Drug & supplement interaction

Garcinia + Chlorpheniramine, Methscopolamine, Phenylpropanolamine

Chlorpheniramine, Methscopolamine, Phenylpropanolamine brand name: Pannaz.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Garcinia has a moderate interaction with Chlorpheniramine, Methscopolamine, Phenylpropanolamine. Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Garcinia and Chlorpheniramine, Methscopolamine, Phenylpropanolamine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

SEROTONERGIC DRUGS

Why this applies to Chlorpheniramine, Methscopolamine, Phenylpropanolamine

Chlorpheniramine, Methscopolamine, Phenylpropanolamine falls under SEROTONERGIC DRUGS — the group Garcinia interacts with.

Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
In one report, a patient experienced serotonin syndrome after taking garcinia extract (60% hydroxycitric acid) 1000 mg daily in combination with escitalopram 20 mg, which had been taken for a year. The patient was switched to sertraline 50 mg daily and again experienced serotonin syndrome.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the honest picture with Pannaz, which combines chlorpheniramine (an antihistamine), methscopolamine (dries secretions), and phenylpropanolamine (a decongestant). The concern on file is that Garcinia might add to the risk of serotonin syndrome, a buildup of too much serotonin activity. This is mostly theoretical and rests on a single case report involving Garcinia plus an antidepressant, so the evidence is weak.

Chlorpheniramine has only mild serotonin-related activity, so the real-world risk here is low. Still, watch for things like agitation, a racing heart, sweating, shivering, or feeling jittery, since the decongestant can also raise heart rate and blood pressure. To be safe, check with your pharmacist or doctor before pairing these, especially given Garcinia's rare liver concerns.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Lopez AM, Kornegay J, Hendrickson RG. Serotonin Toxicity Associated with Garcinia cambogia Over-the-counter Supplement. J Med Toxicol. 2014 Apr 4. [Epub ahead of print]. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Garcinia Also Interacts With Other Medications

Garcinia has 705 moderate known drug interactions in our database — the Chlorpheniramine, Methscopolamine, Phenylpropanolamine one above is one of them. If you take anything else, check it against the full list below.

Moderate 705 No known interaction 2,125 (incl. Chlorpheniramine, Methscopolamine, Phenylpropanolamine)
Taking anything else?

Check Another of Your Medications Against Garcinia

Covers the 2,830 medications we’ve checked against Garcinia. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Chlorpheniramine, Methscopolamine, Phenylpropanolamine

This page covers Garcinia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlorpheniramine, Methscopolamine, Phenylpropanolamine page lists 230 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Grapefruit (major), Henbane (major) and Lithium (major).

By severity: 10 major · 175 moderate · 45 minor.

From our pharmacist’s overview on the Chlorpheniramine, Methscopolamine, Phenylpropanolamine page

“Pannaz combines an antihistamine, an anticholinergic, and phenylpropanolamine, a stimulant decongestant, and that three-way mix is why 10 of its 230 supplement interactions rate major and why I'd want those ten understood before any other line on this page. Stimulant herbs, ephedra chief among them, stack heart-rate and blood-pressure…”

Reviewed by 2 · Jul 18, 2026

Open the Chlorpheniramine, Methscopolamine, Phenylpropanolamine interaction page

One more smart check

Taking Garcinia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,374 real supplement products containing Garcinia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Garcinia. Your product may carry other ingredients that interact with Chlorpheniramine, Methscopolamine, Phenylpropanolamine too, on top of Garcinia — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Garcinia and Chlorpheniramine, Methscopolamine, Phenylpropanolamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Garcinia
Top 25%

#153 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chlorpheniramine, Methscopolamine, Phenylpropanolamine
Top 5%

#109 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Garcinia

What is Garcinia?

Garcinia
  • Weight loss
  • Appetite suppression
  • Curbing sugar and carb cravings
  • Supporting metabolism
  • Traditional cooking and souring agent

Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific evidence is weak and mixed, with most studies showing only small or no meaningful weight effects, and rare reports of liver problems raise safety concerns. Talk to a pharmacist or doctor before trying it, especially if you have liver issues, are pregnant, or are breastfeeding.

Read the full Garcinia monograph & all interactions
Keep checking

Other Drugs & Garcinia

Browse every other medication we’ve checked against Garcinia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
705Moderate
0Minor
2,124No known interaction
705 Moderate 2,124 No interaction
Moderate

705 interactions

Showing 60 of 705 moderate interactions — see all 705 on the Garcinia page.

No interaction 2,124 drugs checked — show the list

We also checked Garcinia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,124 medications checked with no known interaction — see the full Garcinia list.

See the full Garcinia interactions page
See every supplement checked against Chlorpheniramine, Methscopolamine, Phenylpropanolamine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Garcinia monograph › Uses, safety, and every drug interaction in one place Chlorpheniramine, Methscopolamine, Phenylpropanolamine supplement interactions › Every supplement checked against Chlorpheniramine, Methscopolamine, Phenylpropanolamine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Garcinia and Chlorpheniramine, Methscopolamine, Phenylpropanolamine Together: Common Questions

Can you take Garcinia with Chlorpheniramine, Methscopolamine, Phenylpropanolamine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Garcinia and Chlorpheniramine, Methscopolamine, Phenylpropanolamine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Chlorpheniramine, Methscopolamine, Phenylpropanolamine and Garcinia?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.