, but long-term safety in humans is not well studied.
Pregnancy Avoid There is not enough safety data, so it is best to avoid use during pregnancy.
Breastfeeding Avoid There is not enough safety data, so it is best to avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diclofenac and Agmatine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Diclofenac

Interactions in our licensed database are recorded against drug classes, not just single drug names. Diclofenac is filed under 10 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), cytochrome p450 2c9 (cyp2c9) substrates, anticoagulant/antiplatelet drugs. Agmatine has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and antihypertensive drugs (moderate) — and none of Diclofenac’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Agmatine Does Interact With Other Medications

Agmatine has 258 moderate known drug interactions in our database — Diclofenac isn’t one of them. If you take anything else, check it against the full list below.

Moderate 258 No known interaction 2,572 (incl. Diclofenac)
Taking anything else?

Check Another of Your Medications Against Agmatine

Covers the 2,830 medications we’ve checked against Agmatine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Agmatine and Diclofenac May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset / Nausea / Diarrhea reported in 6.1% of FDA reports for Diclofenac Additional detail

    Agmatine

    “Orally, agmatine has been reported to cause diarrhea, dyspepsia, and nausea in two small clinical studies. Mild-to-moderate diarrhea and nausea were reported in 3 out of 24 patients taking agmatine sulfate 3.56 grams daily. These adverse effects appeared within 2-3 days of therapy and resolved upon treatment discontinuation.”

    Agmatine · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 94736. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
    2. 94742. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

    Diclofenac

    Listed in the ADVERSE REACTIONS section of the FDA label for Diclofenac, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Diclofenac come from the ADVERSE REACTIONS section of its FDA label; effects for Agmatine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 164,880 voluntary FDA FAERS reports for Diclofenac that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Agmatine or Diclofenac

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Agmatine or Diclofenac, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Diclofenac

This page covers Agmatine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diclofenac page lists 306 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Piracetam (major).

By severity: 7 major · 265 moderate · 34 minor.

From our pharmacist’s overview on the Diclofenac page

“Diclofenac (Zorvolex) is an NSAID pain reliever that already stresses the stomach lining and kidneys on its own, so treat this list as a real safety issue, not fine print. Two thirds of the 306 supplements on file can thin the blood or slow clotting, and stacked on an NSAID that raises the odds of stomach bleeding.”

Reviewed by 2 · Jul 18, 2026

Open the Diclofenac interaction page

One more smart check

Taking Agmatine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,058 real supplement products containing Agmatine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Agmatine. Even though Agmatine itself has no known interaction with Diclofenac, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Agmatine and Diclofenac Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Agmatine
Top 25%

#159 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diclofenac
Top half

#820 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Agmatine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Agmatine and Diclofenac records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Agmatine

What is Agmatine?

Agmatine
  • Pre- and post-workout support
  • Muscle pumps and exercise performance
  • Cognitive support and mood
  • Nerve pain
  • General well-being

Agmatine is a compound your body makes from the amino acid arginine, and it is sold mainly as a workout and 'pump' supplement. Human evidence for most of its claimed benefits is limited and preliminary, so its true effects are uncertain. If you want to try it, talk with your pharmacist or doctor first, especially if you have health conditions or take other medicines.

Not a plant part; a compound made from the amino acid arginine · Capsules, tablets, bulk powder (usually as agmatine sulfate)

An interaction check asks whether these two react with each other — it does not ask whether Agmatine is a good idea for someone in your situation. Here is what our Agmatine record says about it on its own.

Agmatine: dosing

There is no officially established or standardized dose for agmatine. Doses used in supplements and small studies vary, and there is not enough evidence to recommend a single best amount.The safest approach is to follow the directions on the product label and start with the lowest suggested amount. Do not assume that taking more will work better or be safer.

From our Agmatine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Agmatine monograph & all interactions
Medication

About Diclofenac

What Is Diclofenac Used For?

Brand name: Zorvolex

Diclofenac sodium topical gel is used to treat actinic keratoses (AK) — rough, scaly skin patches that form after years of sun exposure. These patches are considered precancerous, meaning they can develop into skin cancer if left untreated.

This is a topical gel, meaning it is applied directly to the skin over the affected area rather than taken by mouth. It belongs to the NSAID (nonsteroidal anti-inflammatory drug) family.

Most-Reported Side Effects for Diclofenac

From FAERS, the FDA’s public side-effect reporting system (164,880 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 14,336 reports
Arthralgia 11,682 reports
Rash 11,262 reports
Rheumatoid arthritis 11,000 reports
Nausea 10,099 reports
See full Diclofenac drug information
Keep checking

Other Drugs & Agmatine

Browse every other medication we’ve checked against Agmatine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
258Moderate
0Minor
2,571No known interaction
258 Moderate 2,571 No interaction
Moderate

258 interactions

Showing 60 of 258 moderate interactions — see all 258 on the Agmatine page.

No interaction 2,571 drugs checked — show the list

We also checked Agmatine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,571 medications checked with no known interaction — see the full Agmatine list.

See the full Agmatine interactions page
See every supplement checked against Diclofenac, ranked by severity
Evidence & sources

Agmatine References

The 3 references that drive our Agmatine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today 2013;18(17-18):880-93. PubMed
  2. Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM. Safety and efficacy of dietary agmatine sulfate in lumbar disc-associated radiculopathy. An open-label, dose-escalating study followed by a randomized, double-blind, placebo-controlled trial. Pain Med 201 PubMed
  3. Shopsin B. The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatr 2013;25(2):113-8. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Agmatine and Diclofenac Together: Common Questions

Is it safe to take Agmatine with Diclofenac?
We do not list a known interaction between Agmatine and Diclofenac. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Agmatine and Diclofenac have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Agmatine and Diclofenac combination checked?
Interactions in our licensed database are recorded against drug classes. Diclofenac is filed under 10 classifications, and Agmatine has documented interactions with 2 drug classes — none of Diclofenac's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Agmatine interact with any other medications?
Yes. Agmatine has 258 documented drug interactions in our database — Diclofenac is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Diclofenac interact with any supplements?
Yes. Diclofenac has documented interactions with 306 supplements in our database — Agmatine is not one of them. The Diclofenac interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Agmatine monograph Uses, safety profile, and every drug interaction in one place Diclofenac drug information The full plain-English guide to this medication Diclofenac supplement interactions Every supplement checked against Diclofenac, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diclofenac and Agmatine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.