Grapefruit - Bavencio (Avelumab) Interaction
Herbal: Grapefruit
Also Known As: Citrus paradisi
Drug: Avelumab
Brand names:
Bavencio
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
There were no interactions found between Avelumab and Grapefruit. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Grapefruit Overview
Grapefruit is a tropical citrus fruit known for its tart and tangy flavor. They are a good source of vitamin C and other nutrients, including vitamin A, potassium, and fiber.
There are several varieties of grapefruits, including white, pink, and red. This color difference is mostly attributed to their respective lycopene content. White grapefruits are the most common and have a slightly bitter taste. Pink and red grapefruits are sweeter and have a more complex flavor.
Grapefruit and grapefruit seed extract is commonly used in dietary supplements for a variety of conditions, such as yeast infections, urinary tract infections, and respiratory infections. It is also sometimes used to treat digestive problems, such as diarrhea and indigestion.
Drug interactions with grapefruit are quite prevalent and if you take prescription medication, you should talk with your doctor or pharmacist first before consuming grapefruit.
Avelumab Overview
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Avelumab injection is used to treat Merkel cell carcinoma (MCC; a type of skin cancer) that has spread to other parts of the body in adults and children 12 years of age and older. Avelumab injection is also used to treat urothelial cancer (cancer of the lining of the bladder and other parts of the urinary tract) that has spread to nearby tissues or other parts of the body in people whose cancer worsened during or within 12 months after it was treated with platinum chemotherapy medications. It is also used as ongoing treatment for urothelial cancer that has spread to nearby tissues or other parts of the body to help maintain the response to platinum chemotherapy. Avelumab injection is also used in combination with axitinib (Inlyta) as a first treatment for renal cell carcinoma (RCC; cancer that begins in the kidney) that has spread or cannot be removed by surgery. Avelumab injection is in a class of medications called monoclonal antibodies. It works by helping the body to slow or stop the growth of cancer cells.
Grapefruit - More Interactions
Grapefruit interacts with 963 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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