Cod Liver Oil + Treprostinil (Inh)
Treprostinil (Inh) brand name: Tyvaso.
Treprostinil (Inh) falls into 2 drug categories that Cod Liver Oil can interact with; the most serious is rated moderate. Theoretically, taking cod liver oil with antihypertensive drugs might increase the risk of hypotension.
Read the full interaction reportCod Liver Oil and Treprostinil (Inh)
These two interact in 2 distinct ways. Each one is explained separately below.
Why Are There 2 Interactions?
Cod Liver Oil interacts with whole categories of medication. Treprostinil (Inh) falls into 2 of those categories, so it can interact with Cod Liver Oil in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
ANTIHYPERTENSIVE DRUGS
1 of 2Why this applies to Treprostinil (Inh)
Treprostinil (Inh) falls under ANTIHYPERTENSIVE DRUGS — the group Cod Liver Oil interacts with.
Cod liver oil can lower blood pressure and might have additive effects in patients treated with antihypertensives; use with caution.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
Here's the thing to keep in mind with inhaled treprostinil (Tyvaso): it's a vasodilator, meaning it relaxes and widens blood vessels, which can naturally lower your blood pressure. Cod liver oil, thanks to its omega-3 fats, may nudge your blood pressure down a little too. Put the two together and those effects could add up.
In real terms, that might show you up as more lightheadedness, dizziness, headache, flushing, or feeling faint, especially when you stand up quickly. The good news is this concern is largely theoretical and based on modest evidence, so it's not a reason to panic. Food amounts of fish are unlikely to matter, but a daily supplement dose could. Before adding cod liver oil, please run it by your pharmacist or doctor first.
- Prisco D, Paniccia R, Bandinelli B, et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res 1998;1:105-12.
- Toft I, Bonaa KH, Ingebretsen OC, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995;123:911-8.
- Jensen T, Stender S, Goldstein K, et al. Partial normalization by dietary cod-liver oil of increased microvascular albumin leakage in patients with insulin-dependent diabetes and albuminuria. N Engl J Med 1989;321:1572-7. PubMed
ANTICOAGULANT/ANTIPLATELET DRUGS
2 of 2Treprostinil (Inh) also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.
High doses of cod liver oil, 20-40 mL daily, have been associated with prolonged bleeding time and reduced platelet aggregation in healthy volunteers.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to know about pairing cod liver oil with inhaled treprostinil (Tyvaso): treprostinil doesn't just open up the blood vessels in your lungs, it also makes your platelets a little less sticky, which slightly slows clotting. Cod liver oil, especially in big concentrated doses (think 20 to 40 mL a day), can do a similar thing on its own. Stacking the two could nudge your bleeding risk up a bit.
In real life that might look like bruising more easily, nosebleeds, or bleeding gums that take longer to stop. This is a theoretical, moderate concern, and the small amounts you'd get from a normal daily supplement dose are much less likely to matter than high doses. Still, before you start or stop anything, run it past your pharmacist or doctor so they can weigh in.
- Brox JH, Killie JE, Gunnes S, Nordoy A. The effect of cod liver oil and corn oil on platelets and vessel wall in man. Thromb Haemost 1981;46:604-11. DOI
- Sanders TA, Vickers M, Haines AP. Effect on blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentainoic and docosahexaenoic acids, in healthy young men. Clin Sci (Colch) 1981;61:317-24.
- Brox JH, Killie JE, Osterud B, et al. Effects of cod liver oil on platelets and coagulation in familial hypercholesterolemia (type IIa). Acta Med Scand 1983;213:137-44.. PubMed
- Lorenz R, Spengler U, Fischer S, Duhm J, Weber PC. Platelet function, thromboxane formation and blood pressure control during supplementation of the Western diet with cod liver oil. Circulation 1983;67(3):504-11. PubMed
- Ahmed AA, Holub BJ. Alteration and recovery of bleeding times, platelet aggregation and fatty acid composition of individual phospholipids in platelets of human subjects receiving a supplement of cod-liver oil. Lipids 1984;19(8):617-24. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Cod Liver Oil Also Interacts With Other Medications
Cod Liver Oil has 374 moderate known drug interactions in our database — the Treprostinil (Inh) one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Cod Liver Oil
We haven’t checked that one against Cod Liver Oil yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Cod Liver Oil. Pick one to open its full report.
Questions About Cod Liver Oil or Treprostinil (Inh)
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Cod Liver Oil or Treprostinil (Inh), not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Treprostinil (Inh)
This page covers Cod Liver Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Treprostinil (Inh) page lists 275 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: American Hellebore (major), American Mistletoe (major), Danshen (major), Piracetam (major) and Tyramine (major).
By severity: 5 major · 251 moderate · 19 minor.
From our pharmacist’s overview on the Treprostinil (Inh) page
“Inhaled treprostinil (Tyvaso) relaxes blood vessels in the lungs to treat pulmonary hypertension, and it also blunts platelet clotting, which is why this list of 275 ingredients warrants real vigilance rather than a shrug. Two themes cover almost everything.”
Reviewed by 2 · Jul 18, 2026
Taking Cod Liver Oil as Part of a Dietary Supplement Product? Check It for Interactions
We hold 17 real supplement products containing Cod Liver Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cod Liver Oil. Your product may carry other ingredients that interact with Treprostinil (Inh) too, on top of Cod Liver Oil — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Cod Liver Oil and Treprostinil (Inh) Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#926 of 1,452 supplements looked up here in the last 7 days
#1,652 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Cod Liver Oil
What is Cod Liver Oil?
- Source of omega-3 fatty acids
- Vitamin A and D supplementation
- Heart health
- Joint and bone health
- Reducing inflammation
Cod liver oil supplies omega-3 fatty acids (EPA and DHA) along with vitamins A and D, and is popular for heart, joint, and general health support. Evidence is strongest for its nutrient content, but proof of specific disease benefits is mixed. Because it contains vitamin A, taking too much can be harmful, so check with your pharmacist or doctor before using it.
About Treprostinil Oral Inhalation
What Is Treprostinil Oral Inhalation Used For?
Brand name: Tyvaso
Treprostinil oral inhalation is used to treat two serious lung conditions that raise pressure in the blood vessels of the lungs. It helps improve how much physical activity you can do.
Tyvaso inhalation solution and Tyvaso DPI are both indicated to treat pulmonary arterial hypertension (PAH; WHO Group 1) and pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3). Clinical studies establishing effectiveness in PAH primarily included patients with moderate symptoms (NYHA Class III) whose PAH was idiopathic, heritable, or related to connective tissue disease. Studies in PH-ILD primarily included patients with idiopathic interstitial pneumonia, combined pulmonary fibrosis and emphysema, or connective tissue disease-related lung disease.
Other Drugs & Cod Liver Oil
Browse every other medication we’ve checked against Cod Liver Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
374 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Insulin (rdna) ›
- Naproxen ›
- Minocycline ›
- Propranolol ›
- Hydrochlorothiazide ›
- Verapamil ›
- Glyburide ›
- Insulin (pork) ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Hydralazine ›
- Insulin (human) ›
- Ketoprofen ›
- Trichlormethiazide ›
- Acarbose ›
- Bendroflumethiazide ›
- Bivalirudin ›
- Insulin Glargine ›
- Lisinopril ›
- Metolazone ›
- Minoxidil ›
- Nicardipine ›
- Prazosin ›
- Semaglutide ›
- Spironolactone ›
- Timolol ›
- Warfarin Sodium ›
- Acebutolol ›
- Acetazolamide ›
- Ambrisentan ›
- Amiloride ›
- Atenolol ›
- Betaxolol ›
- Bromfenac Sodium ›
- Candesartan Cilexetil ›
- Captopril ›
- Carteolol ›
- Carvedilol ›
- Chlorpropamide ›
- Chlorthalidone ›
- Cyclothiazide ›
- Dabigatran ›
- Diclofenac Epolamine ›
- Enalapril Maleate ›
- Exenatide ›
- Felodipine ›
- Glipizide ›
- Glucagon ›
- Guanethidine Monosulfate ›
- Iloprost ›
- Indapamide ›
- Insulin Lispro ›
- Irbesartan ›
- Labetalol ›
- Mannitol ›
Showing 60 of 374 moderate interactions — see all 374 on the Cod Liver Oil page.
No interaction 2,455 drugs checked — show the list
We also checked Cod Liver Oil against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Sertraline ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Atorvastatin ›
- Isotretinoin ›
- Methamphetamine ›
- Docusate ›
- Sumatriptan ›
- Tadalafil ›
- Valacyclovir ›
- Hydroxyurea ›
- Prednisone ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Amphetamine ›
- Levothyroxine, Liothyronine ›
- Amoxicillin ›
- Methotrexate ›
- Bupropion ›
- Fluoxetine ›
- Bendamustine ›
- Azithromycin ›
- Pregabalin ›
- Doxycycline ›
- Dextroamphetamine ›
- Gabapentin ›
- Lamotrigine ›
- Acyclovir ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Citalopram ›
- Acetaminophen, Codeine ›
- Methylene Blue ›
- Ciprofloxacin ›
- Amoxicillin, Clavulanate Potassium ›
- Acetaminophen, Butalbital, Caffeine ›
- Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine ›
- Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide ›
- Acetaminophen, Caffeine, Codeine ›
- Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine ›
- Acetaminophen, Oxycodone ›
- Diazepam ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine ›
- Ezetimibe ›
- Dapsone ›
- Cyclopentolate ›
- Cephalexin ›
- Isoniazid, Pyrazinamide, Rifampin ›
- Acetaminophen, Dichloralphenazone, Isometheptene ›
Showing the 60 most looked-up of 2,455 medications checked with no known interaction — see the full Cod Liver Oil list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Treprostinil (Inh) Is Linked to Lower Levels of One Nutrient
Natural Medicines records Treprostinil (Inh) as a medicine that can lower these. This is not an interaction with Cod Liver Oil — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Treprostinil (Inh) nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Cod Liver Oil and Treprostinil (Inh) Together: Common Questions
Can you take Cod Liver Oil with Treprostinil (Inh)?
Why are there 2 interactions listed for Cod Liver Oil and Treprostinil (Inh)?
How serious is the Cod Liver Oil and Treprostinil (Inh) interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Treprostinil (Inh) and Cod Liver Oil?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.