Drug & supplement interaction

Burdock + Atovaquone

Atovaquone brand name: Mepron.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Burdock and Atovaquone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Atovaquone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Burdock and Atovaquone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Atovaquone and Burdock in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Burdock safety at a glance

Burdock overall Use caution Likely safe as a food and for short-term use in healthy adults, but human safety data are limited.
Pregnancy Avoid Avoid medicinal amounts during pregnancy due to lack of safety data and possible effects on the uterus.
Breastfeeding Avoid Not enough safety information, so avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis

While burdock root has been traditionally used in herbal medicine for a variety of health conditions, its potential interactions with medications have not been well studied. Currently, there is only limited information available.

Burdock contains a variety of different compounds, includin arctigenin, arctiin, beta-eudesmol, caffeic acid, chlorogenic acid, diarctigenin, inulin, lappaol, tannin, trachelogenin, and sitosterol-beta-D-glucopyranoside, all of which can have a wide range of effects.

One of the only theoretical interactions that have been suggested is with anticoagulant and antiplatelet medications, as burdock root may have mild blood-thinning effects. This has only been seen in animal studies, however.

Further research is needed to fully understand the potential interactions between burdock root and medications.

—

Still wondering about combining Atovaquone and Burdock? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Atovaquone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Atovaquone is filed under a single classification — oral drugs. Burdock has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Atovaquone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Burdock Does Interact With Other Medications

Burdock has 122 moderate known drug interactions in our database — Atovaquone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Atovaquone)
Taking anything else?

Check Another of Your Medications Against Burdock

Covers the 2,830 medications we’ve checked against Burdock. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Burdock and Atovaquone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 5 of them are worth acting on rather than waiting out — marked below.

  • A low platelet count Worth acting on Additional detail

    Burdock

    “In one case report, a 38-year-old female developed immune-mediated thrombocytopenia after consuming a "cleansing" tea containing unknown amounts of burdock and yellow dock. The patient presented with bruising, mild weakness, and fatigue, which started 2-3 days after consuming the tea, and was found to have a platelet count of 5,000 per mcL.”

    Burdock · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 108971. Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed

    Atovaquone

    Listed in the ADVERSE REACTIONS section of the FDA label for Atovaquone. Read the label on DailyMed ›

  • A severe allergic reaction Worth acting on Additional detail

    Burdock

    “Orally, burdock is well tolerated when consumed as a food. Although a thorough evaluation of safety outcomes is lacking, there has been long-standing historical use of burdock with few noted adverse effects.

    Serious Adverse Effects (Rare):

    All ROAs: Allergic reactions, including contact dermatitis and anaphylaxis.”

    Burdock · Natural Medicines adverse-effect record, reported in dermatitis.

    “There is one case of anaphylactic shock secondary to eating boiled burdock. One hour after eating boiled burdock the patient presented with redness over the entire body and dyspnea. He was found to have low blood pressure and was treated with subcutaneous epinephrine 1 mg and intravenous lactated ringer's solution containing hydrocortisone 100 mg and dexamethasone 8 mg.”

    Burdock · Natural Medicines adverse-effect record, reported in hypotension.

    1 source cited
    1. 12660. Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. PubMed

    Atovaquone

    Listed in the ADVERSE REACTIONS section of the FDA label for Atovaquone. Read the label on DailyMed ›

  • Hives Worth acting on Additional detail

    Burdock

    Recorded for Burdock in the same Natural Medicines adverse-effect record shown under A severe allergic reaction above.

    Atovaquone

    Listed in the ADVERSE REACTIONS section of the FDA label for Atovaquone. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Burdock

    “A case of idiosyncratic drug-induced liver disease (DILI) is reported in a 36-year-old female who presented with abdominal pain after 1 month of taking an herbal liver detox tea containing burdock and other ingredients. Remarkable laboratory values included elevated liver enzymes, alkaline phosphatase, and total bilirubin. The patient received a loading dose of N-acetylcysteine and was hospitalized for 12 days.”

    Burdock · Natural Medicines adverse-effect record, reported in cirrhosis.

    1 source cited
    1. 112178. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed

    Atovaquone

    Listed in the ADVERSE REACTIONS section of the FDA label for Atovaquone. Read the label on DailyMed ›

  • An allergic reaction Worth acting on Additional detail

    Burdock

    Recorded for Burdock in the same Natural Medicines adverse-effect record shown under A severe allergic reaction above.

    Atovaquone

    Listed in the ADVERSE REACTIONS section of the FDA label for Atovaquone. Read the label on DailyMed ›

  • A skin rash Additional detail

    Burdock

    “Contact dermatitis has been reported secondary to burdock, especially after prolonged use of the root oil. There are cases of allergic dermatitis secondary to using burdock plasters. Two males and a 14 year-old female developed erythematous and vesicular, pruritic, and exudative reactions in areas corresponding to the application of burdock root plasters. Reactions occurred up to 7 days after initial use.”

    Burdock · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 37422. Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
    2. 12667. Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.

    Atovaquone

    Listed in the ADVERSE REACTIONS section of the FDA label for Atovaquone. Read the label on DailyMed ›

Reported for Burdock but not commonly for Atovaquone: trouble passing urine, low blood pressure, stomach pain and blurred vision.

Effects for Atovaquone come from the ADVERSE REACTIONS section of its FDA label; effects for Burdock come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Atovaquone Products Have a Food Rule — Burdock Should Not Break It

At least one FDA label for a product containing Atovaquone says to take it with food. If you take Burdock on an empty stomach out of habit, keep them separate — and take Atovaquone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Atovaquone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

jirovecii Pneumonia The recommended oral dosage is 1,500 mg (10 mL) once daily administered with food.

From the Dosage and Administration section of the FDA label we read for Atovaquone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Burdock or Atovaquone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Burdock or Atovaquone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Atovaquone

This page covers Burdock only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Atovaquone page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Atovaquone page

“Atovaquone (Mepron) is usually taken to prevent or treat Pneumocystis pneumonia, often when the immune system is already weakened, so a dose that never absorbs is a treatment failure, not a nuisance. All 17 supplement interactions on file act in the gut, changing how much of the drug reaches the blood, and I read this list as one deser…”

Reviewed by 2 · Jul 18, 2026

Open the Atovaquone interaction page

One more smart check

Taking Burdock as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,982 real supplement products containing Burdock, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Burdock. Even though Burdock itself has no known interaction with Atovaquone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Burdock and Atovaquone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Burdock
Top 10%

#136 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Atovaquone
Top half

#1,173 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Burdock reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Burdock and Atovaquone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Burdock

What is Burdock?

Burdock
  • Skin conditions like acne and eczema
  • Digestive support
  • Diuretic ('detox') and blood purifier
  • Sore throat and cold symptoms
  • Antioxidant support

Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is widely eaten as a vegetable and is generally considered low-risk for short-term use in healthy adults, but it should be avoided during pregnancy and breastfeeding and by people allergic to ragweed or daisy-family plants.

Arctium lappa · Asteraceae · Root, leaves, and seeds (fruit) · Tea, dried root, capsules, tinctures, liquid extracts, and fresh root used as food

An interaction check asks whether these two react with each other — it does not ask whether Burdock is a good idea for someone in your situation. Here is what our Burdock record says about it on its own.

Burdock: dosing

There is no well-established standard dose of burdock for any medical condition. Amounts vary widely depending on whether you use the fresh root, dried root tea, a tincture, or a capsule.The best approach is to follow the directions on the product label and start with the lowest suggested amount.

From our Burdock monograph — the full record covers uses, side effects and every documented interaction.

Read the full Burdock monograph & all interactions
Medication

About Atovaquone

What Is Atovaquone Used For?

Brand name: Mepron

Atovaquone oral suspension — available as the brand Mepron and as generic products — is used in adults and adolescents aged 13 and older who cannot tolerate trimethoprim-sulfamethoxazole (TMP-SMX), the usual first-choice treatment.

It is approved for two purposes: preventing PCP in people at high risk, and treating mild-to-moderate PCP in those who already have it. It has not been studied for severe PCP or for people whose PCP is not responding to TMP-SMX, so it is not used in those situations.

See full Atovaquone drug information
Keep checking

Other Drugs & Burdock

Browse every other medication we’ve checked against Burdock — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Burdock page.

No interaction 2,707 drugs checked — show the list

We also checked Burdock against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Burdock list.

See the full Burdock interactions page
See every supplement checked against Atovaquone, ranked by severity
Evidence & sources

Burdock References

The 11 references that drive our Burdock monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
  2. Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. PubMed
  3. Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. PubMed
  4. Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.
  5. Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. DOI
  6. Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
  7. Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20.
  8. Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. DOI
  9. <p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> DOI
  10. Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed
  11. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Burdock and Atovaquone Together: Common Questions

Is it safe to take Burdock with Atovaquone?
We do not list a known interaction between Burdock and Atovaquone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Burdock and Atovaquone have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Burdock and Atovaquone at the same time of day?
At least one FDA label for a product containing Atovaquone says to take it with food. If you take Burdock on an empty stomach out of habit, keep them separate and take Atovaquone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Atovaquone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Burdock and Atovaquone combination checked?
Interactions in our licensed database are recorded against drug classes. Atovaquone is filed under 1 classification, and Burdock has documented interactions with 1 drug class — none of Atovaquone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Burdock interact with any other medications?
Yes. Burdock has 122 documented drug interactions in our database — Atovaquone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Atovaquone interact with any supplements?
Yes. Atovaquone has documented interactions with 17 supplements in our database — Burdock is not one of them. The Atovaquone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Burdock monograph Uses, safety profile, and every drug interaction in one place Atovaquone drug information The full plain-English guide to this medication Atovaquone supplement interactions Every supplement checked against Atovaquone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 11 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Atovaquone and Burdock?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.