Drug & supplement interaction

Ilex Guayusa + Griseofulvin

Griseofulvin brand names: Fulvicin PG, Fulvicin-U/F, Grisactin Ultra, Grisactin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Ilex Guayusa and Griseofulvin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Ilex Guayusa and Griseofulvin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Griseofulvin and Ilex Guayusa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ilex Guayusa safety at a glance

Ilex Guayusa overall Use caution Generally well tolerated in tea amounts, but it contains caffeine that can cause stimulant side effects.
Pregnancy Use caution Limit or avoid because of its caffeine content and a lack of safety studies in pregnancy.
Breastfeeding Use caution Caffeine passes into breast milk, so limit intake or avoid until more is known.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Griseofulvin and Ilex Guayusa? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Griseofulvin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Griseofulvin is filed under 5 classifications — including antifungals, cytochrome p450 3a4 (cyp3a4) inducers, photosensitizing drugs. Ilex Guayusa has documented interactions with 37 drug classes — the most serious being ephedrine (major), adenosine (adenocard) (moderate) and anticoagulant/antiplatelet drugs (moderate) — and none of Griseofulvin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ilex Guayusa Does Interact With Other Medications

Ilex Guayusa has 8 major, 470 moderate, 127 minor known drug interactions in our database — Griseofulvin isn’t one of them. If you take anything else, check it against the full list below.

Major 8 Moderate 470 Minor 127 No known interaction 2,225 (incl. Griseofulvin)
Taking anything else?

Check Another of Your Medications Against Ilex Guayusa

Covers the 2,830 medications we’ve checked against Ilex Guayusa. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Ilex Guayusa and Griseofulvin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Confusion Worth acting on Additional detail

    Ilex Guayusa

    “Chronic use of caffeine, especially in large amounts, may produce tolerance, habituation, and psychological dependence. There is some concern that stopping regular use of caffeine may cause withdrawal symptoms such as headache, tiredness and fatigue, decreased energy, alertness, and attentiveness, drowsiness, decreased contentedness, depressed mood, difficulty concentrating, irritability, and lack of clear-headedness…”

    Ilex Guayusa · Natural Medicines adverse-effect record, reported in anxiety.

    5 sources cited
    1. 3719. Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24. PubMed
    2. 13738. Juliano LM, Griffiths RR. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology (Berl) 2004;176:1-29. PubMed
    3. 2723. Dews PB, Curtis GL, Hanford KJ, O'Brien CP. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. J Clin Pharmacol 1999;39:1221-32. PubMed
    4. 11839. Dews PB, O'Brien CP, Bergman J. Caffeine: behavioral effects of withdrawal and related issues. Food Chem Toxicol 2002;40:1257-61. PubMed
    5. 13736. Anderson BJ, Gunn TR, Holford NH, Johnson R. Caffeine overdose in a premature infant: clinical course and pharmacokinetics. Anaesth Intensive Care 1999;27:307-11. PubMed

    Griseofulvin

    Listed in the ADVERSE REACTIONS section of the FDA label for Griseofulvin. Read the label on DailyMed ›

  • Swelling Additional detail

    Ilex Guayusa

    “Some evidence shows that caffeine, a constituent of Ilex guayusa, is associated with fibrocystic breast disease, breast cancer, and endometriosis in females; however, this is controversial since findings are conflicting. Restricting caffeine in females with fibrocystic breast conditions doesn't seem to affect breast nodularity, swelling, or pain.”

    Ilex Guayusa · Natural Medicines adverse-effect record, reported in breast cancer.

    5 sources cited
    1. 8043. Ferrini RL, Barrett-Connor E. Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. Am J Epidemiol 1996:144:642-4. PubMed
    2. 8996. Horner NK, Lampe JW. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. J Am Diet Assoc 2000;100:1368-80. PubMed
    3. 108806. Zheng KH, Zhu K, Wactawski-Wende J, et al. Caffeine intake from coffee and tea and invasive breast cancer incidence among postmenopausal women in the Women's Health Initiative. Int J Cancer 2021;149(12):2032-2044. PubMed
    4. 108807. Wang S, Li X, Yang Y, et al. Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis. Public Health Nutr 2021;24(18):6377-6389. PubMed
    5. 91023. Beaudoin MS, Allen B, Mazzetti G, Sullivan PJ, Graham TE. Caffeine ingestion impairs insulin sensitivity in a dose-dependent manner in both men and women. Appl Physiol Nutr Metab. 2013;38(2):140-7. doi: 10.1139/apnm-2012-0201. Epub 2012 9. PubMed

    Griseofulvin

    Listed in the ADVERSE REACTIONS section of the FDA label for Griseofulvin. Read the label on DailyMed ›

  • Tiredness / Headache Additional detail

    Ilex Guayusa

    Recorded for Ilex Guayusa in the same Natural Medicines adverse-effect record shown under Confusion above.

    Griseofulvin

    Listed in the ADVERSE REACTIONS section of the FDA label for Griseofulvin. Read the label on DailyMed ›

Reported for Ilex Guayusa but not commonly for Griseofulvin: trouble concentrating, dependence or withdrawal symptoms, raised blood pressure and low mood.

Effects for Griseofulvin come from the ADVERSE REACTIONS section of its FDA label; effects for Ilex Guayusa come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Griseofulvin

This page covers Ilex Guayusa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Griseofulvin page lists 61 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Alfalfa (moderate), Alkanna (moderate), Alpine Ragwort (moderate) and Angelica Archangelica (moderate).

By severity: 1 major · 47 moderate · 13 minor.

From our pharmacist’s overview on the Griseofulvin page

“If you take griseofulvin for a fungal infection of the skin, scalp, or nails, give this list of 61 ingredients real attention. The single major entry is activated charcoal, which binds the drug in your gut so less of it reaches your blood and the infection gets less treatment.”

Reviewed by 2 · Jul 18, 2026

Open the Griseofulvin interaction page

How much people look this up

Where Ilex Guayusa and Griseofulvin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ilex Guayusa
Steady interest

#821 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Griseofulvin
Top half

#860 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ilex Guayusa reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Ilex Guayusa and Griseofulvin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ilex Guayusa

What is Ilex Guayusa?

  • Energy and alertness
  • Mental focus
  • Antioxidant support
  • Appetite control
  • Athletic and physical performance

Ilex guayusa is a caffeine-containing holly leaf from the Amazon, traditionally brewed as a tea for energy and alertness, much like yerba mate or green tea. There is limited human research confirming specific health benefits, and its main reliable effect comes from its caffeine content. Because it is a stimulant, use it cautiously and check with your pharmacist or doctor if you have heart concerns or are pregnant.

Ilex guayusa · Aquifoliaceae · Leaves · Tea, brewed infusion, capsules, powdered extract, energy drinks

An interaction check asks whether these two react with each other — it does not ask whether Ilex Guayusa is a good idea for someone in your situation. Here is what our Ilex Guayusa record says about it on its own.

Ilex Guayusa: dosing

There is no official standardized dose for guayusa. It is most commonly taken as a brewed tea, and the amount of caffeine you get can vary widely depending on how much leaf you use and how long you steep it.If you use a packaged product, follow the directions on the label and do not exceed the recommended serving. Keep your total daily caffeine from all sources in mind.

From our Ilex Guayusa monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ilex Guayusa monograph & all interactions
Medication

About Griseofulvin

What Is Griseofulvin Used For?

Brand names: Fulvicin PG, Fulvicin-U/F, Grisactin Ultra, Grisactin

Griseofulvin treats dermatophyte (ringworm-type) fungal infections of the skin, hair, and nails that haven't cleared up with topical (cream or ointment) treatment alone. It is used for tinea corporis (ringworm of the body), tinea pedis (athlete's foot), tinea cruris (jock itch), tinea barbae (ringworm of the beard area), tinea capitis (ringworm of the scalp), and tinea unguium (fungal nail infection).

It only works against specific dermatophyte fungi. Griseofulvin does not treat bacterial infections, yeast infections (candidiasis), or other fungal infections such as histoplasmosis, sporotrichosis, or tinea versicolor. A lab test or fungal culture should confirm the infection before treatment starts.

See full Griseofulvin drug information
Keep checking

Other Drugs & Ilex Guayusa

Browse every other medication we’ve checked against Ilex Guayusa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

8Major
470Moderate
127Minor
2,224No known interaction
8 Major 470 Moderate 127 Minor 2,224 No interaction
Major

8 interactions

Moderate

470 interactions

Showing 60 of 470 moderate interactions — see all 470 on the Ilex Guayusa page.

Minor

127 interactions

Showing 60 of 127 minor interactions — see all 127 on the Ilex Guayusa page.

No interaction 2,224 drugs checked — show the list

We also checked Ilex Guayusa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,224 medications checked with no known interaction — see the full Ilex Guayusa list.

See the full Ilex Guayusa interactions page
See every supplement checked against Griseofulvin, ranked by severity
Evidence & sources

Ilex Guayusa References

The 90 references that drive our Ilex Guayusa monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. PubMed
  3. Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. PubMed
  4. Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. PubMed
  5. Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. PubMed
  6. Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3.
  7. Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. PubMed
  8. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  9. Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669-73. PubMed
  10. Hodgson JM, Puddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457-63. PubMed
  11. Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700. PubMed
  12. Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40. PubMed
  13. Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999;53:831-9. PubMed
  14. Dews PB, Curtis GL, Hanford KJ, O'Brien CP. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. J Clin Pharmacol 1999;39:1221-32. PubMed
  15. Boozer CN, Nasser JA, Heymsfield SB, et al. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes Relat Metab Disord 2001;25:316-24. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ilex Guayusa and Griseofulvin Together: Common Questions

Is it safe to take Ilex Guayusa with Griseofulvin?
We do not list a known interaction between Ilex Guayusa and Griseofulvin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Ilex Guayusa and Griseofulvin have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Ilex Guayusa and Griseofulvin combination checked?
Interactions in our licensed database are recorded against drug classes. Griseofulvin is filed under 5 classifications, and Ilex Guayusa has documented interactions with 37 drug classes — none of Griseofulvin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ilex Guayusa interact with any other medications?
Yes. Ilex Guayusa has 605 documented drug interactions in our database — Griseofulvin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Griseofulvin interact with any supplements?
Yes. Griseofulvin has documented interactions with 61 supplements in our database — Ilex Guayusa is not one of them. The Griseofulvin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ilex Guayusa monograph Uses, safety profile, and every drug interaction in one place Griseofulvin drug information The full plain-English guide to this medication Griseofulvin supplement interactions Every supplement checked against Griseofulvin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 90 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.