Medication interaction hub

What Supplements Interact with Aspirin, Caffeine, Orphenadrine?

Aspirin, Caffeine, Orphenadrine brand names: Norgesic Forte, Invagesic, Invagesic Forte, Orphengesic, Norgesic, and others. Every interaction below applies to the brands too.

350 Interactions 14 Major 289 Moderate 47 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Aspirin, Caffeine, Orphenadrine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Aspirin, Caffeine, Orphenadrine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Aspirin, caffeine, and orphenadrine (the Norgesic and Orphengesic brands) come with a supplement list that deserves real vigilance, with 14 of its 350 entries rated major. Over 200 of those ingredients can add to aspirin's effect on platelets and raise bleeding risk, another 44 stack stimulant effects on top of the caffeine, and grapefruit earned its major rating by raising levels of drugs cleared through a liver enzyme this product relies on.

Alcohol matters here too. Beer and wine both carry major ratings because alcohol alongside an aspirin-type anti-inflammatory makes stomach bleeding more likely, and a handful of ephedrine-containing herbs rate major for driving up blood pressure and heart strain. The 289 moderate entries mostly repeat the bleeding and stimulant themes with less force, and the 47 minors rank lowest. Learn the 14 majors first, and treat unexplained bruising or black stools as a warning sign, not a wait-and-see symptom.

— , Clinical Pharmacist · July 18, 2026

Major 14 Moderate 289 Minor 47 No known interaction 1,102

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Aspirin, Caffeine, Orphenadrine: Top Interactions at a Glance

The Aspirin, Caffeine, Orphenadrine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 350 interacting ingredients — plus 1,102 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Aspirin, Caffeine, Orphenadrine Combinations Today

The Aspirin, Caffeine, Orphenadrine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Niacin + Aspirin, Caffeine, Orphenadrinei

Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Eleuthero + Aspirin, Caffeine, Orphenadrinei

Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Read the full interaction Moderate Likelihood Probable Magnesium + Aspirin, Caffeine, Orphenadrinei

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.

Read the full interaction Major Likelihood Likely Grapefruit + Aspirin, Caffeine, Orphenadrinei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Minor Likelihood Possible Passion Flower + Aspirin, Caffeine, Orphenadrinei

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Read the full interaction Major Likelihood Probable Ephedra + Aspirin, Caffeine, Orphenadrinei

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Aspirin, Caffeine, Orphenadrine

All 1,452 ingredients in our database, ranked by severity — 350 with a Aspirin, Caffeine, Orphenadrine interaction on file and 1,102 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Aspirin, Caffeine, Orphenadrine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Niacin with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Full Niacin + Aspirin, Caffeine, Orphenadrine answer

Can you take Eleuthero with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.

Full Eleuthero + Aspirin, Caffeine, Orphenadrine answer

Can you take Magnesium with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect...

Full Magnesium + Aspirin, Caffeine, Orphenadrine answer

Can you take Grapefruit with Aspirin, Caffeine, Orphenadrine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Full Grapefruit + Aspirin, Caffeine, Orphenadrine answer

Can you take Passion Flower with Aspirin, Caffeine, Orphenadrine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, passion flower might decrease the effects of CYP3A4 substrates.

Full Passion Flower + Aspirin, Caffeine, Orphenadrine answer

Can you take Gum Arabic with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Aspirin, Caffeine, Orphenadrine answer

Can you take Gymnema with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.

Full Gymnema + Aspirin, Caffeine, Orphenadrine answer

Can you take Hawthorn with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hawthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Hawthorn + Aspirin, Caffeine, Orphenadrine answer

Can you take Hesperidin with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hesperidin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Hesperidin + Aspirin, Caffeine, Orphenadrine answer

Can you take Higenamine with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.

Full Higenamine + Aspirin, Caffeine, Orphenadrine answer

Can you take Holy Basil with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.

Full Holy Basil + Aspirin, Caffeine, Orphenadrine answer

Can you take Honeysuckle with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, honeysuckle might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Honeysuckle + Aspirin, Caffeine, Orphenadrine answer

Can you take Hordenine with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hordenine is structurally similar to N-methyltyramine and synephrine, constituents in bitter orange known to have stimulant properties.

Full Hordenine + Aspirin, Caffeine, Orphenadrine answer

Can you take Horny Goat Weed with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.

Full Horny Goat Weed + Aspirin, Caffeine, Orphenadrine answer

Can you take Horse Chestnut with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Horse Chestnut + Aspirin, Caffeine, Orphenadrine answer

Can you take Hu Zhang with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.

Full Hu Zhang + Aspirin, Caffeine, Orphenadrine answer

Can you take Indian Gooseberry with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is co...

Full Indian Gooseberry + Aspirin, Caffeine, Orphenadrine answer

Can you take Indian Long Pepper with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase the effects and adverse effects of CYP3A4 substrates.

Full Indian Long Pepper + Aspirin, Caffeine, Orphenadrine answer

Can you take Indian Snakeroot with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Indian snakeroot might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Full Indian Snakeroot + Aspirin, Caffeine, Orphenadrine answer

Can you take Indole-3-carbinol with Aspirin, Caffeine, Orphenadrine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.

Full Indole-3-carbinol + Aspirin, Caffeine, Orphenadrine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Aspirin, Caffeine, Orphenadrine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Aspirin, Caffeine, Orphenadrine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Aspirin, Caffeine, Orphenadrine sits in 15 interaction categories. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Aspirin 22 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

22 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Caffeine 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Cytochrome P450 2B6 (Cyp2B6) Substrates 15 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

15 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Methylxanthines 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Nonsteroidal Anti-Inflammatory Drugs (Nsaids) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Skeletal Muscle Relaxants 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Aspirin, Caffeine, Orphenadrine through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Aspirin, Caffeine, Orphenadrine through this category.

Related: does Aspirin, Caffeine, Orphenadrine deplete any nutrients?

Aspirin, Caffeine, Orphenadrine has 30 reported nutrient associations in the research literature — see the Aspirin, Caffeine, Orphenadrine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Aspirin, Caffeine, Orphenadrine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Aspirin, Caffeine, Orphenadrine.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Aspirin, Caffeine, Orphenadrine & Supplements: Common Questions

What supplements interact with Aspirin, Caffeine, Orphenadrine?
Our database currently documents 350 ingredients with a known Aspirin, Caffeine, Orphenadrine interaction (14 major, 289 moderate, 47 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 350. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Aspirin, Caffeine, Orphenadrine supplement interactions are the most serious?
The 14 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and Danshen — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Aspirin, Caffeine, Orphenadrine?
Plenty of supplements coexist fine with Aspirin, Caffeine, Orphenadrine; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Norgesic Forte have the same supplement interactions as Aspirin, Caffeine, Orphenadrine?
Yes — Norgesic Forte, Invagesic, Invagesic Forte, Orphengesic, Norgesic and other brands all contain Aspirin, Caffeine, Orphenadrine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Aspirin, Caffeine, Orphenadrine deplete any vitamins or nutrients?
It might — Aspirin, Caffeine, Orphenadrine has 30 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Aspirin, Caffeine, Orphenadrine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Aspirin, Caffeine, Orphenadrine and my other medications?
This page covers Aspirin, Caffeine, Orphenadrine against supplements and herbal ingredients. Checking Aspirin, Caffeine, Orphenadrine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.