Drug & supplement interaction

Chirata + Aspirin, Caffeine, Orphenadrine

Aspirin, Caffeine, Orphenadrine brand names: Norgesic Forte, Invagesic, Invagesic Forte, Orphengesic, Norgesic, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chirata and Aspirin, Caffeine, Orphenadrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Chirata and Aspirin, Caffeine, Orphenadrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Aspirin, Caffeine, Orphenadrine and Chirata in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chirata safety at a glance

Chirata overall Use caution Generally used in small amounts in traditional medicine, but human safety data are limited.
Pregnancy Avoid Not enough safety data; avoid use during pregnancy.
Breastfeeding Avoid Not enough safety data; avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Aspirin, Caffeine, Orphenadrine and Chirata? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Aspirin, Caffeine, Orphenadrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Aspirin, Caffeine, Orphenadrine is filed under 15 classifications — including caffeine, skeletal muscle relaxants, cytochrome p450 2b6 (cyp2b6) substrates. Chirata has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Aspirin, Caffeine, Orphenadrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chirata Does Interact With Other Medications

Chirata has 86 moderate known drug interactions in our database — Aspirin, Caffeine, Orphenadrine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Aspirin, Caffeine, Orphenadrine)
Taking anything else?

Check Another of Your Medications Against Chirata

Covers the 2,830 medications we’ve checked against Chirata. Pick one to open its full report.

What to actually watch for

What Aspirin, Caffeine, Orphenadrine’s Own FDA Label Lists

This is not an interaction — none of it involves Chirata. These are the most notable effects listed in the ADVERSE REACTIONS section of Aspirin, Caffeine, Orphenadrine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 6 of them are worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on
  • Fainting Worth acting on
  • Confusion Worth acting on
  • Anemia Worth acting on
  • Hives Worth acting on
  • Bleeding or bruising Worth acting on
  • Blurred vision
  • Dry mouth
  • A fast or pounding heartbeat
  • Drowsiness

Showing the 10 most notable of 15 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Aspirin, Caffeine, Orphenadrine. Read the label on DailyMed › Chirata’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Chirata side to compare — that is a limit of the record, not a statement that Chirata has no side effects.

Everything else you take

See Every Supplement That Interacts With Aspirin, Caffeine, Orphenadrine

This page covers Chirata only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Caffeine, Orphenadrine page lists 350 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Ephedra (major).

By severity: 14 major · 289 moderate · 47 minor.

From our pharmacist’s overview on the Aspirin, Caffeine, Orphenadrine page

“Aspirin, caffeine, and orphenadrine (the Norgesic and Orphengesic brands) come with a supplement list that deserves real vigilance, with 14 of its 350 entries rated major. Over 200 of those ingredients can add to aspirin's effect on platelets and raise bleeding risk, another 44 stack stimulant effects on top of the caffeine, and grapef…”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Caffeine, Orphenadrine interaction page

One more smart check

Taking Chirata as Part of a Dietary Supplement Product? Check It for Interactions

We hold 26 real supplement products containing Chirata, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chirata. Even though Chirata itself has no known interaction with Aspirin, Caffeine, Orphenadrine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chirata and Aspirin, Caffeine, Orphenadrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chirata
Steady interest

#813 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Caffeine, Orphenadrine
Top 5%

#115 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chirata reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chirata and Aspirin, Caffeine, Orphenadrine records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chirata

What is Chirata?

  • Digestive upset and loss of appetite
  • Fever
  • Blood sugar support
  • Liver health support
  • Skin conditions
  • General 'blood purifier' or tonic

Chirata is a very bitter herb used in traditional Ayurvedic and South Asian medicine, mainly for digestion, fever, and as a general tonic. Human evidence for its benefits is limited, so it should not replace proven treatments, and you should talk to a pharmacist or doctor before using it.

Swertia chirayita · Gentianaceae · Whole plant, especially the dried stems and leaves · Powder, capsules, tablets, water infusion (cold or hot), liquid extract, and traditional herbal blends

An interaction check asks whether these two react with each other — it does not ask whether Chirata is a good idea for someone in your situation. Here is what our Chirata record says about it on its own.

Chirata: dosing

There is no well-established, standardized dose for chirata. The right amount can depend on the form (powder, capsule, or infusion) and the strength of the product.The safest approach is to follow the directions on the product label and not exceed the recommended amount.

From our Chirata monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chirata monograph & all interactions
Keep checking

Other Drugs & Chirata

Browse every other medication we’ve checked against Chirata — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Chirata page.

No interaction 2,743 drugs checked — show the list

We also checked Chirata against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Chirata list.

See the full Chirata interactions page
See every supplement checked against Aspirin, Caffeine, Orphenadrine, ranked by severity
Evidence & sources

Chirata References

The 1 references that drive our Chirata monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sekar, B. C., Mukherjee, B., Chakravarti, R. B., and Mukherjee, S. K. Effect of different fractions of Swertia chirayita on the blood sugar level of albino rats. J.Ethnopharmacol. 1987;21(2):175-181. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chirata and Aspirin, Caffeine, Orphenadrine Together: Common Questions

Is it safe to take Chirata with Aspirin, Caffeine, Orphenadrine?
We do not list a known interaction between Chirata and Aspirin, Caffeine, Orphenadrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Chirata and Aspirin, Caffeine, Orphenadrine combination checked?
Interactions in our licensed database are recorded against drug classes. Aspirin, Caffeine, Orphenadrine is filed under 15 classifications, and Chirata has documented interactions with 1 drug class — none of Aspirin, Caffeine, Orphenadrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Chirata interact with any other medications?
Yes. Chirata has 86 documented drug interactions in our database — Aspirin, Caffeine, Orphenadrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Aspirin, Caffeine, Orphenadrine interact with any supplements?
Yes. Aspirin, Caffeine, Orphenadrine has documented interactions with 350 supplements in our database — Chirata is not one of them. The Aspirin, Caffeine, Orphenadrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chirata monograph Uses, safety profile, and every drug interaction in one place Aspirin, Caffeine, Orphenadrine supplement interactions Every supplement checked against Aspirin, Caffeine, Orphenadrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Aspirin, Caffeine, Orphenadrine and Chirata?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.