Drug & supplement interaction

Bridelia + Alosetron

Alosetron brand name: Lotronex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Bridelia and Alosetron in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Bridelia and Alosetron

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Alosetron and Bridelia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bridelia safety at a glance

Bridelia overall Not established Human safety data are very limited, so use cautiously and under professional guidance.
Pregnancy Likely Unsafe When used orally. There is concern that Bridelia might have labor-inducing effects. In animals, Bridelia atroviridis leaf extract induces uterine contractions i... Read the full pregnancy detail
Breastfeeding Avoid There is no reliable safety data during breastfeeding, so avoid it.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Alosetron and Bridelia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Alosetron

Interactions in our licensed database are recorded against drug classes, not just single drug names. Alosetron is filed under 3 classifications — serotonergic drugs, serotonergic drugs, oral drugs. Bridelia has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antihypertensive drugs (moderate) and estrogens (moderate) — and none of Alosetron’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bridelia Does Interact With Other Medications

Bridelia has 330 moderate known drug interactions in our database — Alosetron isn’t one of them. If you take anything else, check it against the full list below.

Moderate 330 No known interaction 2,500 (incl. Alosetron)
Taking anything else?

Check Another of Your Medications Against Bridelia

Covers the 2,830 medications we’ve checked against Bridelia. Pick one to open its full report.

What to actually watch for

What Alosetron’s Own FDA Label Lists

This is not an interaction — none of it involves Bridelia. These are the most notable effects listed in the ADVERSE REACTIONS section of Alosetron’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A bowel blockage Worth acting on
  • Low blood sugar Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • High blood sugar Worth acting on
  • An irregular heartbeat Worth acting on
  • Confusion Worth acting on
  • Raised blood pressure Worth acting on
  • Hives Worth acting on
  • Liver problems Worth acting on
  • Bleeding or bruising Worth acting on

Showing the 10 most notable of 31 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Alosetron. Read the label on DailyMed › Bridelia’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Bridelia side to compare — that is a limit of the record, not a statement that Bridelia has no side effects.

Special populations

Bridelia in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. There is concern that Bridelia might have labor-inducing effects. In animals, Bridelia atroviridis leaf extract induces uterine contractions in a concentration-dependent manner.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Bridelia or Alosetron

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Bridelia or Alosetron, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Alosetron

This page covers Bridelia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Alosetron page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lithium (major), 5-htp (moderate), Acetyl-l-carnitine (moderate) and Ayahuasca (moderate).

By severity: 2 major · 25 moderate · 11 minor.

From our pharmacist’s overview on the Alosetron page

“Alosetron (Lotronex) treats severe diarrhea-predominant IBS by acting on serotonin receptors in the gut, and that is where most of its 38 supplement interactions come from. Twenty of the ingredients, 5-HTP among them, raise serotonin on their own, and stacking them on a serotonin-acting drug is a combination I want you to treat with re…”

Reviewed by 2 · Jul 18, 2026

Open the Alosetron interaction page

How much people look this up

Where Bridelia and Alosetron Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bridelia
Steady interest

#868 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Alosetron
Top half

#1,298 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bridelia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Bridelia and Alosetron records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bridelia

What is Bridelia?

  • Blood sugar support
  • Digestive complaints and diarrhea
  • Wound care and skin conditions
  • Antimicrobial use
  • Mouth and gum care (traditional chewing stick)

Bridelia is a group of tropical plants, with Bridelia ferruginea widely used in traditional African medicine for diabetes, infections, and digestive problems. Scientific evidence is mostly limited to laboratory and animal studies, so its benefits and safety in people are not well established. Talk to a pharmacist or doctor before using it, especially if you take other medicines or have a health condition.

Bridelia ferruginea · Phyllanthaceae · Bark, leaves, stem, and roots · Bark or leaf decoction (tea), powder, traditional extracts, capsules

An interaction check asks whether these two react with each other — it does not ask whether Bridelia is a good idea for someone in your situation. Here is what our Bridelia record says about it on its own.

Bridelia: dosing

There is no established or standardized dose for Bridelia. Traditional preparations vary widely, and product strength is not consistent.If you choose to use a Bridelia product, follow the directions on the label and do not exceed the recommended amount.

From our Bridelia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bridelia monograph & all interactions
Medication

About Alosetron

What Is Alosetron Used For?

Brand name: Lotronex

Alosetron tablets — available as Alosetron, Alosetron Hydrochloride, and Lotronex — are approved only for women with severe diarrhea-predominant irritable bowel syndrome (IBS) whose symptoms have lasted 6 months or longer and who have not gotten adequate relief from conventional therapy. Other causes of GI symptoms must be ruled out first.

To qualify as severe, diarrhea-predominant IBS must include diarrhea plus at least one of the following: frequent and severe abdominal pain or discomfort, frequent bowel urgency or fecal incontinence (accidental stool leakage), or significant disruption to daily activities. Clinical studies have not confirmed the same benefit in men.

See full Alosetron drug information
Keep checking

Other Drugs & Bridelia

Browse every other medication we’ve checked against Bridelia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
330Moderate
0Minor
2,499No known interaction
330 Moderate 2,499 No interaction
Moderate

330 interactions

Showing 60 of 330 moderate interactions — see all 330 on the Bridelia page.

No interaction 2,499 drugs checked — show the list

We also checked Bridelia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,499 medications checked with no known interaction — see the full Bridelia list.

See the full Bridelia interactions page
See every supplement checked against Alosetron, ranked by severity
Evidence & sources

Bridelia References

The 4 references that drive our Bridelia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Corallo A, Foungbe S, Davy M, Cohen Y. Cardiovascular pharmacology of aqueous extract of the leaves of Bridelia atroviridis Muell. Arg. (Euphorbiaceae) in the rat. J Ethnopharmacol 1997;57(3):189-96. PubMed
  2. Njamen D, Magne Nde CB, Tanee Fomum Z, Vollmer G. Effects of the extracts of some tropical medicinal plants on estrogen inducible yeast and Ishikawa screens, and on ovariectomized Wistar rats. Pharmazie 2008;63(2):164-8. DOI
  3. Corallo A, Savineau JP, Tricoche R, Foungbe S. The uterotonic action of the aqueous extract of Bridelia atroviridis in the rat. Fundam Clin Pharmacol 1991;5(4):319-29. PubMed
  4. Olajide, O. A. Investigation of the effects of selected medicinal plants on experimental thrombosis. Phytother Res 1999;13(3):231-232. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bridelia and Alosetron Together: Common Questions

Is it safe to take Bridelia with Alosetron?
We do not list a known interaction between Bridelia and Alosetron. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Bridelia and Alosetron combination checked?
Interactions in our licensed database are recorded against drug classes. Alosetron is filed under 3 classifications, and Bridelia has documented interactions with 3 drug classes — none of Alosetron's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bridelia interact with any other medications?
Yes. Bridelia has 330 documented drug interactions in our database — Alosetron is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Alosetron interact with any supplements?
Yes. Alosetron has documented interactions with 38 supplements in our database — Bridelia is not one of them. The Alosetron interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bridelia monograph Uses, safety profile, and every drug interaction in one place Alosetron drug information The full plain-English guide to this medication Alosetron supplement interactions Every supplement checked against Alosetron, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Alosetron and Bridelia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.