Flaxseed Oil + Treprostinil (Inh)
Treprostinil (Inh) brand name: Tyvaso.
Treprostinil (Inh) falls into 2 drug categories that Flaxseed Oil can interact with; the most serious is rated moderate. Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full interaction reportFlaxseed Oil and Treprostinil (Inh)
These two interact in 2 distinct ways. Each one is explained separately below.
Why Are There 2 Interactions?
Flaxseed Oil interacts with whole categories of medication. Treprostinil (Inh) falls into 2 of those categories, so it can interact with Flaxseed Oil in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
ANTIHYPERTENSIVE DRUGS
1 of 2Why this applies to Treprostinil (Inh)
Treprostinil (Inh) falls under ANTIHYPERTENSIVE DRUGS — the group Flaxseed Oil interacts with.
Some clinical evidence suggests that long-term consumption of flaxseed oil can modestly lower systolic and diastolic blood pressure, while other clinical research shows no effect.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the simple version for anyone using inhaled treprostinil (Tyvaso). This medicine works by relaxing and widening blood vessels, so it can lower blood pressure as part of how it treats your lung condition. Flaxseed oil may nudge blood pressure down a little too. Put together, the two could add up and drop your pressure a bit more than expected.
If that happened, you might feel dizzy, lightheaded, or extra tired, especially when standing up quickly. I want to be honest though: this is mostly a theoretical concern based on how they work, and studies on flaxseed and blood pressure are mixed. Food amounts of flax are unlikely to matter. Before adding a flaxseed oil supplement, just check with your pharmacist or doctor.
- Paschos GK, Magkos F, Panagiotakos DB, et al. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 2007;61:1201-6. PubMed
- Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. Effects of flaxseed supplements on blood pressure: a systematic review and meta-analysis of controlled clinical trial. Clin Nutr. 2016 Jun;3 PubMed
- Morshedzadeh N, Shahrokh S, Aghdaei HA, et al. Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis. Complement Ther Med. 2019;46:36-43. PubMed
- Saleh-Ghadimi S, Kheirouri S, Golmohammadi A, Moludi J, Jafari-Vayghan H, Alizadeh M. Effect of flaxseed oil supplementation on anthropometric and metabolic indices in patients with coronary artery disease: A double-blinded randomized controlled trial. J PubMed
- Li L, Li H, Gao Y, Vafaei S, Zhang X, Yang M. Effect of flaxseed supplementation on blood pressure: a systematic review, and dose-response meta-analysis of randomized clinical trials. Food Funct 2023;14(2):675-690. PubMed
- Mahmudiono T, Jasim SA, Karim YS, et al. The effect of flaxseed oil consumption on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials. Phytother Res 2022;36(10):
ANTICOAGULANT/ANTIPLATELET DRUGS
2 of 2Treprostinil (Inh) also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.
Small clinical studies show that consuming flaxseed oil might decrease platelet aggregation and increase bleeding time.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to know about pairing flaxseed oil with inhaled treprostinil (Tyvaso): treprostinil already works partly by making your platelets less sticky, which slightly slows clotting. Flaxseed oil, in some small studies, seems to do a similar thing. Stack them together and you may get a little extra of that blood-thinning effect.
In real life, that could mean things like easier bruising, nosebleeds, or bleeding that takes longer to stop. I want to be honest, though: this concern is mostly theoretical, based on how each one behaves, not on strong studies of the two used together. Treprostinil isn't a prodrug, so flaxseed oil doesn't change how your body activates it. Still, if you have any bleeding risk, check with your doctor or pharmacist before starting flaxseed oil.
- Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
- Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur.J Clin.Nutr. 1995;49(3):169-178.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Flaxseed Oil Also Interacts With Other Medications
Flaxseed Oil has 292 moderate known drug interactions in our database — the Treprostinil (Inh) one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Flaxseed Oil
We haven’t checked that one against Flaxseed Oil yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Flaxseed Oil. Pick one to open its full report.
See Every Supplement That Interacts With Treprostinil (Inh)
This page covers Flaxseed Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Treprostinil (Inh) page lists 275 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: American Hellebore (major), American Mistletoe (major), Danshen (major), Piracetam (major) and Tyramine (major).
By severity: 5 major · 251 moderate · 19 minor.
From our pharmacist’s overview on the Treprostinil (Inh) page
“Inhaled treprostinil (Tyvaso) relaxes blood vessels in the lungs to treat pulmonary hypertension, and it also blunts platelet clotting, which is why this list of 275 ingredients warrants real vigilance rather than a shrug. Two themes cover almost everything.”
Reviewed by 2 · Jul 18, 2026
Taking Flaxseed Oil as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1,329 real supplement products containing Flaxseed Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Flaxseed Oil. Your product may carry other ingredients that interact with Treprostinil (Inh) too, on top of Flaxseed Oil — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Flaxseed Oil and Treprostinil (Inh) Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#175 of 1,452 supplements looked up here in the last 7 days
#1,129 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Flaxseed Oil
What is Flaxseed Oil?
- Source of omega-3 (ALA) fatty acids
- Heart and cholesterol health
- Dry skin and inflammation
- Constipation
- General wellness
Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy fats, but evidence for most specific health claims is limited or mixed. It is generally well tolerated, but talk to your pharmacist or doctor before starting, especially if you are pregnant or have a bleeding risk.
About Treprostinil Oral Inhalation
What Is Treprostinil Oral Inhalation Used For?
Brand name: Tyvaso
Treprostinil oral inhalation is used to treat two serious lung conditions that raise pressure in the blood vessels of the lungs. It helps improve how much physical activity you can do.
Tyvaso inhalation solution and Tyvaso DPI are both indicated to treat pulmonary arterial hypertension (PAH; WHO Group 1) and pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3). Clinical studies establishing effectiveness in PAH primarily included patients with moderate symptoms (NYHA Class III) whose PAH was idiopathic, heritable, or related to connective tissue disease. Studies in PH-ILD primarily included patients with idiopathic interstitial pneumonia, combined pulmonary fibrosis and emphysema, or connective tissue disease-related lung disease.
Other Drugs & Flaxseed Oil
Browse every other medication we’ve checked against Flaxseed Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
292 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Naproxen ›
- Minocycline ›
- Propranolol ›
- Hydrochlorothiazide ›
- Verapamil ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Hydralazine ›
- Ketoprofen ›
- Trichlormethiazide ›
- Bendroflumethiazide ›
- Bivalirudin ›
- Lisinopril ›
- Metolazone ›
- Minoxidil ›
- Nicardipine ›
- Prazosin ›
- Spironolactone ›
- Timolol ›
- Warfarin Sodium ›
- Acebutolol ›
- Acetazolamide ›
- Ambrisentan ›
- Amiloride ›
- Atenolol ›
- Betaxolol ›
- Bromfenac Sodium ›
- Candesartan Cilexetil ›
- Captopril ›
- Carteolol ›
- Carvedilol ›
- Chlorthalidone ›
- Cyclothiazide ›
- Dabigatran ›
- Diclofenac Epolamine ›
- Enalapril Maleate ›
- Felodipine ›
- Guanethidine Monosulfate ›
- Iloprost ›
- Indapamide ›
- Irbesartan ›
- Labetalol ›
- Mannitol ›
- Methyclothiazide ›
- Methyldopa ›
- Metoprolol ›
- Nadolol ›
- Nebivolol ›
- Nimodipine ›
- Olmesartan Medoxomil ›
- Oxprenolol ›
- Pindolol ›
- Piroxicam ›
- Quinapril ›
- Reserpine ›
Showing 60 of 292 moderate interactions — see all 292 on the Flaxseed Oil page.
No interaction 2,537 drugs checked — show the list
We also checked Flaxseed Oil against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Sertraline ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Atorvastatin ›
- Isotretinoin ›
- Tirzepatide ›
- Methamphetamine ›
- Levothyroxine, Liothyronine ›
- Docusate ›
- Prednisone ›
- Metformin ›
- Valacyclovir ›
- Amitriptyline ›
- Tadalafil ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Lisdexamfetamine ›
- Amphetamine ›
- Methotrexate ›
- Amoxicillin ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Pregabalin ›
- Doxycycline ›
- Gabapentin ›
- Dextroamphetamine ›
- Bendamustine ›
- Lamotrigine ›
- Quetiapine ›
- Acyclovir ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
- Ciprofloxacin ›
- Acetaminophen, Codeine ›
- Amoxicillin, Clavulanate Potassium ›
- Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine ›
- Acetaminophen, Butalbital, Caffeine ›
- Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide ›
- Acetaminophen, Caffeine, Codeine ›
- Insulin Degludec, Liraglutide ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine ›
- Acetaminophen, Oxycodone ›
- Diazepam ›
- Acetaminophen, Chlorpheniramine, Phenylpropanolamine ›
- Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine ›
- Acetaminophen, Dichloralphenazone, Isometheptene ›
Showing the 60 most looked-up of 2,537 medications checked with no known interaction — see the full Flaxseed Oil list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Treprostinil (Inh) Is Linked to Lower Levels of One Nutrient
Natural Medicines records Treprostinil (Inh) as a medicine that can lower these. This is not an interaction with Flaxseed Oil — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Treprostinil (Inh) nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Flaxseed Oil and Treprostinil (Inh) Together: Common Questions
Can you take Flaxseed Oil with Treprostinil (Inh)?
Why are there 2 interactions listed for Flaxseed Oil and Treprostinil (Inh)?
How serious is the Flaxseed Oil and Treprostinil (Inh) interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Treprostinil (Inh) and Flaxseed Oil?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.