Drug & supplement interaction

Bulbine Natalensis + Metolazone

Metolazone brand names: Diulo, Zaroxolyn, Mykrox.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Bulbine Natalensis and Metolazone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Bulbine Natalensis and Metolazone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Metolazone and Bulbine Natalensis in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bulbine Natalensis safety at a glance

Bulbine Natalensis overall Use caution Human safety data are lacking, and animal studies suggest possible liver and kidney toxicity at higher doses.
Pregnancy Possibly Unsafe When used orally in large amounts. Animal research shows that Bulbine natalensis stem extract might be embryotoxic when administered at a dose of 100 mg/kg. Unt... Read the full pregnancy detail
Breastfeeding Avoid No safety information exists, so avoid use while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Metolazone and Bulbine Natalensis? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Metolazone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Metolazone is filed under 5 classifications — including thiazide diuretics, diuretic drugs, antihypertensive drugs. Bulbine Natalensis has documented interactions with 7 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and cytochrome p450 2c9 (cyp2c9) substrates (moderate) — and none of Metolazone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bulbine Natalensis Does Interact With Other Medications

Bulbine Natalensis has 919 moderate known drug interactions in our database — Metolazone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 919 No known interaction 1,911 (incl. Metolazone)
Taking anything else?

Check Another of Your Medications Against Bulbine Natalensis

Covers the 2,830 medications we’ve checked against Bulbine Natalensis. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Bulbine Natalensis and Metolazone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea / Diarrhea / Vomiting reported in 6.8% of FDA reports for Metolazone Additional detail

    Bulbine Natalensis

    “Analysis of Bulbine natalensis root obtained from open street markets in South Africa shows that the plant root might contain high levels of aluminum (5559 mg/kg dry weight) and iron (4164 mg/kg dry weight). Theoretically, ingestion of plants containing this quantity of aluminum might impair cognitive function and lead to neurodegenerative diseases.”

    Bulbine Natalensis · Natural Medicines adverse-effect record, reported in cognitive function.

    1 source cited
    1. 91621. Okem A, Southway C, Stirk WA, et al. Heavy metal contamination in South African medicinal plants: A cause for concern. South African J Bot. 2014;93(2014):125-130. DOI

    Metolazone

    Listed in the ADVERSE REACTIONS section of the FDA label for Metolazone, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Metolazone come from the ADVERSE REACTIONS section of its FDA label; effects for Bulbine Natalensis come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 11,176 voluntary FDA FAERS reports for Metolazone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Bulbine Natalensis in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally in large amounts. Animal research shows that Bulbine natalensis stem extract might be embryotoxic when administered at a dose of 100 mg/kg. Until more is known about its effects in humans, avoid using during pregnancy. There is insufficient reliable information about the safety of using topical Bulbine natalensis during pregnancy; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Metolazone

This page covers Bulbine Natalensis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metolazone page lists 222 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Dolomite (major) and Lithium (major).

By severity: 8 major · 190 moderate · 24 minor.

Open the Metolazone interaction page

One more smart check

Taking Bulbine Natalensis as Part of a Dietary Supplement Product? Check It for Interactions

We hold 51 real supplement products containing Bulbine Natalensis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bulbine Natalensis. Even though Bulbine Natalensis itself has no known interaction with Metolazone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bulbine Natalensis and Metolazone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bulbine Natalensis
Top half

#563 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Metolazone
Top 25%

#538 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bulbine Natalensis reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Bulbine Natalensis and Metolazone records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bulbine Natalensis

What is Bulbine Natalensis?

  • Boosting testosterone
  • Improving libido
  • Muscle building and athletic performance
  • General male vitality

Bulbine natalensis is a South African plant marketed mainly as a testosterone-boosting and libido supplement, but the human evidence is essentially absent and most claims come from animal studies. Animal research has also raised concerns about possible liver and kidney harm at higher doses, so caution is warranted. Talk to your pharmacist or doctor before trying it.

Bulbine natalensis · Asphodelaceae · Roots and stems (sometimes leaves) · Capsules, powder, extracts

An interaction check asks whether these two react with each other — it does not ask whether Bulbine Natalensis is a good idea for someone in your situation. Here is what our Bulbine Natalensis record says about it on its own.

Bulbine Natalensis: dosing

There is no established safe or effective dose for Bulbine natalensis in humans. The amounts used in animal studies do not translate directly to people.If you choose to use a product despite the limited evidence, follow the directions on the label and do not exceed them.

From our Bulbine Natalensis monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bulbine Natalensis monograph & all interactions
Medication

About Metolazone

What Is Metolazone Used For?

Brand names: Diulo, Zaroxolyn, Mykrox

Metolazone tablets are used to treat edema (excess fluid buildup) linked to congestive heart failure or kidney diseases — including nephrotic syndrome and conditions with reduced kidney function. They are also used to treat high blood pressure (hypertension), either alone or alongside other blood pressure medications.

Metolazone tablets may also be used during pregnancy when edema is caused by a medical condition rather than normal pregnancy changes — but routine use in otherwise healthy pregnant women is not appropriate.

Most-Reported Side Effects for Metolazone

From FAERS, the FDA’s public side-effect reporting system (11,176 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 1,247 reports
Acute kidney injury 799 reports
Nausea 761 reports
Renal failure 716 reports
Cardiac failure congestive 683 reports
See full Metolazone drug information
Keep checking

Other Drugs & Bulbine Natalensis

Browse every other medication we’ve checked against Bulbine Natalensis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
919Moderate
0Minor
1,910No known interaction
919 Moderate 1,910 No interaction
Moderate

919 interactions

Showing 60 of 919 moderate interactions — see all 919 on the Bulbine Natalensis page.

No interaction 1,910 drugs checked — show the list

We also checked Bulbine Natalensis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,910 medications checked with no known interaction — see the full Bulbine Natalensis list.

See the full Bulbine Natalensis interactions page
See every supplement checked against Metolazone, ranked by severity
Evidence & sources

Bulbine Natalensis References

The 8 references that drive our Bulbine Natalensis monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Afolayan AJ, Yakubu MT. Effect of Bulbine natalensis Baker Stem Extract on the Functional Indices and Histology of the Liver and Kidney of Male Wistar Rats. J Med Food. 2009;12(4):814-820.
  2. Mosa RA, Lazarus GG, Gwala PE, Oyedeji AO, Opoku AR. In Vitro Anti-platelet Aggregation, Antioxidant and Cytotoxic Activity of Extracts of Some Zulu Medicinal Plants. J Nat Prod. 2011;4(2011):136-146.
  3. Okem A, Southway C, Stirk WA, et al. Heavy metal contamination in South African medicinal plants: A cause for concern. South African J Bot. 2014;93(2014):125-130. DOI
  4. Yakubu MT, Afolayan AJ. Reproductive toxicologic evaluations of Bulbine natalensis Baker stem extract in albino rats. Theriogenology. 2009;72(3):322-32. PubMed
  5. Yakubu MT, Afolayan AJ. Effect of aqueous extract of Bulbine natalensis (Baker) stem on the sexual behaviour of male rats. Int J Androl. 2009;32(6):629-36.
  6. Yakubu MT, Afolayan AJ. Anabolic and androgenic activities of Bulbine natalensis stem in male Wistar rats. Pharm Biol. 2010;48(5):568-76.
  7. Husain I, Manda V, Alhusban M, et al. Modulation of CYP3A4 and CYP2C9 activity by Bulbine natalensis and its constituents: An assessment of HDI risk of B. natalensis containing supplements. Phytomedicine 2021;81:153416. PubMed
  8. Husain I, Dale OR, Manda V, et al. Bulbine natalensis (currently Bulbine latifolia) and select bulbine knipholones modulate the activity of AhR, CYP1A2, CYP2B6, and P-gp. Planta Med 2022;88(12):975-984. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bulbine Natalensis and Metolazone Together: Common Questions

Is it safe to take Bulbine Natalensis with Metolazone?
We do not list a known interaction between Bulbine Natalensis and Metolazone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Bulbine Natalensis and Metolazone have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Bulbine Natalensis and Metolazone combination checked?
Interactions in our licensed database are recorded against drug classes. Metolazone is filed under 5 classifications, and Bulbine Natalensis has documented interactions with 7 drug classes — none of Metolazone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bulbine Natalensis interact with any other medications?
Yes. Bulbine Natalensis has 919 documented drug interactions in our database — Metolazone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Metolazone interact with any supplements?
Yes. Metolazone has documented interactions with 222 supplements in our database — Bulbine Natalensis is not one of them. The Metolazone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bulbine Natalensis monograph Uses, safety profile, and every drug interaction in one place Metolazone drug information The full plain-English guide to this medication Metolazone supplement interactions Every supplement checked against Metolazone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Metolazone and Bulbine Natalensis?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.