Garcinia + Sirolimus
Sirolimus brand name: Rapamune.
We found no known interaction between Garcinia and Sirolimus in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Garcinia and Sirolimus
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Sirolimus and Garcinia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Garcinia safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Sirolimus
Interactions in our licensed database are recorded against drug classes, not just single drug names. Sirolimus is filed under 5 classifications — including immunosuppressants, p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates. Garcinia has documented interactions with 4 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and hepatotoxic drugs (moderate) — and none of Sirolimus’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Garcinia Does Interact With Other Medications
Garcinia has 704 moderate known drug interactions in our database — Sirolimus isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Garcinia
We haven’t checked that one against Garcinia yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Garcinia. Pick one to open its full report.
Questions About Garcinia or Sirolimus
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Garcinia or Sirolimus, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Sirolimus
This page covers Garcinia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sirolimus page lists 188 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).
By severity: 3 major · 149 moderate · 36 minor.
From our pharmacist’s overview on the Sirolimus page
“Sirolimus (Rapamune) is the anti-rejection medicine transplant patients depend on, and it is a narrow-therapeutic-index drug, meaning small shifts in its blood level can invite rejection on one side or toxicity on the other. That is why the 188 supplements on this page deserve genuine wariness, starting with the three rated major.”
Reviewed by 2 · Jul 18, 2026
Taking Garcinia as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1,374 real supplement products containing Garcinia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Garcinia. Even though Garcinia itself has no known interaction with Sirolimus, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Garcinia and Sirolimus Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#164 of 1,452 supplements looked up here in the last 7 days
#2,157 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Garcinia reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Garcinia and Sirolimus records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Garcinia
What is Garcinia?
- Weight loss
- Appetite suppression
- Curbing sugar and carb cravings
- Supporting metabolism
- Traditional cooking and souring agent
Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific evidence is weak and mixed, with most studies showing only small or no meaningful weight effects, and rare reports of liver problems raise safety concerns. Talk to a pharmacist or doctor before trying it, especially if you have liver issues, are pregnant, or are breastfeeding.
Garcinia gummi-gutta · Clusiaceae · Fruit rind (pericarp) · Capsules, tablets, powders, gummies, and liquid extracts (often standardized to a percentage of HCA)
An interaction check asks whether these two react with each other — it does not ask whether Garcinia is a good idea for someone in your situation. Here is what our Garcinia record says about it on its own.
Garcinia: dosing
There is no well-established, proven dose for Garcinia. Products vary widely in their strength and in how much HCA they contain, which makes it hard to compare one product to another.If you choose to use it, follow the directions on the product label and do not exceed the recommended amount.
From our Garcinia monograph — the full record covers uses, side effects and every documented interaction.
About Sirolimus
What Is Sirolimus Used For?
Brand name: Rapamune
Sirolimus oral solution and tablets are used to help prevent organ rejection in kidney (renal) transplant patients aged 13 and older. They are also used to treat lymphangioleiomyomatosis (LAM) — a rare lung disease in which abnormal muscle-like cells invade lung tissue.
Fyarro (sirolimus, intravenous injection) is used to treat adults with locally advanced, unresectable, or metastatic malignant PEComa — a rare tumor that grows in soft tissue or organs. Hyftor (sirolimus topical gel) is used to treat facial angiofibroma (small benign skin growths on the face) associated with tuberous sclerosis in adults and children aged 6 and older.
Most-Reported Side Effects for Sirolimus
From FAERS, the FDA’s public side-effect reporting system (13,394 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Garcinia
Browse every other medication we’ve checked against Garcinia — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
704 interactions
- Diclofenac Sodium ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Insulin (rdna) ›
- Methylphenidate ›
- Naproxen ›
- Doxycycline ›
- Minocycline ›
- Tetracycline ›
- Amoxicillin ›
- Testosterone ›
- Verapamil ›
- Fenofibrate ›
- Levonorgestrel ›
- Quinidine ›
- Cyclosporine ›
- Glyburide ›
- Insulin (pork) ›
- Methyltestosterone ›
- Ciprofloxacin ›
- Fentanyl ›
- Phenytoin ›
- Allopurinol ›
- Carbamazepine ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Insulin (human) ›
- Phenylephrine ›
- Trimipramine ›
- Acetaminophen ›
- Buprenorphine ›
- Ketoprofen ›
- Methotrexate ›
- Nitrofurantoin ›
- Nortriptyline ›
- Ofloxacin ›
- Propoxyphene ›
- Rifampin ›
- Selegiline ›
- Sumatriptan Succinate ›
- Testosterone Undecanoate ›
- Acarbose ›
- Aripiprazole ›
- Bivalirudin ›
- Cyclobenzaprine ›
- Dapsone ›
- Desipramine ›
- Doxepin ›
- Doxycycline Hyclate ›
- Duloxetine ›
- Eltrombopag ›
- Insulin Glargine ›
- Interferon Alfa-2b ›
- Interferon Beta-1b ›
- Isoniazid ›
- Itraconazole ›
- Levofloxacin ›
- Metoclopramide ›
Showing 60 of 704 moderate interactions — see all 704 on the Garcinia page.
No interaction 2,125 drugs checked — show the list
We also checked Garcinia against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Amlodipine ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Metoprolol ›
- Tadalafil ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Prednisone ›
- Propranolol ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Gabapentin ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Omeprazole ›
- Letrozole ›
- Bisoprolol ›
- Candesartan Cilexetil ›
- Diazepam ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Cyclopentolate ›
- Cephalexin ›
- Mannitol ›
- Roxithromycin ›
- Levetiracetam ›
- Ezetimibe ›
- Spironolactone ›
- Phentermine, Topiramate ›
- Amlodipine Besylate, Benazepril ›
- Levothyroxine Sodium ›
- Finasteride ›
- Carbidopa, Levodopa ›
- Thyroid Hormone ›
- Pizotifen ›
- Valsartan ›
- Estrogen ›
- Daptomycin ›
- Amlodipine Besilate ›
- Levodopa ›
- Hexobarbitone ›
- Mitomycin ›
- Bromocriptine ›
- Flutemetamol F-18 ›
- Magnesium Hydroxide (otc Drug) ›
- Alprazolam ›
- Pegunigalsidase Alfa-iwxj ›
- Caffeine (otc Drug) ›
- Bentoquatam ›
- Progestin, Oral Contraceptive ›
Showing the 60 most looked-up of 2,125 medications checked with no known interaction — see the full Garcinia list.
Garcinia References
The 44 references that drive our Garcinia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 1998;280:1596-600. PubMed
- Soni MG, Burdock GA, Preuss HG, et al. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 2004;42:1513-29. PubMed
- Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
- Willis SL, Moawad FJ, Hartzell JD, et al. Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut. MedGenMed 2006;8:82.
- Preuss HG, Bagchi D, Bagchi M, et al. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 2004;6:171-180.
- Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. Am J Med Sci 2004;327:356-357. PubMed
- Lopez AM, Kornegay J, Hendrickson RG. Serotonin Toxicity Associated with Garcinia cambogia Over-the-counter Supplement. J Med Toxicol. 2014 Apr 4. [Epub ahead of print]. PubMed
- Michno A, Skibowska A, Raszeja-Specht A, Cwikowska J, Szutowicz A. The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus. Metabolism 2004;53(1):66-72. PubMed
- Asghar M, Monjok E, Kouamou G, et al. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem 2007;304(1-2):93-99. PubMed
- Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol 2005;288(6):G1144-G1149. PubMed
- Leonhardt M, Balkan B, Langhans W. Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding. Nutrition 2004;20(10):911-915. PubMed
- Bunchorntavakul, C. and Reddy, K. R. Review article: herbal and dietary supplement hepatotoxicity. Aliment.Pharmacol.Ther 2013;37(1):3-17. PubMed
- Vasques CA, Schneider R, Klein-Júnior LC, et al. Hypolipemic effect of Garcinia Cambogia in obese women. Phytother Res 2014;28(6):887-91.
- Marquez F, Babio N, Bullo M, Salas-Salvado J. Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. Crit Rev Food Sci Nutr 2012;52:585-94.
- Allen SF, Godley RW, Evron JM, et al. Acute necrotizing eosinophilic myocarditis in a patient taking Garcinia cambogia extract successfully treated with high-dose corticosteroids. Can J Cardiol 2014;30(12):1732 e13-1732 e15. PubMed
- Dara L, Hewett J, Lim JK. Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements. World J Gastroenterol. 2008 Dec 7;14(45):6999-7004. PubMed
- Sharma T, Wong L, Tsai N, Wong RD. Hydroxycut(®) (herbal weight loss supplement) induced hepatotoxicity: a case report and review of literature. Hawaii Med J. 2010 Aug;69(8):188-90.
- Rashid NN, Grant J. Hydroxycut hepatotoxicity. Med J Aust. 2010 Feb 1;192(3):173-4. PubMed
- Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis. 2007 Oct;39(10):953-5. PubMed
- Corey R, Werner KT, Singer A, Moss A, Smith M, Noelting J, Rakela J. Acute liver failure associated with Garcinia cambogia use. Ann Hepatol. 2016 Jan-Feb;15(1):123-6. PubMed
- Melendez-Rosado J, Snipelisky D, Matcha G, Stancampiano F. Acute hepatitis induced by pure Garcinia cambogia. J Clin Gastroenterol. 2015 May-Jun;49(5):449-50. PubMed
- García-Cortés M, Robles-Díaz M, Ortega-Alonso A, Medina-Caliz I, Andrade RJ. Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics. Int J Mol Sci. 2016 Apr 9;17(4):537. PubMed
- Dehoney S, Wellein M. Rhabdomyolysis associated with the nutritional supplement Hydroxycut. Am J Health Syst Pharm. 2009;66(2):142-8. PubMed
- Fong TL, Klontz KC, Canas-Coto A, et al. Hepatotoxicity due to hydroxycut: a case series. Am J Gastroenterol. 2010;105(7):1561-6. PubMed
- Hendrickson BP, Shaikh N, Occhiogrosso M, Penzner JB. Mania Induced by Garcinia cambogia: A Case Series. Prim Care Companion CNS Disord. 2016;18(2).
- Kaswala D, Shah S, Patel N, Raisoni S, Swaminathan S. Hydroxycut-induced Liver Toxicity. Ann Med Health Sci Res. 2014; 4(1):143-5. PubMed
- Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol. 2009;15(14):1786-7. PubMed
- Lunsford KE, Bodzin AS, Reino DC, Wang HL, Busuttil RW. Dangerous dietary supplements: Garcinia cambogia -associated hepatic failure requiring transplantation. World J Gastroenterol. 2016;22(45):10071-10076.
- Narasimha A, Shetty PH, Nanjundaswamy MH, Viswanath B, Bada Math S. Hydroxycut - Dietary supplements for weight loss: Can they induce mania? Aust N Z J Psychiatry. 2013;47(12):1205-6. PubMed
- Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci. 2009;54(2):406-8. PubMed
- Stohs SJ, Preuss HG, Ohia SE, et al. No evidence demonstrating hepatotoxicity associated with hydroxycitric acid. World J Gastroenterol. 2009;15(32):4087-9. PubMed
- Gavril A, Ribnikar M, Smid L, Luzar B, Stabuc B. Fat burner-induced acute liver injury: case series of four patients. Nutrition. 2018;47:110-114. doi: 10.1016/j.nut.2017.10.002. PubMed
- Bystrak T, Cervera-Hernandez ME, Reddy N, King Z, Bratberg J. Garcinia cambogia, diabetic ketoacidosis, and pancreatitis. R I Med J (2013). 2017 Oct 2;100(10):48-50. NO DOI
- Smith RJ, Bertilone C, Robertson AG. Fulminant liver failure and transplantation after use of dietary supplements. Med J Aust. 2016;204(1):30-2. PubMed
- Nguyen DC, Timmer TK, Davison BC, McGrane IR. Possible Garcinia cambogia-induced mania with psychosis: a case report. J Pharm Pract 2019;32(1):99-102. doi: 10.1177/0897190017734728.
- Yousaf MN, Chaudhary FS, Hodanazari SM, Sittambalam CD. Hepatotoxicity associated with Garcinia cambogia: a case report. World J Hepatol 2019;11(11):735-42.
- Mas Ordeig A, Bordón García N. Hepatotoxicity caused by Garcinia cambogia. Gastroenterol Hepatol 2020;43(3):134-5. DOI
- Cho HK, Han YS, Park JM. Ocular complications of Garcinia cambogia extract diet pills: case report. Eur J Ophthalmol 2019:1120672119872364. PubMed
- Ferreira V, Mathieu A, Soucy G, Giard JM, Erard-Poinsot D. Acute severe liver injury related to long-term Garcinia cambogia intake. ACG Case Rep J. 2020;7(8):e00429. PubMed
- Iqbal U, Anwar H, Siddiqui HU, Mehmood A. Acute Pancreatitis Secondary to Use of Appetite Suppressant: Garcinia cambogia. Cureus. 2019;11(5):e4676. PubMed
- Grigos A, Benmoussa J, Sandhu J, Chaucer B, Clarke M, SH Patel. Acute pancreatitis secondary to Garcinia cambogia; the unknown cost of herbal supplements. JOP. J Pancreas (Online) 2016; 17(3):316-317.
- Sidhu RLS, Labana S, Khehra L. Garcinia cambogia: a link between the "miracle" weight loss pill and acute pancreatitis. Am J Gastroenterol. 2016. 111:S560-S561. DOI
- Vuppalanchi R, Bonkovsky HL, Ahmad J, et al. Garcinia cambogia, Either Alone or in Combination With Green Tea, Causes Moderate to Severe Liver Injury. Clin Gastroenterol Hepatol 2021. PubMed
- Calaquian LL, Yau I. Garcinia cambogia-A Supplement-Related Liver Injury. Cureus 2022;14(2):e22225. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Garcinia and Sirolimus Together: Common Questions
Is it safe to take Garcinia with Sirolimus?
Do Garcinia and Sirolimus have any of the same side effects?
How was the Garcinia and Sirolimus combination checked?
Does Garcinia interact with any other medications?
Does Sirolimus interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.