Drug & supplement interaction

Cilantro + Loperamide, Simethicone

Loperamide, Simethicone brand name: Imodium Advanced.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Cilantro and Loperamide, Simethicone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Loperamide, Simethicone states a food rule worth keeping to.

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Interaction report

Cilantro and Loperamide, Simethicone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Loperamide, Simethicone and Cilantro in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cilantro safety at a glance

Cilantro overall Generally safe Cilantro is generally safe when eaten as a food, but concentrated supplements are less studied.
Pregnancy Use caution Food amounts are likely fine, but medicinal or supplement doses lack safety data and should be avoided.
Breastfeeding Use caution Food amounts are likely fine, but there is not enough information on concentrated supplements.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Loperamide, Simethicone and Cilantro? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Loperamide, Simethicone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Loperamide, Simethicone is filed under 3 classifications — anticholinergic drugs, p-glycoprotein substrates, oral drugs. Cilantro has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and photosensitizing drugs (moderate) — and none of Loperamide, Simethicone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cilantro Does Interact With Other Medications

Cilantro has 434 moderate known drug interactions in our database — Loperamide, Simethicone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 434 No known interaction 2,396 (incl. Loperamide, Simethicone)
Taking anything else?

Check Another of Your Medications Against Cilantro

Covers the 2,830 medications we’ve checked against Cilantro. Pick one to open its full report.

What to actually watch for

What Cilantro Itself Has Been Linked To

This is not an interaction — nothing below involves Loperamide, Simethicone. It is the side-effect record for Cilantro on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Cilantro, this list is the first place to look. 3 entries are worth acting on rather than waiting out — marked below.

  • Dehydration / Low mood Worth acting on Additional detail

    “Orally, cilantro extract has been associated with a case of endocrine toxicity. A case report describes severe diarrhea, stomach pain, skin darkness, depressed mood, amenorrhea, and dehydration following consumption of 200 mL of a 10% cilantro extract for 7 days.”

    Cilantro · Natural Medicines adverse-effect record, reported in amenorrhea.

    1 source cited
    1. 10635. Zabihi E, Abdollahi M. Endocrinotoxicity induced by Coriandrum sativa: a case report. WHO Drug Information. 2001;16:15.
  • A severe allergic reaction Worth acting on Additional detail

    “Topically, cilantro has been reported to cause contact dermatitis. In sensitive individuals, it has also been reported to cause anaphylaxis.”

    Cilantro · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 46230. Zuskin, E., Kanceljak, B., Skuric, Z., Pokrajac, D., Schachter, E. N., Witek, T. J., and Maayani, S. Immunological and respiratory findings in spice-factory workers. Environ.Res 1988;47(1):95-108. PubMed
    2. 92663. Unkle DW, Ricketti AJ, Ricketti PA, Cleri DJ, Vernaleo JR. C. Ann Allergy Asthma Immunol. 2012;109(6):471-2.

    “Cilantro can cause anaphylaxis in some patients. One case report describes a 52 year-old man who experienced diffuse urticaria following a single ingestion of cilantro, followed by severe angioedema of the face, urticaria, and laryngeal edema following a second ingestion of cilantro. Treatment consisted of treatment with intravenous methylprednisolone, diphenhydramine, and famotidine.”

    Cilantro · Natural Medicines adverse-effect record, reported in pregnancy-related edema.

    1 source cited
    1. 92663. Unkle DW, Ricketti AJ, Ricketti PA, Cleri DJ, Vernaleo JR. C. Ann Allergy Asthma Immunol. 2012;109(6):471-2.
  • Hives Worth acting on Additional detail

    “Topically, cilantro may cause contact dermatitis, with symptoms including hives or itching.”

    Cilantro · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 46230. Zuskin, E., Kanceljak, B., Skuric, Z., Pokrajac, D., Schachter, E. N., Witek, T. J., and Maayani, S. Immunological and respiratory findings in spice-factory workers. Environ.Res 1988;47(1):95-108. PubMed
  • Changes to your period / Stomach pain / Diarrhea Additional detail

    Recorded for Cilantro in the same Natural Medicines adverse-effect record shown under Dehydration / Low mood above.

  • Itching Additional detail

    Recorded for Cilantro in the same Natural Medicines adverse-effect record shown under Hives above.

  • Swelling Additional detail

    Recorded for Cilantro in the same Natural Medicines adverse-effect record shown under A severe allergic reaction above.

  • A skin rash Additional detail

    Recorded for Cilantro in the same Natural Medicines adverse-effect record shown under A severe allergic reaction above.

Everything above comes from the Natural Medicines adverse-effect record for Cilantro — expand a row for the licensed statement it rests on. We haven’t matched Loperamide, Simethicone to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Loperamide, Simethicone.

How to take them

Some Loperamide, Simethicone Products Have a Food Rule — Cilantro Should Not Break It

At least one FDA label for a product containing Loperamide, Simethicone says to take it on an empty stomach. Most supplements — Cilantro included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Loperamide, Simethicone on its own and move Cilantro to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Loperamide, Simethicone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Directions drink plenty of clear fluids to help prevent dehydration caused by diarrhea take only on an empty stomach (1 hour before or 2 hours after a meal) take with a full (8 oz.) glass of water find right dose on chart below.

From the Dosage and Administration section of the FDA label we read for Loperamide, Simethicone — where that label names a specific product, the instruction is that product's.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Loperamide, Simethicone

This page covers Cilantro only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Loperamide, Simethicone page lists 82 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Scopolia (major), St. John's Wort (major) and Angel's Trumpet (moderate).

By severity: 4 major · 59 moderate · 19 minor.

From our pharmacist’s overview on the Loperamide, Simethicone page

“Imodium Advanced combines loperamide, an anti-diarrheal opioid that normally stays out of the brain thanks to a transporter called P-glycoprotein, with simethicone for gas, and I treat its interaction list with more respect than most over-the-counter medicines warrant. Thirty-seven of the 82 interacting ingredients on file affect that…”

Reviewed by 2 · Jul 18, 2026

Open the Loperamide, Simethicone interaction page

How much people look this up

Where Cilantro and Loperamide, Simethicone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cilantro
Steady interest

#760 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Loperamide, Simethicone
Top 25%

#311 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cilantro reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Cilantro and Loperamide, Simethicone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cilantro

What is Cilantro?

  • Digestive upset and bloating
  • Antimicrobial support
  • Antioxidant support
  • Heavy metal 'detox' (chelation) claims
  • Culinary flavoring

Cilantro is the leafy part of the Coriandrum sativum plant and is widely eaten as a food, where it is considered safe for most people. While it has antioxidant and antimicrobial properties in lab studies, strong human evidence for any specific health benefit is lacking, and popular 'detox' claims are not well supported. Talk with your pharmacist or doctor before using concentrated cilantro supplements or essential oil.

Coriandrum sativum · Apiaceae · Leaves, stems, seeds (coriander), and essential oil · Fresh herb, dried herb, seeds, capsules, extracts, essential oil, tea

An interaction check asks whether these two react with each other — it does not ask whether Cilantro is a good idea for someone in your situation. Here is what our Cilantro record says about it on its own.

Cilantro: dosing

There is no standardized medicinal dose for cilantro. As a food, it is simply used to taste in cooking, which is considered safe for most people.For supplements such as capsules, extracts, or teas, follow the directions on the product label, since strengths vary widely between products. Essential oil is highly concentrated and should not be taken by mouth unless directed by a qualified professional.

From our Cilantro monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cilantro monograph & all interactions
Keep checking

Other Drugs & Cilantro

Browse every other medication we’ve checked against Cilantro — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
434Moderate
0Minor
2,395No known interaction
434 Moderate 2,395 No interaction
Moderate

434 interactions

Showing 60 of 434 moderate interactions — see all 434 on the Cilantro page.

No interaction 2,395 drugs checked — show the list

We also checked Cilantro against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,395 medications checked with no known interaction — see the full Cilantro list.

See the full Cilantro interactions page
See every supplement checked against Loperamide, Simethicone, ranked by severity
Evidence & sources

Cilantro References

The 5 references that drive our Cilantro monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Zabihi E, Abdollahi M. Endocrinotoxicity induced by Coriandrum sativa: a case report. WHO Drug Information. 2001;16:15.
  2. Suneetha WJ, Krishnakantha TP. Antiplatelet activity of coriander and curry leaf spices. Pharm Biol. 2005;43(3):230-3. DOI
  3. Ashwood-Smith, M. J., Warrington, P. J., Jenkins, M., Ceska, O., and Romaniuk, P. J. Photobiological properties of a novel, naturally occurring furoisocoumarin, coriandrin. Photochem.Photobiol. 1989;50(6):745-751. PubMed
  4. Zuskin, E., Kanceljak, B., Skuric, Z., Pokrajac, D., Schachter, E. N., Witek, T. J., and Maayani, S. Immunological and respiratory findings in spice-factory workers. Environ.Res 1988;47(1):95-108. PubMed
  5. Unkle DW, Ricketti AJ, Ricketti PA, Cleri DJ, Vernaleo JR. C. Ann Allergy Asthma Immunol. 2012;109(6):471-2.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cilantro and Loperamide, Simethicone Together: Common Questions

Is it safe to take Cilantro with Loperamide, Simethicone?
We do not list a known interaction between Cilantro and Loperamide, Simethicone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Cilantro and Loperamide, Simethicone at the same time of day?
At least one FDA label for a product containing Loperamide, Simethicone says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Loperamide, Simethicone on its own and move Cilantro to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Cilantro and Loperamide, Simethicone combination checked?
Interactions in our licensed database are recorded against drug classes. Loperamide, Simethicone is filed under 3 classifications, and Cilantro has documented interactions with 2 drug classes — none of Loperamide, Simethicone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Cilantro interact with any other medications?
Yes. Cilantro has 434 documented drug interactions in our database — Loperamide, Simethicone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Loperamide, Simethicone interact with any supplements?
Yes. Loperamide, Simethicone has documented interactions with 82 supplements in our database — Cilantro is not one of them. The Loperamide, Simethicone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cilantro monograph Uses, safety profile, and every drug interaction in one place Loperamide, Simethicone supplement interactions Every supplement checked against Loperamide, Simethicone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Loperamide, Simethicone and Cilantro?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.